Preoperative Carbohydrate Antigen 195 (CA195) and CEA Serum Levels as Prognostic Factors in Patients with Colorectal Cancer

1998 ◽  
Vol 13 (3) ◽  
pp. 158-164 ◽  
Author(s):  
A. Andicoechea ◽  
F. Vizoso ◽  
E. Alexandre ◽  
E. Cuesta ◽  
M. Cruz Díez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Multivariate Analysis ◽  
Prognostic Value ◽  
Serum Levels ◽  
Tumor Location ◽  
Carbohydrate Antigen ◽  
Primary Colorectal Cancer ◽  
Preoperative Serum ◽  
The Mean

We evaluated in 214 patients with primary colorectal cancer the prognostic value of the preoperative serum levels of CEA and CA195. For CEA these levels were above the cutoff of 6 ng/ml in 31.3% of patients, whereas for CA195 they were higher than 12 U/ml in 35.9% of patients. The simultaneous use of both antigens increased the sensitivity to 49%, which was significantly higher than that of CEA (p<0.001) and CA195 (p<0.01) taken singly. The mean preoperative CEA levels were significantly (p<0.001) correlated with Dukes’ stage only, while there was a significant correlation between preoperative serum levels of CA195 and Dukes’ stage (p<0.001), grade of differentiation (p<0.01) and tumor location (p<0.05). The results indicated that high preoperative serum levels of CEA and CA195 were associated with a shorter overall survival (p<0.0001). In addition, separate Cox multivariate analysis showed that preoperative CA195 was, after Dukes’ stage, the strongest factor to predict overall survival (p<0.0001).

The prognostic value of preoperative serum levels of IL-12p40 and IL-23 for survival of patients with colorectal cancer

Apmis ◽  
2014 ◽  
Vol 122 (12) ◽  
pp. 1223-1229 ◽  
Author(s):  
Noyko Stanilov ◽  
Lyuba Miteva ◽  
Jovcho Jovchev ◽  
Geo Cirovski ◽  
Spaska Stanilova
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Serum Levels ◽  
Preoperative Serum

Prognostic Value of Preoperative Serum Levels of CEA and CA19-9 in Patients with Colorectal Cancer

2007 ◽  
Vol 23 (5) ◽  
pp. 338
Author(s):  
Byong Ku Bae ◽  
Seong Woo Hong ◽  
Yeo Goo Chang ◽  
Koo Yong Hahn ◽  
In Wook Paik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Serum Levels ◽  
Preoperative Serum

Association between primary tumor site, perioperative CEA ratio, and overall survival in patients with colorectal cancer.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 518-518
Author(s):  
Thomas A Odeny ◽  
Nicole Farha ◽  
Wilfred Vazquez ◽  
Amna Batool ◽  
Anwaar Saeed ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Multivariate Analysis ◽  
Smoking Status ◽  
Tumor Stage ◽  
Tumor Location ◽  
Effect Modification ◽  
Cox Proportional Hazards ◽  
P Value ◽  
Primary Tumor Site

518 Background: There are differences in the incidence, clinical presentation, molecular pathogenesis and outcome of colorectal cancer (CRC) based on the tumor location. Emerging research suggests that the perioperative carcinoembryonic antigen (CEA) ratio is a prognostic factor for CRC patients. We aimed to determine the association between tumor location, perioperative CEA ratio, and 5-year survival among patients with CRC. Methods: We analyzed 111 patients who underwent resection for CRC at KUMC. After excluding patients without pre- or post-operative CEA data, 62 patients for whom we could calculate a CEA ratio (post-op/pre-op CEA) were classified as either high ( ≥ 0.5) or low ( < 0.5) ratio. The primary outcomes were: 1) overall survival (OS) stratified by tumor location; 2) OS stratified by CEA ratio; and 3) whether there was effect modification by tumor location, of the association between perioperative CEA ratio and OS, after adjusting for tumor stage and smoking status. Kaplan-Meier method was used to estimate survival rates, and Cox proportional hazards models for multivariate analysis. Results: The median age was 61 years, 54% male, 31% smokers, 74% left-sided tumors, median pre-operative CEA was 3.3, and 60% had CEA ratio ≥ 0.5. The OS rates were 89.1% and 81.3% in patients with left-sided versus right-sided tumors respectively (p-value = 0.4). The OS rates were 83.8% and 92.0% in patients with high versus low CEA ratios respectively (p-value = 0.3). There was effect modification by tumor location on association between CEA ratio and OS, after adjusting for smoking status and tumor stage (p-value < 0.001). However, in the stratified analysis, the n was too small to permit inferential analysis. In multivariate analysis, both tumor location (HR 0.4; p = 0.3) and perioperative CEA ratio (HR 2.7; p = 0.3) were not significantly associated with OS after adjusting for smoking status and tumor stage. Conclusions: There was no difference in OS between left versus right-sided tumors. The association between perioperative CEA ratio and OS was significantly modified by tumor location. However, to attribute this modification to left versus right warrants validation in a larger cohort as our sample size was limited.

scholarly journals Elevated Serum Endothelin-1 Levels in Patients with Colorectal Cancer; Relevance for Prognosis

2000 ◽  
Vol 15 (4) ◽  
pp. 288-293 ◽  
Author(s):  
C.F. Peeters ◽  
C.M. Thomas ◽  
F.C. Sweep ◽  
P.N. Span ◽  
T. Wobbes ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Prognostic Value ◽  
Elevated Serum ◽  
Serum Levels ◽  
Endothelin 1 ◽  
Kaplan Meier ◽  
Preoperative Serum ◽  
Potent Vasoconstrictor ◽  
Group B

Background It has been demonstrated that the Doppler Perfusion Index (DPI) is increased in patients who are at risk of developing liver metastases from colorectal cancer. It has been postulated that a circulating hormonal factor is involved in the relative vasoconstriction throughout the splanchnic bed. Endothelin-1 (ET-1), a potent vasoconstrictor which has been associated with tumor growth and is produced by colorectal tumors, may play an important role in this phenomenon. In this paper the prognostic value of serum ET-1 in colorectal cancer is discussed. Methods Preoperative serum levels of ET-1 were assessed in three groups of patients: group A underwent resection of the colorectal tumor and remained free of recurrence (n=20); group B developed metachronous liver metastases at least six months after colorectal resection (n=14); and group C presented with colorectal cancer and synchronous liver metastases (n=22). Results The mean (SD) serum ET-1 levels in groups A, B and C were 1.59 (0.41) pmol/L, 1.70 (0.32) pmol/L and 1.85 (0.47) pmol/L, respectively. These values were significantly different from those of healthy controls (1.22 (0.31), p<0.05). Kaplan-Meier analyses revealed no prognostic value of preoperative serum ET-1 levels. Conclusions These preliminary results demonstrate that serum ET-1 levels are raised in patients with colorectal cancer. Serum ET-1 levels do not seem to be of prognostic value for survival.

Association between primary tumor site, perioperative CEA ratio, smoking status, and overall survival in patients with colorectal cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15156-e15156
Author(s):  
Thomas A Odeny ◽  
Nicole Farha ◽  
Hannah Hildebrand ◽  
Jessica Allen ◽  
Wilfred Vazquez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Multivariate Analysis ◽  
Proportional Hazards ◽  
Smoking Status ◽  
Tumor Stage ◽  
Tumor Location ◽  
Cox Proportional Hazards ◽  
P Value ◽  
Primary Tumor Site

e15156 Background: There are differences in the incidence, clinical presentation, molecular pathogenesis and outcome of colorectal cancer (CRC) based on tumor location. Emerging research suggests that perioperative carcinoembryonic antigen (CEA) ratio (post-op/pre-op CEA) is a prognostic factor for CRC patients. We aimed to determine the association between tumor location, CEA ratio, smoking status and overall survival (OS) among patients with CRC. Methods: We analysed 323 patients who underwent resection for CRC at KUMC. After excluding those without pre- or post-operative CEA data, 162 patients were classified as either high ( > = 0.5) or low ( < 0.5) ratio. Primary outcomes were: 1) OS stratified by tumor location; 2) OS stratified by CEA ratio; and 3) whether the association between CEA ratio and OS differed by tumor location, after adjusting for stage and smoking status. Kaplan-Meier method was used to estimate survival rates, and Cox proportional hazards models for multivariate analysis. Results: The median age was 63 years (inter-quartile range 53-72), 61% male, 43% smokers, 73% left-sided tumors, median pre-operative CEA was 3.0 (IQR 1.5-7), and 64% had CEA ratio > = 0.5. The OS rates were 85.7% and 91.9% in patients with left-sided vs right-sided tumors respectively (log-rank p-value = 0.9). The OS rates were 83.5% and 91.5% in patients with high vs low CEA ratios respectively (log-rank p-value = 0.3). The effect of CEA ratio on OS was significantly different when stratified by tumor location (p-value for interaction < 0.001). However, in the stratified analysis, the n was too small to permit further inferential analysis. In multivariate analysis, both tumor location (HR 0.6; p = 0.5) and CEA ratio (HR 1.5; p = 0.5) were not significantly associated with OS after adjusting for smoking status and tumor stage. Smoking was significantly associated with higher rates of death (HR 3.9; p = 0.04) when adjusted for tumor location, CEA ratio, and tumor stage. Conclusions: There was no difference in OS between left versus right-sided tumors. The association between CEA ratio and OS was significantly modified by tumor location. However, to attribute this modification to left vs right warrants validation in a larger cohort as our sample size was limited. Smoking increases mortality irrespective of right vs left sided CRC.

Sign in / Sign up

Export Citation Format

Share Document