Impact of Manual Coordination on Usability of Clothing Fasteners in People With Parkinson’s Disease

2021 ◽  
pp. 106480462110055
Author(s):  
Leticia Nardoni Marteli ◽  
Fabio Augusto Barbieri ◽  
Gabriel Gerizani ◽  
Érica Pereira das Neves ◽  
Luis Carlos Paschoarelli
Keyword(s):  
Older Adults ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Skills ◽  
Daily Life ◽  
Control Group ◽  
Healthy Individuals ◽  
Group Coordination

People with Parkinson’s disease (PD) manipulate clothing as part of their daily life. To understand how deteriorating motor skills affect the performance of dressing/undressing activities, this study investigated performance in handling clothing fastening. Participants were distributed into two groups: older adults with PD and neurologically matched healthy individuals (control group). Coordination and usability were evaluated. The PD group demonstrated worse performance than the control group in usability for types of buttons, and this was affected more intensely by small compared with large fasteners. This study demonstrated the need for increased awareness by clothing companies to develop products that can promote independence.

scholarly journals Validation of IMU-based gait event detection during curved walking and turning in older adults and Parkinson’s Disease patients

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Robbin Romijnders ◽  
Elke Warmerdam ◽  
Clint Hansen ◽  
Julius Welzel ◽  
Gerhard Schmidt ◽  
...  
Keyword(s):  
Older Adults ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Daily Life ◽  
Neurological Diseases ◽  
Detection Performance ◽  
Measurement Unit ◽  
Straight Line ◽  
Optical Motion ◽  
Task Conditions

Abstract Background Identification of individual gait events is essential for clinical gait analysis, because it can be used for diagnostic purposes or tracking disease progression in neurological diseases such as Parkinson’s disease. Previous research has shown that gait events can be detected from a shank-mounted inertial measurement unit (IMU), however detection performance was often evaluated only from straight-line walking. For use in daily life, the detection performance needs to be evaluated in curved walking and turning as well as in single-task and dual-task conditions. Methods Participants (older adults, people with Parkinson’s disease, or people who had suffered from a stroke) performed three different walking trials: (1) straight-line walking, (2) slalom walking, (3) Stroop-and-walk trial. An optical motion capture system was used a reference system. Markers were attached to the heel and toe regions of the shoe, and participants wore IMUs on the lateral sides of both shanks. The angular velocity of the shank IMUs was used to detect instances of initial foot contact (IC) and final foot contact (FC), which were compared to reference values obtained from the marker trajectories. Results The detection method showed high recall, precision and F1 scores in different populations for both initial contacts and final contacts during straight-line walking (IC: recall $$=$$ = 100%, precision $$=$$ = 100%, F1 score $$=$$ = 100%; FC: recall $$=$$ = 100%, precision $$=$$ = 100%, F1 score $$=$$ = 100%), slalom walking (IC: recall $$=$$ = 100%, precision $$\ge$$ ≥ 99%, F1 score $$=$$ = 100%; FC: recall $$=$$ = 100%, precision $$\ge$$ ≥ 99%, F1 score $$=$$ = 100%), and turning (IC: recall $$\ge$$ ≥ 85%, precision $$\ge$$ ≥ 95%, F1 score $$\ge$$ ≥ 91%; FC: recall $$\ge$$ ≥ 84%, precision $$\ge$$ ≥ 95%, F1 score $$\ge$$ ≥ 89%). Conclusions Shank-mounted IMUs can be used to detect gait events during straight-line walking, slalom walking and turning. However, more false events were observed during turning and more events were missed during turning. For use in daily life we recommend identifying turning before extracting temporal gait parameters from identified gait events.

scholarly journals Validation of IMU-Based Gait Event Detection During Curved Walking and Turning in Older Adults and Parkinson's Disease Patients

2020 ◽  
Author(s):  
Robbin Romijnders ◽  
Elke Warmerdam ◽  
Clint Hansen ◽  
Julius Welzel ◽  
Gerhard Schmidt ◽  
...  
Keyword(s):  
Older Adults ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Daily Life ◽  
Neurological Diseases ◽  
Detection Performance ◽  
Straight Line ◽  
Optical Motion ◽  
Optical Motion Capture ◽  
Task Conditions

Abstract Background: Identication of individual gait events is essential for clinical gait analysis, because it can beused for diagnostic purposes or tracking disease progression in neurological diseases such as Parkinson'sdisease. Previous research has shown that gait events can be detected from a shank-mounted inertialmeasurement unit (IMU), however detection performance was often evaluated only from straight-line walking.For use in daily life, the detection performance needs to be evaluated in curved walking and turning as well asin single-task and dual-task conditions.Methods: Participants (older adults, people with Parkinson's disease, or people who had suered from astroke) performed three dierent walking trials: 1) straight-line walking, 2) slalom walking, 3) Stroop-and-walktrial. An optical motion capture system was used a reference system. Markers were attached to the heel andtoe regions of the shoe, and participants wore IMUs on the lateral sides of both shanks. The angular velocity ofthe shank IMUs was used to detect instances of initial foot contact (IC) and nal foot contact (FC), whichwere compared to reference values obtained from the marker trajectories.Results: The detection method showed high recall, precision and F1 scores in dierent populations for bothinitial contacts and nal contacts during straight-line walking (IC: recall = 100%, precision = 100%, F1 score= 100%; FC: recall = 100%, precision = 100%, F1 score = 100%), slalom walking (IC: recall = 100%,precision 99%, F1 score =100%; FC: recall = 100%, precision 99%, F1 score =100%), and turning (IC:recall 85%, precision 95%, F1 score 91%; FC: recall 84%, precision 95%, F1 score 89%).Conclusions: Shank-mounted IMUs can be used to detect gait events during straight-line walking, slalomwalking and turning. However, more false events were observed during turning and more events were missedduring turning. For use in daily life we recommend identifying turning before extracting temporal gaitparameters from identied gait events.

Early effect of thalamotomy on cognitive function in patients with Parkinson’s disease

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Edward J. Gorzelańczyk ◽  
Dorota Ackermann-Szulgit ◽  
Marek Kunc ◽  
Marek Harat ◽  
Piotr Walecki
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Function ◽  
Verbal Memory ◽  
Spatial Working Memory ◽  
Verbal Learning ◽  
Control Group ◽  
Healthy Individuals ◽  
Early Effect ◽  
Visual Spatial

Abstract Thalamotomy is a neurosurgical procedure used in the treatment of advanced Parkinson’s disease (PD). The aim of our research is to evaluate the early impact of a lesion in the ventrointermedial nucleus (VIM) of the thalamus on cognitive and motor function in people with PD. Sixty patients who qualified for right- or left-sided VIM thalamotomy were involved in the study. The cognitive and motor functions of each patient were assessed both prior to and following the surgical procedure. Twenty-nine PD patients without ablative treatment were qualified for the comparison group, and 57 neurologically healthy individuals were assigned to the control group. The following tests were carried out: Mini Mental State Examination, Benton Visual Retention Test, Stroop Color and Word Test, Trail Making Test A&B, and Rey Auditory Verbal Learning Test. Statistically significant differences were found in reaction time, visual-spatial working memory, auditory-verbal memory, and overall level of cognitive function when comparing the results of tests carried out before and after thalamotomy and when comparing patients who had undergone surgery with untreated or healthy individuals. In patients with right-sided and left-sided thalamotomy differences were also found in the mean number of perseverative errors and recalled words.

scholarly journals α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy

2021 ◽  
Author(s):  
Suman Dutta ◽  
Simon Hornung ◽  
Adira Kruayatidee ◽  
Katherine N. Maina ◽  
Irish del Rosario ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multiple System Atrophy ◽  
Logistic Model ◽  
Validation Cohort ◽  
High Sensitivity ◽  
Control Group ◽  
Healthy Individuals ◽  
Discovery Cohort ◽  
Multinomial Logistic Model

AbstractThe diagnosis of Parkinson’s disease (PD) and atypical parkinsonian syndromes is difficult due to the lack of reliable, easily accessible biomarkers. Multiple system atrophy (MSA) is a synucleinopathy whose symptoms often overlap with PD. Exosomes isolated from blood by immunoprecipitation using CNS markers provide a window into the brain’s biochemistry and may assist in distinguishing between PD and MSA. Thus, we asked whether α-synuclein (α-syn) in such exosomes could distinguish among healthy individuals, patients with PD, and patients with MSA. We isolated exosomes from the serum or plasma of these three groups by immunoprecipitation using neuronal and oligodendroglial markers in two independent cohorts and measured α-syn in these exosomes using an electrochemiluminescence ELISA. In both cohorts, α-syn concentrations were significantly lower in the control group and significantly higher in the MSA group compared to the PD group. The ratio between α-syn concentrations in putative oligodendroglial exosomes compared to putative neuronal exosomes was a particularly sensitive biomarker for distinguishing between PD and MSA. Combining this ratio with the α-syn concentration itself and the total exosome concentration, a multinomial logistic model trained on the discovery cohort separated PD from MSA with an AUC = 0.902, corresponding to 89.8% sensitivity and 86.0% specificity when applied to the independent validation cohort. The data demonstrate that a minimally invasive blood test measuring α-syn in blood exosomes immunoprecipitated using CNS markers can distinguish between patients with PD and patients with MSA with high sensitivity and specificity. Future optimization and validation of the data by other groups would allow this strategy to become a viable diagnostic test for synucleinopathies.

scholarly journals Residual signal auto-correlation to evaluate speech in Parkinson’s disease patients

2006 ◽  
Vol 64 (4) ◽  
pp. 912-915 ◽  
Author(s):  
José Carlos Pereira ◽  
Arthur Oscar Schelp ◽  
Arlindo Neto Montagnoli ◽  
Ana Rita Gatto ◽  
André Augusto Spadotto ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Statistical Difference ◽  
Control Group ◽  
Healthy Individuals ◽  
Age And Gender ◽  
Residual Signal ◽  
Auto Correlation ◽  
Significant Difference ◽  
And Gender

OBJECTIVE: To evaluate the maximum residual signal auto-correlation also known as pitch amplitude (PA) values in patients with Parkinson’s disease (PD) patients. METHOD: The signals of 21 Parkinson’s patients were compared with 15 healthy individuals, divided according age and gender. RESULTS: Statistical difference was seen between groups for PA, 0.39 for controls and 0.25 for PD. Normal value threshold was set as 0.3; (p<0.001). In the Parkinson’s group 80.77%, and in the control group only 12.28%, had a PA<0.3 demonstrating an association between these variables. The dispersion diagram for age and PA for PD individuals showed p=0.01 and r=0.54. There was no significant difference in relation to gender and PA between groups. CONCLUSION: The significant differences in pitch’s amplitude between PD patients and healthy individuals demonstrate the methods specificity. The results showed the need of prospective controlled studies to improve the use and indications of residual signal auto-correlation to evaluate speech in PD patients.

scholarly journals Validation of IMU-based gait event detection during curved walking and turning in older adults and Parkinson's Disease patients

2021 ◽  
Author(s):  
Robbin Romijnders ◽  
Elke Warmerdam ◽  
Clint Hansen ◽  
Julius Welzel ◽  
Gerhard Schmidt ◽  
...  
Keyword(s):  
Older Adults ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Daily Life ◽  
Neurological Diseases ◽  
Detection Performance ◽  
Measurement Unit ◽  
Straight Line ◽  
Optical Motion ◽  
Task Conditions

Abstract Background: Identification of individual gait events is essential for clinical gait analysis, because it can be used for diagnostic purposes or tracking disease progression in neurological diseases such as Parkinson's disease. Previous research has shown that gait events can be detected from a shank-mounted inertial measurement unit (IMU), however detection performance was often evaluated only from straight-line walking. For use in daily life, the detection performance needs to be evaluated in curved walking and turning as well as in single-task and dual-task conditions. Methods: Participants (older adults, people with Parkinson's disease, or people who had suffered from a stroke) performed three different walking trials: 1) straight-line walking, 2) slalom walking, 3) Stroop-and-walk trial. An optical motion capture system was used a reference system. Markers were attached to the heel and toe regions of the shoe, and participants wore IMUs on the lateral sides of both shanks. The angular velocity of the shank IMUs was used to detect instances of initial foot contact (IC) and final foot contact (FC), which were compared to reference values obtained from the marker trajectories. Results: The detection method showed high recall, precision and F1 scores in different populations for both initial contacts and final contacts during straight-line walking (IC: recall = 100%, precision = 100%, F1 score = 100%; FC: recall = 100%, precision = 100%, F1 score = 100%), slalom walking (IC: recall = 100%,precision ≥ 99%, F1 score =100%; FC: recall = 100%, precision ≥ 99%, F1 score =100%), and turning (IC: recall ≥ 85%, precision ≥ 95%, F1 score ≥ 91%; FC: recall ≥ 84%, precision ≥ 95%, F1 score ≥ 89%). Conclusions: Shank-mounted IMUs can be used to detect gait events during straight-line walking, slalom walking and turning. However, more false events were observed during turning and more events were missed during turning. For use in daily life we recommend identifying turning before extracting temporal gait parameters from identified gait events.

scholarly journals Serum Homocysteine Level in Parkinson’s Disease and Its Association with Duration, Cardinal Manifestation, and Severity of Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Payam Saadat ◽  
Alijan Ahmadi Ahangar ◽  
Seyed Ehsan Samaei ◽  
Alireza Firozjaie ◽  
Fatemeh Abbaspour ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Homocysteine Level ◽  
Financial Burden ◽  
Multivariate Logistic Regression Analysis ◽  
High Serum ◽  
Control Group ◽  
Healthy Individuals ◽  
Mobility Impairment ◽  
Serum Homocysteine

Background and Purpose. Due to the high prevalence of Parkinson’s disease (PD) in the elderly, a large financial burden is imposed on the families and health systems of countries in addition to the problems related to the mobility impairment caused by the disease for the patients. Studies on controversial issues in this disease are taken into consideration, and one of these cases is the role of serum homocysteine level in Parkinson’s patients. In this study, the serum level of homocysteine and its association with various variables in relation to this disease was compared with healthy individuals. Materials and Methods. In this study, 100 patients with PD and 100 healthy individuals as control group were investigated. Serum homocysteine level and demographic and clinical data were included in the checklist. Data were analyzed by SPSS version 23. In all tests, the significance level was below 0.05. Results. The mean level of serum homocysteine in case and control groups was 14.93 ± 8.30 and 11.52 ± 2.86 µmol/L, respectively (95% CI: 1.68; 5.14, P<0.001). In total patients, 85 had normal serum homocysteine level, while 15 had high serum homocysteine level. In controls, the homocysteine level was 98 and 2, respectively (P=0.002). In multivariate logistic regression analysis, serum homocysteine level higher than 20 µmol/L was accompanied by 8.64-fold in Parkinson’s disease involvement (95% CI: 1.92; 38.90, P=0.005). Conclusion. Increasing serum homocysteine level elevates the rate to having PD. Serum homocysteine levels did not have any relationship with the duration of the disease, type of cardinal manifestation, and the severity of Parkinson’s disease.

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