scholarly journals Relationship between Leptin, Insulin Resistance, Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 in Patients with Chronic Kidney Disease

2008 ◽  
Vol 36 (3) ◽  
pp. 522-528 ◽  
Author(s):  
A Atamer ◽  
S Alisir Ecder ◽  
Z Akkus ◽  
Y Kocyigit ◽  
Y Atamer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Kidney Disease ◽  
Growth Factor ◽  
Kidney Disease ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Association between serum insulin like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 levels and chronic kidney disease in diabetic patients

2020 ◽  
Vol 10 (1) ◽  
pp. e05-e05
Author(s):  
Volha N. Vasilkova ◽  
Tatsiana V. Mokhort ◽  
Ivan Y. Pchelin ◽  
Valentina K. Bayrasheva ◽  
Elena P. Naumenko ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Growth Factor ◽  
Kidney Disease ◽  
Cystatin C ◽  
Binding Protein ◽  
Diabetic Patients ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Patients With Diabetes ◽  
Igfbp 3

Introduction: Insulin-like growth factor-1 (IGF-1) is a potent mitogen for glomerular mesangial cells which can stimulate cell migration and the production of fibronectin, proteoglycan, and type IV collagen, thereby promoting the development of the chronic kidney disease (CKD) in patients with diabetes. Objectives: The aim of the study was to assess the associations between serum levels of IGF-1 and insulin-like growth factor-binding protein-3 (IGFBP-3) and CKD in diabetic patients. Patients and Methods: We investigated 102 Belarusian men and women with diabetes type 2 aged 56.67±0.81 years. Control group included 68 healthy people the same age. We estimated GFR with the use of the CKD-EPI creatinine-cystatin C equation to determine eGFRcr_cys. Serum total IGF-1 and IGFBP-3 levels were measured using immunoradiometric assay (IRMA) (Beckman Coulter, Czech Republic s.r.o.). Results: Patients with diabetes had significantly lower level of IGF-1 than controls. However, IGFBP-3 levels were similar in the two groups. Diabetic patients with CKD had significantly higher levels of IGF-1 and IGFBP-3 than diabetic patients without CKD (P=0.0031). However, according to multivariate analysis, only IGF-1 and cystatin C were associated with renal impairment. In detail, the odds of having eGFR<60 mL/min/1.73 m2 increased with rising IGF-1 levels (OR: 1.025, [CI 1.002-1.048]). Conclusion: Our study revealed that higher serum IGF-1 levels were positively associated with CKD in patients with diabetes. We suggest that IGF-1 might be a predictor of CKD in patients with diabetes. Further research is necessary to confirm the observed this association and to detect the causal relations.

217 Insulin-like Growth Factor Binding Protein-1 Enhances Vascular Endothelial Repair in the Setting of Insulin Resistance

Heart ◽  
2014 ◽  
Vol 100 (Suppl 3) ◽  
pp. A118.2-A119
Author(s):  
Amir Aziz ◽  
Nadira Yuldasheva ◽  
Jess Smith ◽  
Kirsten Riches ◽  
Matthew Gage ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Growth Factor ◽  
Binding Protein ◽  
Vascular Endothelial ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Endothelial Repair

scholarly journals Insulin-Like Growth Factor Binding Protein-3 Leads to Insulin Resistance in Adipocytes

2005 ◽  
Vol 90 (12) ◽  
pp. 6588-6595 ◽  
Author(s):  
Sophie S. Y. Chan ◽  
Stephen M. Twigg ◽  
Sue M. Firth ◽  
Robert C. Baxter
Keyword(s):  
Insulin Resistance ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

Progranulin and insulin-like Growth Factor Binding Protein-2 as Biomarkers of Disease Activity and Pathological Changes in Lupus Nephritis

2017 ◽  
Vol 44 (02) ◽  
pp. 121-127
Author(s):  
Samar Goma ◽  
Marwa Abdelaziz ◽  
Eman El-Hakeim ◽  
Mona El Zohri ◽  
Sohair Sayed
Keyword(s):  
Growth Factor ◽  
Kidney Disease ◽  
Lupus Nephritis ◽  
Disease Activity ◽  
Renal Biopsy ◽  
Activity Index ◽  
Binding Protein ◽  
Disease Activity Index ◽  
Insulin Like Growth Factor ◽  
Factor Binding

Abstract Background Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease, characterised by the production of auto-antibodies and the formation of immune complexes due to the polyclonal activation of T and B lymphocytes, which results in tissue and organ damage. During inflammation, neutrophils and macrophages release serine proteases to cleave progranulin (PGRN) into granulin, which exerts its pro-inflammatory effects that counteract the anti-inflammatory effects of intact PGRN. It is suggested that insulin-like growth factor binding protein-2 (IGFBP-2) is a dependable biomarker of renal deterioration but it is still unclear if it has high sensitivity and specificity for discriminating SLE-caused kidney disease from other-cause kidney disease.This study aimed to investigate the diagnostic value of PGRN and ILGFBP-2 in patients with lupus nephritis (LN) and the correlation of these biomarkers with disease activity and renal biopsy pathology. Patients and methods Patients with SLE (n=25) and chronic kidney disease (CKD) (n=25), and age- and sex-matched controls (n=25) were enrolled in the study. Serum PGRN and ILGFBP-2 levels were measured for each group. Results Disease duration was 4.78±4.26 years in the SLE patients. The mean SLE Disease Activity Index score was 15.04±7.54. All renal biopsy results were class 2, 3, and 5 with a percentage of 32, 24, and 44% respectively. PGRN and ILGFBP-2 were significantly higher in SLE patients (p<0.001 all) than in the CKD and control groups. All patients with high levels of biomarkers showed higher values of SLE disease activity. No significant difference was noted between active and inactive LN or classes of renal biopsy with PGRN and ILGFBP-2. Conclusion PGRN and ILGFBP-2 are significantly elevated in SLE compared to CKD and the general population and were associated with the SLE Disease Activity Index but not with active LN or classes of renal biopsy.

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