Gastroschisis Is Associated With Placental Delayed Villous Maturation

2019 ◽  
Vol 23 (3) ◽  
pp. 197-203
Author(s):  
Brittany Ruschkowski ◽  
Anthea Lafreniere ◽  
Dina El Demellawy ◽  
David Grynspan
Keyword(s):  
Risk Factors ◽  
Abdominal Wall ◽  
Maternal Age ◽  
Congenital Abnormality ◽  
Abdominal Wall Defect ◽  
Control Group ◽  
Control Groups ◽  
Wall Defect ◽  
Previous Diagnosis ◽  
Kappa Agreement

Gastroschisis is a congenital abnormality characterized by visceral herniation through an abdominal wall defect. While the cause of gastroschisis is unknown, it has been linked to risk factors including young maternal age, smoking, and alcohol use during pregnancy. To date, the only established placental correlate is amniocyte vacuolization. Based on our clinical experience, we hypothesized that delayed villous maturation (DVM) is also associated with gastroschisis. We conducted a retrospective slide review of 23 placentas of neonates with gastroschisis. Additionally, we selected 2 control groups of placentas: 1 with a previous diagnosis of DVM and 1 with normal villous morphology. All placentas were randomized and reviewed by 2 perinatal pathologists, who were blinded to the group; DVM and amniocyte vacuolization were assessed. Gastroschisis was associated with increased placental DVM in 65.2% of cases (vs 13.6% of controls; P = .0007) and increased amniocyte vacuolization in 52.2% of cases (vs 9.1% of controls; P = .003) compared to the control group. Based on the normal and DVM groups, kappa agreement between current slide review and initial pathology diagnosis was 0.419, indicating moderate agreement. Our study shows that gastroschisis is associated with placental DVM. This association may be due to (1) a common upstream factor contributing to both gastroschisis and DVM or (2) DVM may be a consequence of the altered placental and amniotic environment in the context of gastroschisis.

scholarly journals Abdominal Wall Defects Among Mexican American Infants: The Effect of Maternal Nativity

2016 ◽  
Vol 26 (2) ◽  
pp. 165 ◽  
Author(s):  
Shayna D. Hibbs ◽  
Amanda Bennett ◽  
Yessenia Castro ◽  
Kristin M. Rankin ◽  
James W. Collins, Jr.
Keyword(s):  
Risk Factors ◽  
Prenatal Care ◽  
Abdominal Wall ◽  
Mexican American ◽  
Maternal Age ◽  
Abdominal Wall Defect ◽  
Abdominal Wall Defects ◽  
Mexican American Women ◽  
Wall Defect ◽  
American Women

<p><strong>Background</strong>: US-born Mexican American women have greater rates of preterm birth and consequent overall infant mortality than their Mexico-born peers. However, the relation of Mexican American women’s<br />nativity to rates of congenital anomalies is poorly understood. Hispanic ethnicity and young maternal age are well-known risk factors for gastroschisis.</p><p><br /><strong>Objective</strong>: To determine the extent to which nativity of Mexican American women is associated with abdominal wall defects.</p><p><strong>Methods</strong>: Stratified and multivariable logistic regression analyses were performed on the 2003-2004 National Center for Health Statistics linked live birth-infant death cohort. Only Mexican American infants were studied. Maternal variables examined included nativity, age, education, marital status, parity, and prenatal care usage.</p><p><strong>Results:</strong> Infants with US-born Mexican American mothers (n=451,272) had an abdominal wall defect rate of 3.9/10,000 compared with 2.0/10,000 for those with Mexico-born mothers (n=786,878), RR=1.9 (1.5-2.4). Though a greater percentage of US-born (compared wtih Mexico-born) Mexican American mothers were teens, the nativity disparity was actually widest among women in their 20s. The adjusted (controlling for maternal age, education, marital status, parity, and prenatal care) odds ratio of abdominal wall defects among infants of US-born (compared with Mexico-born) Mexican American mothers was 1.6 (1.2-2.0).</p><p><strong>Conclusions</strong>: US-born Mexican American women have nearly a two-fold greater rate of delivering an infant with an abdominal wall defect than their Mexico-born counterparts. This phenomenon is only partially explained by traditional risk factors and highlights a detrimental impact of lifelong residence in the United States, or something closely related to it, on the<br />pregnancy outcome of Mexican American women. Ethn Dis; 2016;26(2):165-170; doi:10.18865/ed.26.2.165</p>

scholarly journals Use of alloplastic meshes in abdominal wounds of rats with induced peritonitis

2014 ◽  
Vol 27 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Rafael Calvão BARBUTO ◽  
Ivana DUVAL-ARAUJO ◽  
Sumara Marques BARRAL ◽  
Raphael Grossi ROCHA ◽  
Cristiane de Souza BECHARA ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Abdominal Wall ◽  
Granulation Tissue ◽  
Abdominal Wall Defect ◽  
Test Group ◽  
Microscopic Analysis ◽  
Female Rats ◽  
Control Group ◽  
Abdominal Wall Defects ◽  
Wall Defect

Background : The use of alloplastic meshes has been historically contra-indicated in patients with infection. Aim : To evaluate the use of polypropylene meshes in the treatment of abdominal wall defects in rats with peritonitis. Methods : Twenty Wistar female rats were divided into two groups: induction of peritonitis (test group) and without peritonitis (control group). An abdominal wall defect was created in all animals, and polypropylene mesh was applied. The evaluation of the tensile strength of the mesh was carried out using tensiometer and microscopic analysis of the healing area was done. Results : More adhesion of the mesh to the rat abdominal wall was observed in test group. The histopathological analyses showed prevalence of moderate to accentuated granulation tissue in both groups, without significant differences. Conclusion : The use of the mesh coverage on abdominal wall defects of rats with induced peritonitis did not show worse results than its use in healthy animals, nor was its integration to the resident tissue any worse.

scholarly journals Examining the Relationship Between Gastroschisis and Placental Fetal Vascular Malperfusion

2021 ◽  
pp. 109352662110296
Author(s):  
Brittany Ruschkowski ◽  
Ahmed Nasr ◽  
Irina Oltean ◽  
Sarah Lawrence ◽  
Dina El Demellawy
Keyword(s):  
Maternal Smoking ◽  
Congenital Malformations ◽  
Maternal Age ◽  
Abdominal Wall Defect ◽  
Control Group ◽  
Wall Defect ◽  
Vascular Disruption ◽  
Histological Data ◽  
Pathology Reports ◽  
The Relationship

Introduction Gastroschisis is a congenital malformation characterized by intestinal herniation through an abdominal wall defect. Despite its unknown pathogenesis, known risk factors include maternal smoking, alcohol use, and young maternal age. Previous work has shown that gastroschisis is associated with placental delayed villous maturation, and the goal of this study was to assess for additional associated placental pathologies that may help clarify the pathogenesis of gastroschisis. Methods We conducted a retrospective slide review of 29 placentas of neonates with gastroschisis. Additionally, we reviewed pathology reports from one control group of 30 placentas with other congenital malformations. Gross and histological data were collected based on a standardized rubric. Results Gastroschisis was associated with increased placental fetal vascular malperfusion (FVM) in 62% of cases (versus 0% of controls, p < 0.0001). It was also associated with increased placental villous maldevelopment in 76% of cases (versus 3% of controls, p < 0.0001). Conclusion Our study demonstrates an association between gastroschisis and FVM. While FVM could be the consequence of vascular disruption due to the ventral location of gastroschisis, it could also reflect estrogen-induced thrombosis in early pregnancy. Further research is needed to separate these possibilities and determine the cause of the placental FVM observed in gastroschisis.

scholarly journals Investigation of a connection between abdominal wall defects and severity of the herniation in fetuses with gastroschisis and omphalocele

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Natasha T. Logsdon ◽  
Carla M. Gallo ◽  
Luciano Alves Favorito ◽  
Francisco J. Sampaio
Keyword(s):  
Abdominal Wall ◽  
Iliac Crest ◽  
Abdominal Wall Defect ◽  
Control Group ◽  
Abdominal Wall Defects ◽  
Internal Organs ◽  
Wall Defect ◽  
Mean Values ◽  
Biometric Parameters ◽  
Post Test

AbstractAnalyze the biometric parameters and the size (area) of abdominal wall defect (AWD) in fetuses with gastroschisis and omphaloceles and correlate them with the herniated internal organs. We studied 22 fetuses (11 with AWDs and 11 without anomalies). In all fetuses we evaluated the xiphopubic distance (XPD) and iliac crest distance (ICD). In fetuses with AWDs we dissected the abdominal wall and measured the width and length of the defect for calculating its area and studying the correlation between the size of the defect with the organs that were herniated. For statistical analysis, the Anova and Tukey post-test were used (p < 0.05). The XPD in the control group had mean of 4.2 mm (2.3–5.9; SD ± 1.11), while in the AWDs it was 4.2 mm (2.9–5.5; SD ± 0.98) (p = 0.4366). The ICD had mean values of 2.5 mm (1.6–3.4; SD ± 0.58) in the control group, and 2.3 mm (1.2–3.0; SD ± 0.56) in AWDs fetuses (p = 0.6963). The number of herniate organs do not have significant correlation with the area of the defect (r2 = 0.2504, p = 0.5068). There is no correlation between the size (area) of abdominal wall defects and the number of the internal organs that herniated. Therefore, the hole size is not a predictor of the severity of the gastroschisis or omphalocele.

Bio‐Multifunctional Hydrogel Patches for Repairing Full‐Thickness Abdominal Wall Defect

2021 ◽  
pp. 2105614
Author(s):  
Xiangyi Yin ◽  
Yuanping Hao ◽  
Yun Lu ◽  
Dongjie Zhang ◽  
Yaodong Zhao ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Abdominal Wall Defect ◽  
Full Thickness ◽  
Wall Defect

Prenatal Diagnosis of a Fetal Abdominal Eventration: A Rare Congenital Abdominal Wall Defect

2007 ◽  
Vol 23 (2) ◽  
pp. 117-120
Author(s):  
Philippe Roth ◽  
Alain Martin ◽  
Fariz Bawab ◽  
Florence Fellmann ◽  
Didier Aubert ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Abdominal Wall ◽  
Abdominal Wall Defect ◽  
Wall Defect

A Newborn Who Has an Abdominal Wall Defect

NeoReviews ◽  
2005 ◽  
Vol 6 (3) ◽  
pp. e160-e163
Author(s):  
Valerie Chock
Keyword(s):  
Abdominal Wall ◽  
Abdominal Wall Defect ◽  
Wall Defect

Evaluation of TiNi-based wire mesh implant for abdominal wall defect management

2018 ◽  
Vol 4 (2) ◽  
pp. 027010 ◽  
Author(s):  
Dmytro Zaworonkow ◽  
Mykola Chekan ◽  
Katarzyna Kusnierz ◽  
Andrzej Lekstan ◽  
Aniela Grajoszek ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Abdominal Wall Defect ◽  
Wire Mesh ◽  
Wall Defect ◽  
Defect Management ◽  
Mesh Implant

scholarly journals Managing a Colonoscopic Perforation in a Patient with No Abdominal Wall

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Jayan George ◽  
Michael Peirson ◽  
Samuel Birks ◽  
Paul Skinner
Keyword(s):  
Abdominal Pain ◽  
Incisional Hernia ◽  
Plastic Surgery ◽  
Abdominal Wall ◽  
Abdominal Wall Defect ◽  
Colonic Perforation ◽  
Conservative Approach ◽  
Wall Defect ◽  
Surgical History ◽  
History Of

We describe the case of a 37-year-old gentleman with Crohn’s disease and a complex surgical history including a giant incisional hernia with no abdominal wall. He presented on a Sunday to the general surgical on-call with a four-day history of generalised abdominal pain, nausea, and decreased stoma output following colonoscopy. After CT imaging, he was diagnosed with a large colonic perforation. Initially, he was worked up for theatre but following early senior input, a conservative approach with antibiotics was adopted. The patient improved significantly and is currently awaiting plastic surgery input for the management of his abdominal wall defect.

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