Massive Perivillous Fibrin Deposition in Congenital Cytomegalovirus Infection: A Case Report

2020 ◽  
pp. 109352662096135
Author(s):  
Catherine K Gestrich ◽  
Yi Yuan Zhou ◽  
Sanjita Ravishankar
Keyword(s):  
Plasma Cells ◽  
Viral Infections ◽  
Recurrence Risk ◽  
Fibrin Deposition ◽  
Cmv Infection ◽  
Hemosiderin Deposition ◽  
Congenital Cmv Infection ◽  
Chronic Villitis ◽  
Clinical Conditions ◽  
Viral Inclusions

Cytomegalovirus (CMV) infection is one of the most common congenital viral infections. Classically associated placental findings include chronic villitis with plasma cells, stromal hemosiderin deposition, and identification of viral inclusions in villous endothelial and stromal cells. We present a case of confirmed congenital CMV infection that lacked these classical findings, but demonstrated massive perivillous fibrin deposition (MPVFD). This is the first report of CMV associated with MPVFD. MPVFD is an uncommon placental lesion associated with adverse fetal outcomes and a high risk of recurrence. However, the recurrence risk in patients with an infectious cause may be lower in than patients with other associated clinical conditions.

scholarly journals Birth Prevalence of Congenital Cytomegalovirus (CMV) infection in a cohort of pregnant women in Bangladesh

2018 ◽  
Vol 43 (2) ◽  
pp. 77-81
Author(s):  
Munira Jahan ◽  
Nahida Sultana ◽  
Ridwana Asma ◽  
Shahina Tabassum ◽  
Md. Nazrul Islam
Keyword(s):  
Pregnant Women ◽  
Viral Infections ◽  
Congenital Infection ◽  
High Seroprevalence ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus ◽  
Birth Prevalence ◽  
Congenital Cmv Infection ◽  
Cmv Reactivation ◽  
Congenital Cmv

Cytomegalovirus (CMV) is a frequent cause of congenital infection in humans in all regions of the world. In contrast to most congenital viral infections, congenital CMV infection and disease have been consistently demonstrated in populations with a high seroprevalence. Three hundred pregnant women were studied prospectively in their 1st, 2nd and 3rd trimester to determine the seroprevalence and seroconversion of CMV in pregnancy. After birth, babies were also tested for anti CMV IgM to determine the rate of birth prevalence. Anti CMV IgG and IgM tests were performed by chemiluminescence methods. All 300 (100%) pregnant women were anti CMV IgG positive and 180 (60%) were subsequently anti CMV IgM positive during different trimesters of pregnancy. Birth prevalence of CMV IgM antibody was 1.3% among babies of anti CMV IgM positive mothers whereas none in CMV IgM negative mothers (OR 1.01, 95% CI .996-1.027).It may be concluded that CMV IgG seroprevalence is high among Bangladeshi pregnant women and the rate of CMV reactivation is also high during pregnancy. Despite protection by maternal immunity a certain percent of babies acquire congenital CMV infection.

A prospective study evaluating congenital CMV infection in Mayotte and La Reunion Islands (France)

2021 ◽  
Vol 138 ◽  
pp. 104793
Author(s):  
Justine Demortier ◽  
Jacques Fourgeaud ◽  
Soumeth Abasse ◽  
Laurent Lambrecht ◽  
Marie Gromand ◽  
...  
Keyword(s):  
Prospective Study ◽  
La Réunion ◽  
Cmv Infection ◽  
Congenital Cmv Infection ◽  
A Prospective Study ◽  
Congenital Cmv

How to Save Money: Congenital CMV Infection and the Economy

2018 ◽  
pp. 121-144
Author(s):  
E. Walter ◽  
C. Brennig ◽  
V. Schöllbauer ◽  
Gabriele Halwachs-Baumann
Keyword(s):  
Cmv Infection ◽  
Congenital Cmv Infection ◽  
Congenital Cmv

scholarly journals OP02.08: Effectiveness of ultrasound in the antenatal prediction of symptomatic congenital CMV infection

2006 ◽  
Vol 28 (4) ◽  
pp. 423-423
Author(s):  
G. Simonazzi ◽  
B. Guerra ◽  
A. Banfi ◽  
G. Pilu ◽  
T. Lazzarotto ◽  
...  
Keyword(s):  
Cmv Infection ◽  
Congenital Cmv Infection ◽  
Congenital Cmv

scholarly journals New approach for congenital CMV infection diagnosis in neonates: sensibility and specificity of CMV detection in dried blood spots

Retrovirology ◽  
2009 ◽  
Vol 6 (Suppl 1) ◽  
pp. O12
Author(s):  
Marianne Leruez-Ville ◽  
Christelle Vauloup-Fellous ◽  
Sophie Couderc ◽  
Sophie Parat ◽  
Salima Oucherif ◽  
...  
Keyword(s):  
Dried Blood Spots ◽  
Cmv Infection ◽  
New Approach ◽  
Blood Spots ◽  
Infection Diagnosis ◽  
Congenital Cmv Infection ◽  
Congenital Cmv

scholarly journals Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Ali Amanati ◽  
Nader Shakibazad ◽  
Bahman Pourabbas ◽  
Mohammad Hossein Nowroozzadeh ◽  
Soheila Zareifar ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Visual Loss ◽  
Viral Infections ◽  
Cmv Infection ◽  
Cmv Retinitis ◽  
Molecular Tests ◽  
Early Diagnose ◽  
Clinical Pictures ◽  
Acute Myeloid

Cytomegalovirus (CMV) retinitis is one of the rare but debilitating presentations of the CMV infection in children with leukemia. Herein, we report a 12-year-old boy with acute myeloid leukemia complicated by rapid progressive visual loss during relapse of leukemia. The definite diagnosis of CMV retinitis was made after vitreous aspiration. Despite prompt treatment and ophthalmologic intervention, he died because of AML relapse. Viral infections, especially cytomegalovirus infection, may present with vague clinical pictures during any time of chemotherapy, which may not be easily distinguishable from bacterial or fungal retinitis and also chemotherapy-induced retinopathies. Clinician should consider CMV retinitis in seropositive patients especially those without detectable viremia.

scholarly journals A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1467
Author(s):  
K. Yeon Choi ◽  
Alistair McGregor
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Neutralizing Antibodies ◽  
T Cell Response ◽  
Control Group ◽  
Type I ◽  
Cmv Infection ◽  
Viral Glycoprotein ◽  
Congenital Cmv Infection ◽  
Congenital Cmv

A vaccine against congenital cytomegalovirus infection is a high priority. Guinea pig cytomegalovirus (GPCMV) is the only congenital CMV small animal model. GPCMV encodes essential glycoprotein complexes for virus entry (gB, gH/gL/gO, gM/gN) including a pentamer complex (gH/gL/GP129/GP131/GP133 or PC) for endocytic cell entry. The cohorts for protection against congenital CMV are poorly defined. Neutralizing antibodies to the viral glycoprotein complexes are potentially more important than an immunodominant T-cell response to the pp65 protein. In GPCMV, GP83 (pp65 homolog) is an evasion factor, and the GP83 mutant GPCMV has increased sensitivity to type I interferon. Although GP83 induces a cell-mediated response, a GP83-only-based vaccine strategy has limited efficacy. GPCMV attenuation via GP83 null deletion mutant in glycoprotein PC positive or negative virus was evaluated as live-attenuated vaccine strains (GP83dPC+/PC-). Vaccinated animals induced antibodies to viral glycoprotein complexes, and PC+ vaccinated animals had sterilizing immunity against wtGPCMV challenge. In a pre-conception vaccine (GP83dPC+) study, dams challenged mid-2nd trimester with wtGPCMV had complete protection against congenital CMV infection without detectable virus in pups. An unvaccinated control group had 80% pup transmission rate. Overall, gB and PC antibodies are key for protection against congenital CMV infection, but a response to pp65 is not strictly necessary.

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