scholarly journals In-Room Assessment of Cerebral Blood Volume for Guidance during Intra-Arterial Thrombolytic Therapy

2012 ◽  
Vol 18 (4) ◽  
pp. 463-468 ◽  
Author(s):  
C-J. Lin ◽  
M. Yu ◽  
S-C. Hung ◽  
M.M.H. Teng ◽  
W-Y. Guo ◽  
...  
Keyword(s):  
Thrombolytic Therapy ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Endovascular Procedures ◽  
Flat Panel ◽  
Hemodynamic Changes ◽  
Post Contrast ◽  
Ischemic Tissue ◽  
Parenchymal Blood Volume ◽  
The Right

In acute ischemic stroke, the ability to estimate the penumbra and infarction core ratio helps to triage those who will potentially benefit from thrombolytic therapies. Flat-panel post-contrast DynaCT imaging can provide both vasculature and parenchymal blood volume within the angio room to monitor hemodynamic changes during the endovascular procedures. We report on an 80-year-old woman who suffered from an acute occlusion of the right distal cervical internal carotid artery. She was transferred to the angio room where in-room post-contrast flat-panel DynaCT imaging (syngo Neuro PBV IR) was performed to access the ischemic tissue, followed by successful mechanical thrombolytic therapy.

scholarly journals Optimal dilution of contrast medium for quantitating parenchymal blood volume using a flat-panel detector

2017 ◽  
Vol 46 (1) ◽  
pp. 464-474 ◽  
Author(s):  
Takumi Kuriyama ◽  
Nobuyuki Sakai ◽  
Mikiya Beppu ◽  
Chiaki Sakai ◽  
Hirotoshi Imamura ◽  
...  
Keyword(s):  
Contrast Medium ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Therapeutic Interventions ◽  
Flat Panel ◽  
Flat Panel Detector ◽  
Perfusion Studies ◽  
Power Injector ◽  
Before And After ◽  
Parenchymal Blood Volume

Objective Similar to perfusion studies after acute ischemic stroke, measuring cerebral blood volume (CBV) via C-arm computed tomography before and after therapeutic interventions may help gauge subsequent revascularization. We tested serial dilutions of intra-arterial injectable contrast medium (CM) to determine the optimal CM concentration for quantifying parenchymal blood volume by flat-panel detector imaging (FD-PBV). Methods CM was diluted via saline power injector, instituting time delays for FD-PBV studies. A red/green/blue (RGB) color scale was employed to quantify/compare FD-PBV and magnetic resonance-derived CBV (MRCBV). Results Contrast values of right and left common carotid arteries did not differ significantly at CM dilutions of ≥20%. RGB analysis of FD-PBV imaging (relative to MR-CVB), showed CM dilution altered the colors (by 16%), increasing red and decreasing blue ratios. Conclusion Diluting CM to 20% resulted in no laterality differential of FD-PBV imaging, with left/right quantitative ratios approaching 1.1 (optimal for clinical use).

scholarly journals Cerebral Hemodynamics in Human Acute Ischemic Stroke: A Study with Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging and SPECT

2000 ◽  
Vol 20 (6) ◽  
pp. 910-920 ◽  
Author(s):  
Yawu Liu ◽  
Jari O. Karonen ◽  
Ritva L. Vanninen ◽  
Leif Østergaard ◽  
Reina Roivainen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ischemic Stroke ◽  
Magnetic Resonance ◽  
Acute Ischemic Stroke ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Acute Stage ◽  
Resonance Imaging ◽  
Relative Cerebral Blood Volume ◽  
Ischemic Tissue

Nineteen patients with acute ischemic stroke (<24 hours) underwent diffusion-weighted and perfusion-weighted (PWI) magnetic resonance imaging at the acute stage and 1 week later. Eleven patients also underwent technetium-99m ethyl cysteinate dimer single-photon emission computed tomography (SPECT) at the acute stage. Relative (ischemic vs. contralateral control) cerebral blood flow (relCBF), relative cerebral blood volume, and relative mean transit time were measured in the ischemic core, in the area of infarct growth, and in the eventually viable ischemic tissue on PWI maps. The relCBF was also measured from SPECT. There was a curvilinear relationship between the relCBF measured from PWI and SPECT ( r = 0.854; P < 0.001). The tissue proceeding to infarction during the follow-up had significantly lower initial CBF and cerebral blood volume values on PWI maps ( P < 0.001) than the eventually viable ischemic tissue had. The best value for discriminating the area of infarct growth from the eventually viable ischemic tissue was 48% for PWI relCBF and 87% for PWI relative cerebral blood volume. Combined diffusion and perfusion-weighted imaging enables one to detect hemodynamically different subregions inside the initial perfusion abnormality. Tissue survival may be different in these subregions and may be predicted.

A search for a pulsatile component in pulmonary capillary blood volume

1965 ◽  
Vol 20 (6) ◽  
pp. 1173-1178 ◽  
Author(s):  
K. T. Fowler ◽  
J. E. Maloney
Keyword(s):  
Blood Volume ◽  
Cardiac Cycle ◽  
Human Subjects ◽  
Small Vessels ◽  
Pulmonary Capillary ◽  
Capillary Blood Volume ◽  
Pulmonary Capillary Blood ◽  
Parenchymal Blood Volume ◽  
Pulmonary Capillary Blood Volume ◽  
The Right

An examination was made of externally detected radioactivity over the thorax of two human subjects after the infusion of red cells labeled with Cr51. An electronic gating technique was used which enabled the mean counting rate to be determined over various preselected time intervals within the cardiac cycle and a comparison made between the rates which obtained during each quarter of this. When counting over the heart the rates were 20—30% greater in diastole than in systole. When counting over rib 2 or rib 4 on the right side no significant variation in count rate could be detected. From this it was deduced that pulmonary parenchymal blood volume in these regions did not vary by more than ± 10% within the cardiac cycle. It was concluded that within the erect lung a proportion of closed capillaries exists in the upper zone, and that the distensibility of the small vessels is insufficient to explain the large vertical inequality of blood flow observed experimentally. pulmonary circulation; parenchymal blood volume; pulsations in volume; distensibility of small vessels Submitted on August 17, 1964

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