scholarly journals The Treatment for a Patient with Cancer of Unknown Primary: A Case Report

Dose-Response ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 155932582110561
Author(s):  
QingTao Ni ◽  
KaiJin Lu ◽  
Chi Pan ◽  
ShengBin Dai ◽  
Peng Wang
Keyword(s):  
Side Effects ◽  
Treatment Options ◽  
Severe Pneumonia ◽  
Additional Treatment ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Patient Tolerance ◽  
Degree Of Malignancy ◽  
The Right ◽  
High Degree

Background Cancer of unknown primary (CUP) is metastatic at diagnosis with an unknown primary site, indicating a high degree of malignancy with a poor prognosis. The development and application of targeted therapy and immunotherapy are current research hotspots, which provide additional treatment options for CUP. Case Presentation A 36-year-old male presented with pain on the right hip in April 2018. After various examinations, he was diagnosed with CUP. This patient received chemotherapy, immunotherapy, and local radiotherapy in our department. However, the use of radiotherapy after immunotherapy resulted in severe pneumonia. Conclusion Compared with traditional treatments, immunotherapy is an effective treatment with fewer side effects and better patient tolerance. However, treating physicians should be still pay special attention to the occurrence of side effects when radiotherapy is combined with immunotherapy.

scholarly journals Immunotherapy Combined With Chemotherapy and Radiotherapy for a Patient With Cancer of Unknown Primary: A Case Report

2020 ◽  
Author(s):  
Qingtao Ni ◽  
KaiJin Lu ◽  
Chi Pan ◽  
ShengBin Dai ◽  
Peng Wang
Keyword(s):  
Side Effects ◽  
Treatment Options ◽  
Severe Pneumonia ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Patient Tolerance ◽  
Degree Of Malignancy ◽  
Case Presentations ◽  
The Right ◽  
High Degree

Abstract Background: Cancer of unknown primary (CUP) is metastatic at diagnosis with unknown primary site, indicating a high degree of malignancy with poor prognosis. The development and application of targeted therapy and Immunotherapy is the current research hotspot, and provide more treatment options for CUP.Case Presentations: A 36-year-old freeworking male presented with pain on the right hip in April 2018. After various examinations, he was diagnosed as CUP. He received chemotherapy, immunotherapy and local radiotherapy in our department. However, the use of radiotherapy after immunotherapy resulted in severe pneumonia. Conclusions: Compared with traditional treatments, immunotherapy is effective treatment with fewer side effects and better patient tolerance. However, treating physicians should continue to pay special attention to the occurrence of side effects, when radiotherapy combined with immunotherapy.

Thymic Carcinoma Presenting as Cranial Metastasis with Intradural and Extracranial Extension: Case Report

Neurosurgery ◽  
2004 ◽  
Vol 54 (1) ◽  
pp. 209-212 ◽  
Author(s):  
Yoji Tamura ◽  
Toshihiko Kuroiwa ◽  
Atsushi Doi ◽  
Kyong-Yob Min
Keyword(s):  
Thymic Carcinoma ◽  
Delayed Diagnosis ◽  
Magnetic Resonance Images ◽  
Computed Tomographic ◽  
Multiple Cycle ◽  
Degree Of Malignancy ◽  
The Right ◽  
Cranial Metastasis ◽  
Upper Mediastinum ◽  
High Degree

Abstract OBJECTIVE AND IMPORTANCE Thymic carcinoma is an uncommon malignant tumor that is different from thymoma. Cranial and brain metastases from this tumor are extremely rare. We report a thymic carcinoma with cranial metastasis and discuss the behavior of this tumor. CLINICAL PRESENTATION A 50-year-old man presented with headache and a palpable scalp tumor. Computed tomographic scans and magnetic resonance images revealed an osteolytic tumor with intradural and extracranial extension in the right occipital bone. INTERVENTION After gross total resection and histological diagnosis, further investigation revealed a primary thymic tumor in the anterior upper mediastinum and liver metastases. The patient received multiple-cycle chemotherapy (cisplatin and gemcitabine) for primary and metastatic lesions. CONCLUSION Thymic carcinoma has a poor prognosis because of a high degree of malignancy, early metastasis, and delayed diagnosis. Thus, treatment of a patient with this tumor calls for prompt diagnosis, surgical treatment, and optimal adjuvant therapy.

scholarly journals Therapeutic Options for Chronic Rhinosinusitis in N-ERD Patients

2021 ◽  
Vol 2 ◽  
Author(s):  
Rik J. L. van der Lans ◽  
Wytske J. Fokkens ◽  
Sietze Reitsma
Keyword(s):  
Chronic Rhinosinusitis ◽  
Treatment Options ◽  
Additional Treatment ◽  
Aspirin Therapy ◽  
Sinus Surgery ◽  
Shared Decision ◽  
Diffuse Type ◽  
Treatment Resistant ◽  
The Right

Patients with non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) often suffer from chronic rhinosinusitis (CRS) with nasal polyps, a form of primary diffuse Type 2 CRS. Although this disease is also seen in NSAID-tolerant patients, CRS in N-ERD often is more severe and more treatment resistant; local nasal therapy (nasal corticosteroids) and endoscopic sinus surgery are employed like in NSAID-tolerant patients, but with limited and/or short-lived effects. This mini-review gives an overview of the current additional treatment options for CRS in N-ERD. As such diets, aspirin therapy after desensitization, antileukotriene therapy and biologicals are discussed based on the current body of literature. Selecting the right treatment strategy depends on shared-decision making, local availability and cooperation between ENT-surgeons, allergists, and pulmonologists.

Cancer of unknown primary

2019 ◽  
pp. 333-340
Keyword(s):  
Overall Survival ◽  
Patient Group ◽  
Poor Prognosis ◽  
Treatment Options ◽  
Unknown Origin ◽  
Final Diagnosis ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Nursing Management

This chapter first considers how cancers of unknown primary (CUP) can be characterized and defined (alongside metastases of unknown origin), before moving on to the incidence of these cancers, associated survival, and overall poor prognosis. Subgroups of patients with CUP with better survival are described. The section then moves on to explore how, in the last 4 years, prior to publication, there has been a change in the approach to managing CUP in an effort to improve overall survival and the treatment options and modalities used to treat CUP. The chapter concludes with a summary of the nursing management of this patient group and how uncertainty around the final diagnosis can have clinical and psychological repercussions.

scholarly journals Prediction of Primary Tumors in Cancers of Unknown Primary

2017 ◽  
Vol 14 (2) ◽  
Author(s):  
Dan Søndergaard ◽  
Svend Nielsen ◽  
Christian N.S. Pedersen ◽  
Søren Besenbacher
Keyword(s):  
Primary Tumor ◽  
Metastatic Cancer ◽  
Large Fraction ◽  
Molecular Data ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Expression Data ◽  
Tumor Biopsy ◽  
Primary Tumors ◽  
The Right

AbstractA cancer of unknown primary (CUP) is a metastatic cancer for which standard diagnostic tests fail to identify the location of the primary tumor. CUPs account for 3–5% of cancer cases. Using molecular data to determine the location of the primary tumor in such cases can help doctors make the right treatment choice and thus improve the clinical outcome. In this paper, we present a new method for predicting the location of the primary tumor using gene expression data: locating cancers of unknown primary (LoCUP). The method models the data as a mixture of normal and tumor cells and thus allows correct classification even in impure samples, where the tumor biopsy is contaminated by a large fraction of normal cells. We find that our method provides a significant increase in classification accuracy (95.8% over 90.8%) on simulated low-purity metastatic samples and shows potential on a small dataset of real metastasis samples with known origin.

Mutational burden of tumors with primary site unknown.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 3039-3039 ◽  
Author(s):  
Laurie M. Gay ◽  
David Fabrizio ◽  
Garrett Michael Frampton ◽  
Caitlin F. Connelly ◽  
James Sun ◽  
...  
Keyword(s):  
Clinical Care ◽  
Treatment Options ◽  
Additional Treatment ◽  
Primary Site ◽  
Unknown Primary ◽  
Tumor Type ◽  
Coding Region ◽  
Tissue Samples ◽  
Primary Tumor Site ◽  
Mutational Burden

3039 Background: Higher levels of tumor mutational burden (TMB) can predict sensitivity to immunotherapies (IO), which are FDA approved to treat NSCLC, melanoma, and urothelial carcinoma (Ca). TMB may be a biomarker for sensitivity to IO, irrespective of tumor type. TMB has not been explored widely for tumors of unknown primary site, but may reveal additional treatment options. Methods: Comprehensive genomic profiling of DNA from FFPE tissue samples was performed using hybrid-capture, next-generation sequencing. TMB was calculated by counting all coding short variant alterations (base substitutions and indels), including synonymous alterations, and subtracting from this functionally oncogenic or germline alterations (per ExAC, dbSNPT, or internal algorithmic analysis). To calculate the TMB per Mb, the total number of relevant mutations is divided by the coding region of the bait set (0.8 Mb, 1.1 Mb, or 1.2 Mb). High, intermediate, and low TMB were defined as ≥20 mut/Mb, ≥6 and <20 mut/Mb, or <6 mut/Mb, respectively. Tumor types with >100 samples were analyzed. Results: From a database of 102,878 samples sequenced during routine clinical care, 6116 samples for which the primary tumor site was unclear at sequencing were identified. Table shows TMB metrics (mut/Mb) and median patient age for these cohorts. Conclusions: Significant numbers of patients with each tumor type have high TMB that may indicate benefit from IO, excepting GIST. As expected, urothelial tumors have higher than average TMB and more patients have high TMB. SCC tumors are commonly TMB high (23%), as are tumors difficult to define histologically (15%). For ACUP or CUP, the most common tumors, 8-11% have high TMB. Analysis of responses to treatment with IO are ongoing. [Table: see text]

scholarly journals Probing the unknown in cancer of unknown primary: which way is the right way?

2010 ◽  
Vol 21 (6) ◽  
pp. 1143-1144 ◽  
Author(s):  
G. Pentheroudakis ◽  
N. Pavlidis
Keyword(s):  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
The Right

EDUKASI TERHADAP REMAJA DALAM PENINGKATAN PENGETAHUAN TENTANG PENGGUNAAN GAME DENGAN BIJAK

2020 ◽  
Vol 2 (1) ◽  
pp. 11
Author(s):  
Ikhsan Fuady ◽  
Rangga Saptya MP
Keyword(s):  
Side Effects ◽  
Violent Behavior ◽  
Daily Lives ◽  
Before And After ◽  
Improper Use ◽  
Effective Role ◽  
Education And Outreach ◽  
The Right ◽  
Dedicated Team ◽  
User Ratings

<p align="center"><strong>Abstrak</strong></p><p><em>Pemanfaatan game dikalangan remaja memiliki peran yang efektif sebagai wadah untuk hiburan. Tetapi pemanfaatan game tidak tepat memiliki efek samping game terhadap kehidupan sehari hari remaja, mulai dari kurang bersosialIsasi hingga perilaku kekerasan dikalangan remaja. Penyuluhan terhadap remaja bertujuan untuk memberikan pemahaman kepada remaja tentang variasi game berdasarkan rating pengguna, maupun cerdas dalam manajemen penggunaan game dalam kehidupan remaja sehari hari. Pengetahuan remaja tentang varian/ragam game berdasarkan rating relatif rendah sebagaian besar pemengetahuannya tersebar pada kategori sangat rendah dan rendah yaitu sebesar 65 persen. Metode edukasi dan sosialisasi ini adalah dengan beberapa tahapan. Tahap pertaman tim pengabdian memberikan edukasi dan diskusi tentang beragam bentuk game, karakteristik, serta karakteristik pengguna game yang tepat. Selanjutnya beberapa permainan dan kuis untuk meingkatkan literasi remaja tentang pemanfaatan game secara bijak. Kegiatan penyuluhan ini mampu meningkatkan pemahaman para remaja dalam mengenali game yang baik digunakan, hal ini dapat dilihat dari peningkatan pengetahuan remaja relatif signifikan sebelum dan sesudah penyuluhan.</em></p><p><strong>Kata kunci<em>:</em></strong><strong><em> </em></strong><strong><em>Edukasi, Game, Penyuluhan </em></strong></p><p align="center"><em> </em></p><p align="center"><strong>Abstract</strong> </p><p><em>The use of games among teenagers has an effective role as a forum for entertainment. But the improper use of games has the side effects of games on the daily lives of adolescents, ranging from lack of socialization to violent behavior in adolescents. Counseling against adolescents aims to provide understanding to adolescents about the variety/variance of games based on user ratings, as well as being smart in managing game use in daily teenage life. Teenagers' knowledge about game variants/based on the rating is relatively low, most of the knowledge is spread in the very low and low categories, which is 65 percent. The method of education and outreach is by several stages. The first stage of the dedicated team provided education and discussion about various forms of games, characteristics, and characteristics of the right game user. Furthermore, some games and quizzes to improve teen literacy about game use wisely. This counseling activity can increase the understanding of teenagers in recognizing games that are well used, this can be seen from the relatively significant increase in adolescent knowledge before and after counseling.</em></p><p><strong>Keywords<em>:</em></strong><em> <strong>Education, Games, Counseling</strong></em></p>

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