scholarly journals Using the Homeland Security Exercise and Evaluation Program (HSEEP) Building Block Approach to Implement System Evaluation Theory (SET)

2021 ◽  
pp. 109821402098661
Author(s):  
Ralph Renger ◽  
Jessica Renger ◽  
Marc D. Basson ◽  
Richard N. Van Eck ◽  
Jirina Renger ◽  
...  
Keyword(s):  
Homeland Security ◽  
Building Block ◽  
Building Blocks ◽  
Lessons Learned ◽  
System Evaluation ◽  
Evaluation Theory ◽  
Evaluation Program ◽  
Support Set ◽  
Working Together ◽  
Block Approach

This article shares lessons learned in applying system evaluation theory (SET) to evaluate a Clinical and Translational Research Center (CTR) funded by the National Institutes of Health. After describing how CTR support cores are intended to work interdependently as a system, the case is made for SET as the best fit for evaluating this evaluand. The article then details how the evaluation was also challenged to facilitate a CTR culture shift, helping support cores to move from working autonomously to working together and understanding how the cores’ individual operating processes impact each other. This was achieved by incorporating the Homeland Security Exercise and Evaluation Program (HSEEP) building block approach to implement SET. Each of the seven HSEEP building blocks is examined for alignment with each of SET’s three steps and the ability to systematically support the goal of moving CTR cores toward working interdependently. The implications of using HSEEP to support SET implementation for future evaluations are discussed.

Developing a comprehensive, integrated and meaningful Multi-year Training and Exercise Plan

2012 ◽  
Vol 10 (5) ◽  
pp. 383
Author(s):  
Ralph Renger, PhD, MEP ◽  
Brenda Granillo, MS
Keyword(s):  
Emergency Management ◽  
Homeland Security ◽  
Building Block ◽  
Evaluation Program ◽  
Continual Improvement ◽  
Response And Recovery ◽  
Core Capabilities ◽  
Block Approach

A Multi-year Training and Exercise Plan (MYTEP) is required for compliance with the Homeland Security Exercise and Evaluation Program (HSEEP). The MYTEP is an important tool to a) assist agencies to identify the capabilities necessary for effective preparation, mitigation, response, and recovery and b) develop a training and exercise schedule to meet this need. Federal guidance in completing the MYTEP focuses on the following three key elements: applying the HSEEP building block approach, capability-based planning, and the cycle of continual improvement. The guidance is helpful but requires thoughtful consideration of the interplay between these elements. This article discusses many challenges and solutions for designing an integrated MYTEP including: a) the extent to which the agency goal is to build agency-level or human-level capability, b) the need to address cross-cutting capabilities in resource scarce environments, c) building and maintaining necessary core capabilities, and d) integrating sponsor-required exercises. The application of these concepts is then illustrated using a case example where a MYTEP was designed with a tribal Office of Emergency Management.

A Building Block Approach to Monofluorinated Organic Compounds

2008 ◽  
Vol 73 (12) ◽  
pp. 1553-1611 ◽  
Author(s):  
Alexander S. Konev ◽  
Alexander F. Khlebnikov
Keyword(s):  
Organic Compounds ◽  
Building Block ◽  
Building Blocks ◽  
Natural Compounds ◽  
Pericyclic Reactions ◽  
Fluoroacetic Acid ◽  
Phosphorus Containing ◽  
Block Approach

Building blocks for the synthesis of monofluorinated organic compounds are reviewed. The synthetic potential of polyhalomethanes, sulfur- and phosphorus-containing building blocks, difluoroethene, polyhaloethanes, fluoroacetic acid derivatives, and other compounds are described. Pericyclic reactions involving fluorinated compounds and application of the methodology of building blocks to the synthesis of monofluorinated pharmaceuticals and analogs of natural compounds are considered. The review with 317 references covers mainly the literature from 1996 through 2007.

Conceptual Synthesis of Compliance at a Single Point

2006 ◽  
Author(s):  
Charles Kim ◽  
Yong-Mo Moon ◽  
Sridhar Kota
Keyword(s):  
Building Block ◽  
Compliant Mechanism ◽  
Single Point ◽  
Geometry Optimization ◽  
Building Blocks ◽  
Kinematic Behavior ◽  
The Mathematical Model ◽  
Insight Into ◽  
Block Approach

In this paper, we investigate a methodology for the conceptual synthesis of compliance at a single point based on a building block approach. The methodology lays the foundation for more general compliant mechanism synthesis problems involving multiple points of interest (i.e. inputs and outputs). In the building block synthesis, the problem specifications are decomposed into related sub-problems if a single building block cannot perform the desired task. The sub-problems are tested against the library of building blocks until a suitable building block is determined. The synthesized design is composed of an assembly of the building blocks to provide the desired functionality. The building block approach is intuitive and provides key insight into how individual building blocks contribute to the overall function. We investigate the basic kinematic behavior of individual building blocks and relate this to the behavior of a design composed of building blocks. This serves to not only generate viable solutions but also to augment the understanding of the designer. Once a feasible concept is thus generated, known methods for size and geometry optimization may be employed to fine tune performance. The key enabler of the building block synthesis is the method of capturing kinematic behavior using Compliance Ellipsoids. The mathematical model of the compliance ellipsoids facilitates the characterization of the building blocks, transformation of problem specifications, decomposition into sub-problems, and the ability to search for alternate solutions. The compliance ellipsoids also give insight into how individual building blocks contribute to the overall kinematic function. The effectiveness and generality of the methodology are demonstrated through a synthesis example. Using only a limited set of building blocks, the methodology is capable of addressing generic kinematic problem specifications.

scholarly journals Changed reactivity of secondary hydroxyl groups in C8-modified adenosine – lessons learned from silylation

2020 ◽  
Author(s):  
Jennifer Frommer ◽  
Sabine Müller
Keyword(s):  
Building Block ◽  
Rna Structure ◽  
Building Blocks ◽  
Structure And Function ◽  
Lessons Learned ◽  
Hydroxyl Groups ◽  
Modified Oligonucleotides ◽  
Secondary Hydroxyl ◽  
Protection Scheme ◽  
And Function

Synthesis of site-specifically modified oligonucleotides has become a major tool for RNA structure and function studies. Reporter groups or specific functional entities are required to be attached at a pre-defined site of the oligomer.  An attractive strategy is the incorporation of suitably functionalized building blocks that allow post-synthetic conjugation of the desired moiety. A C8-alkynyl modified adenosine derivative was synthesized, reviving an old synthetic pathway for iodination of purine nucleobases. Silylation of the C8-alkynyl modified adenosine revealed unexpected selectivity of the two secondary sugar hydroxyl groups, with the 3'-O-isomer being preferentially formed. Optimization of the protection scheme lead to a new and economic route to the desired C8-alkynylated building block and its incorporation in RNA.

scholarly journals Synthesis of homo- and heteromultivalent carbohydrate-functionalized oligo(amidoamines) using novel glyco-building blocks

2013 ◽  
Vol 9 ◽  
pp. 2395-2403 ◽  
Author(s):  
Felix Wojcik ◽  
Sinaida Lel ◽  
Alexander G O’Brien ◽  
Peter H Seeberger ◽  
Laura Hartmann
Keyword(s):  
Double Bond ◽  
Building Block ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Building Blocks ◽  
Phase Synthesis ◽  
Highly Efficient ◽  
Monomer Sequence ◽  
Full Control ◽  
Block Approach

We present the solid phase synthesis of carbohydrate-functionalized oligo(amidoamines) with different functionalization patterns utilizing a novel alphabet of six differently glycosylated building blocks. Highly efficient in flow conjugation of thioglycosides to a double-bond presenting diethylentriamine precursor is the key step to prepare these building blocks suitable for fully automated solid-phase synthesis. Introduction of the sugar ligands via functionalized building blocks rather than postfunctionalization of the oligomeric backbone allows for the straightforward synthesis of multivalent glycoligands with full control over monomer sequence and functionalization pattern. We demonstrate the potential of this building-block approach by synthesizing oligomers with different numbers and spacing of carbohydrates and also show the feasibility of heteromultivalent glycosylation patterns by combining building blocks presenting different mono- and disaccharides.

Functional Characterization of Compliant Building Blocks Utilizing Eigentwists and Eigenwrenches

2008 ◽  
Author(s):  
Charles J. Kim
Keyword(s):  
Building Block ◽  
Compliant Mechanisms ◽  
Compliant Mechanism ◽  
Deformable Body ◽  
Functional Characterization ◽  
Building Blocks ◽  
Future Research ◽  
Special Cases ◽  
Block Approach

Compliant mechanisms are devices which utilize the flexibility of their constituent members to transmit motion and forces. Unlike their rigid body counterparts, compliant mechanisms typically contain no traditional joints. The focus of this research is the development of a building block approach for the synthesis of compliant mechanisms. Building block methods better facilitate the augmentation of designer intuition while offering a systematic approach to open-ended problems. In this paper, we investigate the use of the eigentwists and eigenwrenches of a deformable body to characterize basic kinematic function. The eigentwists and eigenwrenches are shown to demonstrate parametric behavior when applied to the compliant dyad building block, and in special cases may be compared to compliance ellipsoids. The paper concludes by articulating future research in a building block approach to compliant mechanism synthesis.

scholarly journals Changed reactivity of secondary hydroxy groups in C8-modified adenosine – lessons learned from silylation

2020 ◽  
Vol 16 ◽  
pp. 2854-2861
Author(s):  
Jennifer Frommer ◽  
Sabine Müller
Keyword(s):  
Building Block ◽  
Rna Structure ◽  
Building Blocks ◽  
Structure And Function ◽  
Lessons Learned ◽  
Modified Oligonucleotides ◽  
Synthetic Pathway ◽  
Protection Scheme ◽  
And Function ◽  
Hydroxy Groups

Synthesis of site-specifically modified oligonucleotides has become a major tool for RNA structure and function studies. Reporter groups or specific functional entities are required to be attached at a pre-defined site of the oligomer. An attractive strategy is the incorporation of suitably functionalized building blocks that allow post-synthetic conjugation of the desired moiety. A C8-alkynyl-modified adenosine derivative was synthesized, reviving an old synthetic pathway for iodination of purine nucleobases. Silylation of the C8-alkynyl-modified adenosine revealed unexpected selectivity of the two secondary sugar hydroxy groups, with the 3'-O-isomer being preferentially formed. Optimization of the protection scheme lead to a new and economic route to the desired C8-alkynylated building block and its incorporation in RNA.

A Building Block Approach to the Conceptual Synthesis of Compliant Mechanisms Utilizing Compliance and Stiffness Ellipsoids

2008 ◽  
Vol 130 (2) ◽  
Author(s):  
Charles J. Kim ◽  
Yong-Mo Moon ◽  
Sridhar Kota
Keyword(s):  
Building Block ◽  
Compliant Mechanisms ◽  
Compliant Mechanism ◽  
Single Point ◽  
Rapid Prototype ◽  
Building Blocks ◽  
Single Input Single Output ◽  
Kinematic Behavior ◽  
Insight Into ◽  
Block Approach

In this paper, we investigate a methodology for the conceptual synthesis of compliant mechanisms based on a building block approach. The building block approach is intuitive and provides key insight into how individual building blocks contribute to the overall function. We investigate the basic kinematic behavior of individual building blocks and relate this to the behavior of a design composed of building blocks. This serves to not only generate viable solutions but also to augment the understanding of the designer. Once a feasible concept is thus generated, known methods for size and geometry optimization may be employed to fine-tune performance. The key enabler of the building block synthesis is the method of capturing kinematic behavior using compliance ellipsoids. The mathematical model of the compliance ellipsoids facilitates the characterization of the building blocks, transformation of problem specifications, decomposition into subproblems, and the ability to search for alternate solutions. The compliance ellipsoids also give insight into how individual building blocks contribute to the overall kinematic function. The effectiveness and generality of the methodology are demonstrated through two synthesis examples. Using only a limited set of building blocks, the methodology is capable of addressing generic kinematic problem specifications for compliance at a single point and for a single-input, single-output compliant mechanism. A rapid prototype of the latter demonstrates the validity of the conceptual solution.

PLASMA-AIDED NANOFABRICATION: "PLASMA-BUILDING BLOCK" APPROACH

2006 ◽  
Vol 05 (04n05) ◽  
pp. 439-444
Author(s):  
KEN OSTRIKOV ◽  
SHUYAN XU
Keyword(s):  
Numerical Simulation ◽  
Gas Phase ◽  
Plasma Diagnostics ◽  
Building Block ◽  
Chemical Structure ◽  
Building Blocks ◽  
Semiconductor Quantum Dots ◽  
Ab Initio Simulation ◽  
Nanostructured Surfaces ◽  
Block Approach

Unique features and benefits of the plasma-aided nanofabrication are considered by using the "plasma-building block" approach, which is based on plasma diagnostics and nanofilm characterization, cross-referenced by numerical simulation of generation and dynamics of building blocks in the gas phase, their interaction with nanostructured surfaces, and ab initio simulation of chemical structure of relevant nanoassemblies. The examples include carbon nanotip microemitter structures, semiconductor quantum dots and nanowires synthesized in the integrated plasma-aided nanofabrication facility.

Using a simulation cell for exercise realism

2013 ◽  
Vol 11 (5) ◽  
pp. 338 ◽  
Author(s):  
Ken Lerner, JD
Keyword(s):  
Emergency Management ◽  
Homeland Security ◽  
Emergency Preparedness ◽  
Current Practice ◽  
Lessons Learned ◽  
Flexible Tool ◽  
Evaluation Program ◽  
Military Application ◽  
Reporting Process ◽  
Simulation Cell

A simulation cell or SimCell is an effective and flexible tool for control of emergency management exercises. It allows exercise participants to interact, via simulation, with a wide variety of nonplaying organizations and officials. Adapted from military application, the Chemical Stockpile Emergency Preparedness Program (CSEPP) applied, developed, and refined the SimCell concept for emergency management exercises. It has now been incorporated into national exercise guidance through the Homeland Security Exercise and Evaluation Program, and has been used in a wide variety of national, regional, and local exercises. This article reviews development of the SimCell concept in CSEPP, briefly surveys current practice incorporating SimCells in exercise control, and offers practical lessons-learned and tips on using a SimCell to best advantage. Lessons learned include using a SimCell as an exercise-control hub; preparing inject material for exercise controllers as part of the Master Scenario Event List; laying the groundwork for success through exercise player and controller training; developing protocol for SimCell communications; and capturing feedback from SimCell controllers for inclusion in the exercise evaluation reporting process. The SimCell concept is flexible and can be applied to a variety of exercise types and through a variety of methods.

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