Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study

2011 ◽  
Vol 19 (4) ◽  
pp. 755-764 ◽  
Author(s):  
SS Anand ◽  
GR Dagenais ◽  
V Mohan ◽  
R Diaz ◽  
J Probstfield ◽  
...  
Keyword(s):  
Cohort Study ◽  
Glucose Tolerance ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Newly Diagnosed ◽  
Men And Women ◽  
Glucose Levels ◽  
Death Event ◽  
Lower Glucose ◽  
Artery Disease

Aims: In an international prospective cohort study we assessed the relationship between glucose levels and incident cardiovascular events and death. Methods and results: 18,990 men and women were screened for entry into the DREAM clinical trial from 21 different countries. All had clinical and biochemical information collected at baseline, including an oral glucose tolerance test (OGTT), and were prospectively followed over a median (IQR) of 3.5 (3.0–4.0) years for incident cardiovascular (CV) events including coronary artery disease (CAD), stroke, congestive heart failure (CHF) requiring hospitalization, and death. After OGTT screening, 8000 subjects were classified as normoglycaemic, 8427 had impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), and 2563 subjects had newly diagnosed type 2 diabetes mellitus (DM). There were incident events in 491 individuals: 282 CAD, 54 strokes, 19 CHF, and 164 died. The annualized CV or death event rate was 0.79/100 person-years in the overall cohort, 0.51/100 person-years in normoglycaemics, 0.92/100 person-years among subjects with IFG and/or IGT at baseline, and 1.27/100 person-years among those with DM ( p for trend <0.0001). Among all subjects, a 1 mmol/l increase in fasting plasma glucose (FPG) or a 2.52 mmol/l increase in the 2-h post-OGTT glucose was associated with a hazard ratio increase in the risk of CV events or death of 1.17 (95% CI 1.13–1.22). Conclusions: In this large multiethnic cohort, the risk of CV events or death increased progressively among individuals who were normoglycaemic, IFG or IGT, and newly diagnosed diabetics. A 1 mmol/l increase in FPG was associated with a 17% increase in the risk of future CV events or death. Therapeutic or behavioural interventions designed to either prevent glucose levels from rising, or lower glucose among individuals with dysglycaemia should be evaluated.

scholarly journals Preliminary phytochemical screening and evaluation of hypoglycemic properties of the root extract of Uveria chamae

2015 ◽  
Vol 10 (2) ◽  
pp. 326 ◽  
Author(s):  
Emordi Jonathan Emeka ◽  
Agbaje Esther Oluwatoyin ◽  
Oreagba Ibrahim Adekunle ◽  
Iribhogbe Osede Ignis
Keyword(s):  
Single Dose ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Phytochemical Screening ◽  
Glucose Levels ◽  
Blood Glucose Levels

<p>The purpose of this study is to evaluate the hypoglycaemic properties and preliminary phytochemical screening of <em>Uveria chamae</em>. The hypoglycaemic properties of <em>Uveria chamae</em> was assessed on normoglycaemic rat that received single dose of the extract at 250 and 500 mg/kg body weight and blood glucose levels estimated at 2, 4, and 6 hours (single dose study). The hypoglycaemic property of the extract was also evaluated in normoglycemic rats by oral glucose tolerance test. Phytochemical screening of the extract for the presence of secondary metabolites was performed with standard methods. The extract showed a significant (p&lt;0.05) reduction in blood glucose levels at 2h and 6h compared to control.  The oral glucose tolerance test  result also showed a significant decrease (p&lt;0.05) in blood glucose levels . The study showed that the extract, <em>Uveria chamae</em> has hypoglycaemic properties which may be accounted for by the presence of the phytochemicals.</p><p> </p>

scholarly journals Analisis Uji Tes Toleransi Glukosa Oral Sebagai Deteksi Dini Pradiabetes Pada Obesitas

2021 ◽  
Vol 6 (2) ◽  
pp. 143-151
Author(s):  
Alfyan Rahim ◽  
Thaslifa ◽  
Irwansyah
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance ◽  
Research Result ◽  
Sampling Technique ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Obese People ◽  
Glucose Levels ◽  
South Sulawesi ◽  
Blood Glucose Levels

Background: Diabetes mellitus (DM) is a dangerous disease with prevalence in Indonesia, including South Sulawesi, until now it has reached 3.4% of the total population. Prediabetes is an early condition for diabetes where blood glucose levels are above normal levels. One of the factors that are most closely related to the incidence of prediabetes is obesity which is also a problem currently faced at the age of children and adolescents. One way to detect a disturbance in glucose metabolism is the Oral Glucose Tolerance Test (TTGO).Objective: This study aims to determine the incidence of prediabetes in obese students. Methods: The study design was analytical descriptive, analyzing the test variables of OGTT as a prediabetes screening in the obese. The population was all active students of Megarezky University who were obese obtained by purposive sampling technique. Results: Based on the research result of 40 respondents, after the measured levels of GDP and two-hour glucose levels after oral glucose administration (postprandial), obtained a mean grade of respondents OGTT was 120,45 mg/dl and 8 (20%) of whom had an abnormal OGTT level ( 140-199 mg/dl). Conclusion: It reveals that the eight respondents experienced impaired glucose tolerance (IGT) and prediabetes. Obese people should begin to keep a balance between intake and energy expended to avoid Diabetes Mellitus.

scholarly journals Real-World Gestational Diabetes Screening: Problems with the Oral Glucose Tolerance Test in Rural and Remote Australia

2019 ◽  
Vol 16 (22) ◽  
pp. 4488 ◽  
Author(s):  
Emma L. Jamieson ◽  
Erica P. Spry ◽  
Andrew B. Kirke ◽  
David N. Atkinson ◽  
Julia V. Marley
Keyword(s):  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Time Course ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Rural And Remote ◽  
Glucose Levels

Gestational diabetes mellitus (GDM) is the most common antenatal complication in Australia. All pregnant women are recommended for screening by 75 g oral glucose tolerance test (OGTT). As part of a study to improve screening, 694 women from 27 regional, rural and remote clinics were recruited from 2015–2018 into the Optimisation of Rural Clinical and Haematological Indicators for Diabetes in pregnancy (ORCHID) study. Most routine OGTT samples were analysed more than four hours post fasting collection (median 5.0 h, range 2.3 to 124 h), potentially reducing glucose levels due to glycolysis. In 2019, to assess pre-analytical plasma glucose (PG) instability over time, we evaluated alternative sample handling protocols in a sample of participants. Four extra samples were collected alongside routine room temperature (RT) fluoride-oxalate samples (FLOXRT): study FLOXRT; ice slurry (FLOXICE); RT fluoride-citrate-EDTA (FC Mix), and RT lithium-heparin plasma separation tubes (PST). Time course glucose measurements were then used to estimate glycolysis from ORCHID participants who completed routine OGTT after 24 weeks gestation (n = 501). Adjusting for glycolysis using FLOXICE measurements estimated 62% under-diagnosis of GDM (FLOXRT 10.8% v FLOXICE 28.5% (95% CI, 20.8–29.5%), p < 0.001). FC Mix tubes provided excellent glucose stability but gave slightly higher results (Fasting PG: +0.20 ± 0.05 mmol/L). While providing a realistic alternative to the impractical FLOXICE protocol, direct substitution of FC Mix tubes in clinical practice may require revision of GDM diagnostic thresholds.

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