The clinical significance of preoperative serum levels of carbohydrate antigen 19-9 in colorectal cancer

We evaluated in 214 patients with primary colorectal cancer the prognostic value of the preoperative serum levels of CEA and CA195. For CEA these levels were above the cutoff of 6 ng/ml in 31.3% of patients, whereas for CA195 they were higher than 12 U/ml in 35.9% of patients. The simultaneous use of both antigens increased the sensitivity to 49%, which was significantly higher than that of CEA (p<0.001) and CA195 (p<0.01) taken singly. The mean preoperative CEA levels were significantly (p<0.001) correlated with Dukes’ stage only, while there was a significant correlation between preoperative serum levels of CA195 and Dukes’ stage (p<0.001), grade of differentiation (p<0.01) and tumor location (p<0.05). The results indicated that high preoperative serum levels of CEA and CA195 were associated with a shorter overall survival (p<0.0001). In addition, separate Cox multivariate analysis showed that preoperative CA195 was, after Dukes’ stage, the strongest factor to predict overall survival (p<0.0001).

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Preoperative serum levels of the carcinoembryonic antigen in hereditary non-polyposis colorectal cancer compared to levels in sporadic colorectal cancer

Cancer Detection and Prevention ◽

10.1016/j.cdp.2005.04.003 ◽

2005 ◽

Vol 29 (4) ◽

pp. 356-360 ◽

Cited By ~ 5

Author(s):

Uwe Schiemann ◽

Silke Günther ◽

Manfred Gross ◽

Gaby Henke ◽

Yvonne Müller-Koch ◽

...

Keyword(s):

Colorectal Cancer ◽

Carcinoembryonic Antigen ◽

Serum Levels ◽

Sporadic Colorectal Cancer ◽

Preoperative Serum

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Clinical Significance of Fibroblast Growth Factor (FGF) Expression in Colorectal Cancer

International Surgery ◽

10.9738/intsurg-d-14-00044.1 ◽

2014 ◽

Vol 99 (5) ◽

pp. 493-499 ◽

Cited By ~ 4

Author(s):

Norie Jibiki ◽

Noboru Saito ◽

Shingo Kameoka ◽

Makio Kobayashi

Keyword(s):

Colorectal Cancer ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Cancer Patients ◽

Clinical Significance ◽

Stage Iv ◽

Serum Levels ◽

Lymphatic Invasion ◽

Fibroblast Growth ◽

Clinicopathological Factors

Abstract In this study, we serologically and pathologically examined the clinical significance of fibroblast growth factor (FGF) expression in patients with colorectal cancer. Serum basic FGF (bFGF) levels in 92 surgical colorectal cancer patients and 31 controls were measured, and the relationship between those levels and clinicopathological factors were examined. Immunohistochemical study was also conducted on specimens from 51 cancer patients, and the association between bFGF staining and serum levels were investigated. An examination of clinicopathological factors revealed significant differences in bFGF levels between stage 0-IIIb and stage IV cancers (P = 0.013). Lymphatic invasion was one factor that differed significantly. Patients with a tumor 30 mm or smaller had a bFGF level of 7.65 ± 1.11 pg/ml while patients with a tumor 31 mm or larger had a bFGF level of 8.53 ± 3.22 pg/ml; significant differences in these bFGF levels were noted (P < 0.05). Patients with a tumor that had no lymphatic invasion (ly0) had a bFGF level of 7.25 ± 0.66 pg/ml, those with a tumor that had minimal lymphatic invasion (ly1) had a bFGF level of 7.99 ± 1.68 pg/ml, and those with a tumor that had moderate lymphatic invasion (ly2) had a bFGF level of 9.17 ± 4.23 pg/ml. bFGF levels differed significantly for tumors with no/minimal lymphatic invasion (ly0-ly1) and those with moderate lymphatic invasion (ly2) (P < 0.0001). Serological examination of bFGF levels during the proliferation of colorectal cancer revealed that moderate lymphatic invasion can be readily distinguished.

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Preoperative serum levels of CEA and CA 242 in colorectal cancer

British Journal of Cancer ◽

10.1038/bjc.1995.167 ◽

1995 ◽

Vol 71 (4) ◽

pp. 868-872 ◽

Cited By ~ 20

Author(s):

M Carpelan-Holmström ◽

C Haglund ◽

P Kuusela ◽

H Järvinen ◽

PJ Roberts

Keyword(s):

Colorectal Cancer ◽

Serum Levels ◽

Ca 242 ◽

Preoperative Serum

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Clinical significance of preoperative serum sialic acid levels in colorectal cancer: utility in the detection of patients at high risk of tumor recurrence

The International Journal of Biological Markers ◽

10.5301/jbm.2008.576 ◽

2004 ◽

Vol 19 (1) ◽

pp. 38-45 ◽

Cited By ~ 9

Author(s):

C. Feijoo-Carnero ◽

F.J. Rodrguez-Berrocal ◽

M. Pez de la Cadena ◽

D. Ayude ◽

A. de Carlos ◽

...

Keyword(s):

Colorectal Cancer ◽

Sialic Acid ◽

High Risk ◽

Clinical Significance ◽

Tumor Recurrence ◽

Preoperative Serum ◽

Serum Sialic Acid

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Expression of matrix metalloproteinases 2, 7 and 9 in patients with colorectal cancer

Vojnosanitetski pregled ◽

10.2298/vsp121221024k ◽

2014 ◽

Vol 71 (1) ◽

pp. 52-59 ◽

Cited By ~ 14

Author(s):

Elena Kostova ◽

Maja Slaninka-Miceska ◽

Nikola Labacevski ◽

Krume Jakovski ◽

Jasmina Trojachanec ◽

...

Keyword(s):

Colorectal Cancer ◽

Matrix Metalloproteinases ◽

Tumor Invasion ◽

Tumor Tissue ◽

Serum Levels ◽

Basement Membranes ◽

Matrix Proteins ◽

Immunohistochemical Expression ◽

Preoperative Serum ◽

Cell Expression

Background/Aim. Matrix metalloproteinases (MMPs) are perceived to play a key role in tumor invasion and metastasis by their capacity to degrade basement membranes and extracellular matrix proteins. The aim of this study was to investigate the expressions of MMP-2, MMP-7 and MMP-9 in tumor tissue and their relation to clinicopathologic features in patients with colorectal cancer. Methods. Specimens of resected colorectal cancer and surrounding normal tissue of 82 patients were immunohistochemically stained for MMP-2, MMP-7 and MMP-9. The results of immunohistochemical expression of MMPs were correlated with some clinical and pathologic parameters. Results. Immunohistochemical expression of MMP-2 was more frequent in the patients with higher preoperative serum levels of carcinoembryonic antigen (CEA) (p = 0.047), MMP-2 (p = 0.018), MMP-9 (p = 0.036) and in those with lymph node metastasis (p = 0.018) and the advanced stage of the disease (p = 0.046). Expression of MMP-7 was more frequent in the patients with elevated preoperative serum levels of: CEA (p = 0.012), MMP-7 (p = 0.036), MMP-9 (p = 0.023) and with deeply invasive neoplasms (p = 0.027). MMP-9 cell expression was in a positive correlation with elevated preoperative serum levels of: CEA (p = 0.013), MMP-2 (p = 0.012), MMP-9 (p = 0.018) and depth of CRC invasion, i.e. Tparameter (p = 0.027). Conclusion. Immunohistochemical expression of MMPs is a useful indicator of the disease development and progression in patients with colorectal cancer.

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