scholarly journals Ultra-brief non-expert-delivered defusion and acceptance exercises for food cravings: A partial replication study

2017 ◽  
Vol 24 (12) ◽  
pp. 1698-1709 ◽  
Author(s):  
Lee Hulbert-Williams ◽  
Nick J Hulbert-Williams ◽  
Wendy Nicholls ◽  
Sian Williamson ◽  
Jivone Poonia ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Clinical Management ◽  
Replication Study ◽  
Expert Group ◽  
Partial Replication ◽  
Food Cravings ◽  
Reduced Frequency ◽  
Tentative Evidence ◽  
Distraction Control

Food cravings are a common barrier to losing weight. This article presents a randomised comparison of non-expert group-delivered ultra-brief defusion and acceptance interventions against a distraction control. A total of 63 participants were asked to carry a bag of chocolates for a week while trying to resist the temptation to eat them. A behavioural rebound measure was administered. Each intervention out-performed control in respect of consumption, but not cravings. These techniques may have a place in the clinical management of food cravings. We provide tentative evidence that the mechanism of action is through decreased reactivity to cravings, not through reduced frequency of cravings.

scholarly journals Clinical management of immune-related adverse events following immunotherapy treatment in patients with non-small cell lung cancer

2021 ◽  
pp. jim-2021-001806
Author(s):  
Hannah Elizabeth Green ◽  
Jorge Nieva
Keyword(s):  
Lung Cancer ◽  
Adverse Events ◽  
Mechanism Of Action ◽  
Immune Checkpoint ◽  
Clinical Management ◽  
Immune Checkpoint Blockade ◽  
Small Cell ◽  
Checkpoint Blockade ◽  
Small Cell Lung ◽  
Autoimmune Conditions

The advent of checkpoint blockade-based immunotherapy is rapidly changing the management of lung cancer. Whereas past anticancer drugs’ primary toxicity was hematologic, the newer agents have primarily autoimmune toxicity. Thus, it is no longer enough for oncology practitioners to be skilled only in hematology. They must also understand management of autoimmune conditions, leveraging the skills of the rheumatologist, endocrinologist and gastroenterologist in the process. Herein we describe the mechanism of action and toxicities associated with immune checkpoint blockade in patients with lung cancer and provide a framework for management of adverse events.

AVATAR therapy

2020 ◽  
pp. 565-572
Author(s):  
Tom K. J. Craig ◽  
Mar Rus-Calafell
Keyword(s):  
Clinical Trial ◽  
Virtual Reality ◽  
Mechanism Of Action ◽  
Controlled Trials ◽  
Virtual Reality Technology ◽  
Present Evidence ◽  
Auditory Verbal Hallucinations ◽  
Future Developments ◽  
Reduced Frequency ◽  
Control Intervention

AVATAR therapy is a newly developed treatment for auditory verbal hallucinations (AVH) that uses virtual reality technology to allow a three-way interaction between therapist, participant, and the entity the person believes is the source of their distressing auditory verbal hallucinations with the aim of reducing the perceived power and hostility of the persecutory voices. Two controlled trials, one a preliminary proof of concept and the second a larger powered clinical trial comparing AVATAR therapy with a supportive counseling control intervention, have demonstrated effectiveness in terms of reduced frequency, omnipotence, and associated distress of targeted AVH. This chapter reviews the present evidence and speculates on possible mechanism of action and future developments.

scholarly journals Juvenile psoriasis and its clinical management: a European expert group consensus

2010 ◽  
Vol 8 (10) ◽  
pp. 812-818 ◽  
Author(s):  
Mona Ståhle ◽  
Nilgun Atakan ◽  
Wolf-Henning Boehncke ◽  
Sergio Chimenti ◽  
Esteban Daudén ◽  
...  
Keyword(s):  
Clinical Management ◽  
Expert Group ◽  
Group Consensus ◽  
Juvenile Psoriasis

scholarly journals Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1678 ◽  
Author(s):  
Katherine H. M. Cox ◽  
David J. White ◽  
Andrew Pipingas ◽  
Kaylass Poorun ◽  
Andrew Scholey
Keyword(s):  
Working Memory ◽  
Stress Reactivity ◽  
Memory Performance ◽  
Replication Study ◽  
Partial Replication ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Mood Disturbance ◽  
And Performance ◽  
Present Trial

Curcumin (a flavonoid isolated from turmeric) affects several processes involved in neurocognitive aging. We have previously reported that short term (4-weeks) administration of a highly bioavailable curcumin preparation (Longvida©) improved working memory and reduced fatigue and stress reactivity in a healthy older cohort. The present trial (ACTRN12616000484448) was a partial replication study, evaluating similar effects at 4 and 12-weeks Longvida© supplementation. A double-blind, placebo-controlled, parallel-groups trial was conducted. Eighty participants aged 50–80 years (mean = 68.1, SD = 6.34) were randomised to receive Longvida© (400 mg daily containing 80 mg curcumin) or a matching placebo. Assessment took place at baseline then following 4 and 12 weeks treatment. Outcome measures included cognitive performance, mood and biomarkers. Compared with placebo, curcumin was associated with several significant effects. These included better working memory performance at 12-weeks (Serial Threes, Serial Sevens and performance on a virtual Morris Water Maze), and lower fatigue scores on the Profile of Mood States (POMS) at both 4 and 12-weeks, and of tension, anger, confusion and total mood disturbance at 4-weeks only. The curcumin group had significantly elevated blood glucose. These results confirm that Longvida© improves aspects of mood and working memory in a healthy older cohort. The pattern of results is consistent with improvements in hippocampal function and may hold promise for alleviating cognitive decline in some populations.

Unifying the current self, ideal self, attributions, self-authenticity, and intended effort: A partial replication study among Chinese university English learners

System ◽  
2020 ◽  
Vol 95 ◽  
pp. 102377
Author(s):  
Sara A. Smith ◽  
Matthew E. Foster ◽  
Jessica Briggs Baffoe-Djan ◽  
Zhengjie Li ◽  
Sun Yu
Keyword(s):  
English Learners ◽  
Replication Study ◽  
Partial Replication ◽  
Ideal Self ◽  
Chinese University
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