The effect of analytical temperature on thromboelastography tracings in dogs

2021 ◽  
pp. 104063872110429
Author(s):  
Marie T. Keith ◽  
Nolan V. Chalifoux ◽  
Yekaterina Buriko
Keyword(s):  
Body Temperature ◽  
Alpha Angle ◽  
In Vitro Study ◽  
Potential Effect ◽  
Body Temperatures ◽  
Normal Body Temperature ◽  
Normal Body ◽  
Clinically Normal ◽  
Very High

Viscoelastic testing methods such as thromboelastography (TEG) are becoming increasingly available to veterinarians in a clinical setting. TEG is useful in determining therapeutic transfusion needs and assessing global abnormalities of hemostasis of patients, given that it provides a more comprehensive assessment of coagulation than traditional tests. TEG is standardly performed at 37°C, which is considered a normal body temperature for human patients; however, 37°C is lower than normal body temperature for most canine patients. In an in vitro study, we investigated the potential effect that this difference in body temperature and test temperature might have on TEG results. Citrated blood samples were collected from clinically normal, as well as sick, dogs with various body temperatures. Samples were analyzed concurrently at the patient’s body temperature and at 37°C. There was very high correlation between TEG performed at body temperature and at 37°C for R (min) and MA (mm), high correlation for K (min) and alpha angle (deg), and moderate correlation for LY30 (%) and LY60 (%). For canine patients with normal to mildly abnormal body temperatures, performance of TEG at the standard 37°C is acceptable.

Effects of Temperature and Volatile Anesthetics on GABAAReceptors 

1999 ◽  
Vol 90 (2) ◽  
pp. 484-491 ◽  
Author(s):  
Andrew Jenkins ◽  
Nicholas P. Franks ◽  
William R. Lieb
Keyword(s):  
Body Temperature ◽  
General Anesthesia ◽  
Volatile Anesthetic ◽  
Gaba Concentration ◽  
Normal Body Temperature ◽  
Gaba A ◽  
Normal Body ◽  
Anesthetic Agents ◽  
Receptor Channel

Background Potentiation of the activity of the gamma-aminobutyric acid type A (GABA(A)) receptor channel by volatile anesthetic agents is usually studied in vitro at room temperature. Systematic variation of temperature can be used to assess the relevance of this receptor to general anesthesia and to characterize the modulation of its behavior by volatile agents at normal body temperature. Methods Potentiation of the GABA(A) receptor by halothane, sevoflurane, isoflurane, and methoxyflurane was studied at six temperatures in the range 10-37 degrees C using the whole-cell patch-clamp technique and mouse fibroblast cells stably transfected with defined GABA(A) receptor subunits. Results Control GABA concentration-response plots showed small and physically reasonable changes in the GABA concentration required for a half-maximal effect, the Hill coefficient, and maximal response over the range 10-30 degrees C. Potentiations of GABA (1 microM) responses by aqueous minimum alveolar concentrations of the volatile anesthetic agents decreased with increasing temperature from 10-37 degrees C in an agent-specific manner (methoxyflurane > isoflurane > sevoflurane > halothane) but tended to equalize at normal body temperature (37 degrees C). These findings are in line with published results on the temperature dependence of anesthetic potencies in animals. Conclusions These results are consistent with direct binding of volatile anesthetic agents to the GABA(A) receptor channel playing an important role in general anesthesia. The finding that the degree of anesthetic potentiation was agent-specific at low temperatures but not at 37 degrees C emphasizes the importance of doing in vitro experiments at normal body temperature.

THE INFLUENCE OF HYPOTHERMIA ON THE UPTAKE OF 131I BY THE THYROID

1953 ◽  
Vol 10 (1) ◽  
pp. 46-53 ◽  
Author(s):  
F. VERZÁR ◽  
V. VIDOVIC ◽  
S. HAJDUKOVIC
Keyword(s):  
Body Temperature ◽  
Thyroid Gland ◽  
Living Animal ◽  
Body Temperatures ◽  
Thyroid Activity ◽  
Normal Body Temperature ◽  
Normal Body ◽  
Long Period

SUMMARY 1. Thyroid activity was studied with 131I injected intraperitoneally. The uptake of 131I was followed in the living animal. The animals were brought into a state of hypoxic hypothermia by Giaja's method [1940]. 2. The thyroid gland is completely inactive at body temperatures of between 15 and 20° C. 3. At body temperatures of between 23 and 28° C, thyroid activity is decreased, but is large enough, over a sufficiently long period of time, to concentrate normal quantities of iodine. 4. Thyroid activity is unchanged when a normal body temperature is regained after a single or four to six successive phases of hypothermia.

scholarly journals Conjunction between the Ladyfinger Likeness and Human Normal Body Temperature in Fahrenheit

2019 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Body Temperature ◽  
Vitamin A ◽  
Undergraduate Students ◽  
Homo Sapiens ◽  
Optimum Temperature ◽  
Body Temperatures ◽  
Normal Body Temperature ◽  
Temperature Range ◽  
Normal Body

The purpose of this study was to show the conjunction between the ladyfinger likeness and human normal body temperature. Normal body temperature in human is the temperature range in Homo sapiens. Normal body temperature in human ranged as 97.7 to 99.5 ºF. It is balanced by the process of thermoregulation. The optimum temperature in the human is 98.6 ºF which is 37.0 in degrees. Ladyfinger is the vegetable which is used to cook. Ladyfinger also improves the vision quality because in it vitamin A is present. During the project designing, we designed the project related to the linkage of likeness of ladyfinger with the normal body temperature. 131 companions were joined in this project studies to whom we asked about their normal body temperatures. These companions were the undergraduate students of University. We took the thermometer. Then we selected the site at which we wanted to measure the temperature. Students came to us one by one. Firstly one student came to us. We placed the thermometer in the mouth. The readings appeared on the thermometer after few seconds and we calculated the reading and noted down on the page. It is excluded that there is no conjunction between the ladyfinger likeness and human normal body temperature.

Effects of successive carbon monoxide exposures on delayed neuronal death in mice under the maintenance of normal body temperature

1991 ◽  
Vol 179 (2) ◽  
pp. 836-840 ◽  
Author(s):  
Hirohisa Ishimaru ◽  
Toshitaka Nabeshima ◽  
Akira Katoh ◽  
Hirotaka Suzuki ◽  
Taneo Fukuta ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Body Temperature ◽  
Neuronal Death ◽  
Delayed Neuronal Death ◽  
Normal Body Temperature ◽  
Normal Body

scholarly journals Distribution of Pediatric Vital Signs in the Emergency Department: A Nationwide Study

Children ◽  
2020 ◽  
Vol 7 (8) ◽  
pp. 89
Author(s):  
Woori Bae ◽  
Kyunghoon Kim ◽  
Bongjin Lee
Keyword(s):  
Emergency Department ◽  
Heart Rate ◽  
Body Temperature ◽  
Respiratory Rate ◽  
Life Support ◽  
Vital Signs ◽  
Reference Ranges ◽  
Normal Body Temperature ◽  
Heart Rates ◽  
Normal Body

To effectively use vital signs as indicators in children, the magnitude of deviation from expected vital sign distribution should be determined. The purpose of this study is to derive age-specific centile charts for the heart rate and respiratory rate of the children who visited the emergency department. This study used the Korea’s National Emergency Department Information System dataset. Patients aged <16 years visiting the emergency department between 1 January 2016 and 31 December 2017 were included. Heart rate and respiratory rate centile charts were derived from the population with normal body temperature (36 to <38 °C). Of 1,901,816 data points retrieved from the database, 1,454,372 sets of heart rates and 1,458,791 sets of respiratory rates were used to derive centile charts. Age-specific centile charts and curves of heart rates and respiratory rates showed a decline in heart rate and respiratory rate from birth to early adolescence. There were substantial discrepancies in the reference ranges of Advanced Paediatric Life Support and Pediatric Advanced Life Support guidelines. Age-based heart rate and respiratory rate centile charts at normal body temperature, derived from children visiting emergency departments, serve as new evidence-based data and can be used in follow-up studies to improve clinical care for children.

scholarly journals The Importance of Changes in Body Temperature in Paediatric Surgery and Anaesthesia

1973 ◽  
Vol 1 (6) ◽  
pp. 480-485 ◽  
Author(s):  
Nerida M. Dilworth
Keyword(s):  
Body Temperature ◽  
Newborn Infant ◽  
Paediatric Anaesthesia ◽  
Considerable Importance ◽  
Accidental Hypothermia ◽  
Paediatric Surgery ◽  
Normal Body Temperature ◽  
Normal Body ◽  
The Subject

An understanding of the maintenance of normal body temperature, and the manner in which surgery, anaesthesia, and related procedures may disturb thermoregulation, is of considerable importance in paediatric anaesthesia. The subject of accidental hypothermia, with particular reference to the newborn infant, is reviewed; and hyperpyrexia is briefly discussed.

scholarly journals Range for Normal Body Temperature in Hemodialysis Patients and Its Comparison with That of Healthy Individuals

2010 ◽  
Vol 114 (4) ◽  
pp. c303-c308 ◽  
Author(s):  
Rabia Hasan ◽  
Mehreen Adhi ◽  
Syed Faisal Mahmood ◽  
Fatima Noman ◽  
Safia Awan ◽  
...  
Keyword(s):  
Body Temperature ◽  
Hemodialysis Patients ◽  
Healthy Individuals ◽  
Normal Body Temperature ◽  
Normal Body

Hemostasis and Thrombosis in Extreme Temperatures (Hypo- and Hyperthermia)

2018 ◽  
Vol 44 (07) ◽  
pp. 651-655 ◽  
Author(s):  
Marcel Levi
Keyword(s):  
Body Temperature ◽  
Clinical Effects ◽  
Bleeding Tendency ◽  
Extreme Temperatures ◽  
Consumption Coagulopathy ◽  
Optimal Temperature ◽  
Prothrombotic State ◽  
Normal Body Temperature ◽  
Cellular Receptors ◽  
Normal Body

AbstractThe delicate biochemistry of coagulation and anticoagulation is greatly affected by deviations from the optimal temperature required for the interactions between various coagulation enzymes, cellular receptors, and intracellular mechanisms. Hyperthermia will lead to a prothrombotic state and, if sufficiently severe such as in heatstroke, a consumption coagulopathy, which will clinically manifest with the simultaneous appearance of intravascular thrombotic obstruction and an increased bleeding tendency. Hypothermia slows down the coagulation process, but as this seems to be adequately balanced by impairment of anticoagulant and fibrinolytic processes, its clinical effects are modest; however, hypothermia may be modestly linked to a somewhat higher risk of localized thrombosis. Restoration of a normal body temperature in patients affected by hyper- or hypothermia is the cornerstone for the management of associated coagulation derangements.

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