The use of Injectable Nonsteroidal Anti-Inflammatory Drugs in Local Accident & Emergency Practice

2002 ◽  
Vol 9 (2) ◽  
pp. 65-71 ◽  
Author(s):  
CH Chung
Keyword(s):  
Computer Systems ◽  
Oral Route ◽  
Intramuscular Administration ◽  
Narcotic Analgesics ◽  
Hospital Authority ◽  
Local Complications ◽  
Utilization Data ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Fast Acting

Objective To review the utilization of injectable NSAID in local A&E practice. Materials and Methods NSAID utilization data, in relation to type and specialty, were retrieved through the hospital and central pharmacy computer systems of the Hospital Authority. Results A&E departments were the main users of injectable NSAID. Their expenditure exceeded other forms of NSAID and narcotic analgesics. Conclusion It seems that the use of injectable NSAID in local A&E practice may be excessive. The oral route should be the first consideration, as fast acting oral preparations are now available. As there are risks of severe local complications, stringent justifications should be confirmed before intramuscular administration.

scholarly journals Prevention and Treatment of Back Pain: Experts’ Consensus Recommendations

Doctor Ru ◽  
2020 ◽  
Vol 19 (9) ◽  
pp. 45-52
Author(s):  
A.L. Vertkin ◽  
◽  
M.M. Shamuilova ◽  
G.Yu. Knorring ◽  
Yu.V. Sedyakina ◽  
...  
Keyword(s):  
Back Pain ◽  
General Practitioners ◽  
Optimal Treatment ◽  
Prolonged Action ◽  
Consensus Recommendations ◽  
Psychological Tools ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Fast Acting ◽  
Action Structure

Objective of the Review: To present, for internists and general practitioners, two sets of multidisciplinary consensus recommendations for the management of patients with back pain. Key Points: The paper includes short diagnostic protocols, red flag screening protocols, and criteria for involving specialists from related fields, starting physiotherapy, and using a battery of psychological tools. Also covered are criteria for optimal treatment with medications, including fast-acting analgesics (particularly non-steroidal anti-inflammatory drugs) and prolonged-action structure-modifying drugs. Conclusion: The management of patients with non-specific back pain is dealt with by internists or general practitioners. It requires a clear, structured approach to identifying red flags and bringing in specialists from related fields; lifestyle and diet modifications; exercise and physical therapy; a battery of psychological tools; and, without question, optimal treatment with medications, including fast-acting analgesics and prolonged-action structure-modifying drugs. Keywords: non-steroidal anti-inflammatory drugs, back pain, treatment protocol, neurotropic B vitamins, prolonged-action structuremodifying drugs.

scholarly journals Justification of the use of non-steroidal anti-inflammatory drugs injectable forms

2020 ◽  
Vol 4 (8) ◽  
pp. 518-524
Author(s):  
A.E. Karateev ◽  
Keyword(s):  
Clinical Studies ◽  
Adverse Reactions ◽  
Ease Of Use ◽  
Open Label ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Fast Acting ◽  
Active Substances ◽  
Russian Medical ◽  
Injectable Form

Treatment of acute intense pain requires the use of strong fast-acting analgesics, such as parenteral forms of non-steroidal anti-inflammatory drugs (NSAIDs). Intravenous and intramuscular (i.m.) NSAIDs administration increases the bioavailability of active substances, allows for analgesic therapy in the presence of restrictions for oral administration, and is predominant in the rate of analgesic action onset versus the latter. When choosing NSAIDs for i.m. administration, the risk of topical post-injection and systemic adverse reactions should be considered. Original meloxicam for i.m. injection is characterized by a favorable risk-benefit ratio and ease of use. In clinical studies, there was no significant increase in creatinine phosphokinase levels, reflecting damage to muscle fibers, after a series of injections of meloxicam i.m. versus other NSAIDs, such as diclofenac and piroxicam. During the search in PubMed, Medline, Google, there was no description of serious topical complications after i.m. administration of meloxicam. In recent years, several large open-label studies have been conducted in Russia demonstrating the efficacy and safety of meloxicam injectable form in acute/subacute non-specific back pain and injuries. The review provides a brief description of the main clinical studies concerning the original meloxicam for i.m. injection.KEYWORDS: NSAIDs, meloxicam, intramuscularly, efficacy, safety.FOR CITATION: Karateev A.E. Justification of the use of non-steroidal anti-inflammatory drugs injectable forms. Russian Medical Inquiry. 2020;4(8):518–524. DOI: 10.32364/2587-6821-2020-4-8-518-524.

scholarly journals Modern Approaches to the Elimination of Visceral Pain

Health of Man ◽  
2021 ◽  
pp. 40-46
Author(s):  
Yurii Kobeliatskyi
Keyword(s):  
Renal Colic ◽  
Visceral Pain ◽  
Pain Syndrome ◽  
Modern Medicine ◽  
Muscle Spasm ◽  
Narcotic Analgesics ◽  
The World ◽  
Inflammatory Drugs ◽  
Antispasmodic Effect ◽  
Anti Inflammatory

In modern medicine, one of the most common situations requiring emergency care is biliary or renal colic as a manifestation of abdominal pain syndrome. In both cases, smooth muscle spasm plays an important role in the pathogenesis of visceral pain syndrome. Taking into account the fact that, regardless of the chosen treatment tactics, at the first stage it is necessary to stop pain, the question arises about the choice of a drug strategy for the relief of these conditions. It used to be thought that the more intense the pain, the more indications for the prescription of narcotic drugs, which were considered reference analgesics. In recent years, the world has become embroiled in an «opioid crisis». This prompted clinicians to consider the use of drugs from other groups, namely, non-steroidal anti-inflammatory drugs and antispasmodics alone or in combination, which turned out to be no less effective and, often, safer in comparison with narcotic analgesics. New opportunities for effective treatment of visceral pain are opened by the drug Neospastil® (PJSC «Pharmaceutical Company «Darnitsa»), which combines the benefits of nonsteroidal anti-inflammatory drugs (ketorolac tromethamine) with antispasmodic effect of cholinolytics, ganglioblockers and phenytoin phenytoin. The drug increases the effectiveness of analgesia, as well as the control of muscle spasm.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

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