Fatty acid binding protein-4 is associated with disability in multiple sclerosis patients

Background: Increased adiposity is a risk factor for multiple sclerosis (MS) and is associated with increased disability scores. Adipokines may mediate the effects of adiposity on MS disease course. Objective: The objective of this study is to examine the association between the adipokines (leptin and fatty acid binding protein-4, FABP4) and clinical course in individuals with MS. Methods: Subjects (18–65 years) with relapsing-remitting MS or clinically isolated syndrome and <10 year disease duration were selected from a longitudinal clinical study. Cross-sectional and longitudinal models assessed the relationship between two adipokines (leptin and FABP4) and disease severity in women and men, adjusting for age, disease duration and disease type, Vitamin D level, testosterone level, and as well by body mass index (BMI). Results: Mean age of subjects ( N = 163, 56% women) was 39.3 years. Higher FABP4 levels were associated with higher Expanded Disability Status Scale (EDSS) scores in women in both univariate and multivariate analyses (odds ratio: 1.30; p = 0.005). In men, higher FABP4 level was significantly associated with change in EDSS over time (estimate: 0.0062; p = 0.035). We found no association of FABP4 levels with time to next relapse or a measure of processing speed. Conclusion: FABP4 levels may be associated with increased disability in both men and women with MS independent of effects of BMI and other hormones. Future studies should expand these analyses and further explore downstream mechanisms of adiposity-related effects in MS.

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Serum intestinal fatty acid binding protein in multiple sclerosis as a marker of intestinal barrier integrity

10.26226/morressier.5b75785e5aff7400151f3459 ◽

2018 ◽

Author(s):

Carlos camara

Keyword(s):

Multiple Sclerosis ◽

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Intestinal Barrier ◽

Fatty Acid Binding ◽

Barrier Integrity ◽

Acid Binding Protein ◽

Intestinal Barrier Integrity

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A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models

EBioMedicine ◽

10.1016/j.ebiom.2021.103582 ◽

2021 ◽

Vol 72 ◽

pp. 103582

Author(s):

An Cheng ◽

Wenbin Jia ◽

Ichiro Kawahata ◽

Kohji Fukunaga

Keyword(s):

Multiple Sclerosis ◽

Fatty Acid ◽

Mouse Models ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Fatty Acid Binding ◽

Acid Binding Protein

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Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats

Journal of Diabetes Research ◽

10.1155/2020/7614035 ◽

2020 ◽

Vol 2020 ◽

pp. 1-14

Author(s):

Jun Tanabe ◽

Yuji Ogura ◽

Keisei Kosaki ◽

Yoshio Nagai ◽

Takeshi Sugaya ◽

...

Keyword(s):

Fatty Acid ◽

Muscle Strength ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Muscle Fibers ◽

Protein L ◽

Cross Sectional ◽

Fatty Acid Binding ◽

Acid Binding Protein ◽

Sd Rats

Background. Type 2 diabetes (T2D) is a known risk factor for diabetic kidney disease (DKD) and sarcopenia in older patients. Because there may be an interaction between DKD and sarcopenia, the aim of the present study is to investigate the relationship between urinary levels of liver-type fatty acid-binding protein (L-FABP) and sarcopenia using a novel rat model of T2D. Methods. Male spontaneously diabetic Torii (SDT) fatty rats (n=5) at 16 weeks of age were used as an animal model of T2D. Age- and sex-matched Sprague-Dawley (SD) rats (n=7) were used as controls. Urine samples were obtained from the rats, and muscle strength was evaluated with the use of the forelimb grip test at 16, 20, and 24 weeks of age. Serum, kidney, soleus, and extensor digitorum longus (EDL) muscle samples were collected at 24 weeks of age. Urinary L-FABP levels were measured using dedicated enzyme-linked immunosorbent assays. Results. Increased urinary L-FABP levels, focal glomerular sclerosis, moderate interstitial inflammation and fibrosis, and accumulation of renal oxidative proteins were significantly observed in the SDT fatty rats, compared to the SD rats. Muscle weight, muscle strength, cross-sectional areas of both type I and type IIb muscle fibers, and increasing rate of muscle strength were significantly decreased in the SDT fatty rats compared to the SD rats at 24 weeks. Urinary L-FABP levels at 20 and 24 weeks were significantly negatively correlated with muscle strength. Urinary L-FABP levels at 16 weeks were significantly negatively correlated with the increasing rate of muscle strength. Conclusions. Urinary L-FABP reflects the degree of muscle strength and weight, as well as cross-sectional areas of muscle fibers. Although further clinical study is needed, urinary L-FABP may be useful to monitor the progression of sarcopenia and DKD in T2D patients.

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