scholarly journals Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiuqing Zhu ◽  
Jinqing Hu ◽  
Shuhua Deng ◽  
Yaqian Tan ◽  
Chang Qiu ◽  
...  
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
Citation Analysis ◽  
Mood Disorders ◽  
Bibliometric Analysis ◽  
The United States ◽  
Kynurenine Pathway ◽  
Current Status ◽  
Future Research ◽  
Low Grade

Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system.Aim: This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field.Methods: Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection (WoSCC), and analyzed in CiteSpace (5.7 R5W), biblioshiny (using R-Studio), and VOSviewer (1.6.16).Results: In total, 1,064 and 948 documents were extracted from the Scopus and WoSCC databases, respectively. The publications have shown rapid growth since 2006, partly owing to the largest research hotspot appearing since then, “quinolinic acid.” All the top five most relevant journals were in the neuropsychiatry field, such as Brain Behavior and Immunity. The United States and Innsbruck Medical University were the most influential country and institute, respectively. Journal co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry field. Reference co-citation analysis revealed that the top four most important research focuses were “kynurenine pathway,” “psychoneuroimmunology,” “indoleamine 2,3-dioxygenase,” and “proinflammatory cytokines,” and the most recent focus was “gut-brain axis,” thus indicating the role of the KP in bridging the GM and the host immune system, and together reflecting the field’s research foundations. Overlap analysis between the thematic map of keywords and the keyword burst analysis revealed that the topics “Alzheimer’s disease,” “prefrontal cortex,” and “acid,” were research frontiers.Conclusion: This comprehensive bibliometric study provides an updated perspective on research associated with the KP in MD, with a focus on the current status of GM research in this field. This perspective may benefit researchers in choosing suitable journals and collaborators, and aid in the further understanding of the field’s hotspots and frontiers, thus facilitating future research.

scholarly journals Production Trends, Collaboration, and Main Topics of the Integrative and Complementary Oncology Research Area: A Bibliometric Analysis

2019 ◽  
Vol 18 ◽  
pp. 153473541984640 ◽  
Author(s):  
Jose A. Moral-Munoz ◽  
Lidia Carballo-Costa ◽  
Enrique Herrera-Viedma ◽  
Manuel J. Cobo
Keyword(s):  
Bibliometric Analysis ◽  
The United States ◽  
Research Area ◽  
Current Status ◽  
Future Research ◽  
Nf Kappa B ◽  
Republic Of China ◽  
The Past ◽  
Oncology Research ◽  
Complementary Oncology

Background: The prevalence of cancer has increased over time worldwide. Nevertheless, the number of deaths has been reduced during the past 2 decades. Thus, one-third of the cancer patients are users of complementary and alternative therapies, looking for other types of interventions. The main aim of the present study is to understand the current status of the research in integrative and complementary oncology. Three different aspects were analyzed: production trends, country collaboration, and leading research topics. Methods: The dataset was obtained from the documents indexed under the Integrative and Complementary Medicine category of the Web of Science database from 1976 to 2017. VOSviewer and SciMAT software were employed to perform the bibliometric analysis. Results: The Journal of Ethnopharmacology, China Medical University and the People’s Republic of China are the leading producers in the field. Regarding the collaboration, the United States and China present a close connection. The scientific community is focused on the following topics: apoptosis, breast cancer, oxidative stress, chemotherapy, and nuclear factor-Kappa-B (NF-Kappa-B). Conclusions: The present article shows potentially important information that allows understanding of the past, present, and future of research in integrative and complementary oncology. It is a useful evidence-based framework on which to base future research actions and academic directions.

scholarly journals Bibliometric Analysis of Current Status on Bioremediation of Petroleum Contaminated Soils during 2000–2019

2021 ◽  
Vol 18 (16) ◽  
pp. 8859
Author(s):  
Yingjin Song ◽  
Ruiyi Li ◽  
Guanyi Chen ◽  
Beibei Yan ◽  
Lei Zhong ◽  
...  
Keyword(s):  
United States ◽  
Bibliometric Analysis ◽  
Contaminated Soils ◽  
Publication Output ◽  
The United States ◽  
Current Status ◽  
Future Research ◽  
Collaboration Network ◽  
Science Data ◽  
H Index

Petroleum contaminated soils have become a great concern worldwide. Bioremediation has been widely recognized as one of the most promising technologies and has played an important role in solving the issues of petroleum contaminated soils. In this study, a bibliometric analysis using VOSviewer based on Web of Science data was conducted to provide an overview on the field of bioremediation of petroleum contaminated soils. A total of 7575 articles were analyzed on various aspects of the publication characteristics, such as publication output, countries, institutions, journals, highly cited papers, and keywords. An evaluating indicator, h-index, was applied to characterize the publications. The pace of publishing in this field increased steadily over last 20 years. China accounted for the most publications (1476), followed by the United States (1032). The United States had the highest h-index (86) and also played a central role in the collaboration network among the most productive countries. The Chinese Academy of Sciences was the institution with the largest number of papers (347) and cooperative relations (52). Chemosphere was the most productive journal (360). Our findings indicate that the influence of developing countries has increased over the years, and researchers tend to publish articles in high-quality journals. At present, mainstream research is centered on biostimulation, bioaugmentation, and biosurfactant application. Combined pollution of petroleum hydrocarbons and heavy metals, microbial diversity monitoring, biosurfactant application, and biological combined remediation technology are considered future research hotspots.

scholarly journals Trends in Piezo Channel Research Over the Past Decade: A Bibliometric Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Jing Guo ◽  
Dongmei Gu ◽  
Tingting Zhao ◽  
Zhanhao Zhao ◽  
Yajun Xiong ◽  
...  
Keyword(s):  
Citation Analysis ◽  
Bibliometric Analysis ◽  
Mammalian Cells ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
The United States ◽  
Activation Mechanism ◽  
Current Status ◽  
The Past ◽  
Piezo Channels

Purpose: We used bibliometric methods to evaluate the global scientific output of research on Piezo channels and explore the current status and trends in this field over the past decade.Methods: Piezo channel-related studies published in 2010–2020 were retrieved from Web of Science. The R bibliometrix package was used for quantitative and qualitative analyses of publication outputs and author contributions. VOSviewer was used to construct networks based on co-authorship of countries/institutions/authors, co-citation analysis of journals/references, citation analysis of documents, and co-occurrence of keywords.Results: In total, 556 related articles and reviews were included in the final analysis. The number of publications has increased substantially with time. The country and institution contributing the most to this field was the United States and Scripps Research Institute, respectively. Ardem Patapoutian was the most productive author and ranked first among the cited authors, h-index, and m-index. The top cited reference was the article published by Coste B et al. in Science (2010) that identified Piezo1/2 in mammalian cells. The top journals in terms of the number of selected articles and citations were Nature Communications and Nature, respectively. The co-occurrence analysis revealed that Piezo channels are involved a variety of cell types (Merkel cells, neurons, endothelial cells, red blood cells), physiological processes (touch sensation, blood pressure, proprioception, vascular development), related ion channels (transient receptor potential, Gardos), and diseases (pain, distal arthrogryposis, dehydrated hereditary stomatocytosis, cancer), and pharmacology (Yoda1, GsMTx-4).Conclusion: Our bibliometric analysis shows that Piezo channel research continues to be a hotspot. The focus has evolved from Piezo identification to architecture, activation mechanism, roles in diseases, and pharmacology.

scholarly journals Bibliometric and Visual Analysis of Research on the Links Between the Gut Microbiota and Depression From 1999 to 2019

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiuqing Zhu ◽  
Jinqing Hu ◽  
Shuhua Deng ◽  
Yaqian Tan ◽  
Chang Qiu ◽  
...  
Keyword(s):  
Network Analysis ◽  
Gut Microbiota ◽  
Citation Analysis ◽  
Molecular Mechanisms ◽  
Visual Analysis ◽  
The United States ◽  
Current Status ◽  
Collaboration Network ◽  
Burst Detection ◽  
National Academy Of Sciences

Background: There is a crucial link between the gut microbiota and the host central nervous system, and the communication between them occurs via a bidirectional pathway termed the “microbiota-gut-brain axis.” The gut microbiome in the modern environment has markedly changed in response to environmental factors. These changes may affect a broad range of host psychiatric disorders, such as depression, by interacting with the host through metabolic, immune, neural, and endocrine pathways. Nevertheless, the general aspects of the links between the gut microbiota and depression have not been systematically investigated through bibliometric analysis.Aim: This study aimed to analyze the current status and developing trends in gut microbiota research in the depression field through bibliometric and visual analysis.Methods: A total of 1,962 publications published between 1999 and 2019 were retrieved from the Web of Science Core Collection. CiteSpace (5.6 R5) was used to perform collaboration network analysis, co-citation analysis, co-occurrence analysis, and citation burst detection.Results: The number of publications has been rapidly growing since 2010. The collaboration network analysis revealed that the USA, University College Cork, and John F. Cryan were the most influential country, institute, and scholar, respectively. The most productive and co-cited journals were Brain Behavior and Immunity and Proceedings of the National Academy of Sciences of the United States of America, respectively. The co-citation analysis of references revealed that the most recent research focus was in the largest theme cluster, “cytokines,” thus reflecting the important research foundation in this field. The co-occurrence analysis of keywords revealed that “fecal microbiota” and “microbiome” have become the top two research hotspots since 2013. The citation burst detection for keywords identified several keywords, including “Parkinson's disease,” “microbiota-gut-brain axis,” “microbiome,” “dysbiosis,” “bipolar disorder,” “impact,” “C reactive protein,” and “immune system,” as new research frontiers, which have currently ongoing bursts.Conclusions: These results provide an instructive perspective on the current research and future directions in the study of the links between the gut microbiota and depression, which may help researchers choose suitable cooperators or journals, and promote their research illustrating the underlying molecular mechanisms of depression, including its etiology, prevention, and treatment.

scholarly journals Research Trends of Acupuncture Therapy on Cancer Over the Past Two Decades: A Bibliometric Analysis

2020 ◽  
Vol 19 ◽  
pp. 153473542095944
Author(s):  
Jing Guo ◽  
Lixia Pei ◽  
Lu Chen ◽  
Hao Chen ◽  
Dongmei Gu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Acupuncture Therapy ◽  
Supportive Care ◽  
Bibliometric Analysis ◽  
Integrative Medicine ◽  
Clinical Studies ◽  
Current Status ◽  
Cancer Center ◽  
Future Research ◽  
The Past

Purpose: Acupuncture has been used for managing cancer-related symptoms. However, there are still few studies concerning the overall trends in acupuncture therapy on cancer based on bibliometric analysis. This study aims to demonstrate the current status and trends in this field over the past 2 decades. Methods: Articles were retrieved from the Web of Science from 2000 to 2019. CiteSpace was used for co-authorship network of countries/institutions, dual-map analysis, and detecting the keywords with citation bursts. VOSviewer was used to construct networks based on co-authorship and co-citation analysis of authors, and co-occurrence of keywords. Results: A total of 927 articles and reviews were included in the final analysis. The number of publications has steadily increased with some fluctuations among years. The country and institution contributing most to this field are the USA and Memorial Sloan Kettering Cancer Center. Mao JJ was the most productive author and Molassiotis A ranked first in the cited authors. The co-occurrence analysis revealed 5 clusters (including “clinical trials,” “clinical studies on chemotherapy/radiation-induced symptoms,” “CAM therapy for cancer,” “clinical studies on vasomotor symptoms,” and “systematic reviews”). Most recent keyword bursts were “neuropathic pain,” “arthralgia,” “prevention,” “supportive care,” and “integrative medicine”. Conclusions: The annual publication output would increase rapidly in the next decade, which shows a promising future in this research field. Future research hotspots would focus on the role of acupuncture in neuropathic pain, arthralgia, prevention, supportive care, and integrative medicine.

scholarly journals A Bibliometric Analysis of the Global Trend of Using Alginate, Gelatine, and Hydroxyapatite for Bone Tissue Regeneration Applications

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 647
Author(s):  
Mohamed Saiful Firdaus Hussin ◽  
Aludin Mohd Serah ◽  
Khairul Azri Azlan ◽  
Hasan Zuhudi Abdullah ◽  
Maizlinda Izwana Idris ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bibliometric Analysis ◽  
Research Work ◽  
The United States ◽  
Research Area ◽  
Bone Tissue Regeneration ◽  
Future Research ◽  
Starting Point

Collecting information from previous investigations and expressing it in a scientometrics study can be a priceless guide to getting a complete overview of a specific research area. The aim of this study is to explore the interrelated connection between alginate, gelatine, and hydroxyapatite within the scope of bone tissue and scaffold. A review of traditional literature with data mining procedures using bibliometric analyses was considered to identify the evolution of the selected research area between 2009 and 2019. Bibliometric methods and knowledge visualization technologies were implemented to investigate diverse publications based on the following indicators: year of publication, document type, language, country, institution, author, journal, keyword, and number of citations. An analysis using a bibliometric study found that 7446 papers were located with the keywords “bone tissue” and “scaffold”, and 1767 (alginate), 185 (gelatine), 5658 (hydroxyapatite) papers with those specific sub keywords. The number of publications that relate to “tissue engineering” and bone more than doubled between 2009 (1352) and 2019 (2839). China, the United States and India are the most productive countries, while Sichuan University and the Chinese Academy of Science from China are the most important institutions related to bone tissue scaffold. Materials Science and Engineering C is the most productive journal, followed by the Journal of Biomedical Materials Research Part A. This paper is a starting point, providing the first bibliometric analysis study of bone tissue and scaffold considering alginate, gelatine and hydroxyapatite. A bibliometric analysis would greatly assist in giving a scientific insight to support desired future research work, not only associated with bone tissue engineering applications. It is expected that the analysis of alginate, gelatine and hydroxyapatite in terms of 3D bioprinting, clinical outcomes, scaffold architecture, and the regenerative medicine approach will enhance the research into bone tissue engineering in the near future. Continued studies into these research fields are highly recommended.

Regulation of Metabolism: A Cross Talk Between Gut Microbiota and Its Human Host

Physiology ◽  
2012 ◽  
Vol 27 (5) ◽  
pp. 300-307 ◽  
Author(s):  
Rémy Burcelin
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
Low Grade ◽  
Gene Products ◽  
Individual Level ◽  
Obesity And Diabetes ◽  
Regulation Of Metabolism ◽  
Molecular Origin ◽  
The Individual ◽  
Low Grade Inflammation

The recent epidemic of obesity and diabetes and the diversity at the individual level could be explained by the intestinal microbiota-to-host relationship. More than four million gene products from the microbiome could interact with the immune system to induce a tissue metabolic infection, which is the molecular origin of the low-grade inflammation that characterizes the onset of obesity and diabetes.

scholarly journals Technologies for Detection of Babesia microti: Advances and Challenges

Pathogens ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1563
Author(s):  
Scott Meredith ◽  
Miranda Oakley ◽  
Sanjai Kumar
Keyword(s):  
United States ◽  
Early Stage ◽  
Parasite Burden ◽  
The United States ◽  
Babesia Microti ◽  
Current Status ◽  
Low Grade ◽  
Babesia Species ◽  
Technological Advances ◽  
Human Babesiosis

The biology of intraerythrocytic Babesia parasites presents unique challenges for the diagnosis of human babesiosis. Antibody-based assays are highly sensitive but fail to detect early stage Babesia infections prior to seroconversion (window period) and cannot distinguish between an active infection and a previously resolved infection. On the other hand, nucleic acid-based tests (NAT) may lack the sensitivity to detect window cases when parasite burden is below detection limits and asymptomatic low-grade infections. Recent technological advances have improved the sensitivity, specificity and high throughput of NAT and the antibody-based detection of Babesia. Some of these advances include genomics approaches for the identification of novel high-copy-number targets for NAT and immunodominant antigens for superior antigen and antibody-based assays for Babesia. Future advances would also rely on next generation sequencing and CRISPR technology to improve Babesia detection. This review article will discuss the historical perspective and current status of technologies for the detection of Babesia microti, the most common Babesia species causing human babesiosis in the United States, and their implications for early diagnosis of acute babesiosis, blood safety and surveillance studies to monitor areas of expansion and emergence and spread of Babesia species and their genetic variants in the United States and globally.

Digital Health Literacy: A Bibliometric Analysis (Preprint)

2021 ◽  
Author(s):  
Keng Yang ◽  
Yekang Hu ◽  
Hanying Qi
Keyword(s):  
Health Literacy ◽  
Health Outcomes ◽  
Digital Divide ◽  
Bibliometric Analysis ◽  
Digital Health ◽  
The United States ◽  
Research Progress ◽  
Future Research ◽  
Scientific Publications ◽  
Number Of Publications

BACKGROUND Digital health is growing at a rapid pace, and digital health literacy has tremendous potential to promote health outcomes, bridge the digital divide, and improve health inequalities. OBJECTIVE The purposes of this study are to conduct a systematic bibliometric analysis on the field of dig-ital health literacy and to understand the research context and trends in this field. METHODS A total of 1,955 scientific publications were collected from the Web of Science (WoS) core col-lection. Institutional cooperation, journal co-citation, theme bursting, keyword co-occurrence, author cooperation, author co-citation, literature co-citation and references in the field of digi-tal health literacy were analyzed using the VOSviewer and CiteSpace knowledge mapping tools. RESULTS The results demonstrated that the United States was the leader in number of publications and citations in this field. The University of California System was first in terms of institutional contributions. The Journal of Medical Internet Research led in number of publications, cita-tions and co-citations. Research areas in the field of digital health literacy mainly include the definition and scale of health literacy, health literacy and health outcomes, health literacy and the digital divide, and the influencing factors of health literacy. CONCLUSIONS We summarize research progress in the field of digital health literacy and reveal the context, trends, and trending topics of digital health literacy research through statistical analysis and network visualization. Our work can serve as a fundamental reference and directional guide for future research in this field.

A comprehensive analysis of the 21st century's research trends in English Mobile Learning: a bibliographic review of the literature

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Rouhollah Khodabandelou ◽  
Masood Fathi ◽  
Mohammad Amerian ◽  
Mohammad Reza Fakhraie
Keyword(s):  
Bibliometric Analysis ◽  
Mobile Learning ◽  
Research Trends ◽  
Current Status ◽  
Future Research ◽  
Review Of Literature ◽  
Content Type ◽  
The Past ◽  
Learning Research ◽  
Points Of View

PurposeThis study examines the importance of English Mobile Learning research as a foundation for lifelong and sustainable education from different points of view, including those of technology innovation experts, psychologists and educators. It aims to explore the current status and relevant research trends through the application of bibliometric mapping and bibliometric analysis.Design/methodology/approachFor this study, all Web of Science records (in total 5,343) from 2000 to 2020 in the field of English Mobile Learning were analyzed using the VOSviewer and CiteSpace software tools. The WoS built-in functions, including “Refine” and “Analyze,” were employed to perform the bibliometric analysis. The study further analyzed a sample of the five most-cited articles to identify the previous studies with the highest quality or impact.FindingsThe results showed that research in English Mobile Learning is growing quickly and steadily with a noticeable emphasis on various device-based technologies and applications. The study also discusses the key implications for research institutions, education policymakers and academicians, and identifies the most prominent avenues for future research on English Mobile Learning. Moreover, the results shared in this review highlight the most important and emerging areas of research in the field.Originality/valueThis article is the most recent bibliographic review of literature that particularly addresses the English Mobile Learning research during the past two decades.

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