scholarly journals Caregiver-Reported Burden in RE-KINECT: Data From a Prospective Real-World Tardive Dyskinesia Screening Study

2021 ◽  
pp. 107839032110235
Author(s):  
Andrew J. Cutler ◽  
Stanley N. Caroff ◽  
Caroline M. Tanner ◽  
Huda Shalhoub ◽  
William R. Lenderking ◽  
...  
Keyword(s):  
Tardive Dyskinesia ◽  
Real World ◽  
Treatment Options ◽  
Body Region ◽  
Full Time ◽  
Abnormal Involuntary Movements ◽  
Involuntary Movements ◽  
Screening Study ◽  
Part Time ◽  
The Impact

Background: RE-KINECT (NCT03062033), a real-world study of possible tardive dyskinesia (TD) in antipsychotic-treated patients, included a questionnaire to assess the effects of patients’ abnormal involuntary movements on caregivers. Objective: To capture the experiences of caregivers who assisted individuals with abnormal involuntary movements that were confirmed by clinicians as being consistent with TD. Methods: Qualified (nonpaid) caregivers were invited to complete a questionnaire that included the following: caregivers’ sociodemographic characteristics, their perceptions about the impact of abnormal involuntary movements on patients, and the impact of these movements on themselves (caregivers). Results: Of the 41 participating caregivers, 25 (61.0%) were women, 20 (48.8%) were employed full time or part time, and 35 (85.4%) were family members or friends. Based on responses from caregivers who noticed patients’ abnormal involuntary movements and were caring for individuals who also noticed those movements, 48.0% of patients had “a lot” of severity in ≥1 body region and 76.0% had abnormal involuntary movements in ≥2 regions. Caregiver ratings were significantly correlated with patient ratings (but not with clinician ratings) for maximum severity of abnormal involuntary movements and the number of affected regions (both p <.05). Based on their own judgments and perceptions, caregivers reported that the patient’s movements had “some” or “a lot” of impact on their (caregiver’s) ability to continue usual activities (50.0%), be productive (58.3%), socialize (55.6%), or take care of self (50.0%). Conclusion: Caregivers as well as patients are negatively affected by TD, and the impact of TD on caregivers’ lives should be considered when determining treatment options.

Effects of full-time v. part-time grazing on seasonal changes in milk coagulation properties and fatty acid composition

2021 ◽  
pp. 1-6
Author(s):  
Franziska S. Akert ◽  
Michael Kreuzer ◽  
Carmen Kunz ◽  
Beat Reidy ◽  
Joel Berard
Keyword(s):  
Fatty Acid ◽  
Seasonal Variations ◽  
Milk Fat ◽  
Seasonal Effects ◽  
Full Time ◽  
Fa Composition ◽  
Part Time ◽  
Milk Coagulation ◽  
The Impact ◽  
Feeding Systems

Abstract For this research communication our objective was to investigate to what extent milk coagulation properties and milk fatty acid (FA) composition were affected by different feeding systems, season and their interaction. Eighteen cows in total were subjected to one of three different feeding system treatments: full-time grazing or part-time grazing combined with indoor feeding of fresh grass with low or high concentrate supplementation. Milk was sampled in spring, summer and autumn. Milk coagulation time was 15.0, 19.0 and 17.7 min, coagulation dynamics 1.67, 3.41 and 1.79 min, and curd firmness 52.7, 32.4 and 47.0 mm in spring, summer and autumn, respectively. Thus, milk coagulation properties of the milk were lower during summer. There were strong seasonal effects on milk FA proportions, but there were not always changes with progressing season, or changes were different with respect to the impact of the feeding systems (system × season interaction). The milk fat was favourably rich in oleic acid, conjugated linoleic acid and α-linolenic acid and had a low n-6/n-3 fatty acid ratio in all systems. Factors like seasonal variations in grass composition and the energy balance of the cows were considered relevant for the milk FA composition. Overall, seasonal variations in milk quality were less pronounced with part-time grazing with fresh grass indoors as compared to full-time grazing without concentrate.

scholarly journals Challenges in Treating Tardive Dyskinesia: Assessing the Impact of Virtual Medical Education

CNS Spectrums ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 165-165
Author(s):  
Amanda Glazar ◽  
Cecilia Peterson ◽  
Michael Lemon ◽  
Chirag Shah ◽  
Prakash Masand
Keyword(s):  
Medical Education ◽  
Tardive Dyskinesia ◽  
Treatment Options ◽  
Respiratory Muscles ◽  
Educational Activity ◽  
Activity Participation ◽  
Chi Square ◽  
Practice Performance ◽  
New Treatments ◽  
The Impact

AbstractIntroductionTardive Dyskinesia (TD) refers to abnormal, involuntary, choreoathetoid movements of the tongue, lips, face, trunk, and extremities and is associated with long-term exposure to dopamine-blocking agents, such as antipsychotic medications. Once established, these movements usually persist. The movements are disfiguring and can bring unwanted attention to affected individuals. When severe, especially if the respiratory muscles are affected, the movements can be disabling, limit activity, and reduce quality of life. The prevalence is 7.2% in individuals on newer antipsychotics who have never been exposed to older neuroleptics. Until recently, there were no effective treatments for TD. In recent years, many new treatments have been investigated for the treatment of TD, including valbenazine, deutetrabenazine, and branched chain amino acids. Valbenazine first, followed by deutetrabenazine are FDA approved to treat TD. A virtual broadcast was developed to assess the ability of continuing medical education (CME) to improve awareness of the recognition and treatment of TD among psychiatrists.MethodsThe virtual broadcast (May 9, 2020) consisted of a two-hour, live-streamed discussion between two expert faculty. Impact of the educational activity was assessed by comparing psychiatrists’ responses to four identical questions presented before and directly after activity participation. A follow-up survey was sent to all participants six-weeks post-activity to measure performance in practice changes. A chi-square test was used to identify significant differences between pre- and post-assessment responses. Cohen’s d was used to calculate the effect size of the virtual broadcast.ResultsActivity participation resulted in a noticeable educational effect among psychiatrists (n=621; d=6.12, P<.001). The following areas showed significant (P<0.05) pre- vs post-educational improvements: recognition of movements in patients with TD, rate of TD in SGA exposed patients, treatment options for TD (on and off-label), and treatment of TD using VMAT inhibitors. Additionally, 54% of psychiatrists reported a change in practice performance as a result of the education received in the activity, including utilization of a standard scale to evaluate movement disorders and educate patients and family members about potential for TD, how to recognize symptoms, and when to treat.ConclusionsThe results indicated that a CME-certified two-hour virtual broadcast was effective at improving knowledge among psychiatrists for the recognition and treatment of TD. This knowledge also resulted in positive changes in practice performance post-activity. Future education should continue to address best practices in the diagnosis, treatment and management of patients with TD, as there remains an increased need for tailored CME among psychiatrists.FundingNeurocrine Biosciences, Inc.

The Nithsdale Schizophrenia Survey V. Follow-up of Tardive Dyskinesia at3-1/2 years

1986 ◽  
Vol 149 (5) ◽  
pp. 621-623 ◽  
Author(s):  
A. D. T. Robinson ◽  
R. G. McCreadie
Keyword(s):  
Tardive Dyskinesia ◽  
Older Patients ◽  
Geographical Area ◽  
Point Prevalence ◽  
Abnormal Involuntary Movements ◽  
Involuntary Movements ◽  
Transient Feature

The point-prevalence of tardive dyskinesia in schizophrenics from a discrete geographical area (Nithsdale, in Dumfries and Galloway Region) in 1981, 1982, and 1984 was 31%, 27%, and 30% respectively. This suggests that the prevalence of tardive dyskinesia in a community of schizophrenics has reached a plateau. In 12% of patients there was persistent dyskinesia, i.e. abnormal involuntary movements were present at all three assessments. Persistent dyskinesia was more common in older patients. The severity of tardive dyskinesia fluctuated between assessments in 41 % of patients, indicating that it is only a transient feature in some cases.

scholarly journals Employee satisfaction and use of flexible working arrangements

2016 ◽  
Vol 31 (4) ◽  
pp. 567-585 ◽  
Author(s):  
Daniel Wheatley
Keyword(s):  
Change Score ◽  
Full Time ◽  
Panel Survey ◽  
Positive Effects ◽  
Score Analysis ◽  
Flexible Working ◽  
Part Time ◽  
Negative Impacts ◽  
Full Time Employment ◽  
The Impact

This article considers the impact of flexible working arrangements (FWAs), using the British Household Panel Survey and Understanding Society, 2001–10/11. Results of panel logit, ANCOVA and change-score analysis are indicative of positive impacts from use of a number of FWAs, including homeworking having positive effects for men and women on job and leisure satisfaction. However, findings reveal gaps in availability and use of FWAs, and highlight the gendered nature of flexible employment. Flexi-time, the most common FWA among men, has positive effects as it facilitates management of household responsibilities while maintaining full-time employment. Part-time and homeworking are also positive, consistent with men using FWAs with a greater degree of choice. Women more often are constrained in their use of FWAs, often into working reduced hours. Consequently, FWAs have negative impacts for some women, on job (part-time when used for extended periods, flexi-time), leisure (job-share, flexi-time) and life satisfaction (job-share).

Tardive Dyskinesia

1992 ◽  
Vol 160 (1) ◽  
pp. 110-112 ◽  
Author(s):  
Robertson Macpherson ◽  
Rachel Collis
Keyword(s):  
Cognitive Function ◽  
Tardive Dyskinesia ◽  
Psychiatric Hospital ◽  
Negative Symptoms ◽  
Cognitive Deficit ◽  
Defect State ◽  
Abnormal Involuntary Movements ◽  
Involuntary Movements ◽  
Short Test

Of 113 patients in long-stay wards of a psychiatric hospital, 43 had TD. Twenty-six of the 39 patients who consented to take part in the study were unaware of abnormal involuntary movements. These patients scored significantly lower on a short test of cognitive function than patients who were aware of such movements. The diagnosis of schizophrenia, perticularly the ‘defect’ state with cognitive deficit and negative symptoms, was found to be associated with lack of awareness of TD.

Ethnic Differences in Women's Employment

1997 ◽  
Vol 11 (3) ◽  
pp. 435-457 ◽  
Author(s):  
Clare Holdsworth ◽  
Angela Dale
Keyword(s):  
Ethnic Groups ◽  
Economic Activity ◽  
White Women ◽  
Occupational Attainment ◽  
Women's Employment ◽  
Full Time ◽  
Women’S Employment ◽  
Part Time ◽  
The Impact ◽  
Minority Ethnic

This paper uses the 1 per cent household file from the Samples of Anonymised Records (SARs) for the 1991 Census and the ONS Longitudinal Study (LS) to explore variations in patterns of employment and occupational attainment among women from different ethnic groups. The analysis of the SARs focuses on the impact of lifecycle events on women's employment status and economic activity. The presence of a partner is identified as having the greatest impact on Pakinstani and Bangladeshi women's employment, while the presence of a pre-school child is most significant for White women's economic activity. White women also have a higher rate of part-time worlding than all other ethnic groups. These patterns are for malised in two models, one for economic activity and a second for full-time/part-time work. The LS is used to investigate the impact of these employment patterns on women's occupational attainment over a ten-year period. The analysis demonstrates that, while minority ethnic women in nonmanual occupations have similar longitudinal occupational profiles to White women, those in manual occupations fare worse than their White counterparts, despite the fact that a larger propotion of minority ethnic women are in fill-time employment.

The importance of farmers' markets for West Virginia direct marketers

2007 ◽  
Vol 22 (1) ◽  
pp. 20-29 ◽  
Author(s):  
Cheryl Brown ◽  
Stacy M. Miller ◽  
Deborah A. Boone ◽  
Harry N. Boone ◽  
Stacy A. Gartin ◽  
...  
Keyword(s):  
West Virginia ◽  
Household Income ◽  
Positive Impact ◽  
Ordinary Least Squares ◽  
Lower Percentage ◽  
Farmers Markets ◽  
Full Time ◽  
Farmers Market ◽  
Part Time ◽  
The Impact

AbstractIn the winter of 2004–2005, over 300 of West Virginia's farmers' market vendors were surveyed with regard to sales levels, promotional techniques and operational characteristics such as hours worked, types of products produced and length of season. Vendors were categorized based on part-time, full-time or retired status, and full-time farmers, both with and without off-farm jobs, were found to be distinct from part-time and retired vendors with respect to 2004 total farmers' market sales and the percentage of household income from farmers' markets. Econometric analysis [ordinary least squares (OLS)] was performed to identify the impact of explanatory variables on total farmers' market sales, percentage of household income from farmers' market sales and amount of household income from farmers' market sales. Independent variables such as bargaining, cost-plus pricing, selling at markets outside West Virginia and providing print materials were found to have a positive impact on annual sales. The number of products produced, distance traveled to market and number of weeks at market were also positively related to the percentage of income obtained from farmers' market sales. Both part-time and retired producers received a lower percentage of household income from farmers' markets relative to full-time producers. Retired and part-time, along with limited-resource vendors (with annual household income less than $20,000) were also found to have lower total sales in the 2004 season. Identifying the characteristics associated with greater farmers' market sales and a higher reliance on such sales for household income will help in the sustained success of markets as engines of economic development and small farm viability.

scholarly journals Attitudes to Moonlighting Politicians: Evidence from the United Kingdom

2015 ◽  
Vol 2 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Rosie Campbell ◽  
Philip Cowley
Keyword(s):  
United Kingdom ◽  
Real World ◽  
Conflict Of Interest ◽  
Medical Doctors ◽  
Members Of Parliament ◽  
The United Kingdom ◽  
Survey Experiments ◽  
Part Time ◽  
Survey Instruments ◽  
The Impact

AbstractResearch has explored the impact of politicians holding second jobs, or moonlighting, on their performance and recruitment, but less is known about how citizens respond to such behavior. Citizens may react negatively to Members of Parliament (MPs) moonlighting, viewing outside earnings as a conflict of interest or a distraction, or instead they might view MPs with second incomes positively, seeing them as a connection with the “real world” beyond politics. Utilizing a series of survey experiments, we assess how British citizens respond to MPs moonlighting. We demonstrate preferences more complex than those revealed by traditional survey instruments. Citizens respond to both size and source of income. They do not respond negatively to all second incomes; they are more sympathetic to the entrepreneur who continues to draw an income than medical doctors or lawyers who continue to practice. They are most hostile to politicians who take on part-time company directorships.

scholarly journals Impact of Federal Fiscal-Monetary Policy on Farm Structure

1983 ◽  
Vol 15 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Luther Tweeten
Keyword(s):  
Price Level ◽  
Aggregate Demand ◽  
Farm Size ◽  
Full Time ◽  
Capital Labor Ratio ◽  
Farm Structure ◽  
Investment Capital ◽  
Part Time ◽  
On Farm ◽  
The Impact

This paper examines the impact of federal fiscal-monetary (FM) policy on farm structure. FM policy is multifaceted but is confined here mainly to policies influencing aggregate demand. Inflation is defined as an increase in the general price level. Farm structure refers to farm size and numbers, tenure, legal organization, investment, capital-labor ratio, productivity, and status (part-time or full-time farming).

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