Syringomyelia Managed with Classical Homeopathy, A Case Report

Background: Syringomyelia (SM) with Chiari malformation is a rare disease with an unpredictable course. Surgery and other interventions help reduce the severity of symptoms, but over 50% patients require re-operation. Auto-resolution is rare in this type of SM, and most cases progress to complications, which may amount to a great burden. Case presentation: We present a case of SM with Arnold-Chiari malformation type 1 in a 54-year-old Russian woman who was treated with individualized classical homeopathy for over eight years with remarkable improvement in the clinical signs and symptoms of the condition and comorbidities. On MRI, the syrinx completely resolved, which further confirmed the benefit of this therapy. Conclusion: This case of SM with Arnold-Chiari malformation type 1 seemed to benefit from individualized classical homeopathy. Scientific investigation into an individualized classical homeopathic approach towards SM is necessary to establish its relevance in this condition.

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Bilateral visual impairment as a rare manifestation of Arnold Chiari malformation type 1

Journal of the Neurological Sciences ◽

10.1016/j.jns.2021.118897 ◽

2021 ◽

Vol 429 ◽

pp. 118897

Author(s):

Pramod Dhonde

Keyword(s):

Visual Impairment ◽

Chiari Malformation ◽

Arnold Chiari Malformation ◽

Rare Manifestation ◽

Chiari Malformation Type 1

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Primary Manifestation of Sarcoidosis Involving the Gingivae

International Journal of Experimental Dental Science ◽

10.5005/jp-journals-10029-1025 ◽

2012 ◽

Vol 1 (2) ◽

pp. 102-105 ◽

Cited By ~ 2

Author(s):

Catherine Saylor ◽

Nabil Beaini ◽

James Rokos ◽

Keerthana Satheesh ◽

Charles Cobb

Keyword(s):

Clinical Signs ◽

Signs And Symptoms ◽

Definitive Diagnosis ◽

Anatomical Location ◽

Case Presentation ◽

Histologic Analysis ◽

Appropriate Treatment ◽

Clinical Signs And Symptoms

ABSTRACT Sarcoidois of the gingiva is rarely the primary manifestation of the disease. The following case presentation highlights clinical signs and symptoms that are not uncommon or unusual except for the anatomical location of the initial expression. Appropriate treatment must be based on a definitive diagnosis which, in turn, requires a biopsy for histologic analysis. How to cite this article Saylor C, Beaini N, Rokos J, Satheesh K, Cobb C. Primary Manifestation of Sarcoidosis Involving the Gingivae. Int J Experiment Dent Sci 2012;1(2):102-105.

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Neurological image of the child with neural tube defect (meningomyelocele) with Arnold-Chiari malformation type 1 with syringomyelia with obstructive hydrocephalus: Observation of folic acid supplementation failure in eliminating the risk of NTD in neonate of the mother taking anti-epileptic medicine

Medical Journal of Dr D Y Patil University ◽

10.4103/0975-2870.164972 ◽

2015 ◽

Vol 8 (5) ◽

pp. 688

Author(s):

Deepak Sharma ◽

Hemanth Parakh ◽

MonicaSachdeva Kapoor ◽

Aniruddha Deshpande

Keyword(s):

Folic Acid ◽

Neural Tube ◽

Neural Tube Defect ◽

Chiari Malformation ◽

Obstructive Hydrocephalus ◽

Folic Acid Supplementation ◽

Acid Supplementation ◽

Arnold Chiari Malformation ◽

Chiari Malformation Type 1

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MicroRNA-Based Therapeutic Perspectives in Myotonic Dystrophy

International Journal of Molecular Sciences ◽

10.3390/ijms20225600 ◽

2019 ◽

Vol 20 (22) ◽

pp. 5600 ◽

Cited By ~ 3

Author(s):

Arturo López Castel ◽

Sarah Joann Overby ◽

Rubén Artero

Keyword(s):

Myotonic Dystrophy ◽

Rna Binding ◽

Clinical Symptoms ◽

Clinical Signs ◽

Neuromuscular Diseases ◽

Signs And Symptoms ◽

Disease Biomarkers ◽

Clinical Signs And Symptoms

Myotonic dystrophy involves two types of chronically debilitating rare neuromuscular diseases: type 1 (DM1) and type 2 (DM2). Both share similarities in molecular cause, clinical signs, and symptoms with DM2 patients usually displaying milder phenotypes. It is well documented that key clinical symptoms in DM are associated with a strong mis-regulation of RNA metabolism observed in patient’s cells. This mis-regulation is triggered by two leading DM-linked events: the sequestration of Muscleblind-like proteins (MBNL) and the mis-regulation of the CUGBP RNA-Binding Protein Elav-Like Family Member 1 (CELF1) that cause significant alterations to their important functions in RNA processing. It has been suggested that DM1 may be treatable through endogenous modulation of the expression of MBNL and CELF1 proteins. In this study, we analyzed the recent identification of the involvement of microRNA (miRNA) molecules in DM and focus on the modulation of these miRNAs to therapeutically restore normal MBNL or CELF1 function. We also discuss additional prospective miRNA targets, the use of miRNAs as disease biomarkers, and additional promising miRNA-based and miRNA-targeting drug development strategies. This review provides a unifying overview of the dispersed data on miRNA available in the context of DM.

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In Reply to "Letter to the Editor Regarding Meningitis or Xenograft: What Is Incriminating for Cerebrospinal Fluid Diversion in Arnold Chiari Malformation Type 1?"

World Neurosurgery ◽

10.1016/j.wneu.2019.08.072 ◽

2019 ◽

Vol 131 ◽

pp. 310

Author(s):

Michael M. McDowell ◽

Robert M. Friedlander

Keyword(s):

Cerebrospinal Fluid ◽

Chiari Malformation ◽

Arnold Chiari Malformation ◽

Cerebrospinal Fluid Diversion ◽

Letter To The Editor ◽

Chiari Malformation Type 1

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Surgical treatment of Chiari malformation with and without syringomyelia: experience with 177 adult patients

Journal of Neurosurgery ◽

10.3171/2012.10.jns12305 ◽

2013 ◽

Vol 118 (2) ◽

pp. 232-242 ◽

Cited By ~ 53

Author(s):

Ulrich Batzdorf ◽

David L. McArthur ◽

John R. Bentson

Keyword(s):

Clinical Outcome ◽

Posterior Fossa ◽

Chiari Malformation ◽

Clinical Signs ◽

Signs And Symptoms ◽

Surgical Decompression ◽

Imaging Studies ◽

Clinical Signs And Symptoms ◽

The Relationship ◽

Cerebellar Tonsils

Object This study aims to show the relationship between clinical outcome in patients who underwent surgical decompression for Chiari malformation (CM) and postoperative imaging studies, with particular emphasis on the subarachnoid cisterns of the posterior fossa. Methods One hundred seventy-seven patients with CM, including 97 with syringomyelia, underwent posterior fossa decompressive surgery. Both the dura and arachnoid were opened in 150 of these patients, and 135 underwent reduction of the cerebellar tonsils. The patients' clinical signs and symptoms were evaluated at 2 time points after surgery. Their imaging studies were analyzed specifically for the size of the retrotonsillar and subtonsillar cisterns and the syringomyelic cavities. The authors evaluated the relationship between these imaging findings and clinical parameters. Results Clinical improvement correlated strongly with enlargement of the subarachnoid cisterns, and enlargement of the cisterns also correlated with reduction in size of the syrinx cavities. Symptoms related to syringomyelia responded to reduction in size of the syrinx cavities. Conclusions Surgical decompression of the posterior fossa should aim to create relatively large subarachnoid cisterns and reduce the size of the syrinx cavity. Reduction of the cerebellar tonsils by surgical means, together with duraplasty, achieves this goal and thereby improves the clinical outcome for patients with CM. An incidental observation of the study is that obesity increases the likelihood of headache in patients with CM.

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