Production Trends, Collaboration, and Main Topics of the Integrative and Complementary Oncology Research Area: A Bibliometric Analysis

Background: The prevalence of cancer has increased over time worldwide. Nevertheless, the number of deaths has been reduced during the past 2 decades. Thus, one-third of the cancer patients are users of complementary and alternative therapies, looking for other types of interventions. The main aim of the present study is to understand the current status of the research in integrative and complementary oncology. Three different aspects were analyzed: production trends, country collaboration, and leading research topics. Methods: The dataset was obtained from the documents indexed under the Integrative and Complementary Medicine category of the Web of Science database from 1976 to 2017. VOSviewer and SciMAT software were employed to perform the bibliometric analysis. Results: The Journal of Ethnopharmacology, China Medical University and the People’s Republic of China are the leading producers in the field. Regarding the collaboration, the United States and China present a close connection. The scientific community is focused on the following topics: apoptosis, breast cancer, oxidative stress, chemotherapy, and nuclear factor-Kappa-B (NF-Kappa-B). Conclusions: The present article shows potentially important information that allows understanding of the past, present, and future of research in integrative and complementary oncology. It is a useful evidence-based framework on which to base future research actions and academic directions.

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Research Trends of Acupuncture Therapy on Cancer Over the Past Two Decades: A Bibliometric Analysis

Integrative Cancer Therapies ◽

10.1177/1534735420959442 ◽

2020 ◽

Vol 19 ◽

pp. 153473542095944

Author(s):

Jing Guo ◽

Lixia Pei ◽

Lu Chen ◽

Hao Chen ◽

Dongmei Gu ◽

...

Keyword(s):

Neuropathic Pain ◽

Acupuncture Therapy ◽

Supportive Care ◽

Bibliometric Analysis ◽

Integrative Medicine ◽

Clinical Studies ◽

Current Status ◽

Cancer Center ◽

Future Research ◽

The Past

Purpose: Acupuncture has been used for managing cancer-related symptoms. However, there are still few studies concerning the overall trends in acupuncture therapy on cancer based on bibliometric analysis. This study aims to demonstrate the current status and trends in this field over the past 2 decades. Methods: Articles were retrieved from the Web of Science from 2000 to 2019. CiteSpace was used for co-authorship network of countries/institutions, dual-map analysis, and detecting the keywords with citation bursts. VOSviewer was used to construct networks based on co-authorship and co-citation analysis of authors, and co-occurrence of keywords. Results: A total of 927 articles and reviews were included in the final analysis. The number of publications has steadily increased with some fluctuations among years. The country and institution contributing most to this field are the USA and Memorial Sloan Kettering Cancer Center. Mao JJ was the most productive author and Molassiotis A ranked first in the cited authors. The co-occurrence analysis revealed 5 clusters (including “clinical trials,” “clinical studies on chemotherapy/radiation-induced symptoms,” “CAM therapy for cancer,” “clinical studies on vasomotor symptoms,” and “systematic reviews”). Most recent keyword bursts were “neuropathic pain,” “arthralgia,” “prevention,” “supportive care,” and “integrative medicine”. Conclusions: The annual publication output would increase rapidly in the next decade, which shows a promising future in this research field. Future research hotspots would focus on the role of acupuncture in neuropathic pain, arthralgia, prevention, supportive care, and integrative medicine.

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A Bibliometric Analysis of the Global Trend of Using Alginate, Gelatine, and Hydroxyapatite for Bone Tissue Regeneration Applications

Polymers ◽

10.3390/polym13040647 ◽

2021 ◽

Vol 13 (4) ◽

pp. 647

Author(s):

Mohamed Saiful Firdaus Hussin ◽

Aludin Mohd Serah ◽

Khairul Azri Azlan ◽

Hasan Zuhudi Abdullah ◽

Maizlinda Izwana Idris ◽

...

Keyword(s):

Tissue Engineering ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Bibliometric Analysis ◽

Research Work ◽

The United States ◽

Research Area ◽

Bone Tissue Regeneration ◽

Future Research ◽

Starting Point

Collecting information from previous investigations and expressing it in a scientometrics study can be a priceless guide to getting a complete overview of a specific research area. The aim of this study is to explore the interrelated connection between alginate, gelatine, and hydroxyapatite within the scope of bone tissue and scaffold. A review of traditional literature with data mining procedures using bibliometric analyses was considered to identify the evolution of the selected research area between 2009 and 2019. Bibliometric methods and knowledge visualization technologies were implemented to investigate diverse publications based on the following indicators: year of publication, document type, language, country, institution, author, journal, keyword, and number of citations. An analysis using a bibliometric study found that 7446 papers were located with the keywords “bone tissue” and “scaffold”, and 1767 (alginate), 185 (gelatine), 5658 (hydroxyapatite) papers with those specific sub keywords. The number of publications that relate to “tissue engineering” and bone more than doubled between 2009 (1352) and 2019 (2839). China, the United States and India are the most productive countries, while Sichuan University and the Chinese Academy of Science from China are the most important institutions related to bone tissue scaffold. Materials Science and Engineering C is the most productive journal, followed by the Journal of Biomedical Materials Research Part A. This paper is a starting point, providing the first bibliometric analysis study of bone tissue and scaffold considering alginate, gelatine and hydroxyapatite. A bibliometric analysis would greatly assist in giving a scientific insight to support desired future research work, not only associated with bone tissue engineering applications. It is expected that the analysis of alginate, gelatine and hydroxyapatite in terms of 3D bioprinting, clinical outcomes, scaffold architecture, and the regenerative medicine approach will enhance the research into bone tissue engineering in the near future. Continued studies into these research fields are highly recommended.

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A Bibliometric Analysis of Researches on Flap Endonuclease 1 From 2005 to 2019

10.21203/rs.3.rs-136655/v1 ◽

2021 ◽

Author(s):

Qiaochu Wei ◽

Jiming Shen ◽

Dongni Wang ◽

Xu Han ◽

Jing Shi ◽

...

Keyword(s):

Bibliometric Analysis ◽

Protein Interactions ◽

Cell Biology ◽

Biological Activities ◽

The United States ◽

Dna Metabolism ◽

Flap Endonuclease 1 ◽

The Past ◽

Oncology Research ◽

Research Frontiers

Abstract Background: Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in a variety of DNA metabolism processes. FEN1 is important for maintaining genomic stability and regulating cell growth and development. It is associated with the occurrence and development of several diseases, especially cancers. There is a lack of systematic bibliometric analyses focusing on research trends and knowledge structures related to FEN1.Purpose: To analyze hotspots, the current state and research frontiers performed for FEN1 over the past 15 years. Methods: Publications were retrieved from the Web of Science Core Collection (WoSCC) database, analyzing publication dates ranging from 2005 to 2019. VOSviewer1.6.15 and Citespace5.7 R1 were used to perform a bibliometric analysis in terms of countries, institutions, authors, journals and research areas related to FEN1. A total of 421 publications were included in this analysis. Results: Our findings indicated that FEN1 has received more attention and interest from researchers in the past 15 years. Institutes in the United States, specifically the Beckman Research Institute of City of Hope published the most research related to FEN1. SHEN BH，ZHENG L and BAMBARA RA were the most active researchers investigating this endonuclease and most of this research was published in the Journal of Biological Chemistry. The main scientific areas of FEN1 were related to biochemistry, molecular biology，cell biology，genetics and oncology. Research hotspots included biological activities, DNA metabolism mechanisms, protein-protein interactions and gene mutations. Research frontiers included oxidative stress, phosphorylation and tumor progression and treatment. Conclusion: This bibliometric study may aid researchers in the understanding of the knowledge base and research frontiers associated with FEN1. In addition, emerging hotspots for research can be used as the subjects of future studies.

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A comprehensive analysis of the 21st century's research trends in English Mobile Learning: a bibliographic review of the literature

International Journal of Information and Learning Technology ◽

10.1108/ijilt-07-2021-0099 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Rouhollah Khodabandelou ◽

Masood Fathi ◽

Mohammad Amerian ◽

Mohammad Reza Fakhraie

Keyword(s):

Bibliometric Analysis ◽

Mobile Learning ◽

Research Trends ◽

Current Status ◽

Future Research ◽

Review Of Literature ◽

Content Type ◽

The Past ◽

Learning Research ◽

Points Of View

PurposeThis study examines the importance of English Mobile Learning research as a foundation for lifelong and sustainable education from different points of view, including those of technology innovation experts, psychologists and educators. It aims to explore the current status and relevant research trends through the application of bibliometric mapping and bibliometric analysis.Design/methodology/approachFor this study, all Web of Science records (in total 5,343) from 2000 to 2020 in the field of English Mobile Learning were analyzed using the VOSviewer and CiteSpace software tools. The WoS built-in functions, including “Refine” and “Analyze,” were employed to perform the bibliometric analysis. The study further analyzed a sample of the five most-cited articles to identify the previous studies with the highest quality or impact.FindingsThe results showed that research in English Mobile Learning is growing quickly and steadily with a noticeable emphasis on various device-based technologies and applications. The study also discusses the key implications for research institutions, education policymakers and academicians, and identifies the most prominent avenues for future research on English Mobile Learning. Moreover, the results shared in this review highlight the most important and emerging areas of research in the field.Originality/valueThis article is the most recent bibliographic review of literature that particularly addresses the English Mobile Learning research during the past two decades.

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A bibliometric analysis of researches on flap endonuclease 1 from 2005 to 2019

BMC Cancer ◽

10.1186/s12885-021-08101-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Qiaochu Wei ◽

Jiming Shen ◽

Dongni Wang ◽

Xu Han ◽

Jing Shi ◽

...

Keyword(s):

Bibliometric Analysis ◽

Protein Interactions ◽

Cell Biology ◽

Biological Activities ◽

The United States ◽

Dna Metabolism ◽

Flap Endonuclease 1 ◽

The Past ◽

Oncology Research ◽

Research Frontiers

Abstract Background Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in a variety of DNA metabolism processes. FEN1 is important for maintaining genomic stability and regulating cell growth and development. It is associated with the occurrence and development of several diseases, especially cancers. There is a lack of systematic bibliometric analyses focusing on research trends and knowledge structures related to FEN1. Purpose To analyze hotspots, the current state and research frontiers performed for FEN1 over the past 15 years. Methods Publications were retrieved from the Web of Science Core Collection (WoSCC) database, analyzing publication dates ranging from 2005 to 2019. VOSviewer1.6.15 and Citespace5.7 R1 were used to perform a bibliometric analysis in terms of countries, institutions, authors, journals and research areas related to FEN1. A total of 421 publications were included in this analysis. Results Our findings indicated that FEN1 has received more attention and interest from researchers in the past 15 years. Institutes in the United States, specifically the Beckman Research Institute of City of Hope published the most research related to FEN1. Shen BH, Zheng L and Bambara Ra were the most active researchers investigating this endonuclease and most of this research was published in the Journal of Biological Chemistry. The main scientific areas of FEN1 were related to biochemistry, molecular biology, cell biology, genetics and oncology. Research hotspots included biological activities, DNA metabolism mechanisms, protein-protein interactions and gene mutations. Research frontiers included oxidative stress, phosphorylation and tumor progression and treatment. Conclusion This bibliometric study may aid researchers in the understanding of the knowledge base and research frontiers associated with FEN1. In addition, emerging hotspots for research can be used as the subjects of future studies.

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Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research

Frontiers in Pharmacology ◽

10.3389/fphar.2021.687757 ◽

2021 ◽

Vol 12 ◽

Author(s):

Xiuqing Zhu ◽

Jinqing Hu ◽

Shuhua Deng ◽

Yaqian Tan ◽

Chang Qiu ◽

...

Keyword(s):

Immune System ◽

Gut Microbiota ◽

Citation Analysis ◽

Mood Disorders ◽

Bibliometric Analysis ◽

The United States ◽

Kynurenine Pathway ◽

Current Status ◽

Future Research ◽

Low Grade

Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system.Aim: This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field.Methods: Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection (WoSCC), and analyzed in CiteSpace (5.7 R5W), biblioshiny (using R-Studio), and VOSviewer (1.6.16).Results: In total, 1,064 and 948 documents were extracted from the Scopus and WoSCC databases, respectively. The publications have shown rapid growth since 2006, partly owing to the largest research hotspot appearing since then, “quinolinic acid.” All the top five most relevant journals were in the neuropsychiatry field, such as Brain Behavior and Immunity. The United States and Innsbruck Medical University were the most influential country and institute, respectively. Journal co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry field. Reference co-citation analysis revealed that the top four most important research focuses were “kynurenine pathway,” “psychoneuroimmunology,” “indoleamine 2,3-dioxygenase,” and “proinflammatory cytokines,” and the most recent focus was “gut-brain axis,” thus indicating the role of the KP in bridging the GM and the host immune system, and together reflecting the field’s research foundations. Overlap analysis between the thematic map of keywords and the keyword burst analysis revealed that the topics “Alzheimer’s disease,” “prefrontal cortex,” and “acid,” were research frontiers.Conclusion: This comprehensive bibliometric study provides an updated perspective on research associated with the KP in MD, with a focus on the current status of GM research in this field. This perspective may benefit researchers in choosing suitable journals and collaborators, and aid in the further understanding of the field’s hotspots and frontiers, thus facilitating future research.

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Interweaving Industrial Ecology and Ecological Modernization: A Comparative Bibliometric Analysis

Sustainability ◽

10.3390/su13179673 ◽

2021 ◽

Vol 13 (17) ◽

pp. 9673

Author(s):

Feng Han ◽

Zhangcong Feng ◽

Chao Wang ◽

Nujie Yang ◽

Dong Yang ◽

...

Keyword(s):

Bibliometric Analysis ◽

Industrial Development ◽

Industrial Ecology ◽

Resource Constraints ◽

Policy Design ◽

Developed Countries ◽

The United States ◽

Future Research ◽

Ecological Modernization ◽

The Past

Although industrial activity has brought about rapid economic growth, it also faces the dual challenges of resource constraints and environmental pressure. Industrial ecology (IE) and ecological modernization (EM) are two theories regarding the conceptualization and implementation of sustainable development that emerged from the natural and social sciences, respectively. Over the past three decades, scholars have conducted copious amounts of theoretical and applied research on IE and EM, but comparative studies from an interdisciplinary perspective on the relationship between the two remain relatively rare. On the basis of a bibliometric analysis, this study offers a comprehensive examination of the background, theoretical connotations, and main content of IE and EM, also exploring the role of both theoretical perspectives in the promotion of sustainable industrial development. The findings are fourfold: (1) the research on IE and EM has been increasing year by year, particularly in the past decade; (2) the research is mostly concentrated in developed countries such as the United States and European Union member nations, and contributions from China have increased significantly in recent years; (3) IE has a broader research community than EM and has evolved clearer and more specific research contents and methods; and (4) IE, which analyzes the problems of specific industrial systems, and EM, which constitutes a higher-level institutional policy design, exhibit a trend of cross-fertilization. This study provides a reference for building a more systematic and comprehensive theoretical system of ecological transformation and discusses the future research directions in this field.

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A Bibliometric Analysis of Research on Acid Rain

Sustainability ◽

10.3390/su11113077 ◽

2019 ◽

Vol 11 (11) ◽

pp. 3077 ◽

Cited By ~ 7

Author(s):

Ziqiang Liu ◽

Jiayue Yang ◽

Jiaen Zhang ◽

Huimin Xiang ◽

Hui Wei

Keyword(s):

United States ◽

Surface Water ◽

Acid Rain ◽

Bibliometric Analysis ◽

Regional Scale ◽

The United States ◽

Research Area ◽

Phosphorus Fractionation ◽

Current Status ◽

Negative Effects

With the continuation of industrialization and urbanization, acid rain (AR) has aroused extensive concern because of its potential negative effects on ecosystems. However, analysis of the current status and development trends in AR research area has seldom been systematically studied. Therefore, we motivated to conduct a bibliometric analysis of AR publications (1900–2018) using HistCite and CiteSpace software programs. Compared to traditional reviews by experts, this study offers an alternative method to quantitatively analyze and visualize the development of AR field at a large time scale. The results indicated that the overall concern of AR research studies had increased from 1900 to 2018. The most productive country was the United States, while the institution with the most publications was Chinese Academy of Sciences. “Environmental Sciences” was the most popular subject category, Water, Air, and Soil Pollution was the dominant journal, and C.T. Driscoll was the most prominent author in AR field. There were three hotspots in the field of AR, including analyzing AR status and its control policies in Europe, the United States, and China in the past few decades, investigating the ecological consequences of AR on plant histological, physiological, and biochemical traits, as well as surface water and soil properties, and the model application for quantitatively assessing AR and its effects on terrestrial and aquatic ecosystems at regional scale. Further, “behavior”, “phosphorus”, “fractionation”, “soil acidification”, “corrosion”, “performance”, “recovery”, “rainwater”, “trace element”, and “surface water” have been emerging active topics in recent years. This study can help new researchers to find out the most relevant subject categories, countries, institutions, journals, authors, and articles, and identify research trends and frontiers in the field of AR.

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Snapshot and Trends of Corporate Governance Research in the Past 5 Years: Statistics and Visual Analysis Based on CiteSpace

Accounting and Finance ◽

10.33146/2307-9878-2020-4(90)-120-129 ◽

2020 ◽

pp. 120-129

Author(s):

Oleh Pasko ◽

◽

Fuli Chen ◽

Xuefeng Yao ◽

◽

...

Keyword(s):

Corporate Governance ◽

Family Firms ◽

Visual Analysis ◽

Emerging Market ◽

Academic Research ◽

The United States ◽

Current Status ◽

Future Research ◽

The Past ◽

Research Hotspots

Corporate governance is not only one of the important issues of modern enterprise management, but also a hot topic in academic research. Bibliometric analysis of the current status of global corporate governance research in the past five years can help researchers and decision-makers grasp the main trends in corporate governance at present and in the future. The purpose of this research is to analyze the current status, hot spots and trends of corporate governance research in the past five years. Using the core collection of the WOS database as the data source, we searched English language journals related to corporate governance and obtained 607 literature search results. We utilize bibliometric methods and use CiteSpace to conduct statistical analysis and visual analysis. Through statistical literature publication year, country (region), author and literature citation situation, draw keyword co-occurrence map, research hotspot map, clustering map, burst hotspot map, systematically show the corporate governance research field in the past 5 years Basic information, research hotspots and development trends.The research results show that the number of corporate governance-related documents has continued to increase in the past five years. The United States, the United Kingdom, China, Spain, and Australia are the five countries with the largest number of corporate governance studies. The top 5 most cited authors are M.C. Jensen, A. Shleifer, E.F. Fama, R.La. Porta and P. Gompers. Among the top 10 most cited documents, the most cited are 178 words and the least cited 65 times. Research hotspots in corporate governance include agency theory, emerging market, capital structure, family firms, and real earnings management. Future research trends include merger, ownership concentration, equity and institution.

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Diagnostic Imaging in Disasters: A Bibliometric Analysis

Disaster Medicine and Public Health Preparedness ◽

10.1017/dmp.2017.52 ◽

2017 ◽

Vol 12 (2) ◽

pp. 265-277 ◽

Cited By ~ 7

Author(s):

Bo Gong ◽

Mohammed F. Mohammed ◽

Savvas Nicolaou ◽

Muazzam Nasrullah ◽

Bruce B. Forster ◽

...

Keyword(s):

Diagnostic Imaging ◽

Bibliometric Analysis ◽

Conventional Radiography ◽

H1n1 Influenza ◽

The United States ◽

Future Research ◽

Original Research ◽

Influenza Outbreak ◽

Republic Of China ◽

Management Plans

AbstractObjectiveTo investigate the role of diagnostic imaging in the clinical diagnosis, treatment, and follow-up management of patients in response to disasters.MethodsA MEDLINE (OVID) search of original research articles identified 177 articles on this topic published since 2000. A bibliometric analysis was conducted on the top 100 articles ranked by average yearly citation.ResultsThe most frequently studied disaster categories were disease outbreak (55 articles), armed conflict (23 articles), terrorist incident (10 articles), and earthquake (7 articles). The most studied disasters were the H1N1 influenza outbreak in 2009 (28 articles), Severe Acute Respiratory Syndrome outbreak in 2003 (24 articles), War in Afghanistan, 2001-2014 (8 articles), Iraq War, 2003-2011 (6 articles), and the Sichuan earthquake (China) in 2008 (6 articles). Among the first authors, 59 were primarily affiliated with Radiology. The United States of America produced the most articles (25 articles), followed by the People’s Republic of China (24 articles). Eighty-one studies were retrospective, with 19 studies being prospective. Computed tomography was the most investigated modality (52.8%), followed by conventional radiography (33.3%) and ultrasound (9.7%).ConclusionsOur study identifies intellectual milestones in the utility of diagnostic imaging in response to various disasters, and could help guide future research in developing disaster management plans. (Disaster Med Public Health Preparedness. 2018;12:265–277)

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