HIF-1α is a Prognostic Marker in Oral Squamous Cell Carcinomas

The critical molecular regulator of hypoxia is the hypoxia-inducible factor 1 alpha (HIF-1α). The prognostic impact of this regulator protein in oral squamous cell carcinomas (OSCC) has not been comprehensively investigated. The aim of this study was to analyze the expression of HIF-1α in 82 patients with OSCC and to correlate it with their disease-specific survival. Immunohistochemical staining for HIF-1α was performed on 82 OSCC specimens using a standard immunoperoxidase technique. The expression of HIF-1α was correlated with poor disease-specific survival for OSCC patients. Patients with negatively or weakly HIF-1α–expressing tumors had a survival rate of 80%, whereas the survival decreased to only 33.6% in case of moderate or strong expression. In multivariate Cox regression analysis, we found a 3.5-fold increased risk of tumor-related death when HIF-1α was strongly expressed (p=0.016) compared to negative or weak expression of HIF-1α. We suggest HIF-1α is an independent prognostic marker in OSCC. Immunohistochemical detection of HIF-1α appears to be useful in the diagnosis of OSCC and to provide prognostic information in addition to TNM stage and histological grade.

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Expression and prognostic impact of indoleamine 2,3-dioxygenase in oral squamous cell carcinomas

Oral Oncology ◽

10.1016/j.oraloncology.2011.03.007 ◽

2011 ◽

Vol 47 (5) ◽

pp. 352-357 ◽

Cited By ~ 32

Author(s):

Klaus Laimer ◽

Birgit Troester ◽

Frank Kloss ◽

Georg Schafer ◽

Peter Obrist ◽

...

Keyword(s):

Squamous Cell ◽

Squamous Cell Carcinomas ◽

Prognostic Impact ◽

Oral Squamous Cell Carcinomas ◽

Indoleamine 2,3 Dioxygenase

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Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy

The Open Dentistry Journal ◽

10.2174/1874210600802010078 ◽

2008 ◽

Vol 2 (1) ◽

pp. 78-88 ◽

Cited By ~ 2

Author(s):

Shuri Ohkura-Hada ◽

Nobuo Kondoh ◽

Akiyuki Hada ◽

Masaaki Arai ◽

Yutaka Yamazaki ◽

...

Keyword(s):

Retinoic Acid ◽

Prognostic Marker ◽

Squamous Cell ◽

Molecular Mechanisms ◽

Growth Suppression ◽

Carbonyl Reductase ◽

Squamous Cell Carcinomas ◽

Oral Squamous Cell Carcinomas ◽

Potential Marker ◽

Oral Malignancy

The molecular mechanisms of growth suppression by retinoic acid (RA) were examined. Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas (OSCCs), and the expression is a potential marker for oral malignancy.

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Does age influence disease‐specific survival in patients with squamous cell carcinomas of the head and neck?

Journal of Surgical Oncology ◽

10.1002/jso.25895 ◽

2020 ◽

Vol 121 (7) ◽

pp. 1058-1066

Author(s):

Joan Lop ◽

Cristina Valero ◽

Jacinto García ◽

Miquel Quer ◽

Ian Ganly ◽

...

Keyword(s):

Head And Neck ◽

Squamous Cell ◽

Squamous Cell Carcinomas ◽

Disease Specific Survival ◽

Disease Specific

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Dysregulation of ß‐catenin, WISP1 and TCF21 predicts disease‐specific survival and primary response against radio(chemo)therapy in patients with locally advanced squamous cell carcinomas of the head and neck

Clinical Otolaryngology ◽

10.1111/coa.13281 ◽

2019 ◽

Vol 44 (3) ◽

pp. 263-272 ◽

Cited By ~ 2

Author(s):

Erich Vyskocil ◽

Johannes Pammer ◽

Gabriela Altorjai ◽

Matthaeus Ch. Grasl ◽

Thomas Parzefall ◽

...

Keyword(s):

Head And Neck ◽

Squamous Cell ◽

Locally Advanced ◽

Primary Response ◽

Squamous Cell Carcinomas ◽

Disease Specific Survival ◽

Disease Specific

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Synchronous and Metachronous Squamous Cell Carcinomas of the Head and Neck Mucosal Sites

Journal of Clinical Oncology ◽

10.1200/jco.2001.19.5.1358 ◽

2001 ◽

Vol 19 (5) ◽

pp. 1358-1362 ◽

Cited By ~ 104

Author(s):

Haldun Ş. Erkal ◽

William M. Mendenhall ◽

Robert J. Amdur ◽

Douglas B. Villaret ◽

Scott P. Stringer

Keyword(s):

Overall Survival ◽

Survival Rate ◽

Head And Neck ◽

Squamous Cell ◽

Squamous Cell Carcinomas ◽

Thoracic Esophagus ◽

Overall Survival Rate ◽

Disease Specific Survival ◽

Disease Specific

PURPOSE: The present study presents the experience at the University of Florida with synchronous and metachronous squamous cell carcinomas of the head and neck mucosal sites. PATIENTS AND METHODS: This study included 1,112 patients with squamous cell carcinomas of the oropharynx, hypopharynx, and supraglottic larynx treated with radiation therapy with curative intent from 1964 to 1997. All patients had follow-up for at least 2 years. No patients were lost to follow-up. RESULTS: The overall survival rate was 45% and the disease-specific survival rate was 67% at 5 years after initial diagnosis of carcinoma of the head and neck mucosal sites. Seventy-seven patients (7%) presented with synchronous carcinomas of the head and neck mucosal sites and 103 patients (9%) developed metachronous carcinomas of the head and neck mucosal sites at 0.6 to 21.7 years (median, 3.6 years). The overall survival rate was 31%, and the disease-specific survival rate was 50% at 5 years after metachronous carcinomas of the head and neck mucosal sites. Seven patients (1%) developed metachronous carcinomas of the thoracic esophagus at 1 to 11.1 years (median, 2.8 years), 15 patients (1%) presented with synchronous carcinomas of the lung, and 83 patients (7%) developed metachronous carcinomas of the lung at 0.6 to 17.6 years (median, 3.5 years). CONCLUSION: Development of synchronous and metachronous squamous cell carcinomas of the head and neck mucosal sites are in part responsible for failure to improve overall survival rates for patients with squamous cell carcinomas of the head and neck mucosal sites, justifying rigorous follow-up and studies on chemoprevention.

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Comparison of the Adult Comorbidity Evaluation 27 and the Charlson Comorbidity indices in patients with laryngeal squamous cell carcinoma

The Journal of Laryngology & Otology ◽

10.1017/s0022215112000254 ◽

2012 ◽

Vol 126 (5) ◽

pp. 516-524 ◽

Cited By ~ 13

Author(s):

V S Nesic ◽

Z M Petrovic ◽

S B Sipetic ◽

S D Jesic ◽

I A Soldatovic ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Charlson Comorbidity Index ◽

Laryngeal Squamous Cell Carcinoma ◽

Prognostic Impact ◽

Disease Specific Survival ◽

Comorbidity Index ◽

The Impact ◽

Disease Specific

AbstractObjective:This study aimed to compare the prognostic impact of comorbidity grading by the Adult Comorbidity Evaluation 27 index and the Charlson Comorbidity Index on the five-year overall and disease-specific survival in patients undergoing surgery for laryngeal squamous cell carcinoma.Methods:The impact of comorbidity and other factors on survival was examined retrospectively in a group of 177 patients with previously untreated tumour stage one to four laryngeal squamous cell carcinoma surgically treated at the Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, between 2000 and 2003. The Cox proportional hazard model was used to identify independent prognostic factors.Results:On univariate analysis, comorbidity had an impact on prognosis regardless of which index was used. On multivariate analysis, the significant predictors of patients' five-year overall and disease-specific survival were tumour–node–metastasis stage and comorbidity as graded by the Adult Comorbidity Evaluation 27 index.Conclusion:The Adult Comorbidity Evaluation 27 index is a more reliable predictor of survival than the Charlson Comorbidity Index in patients with laryngeal squamous cell carcinoma.

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