scholarly journals Agreed definitions and a shared vision for new standards in stroke recovery research: The Stroke Recovery and Rehabilitation Roundtable taskforce

2017 ◽  
Vol 12 (5) ◽  
pp. 444-450 ◽  
Author(s):  
Julie Bernhardt ◽  
Kathryn S Hayward ◽  
Gert Kwakkel ◽  
Nick S Ward ◽  
Steven L Wolf ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Basic Science ◽  
Intervention Development ◽  
Shared Vision ◽  
Stroke Recovery ◽  
Common Language ◽  
Agreed Framework ◽  
Working Groups

The first Stroke Recovery and Rehabilitation Roundtable established a game changing set of new standards for stroke recovery research. Common language and definitions were required to develop an agreed framework spanning the four working groups: translation of basic science, biomarkers of stroke recovery, measurement in clinical trials and intervention development and reporting. This paper outlines the working definitions established by our group and an agreed vision for accelerating progress in stroke recovery research.

scholarly journals Agreed Definitions and a Shared Vision for New Standards in Stroke Recovery Research: The Stroke Recovery and Rehabilitation Roundtable Taskforce

2017 ◽  
Vol 31 (9) ◽  
pp. 793-799 ◽  
Author(s):  
Julie Bernhardt ◽  
Kathryn S. Hayward ◽  
Gert Kwakkel ◽  
Nick S. Ward ◽  
Steven L. Wolf ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Basic Science ◽  
Intervention Development ◽  
Shared Vision ◽  
Stroke Recovery ◽  
Common Language ◽  
Agreed Framework ◽  
Working Groups

The first Stroke Recovery and Rehabilitation Roundtable established a game changing set of new standards for stroke recovery research. Common language and definitions were required to develop an agreed framework spanning the four working groups: translation of basic science, biomarkers of stroke recovery, measurement in clinical trials and intervention development and reporting. This paper outlines the working definitions established by our group and an agreed vision for accelerating progress in stroke recovery research.

scholarly journals Setting the scene for the Second Stroke Recovery and Rehabilitation Roundtable

2019 ◽  
Vol 14 (5) ◽  
pp. 450-456 ◽  
Author(s):  
Julie Bernhardt ◽  
Karen N Borschmann ◽  
Gert Kwakkel ◽  
Jane H Burridge ◽  
Janice J Eng ◽  
...  
Keyword(s):  
Intervention Development ◽  
Stroke Recovery ◽  
Evidence Based ◽  
Evidence Based Treatments ◽  
Human Stroke ◽  
Working Groups ◽  
Quality Of Movement ◽  
Standardized Measurement ◽  
The Impact

The Stroke Recovery and Rehabilitation Roundtable (SRRR) meetings bring together an international group of preclinical and clinical researchers along with statisticians, methodologists, funders and consumers, working to accelerate the development of effective treatments for stroke recovery and to support best-evidence uptake in rehabilitation practice. The first meeting (2016) focused on four recommendation areas: translation of preclinical evidence into human discovery trials; recovery biomarkers to provide knowledge of therapeutic targets and prognosis in human stroke; intervention development, monitoring, and reporting standards; and standardized measurement in motor recovery trials. The impact of SRRR is growing, with uptake of recommendations emerging, and funders exploring ways to incorporate research targets and recommendations. At our second meeting (SRRR2, 2018), we worked on new priority areas: (1) cognitive impairment, (2) standardizing metrics for measuring quality of movement, (3) improving development of recovery trials, and (4) moving evidence-based treatments into practice. To accelerate progress towards breakthrough treatments, formation of an International Stroke Recovery and Rehabilitation Alliance is our next step, where working groups will take recommendations and build partnerships needed to achieve our goals.

scholarly journals Inflammation and Atherosclerosis

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1197
Author(s):  
Klaus Ley
Keyword(s):  
Clinical Trials ◽  
Animal Models ◽  
Basic Science ◽  
Translational Science ◽  
Special Issue

This 11-chapter Special Issue of Cells spans the gamut from basic science in mechanistic animal models to translational science to outcomes of clinical trials, all focused on the role of inflammation in atherosclerosis [...]

How to Overcome the Valley of Death from Basic Science to Clinical Trials

2019 ◽  
pp. 213-220
Author(s):  
Kelly Bridgham ◽  
Akash Chandawarkar ◽  
Halley Darrach ◽  
Justin M. Sacks
Keyword(s):  
Clinical Trials ◽  
Basic Science ◽  
Valley Of Death

scholarly journals A Progress Report on Cooperative Working Groups for Improving Efficiency of Clinical Trials for New Drug Development (Chiken)

2015 ◽  
Vol 46 (3) ◽  
pp. 127-132
Author(s):  
Mariko TANIGUCHI ◽  
Masayoshi NAKABAYASHI ◽  
Ichiro OSHIBA ◽  
Satoshi SUGIHARA ◽  
Shuhei NOBUTANI ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Drug Development ◽  
Progress Report ◽  
New Drug ◽  
Working Groups ◽  
New Drug Development

scholarly journals Regenerative Cardiovascular Therapies: Stem Cells and Beyond

2019 ◽  
Vol 20 (6) ◽  
pp. 1420 ◽  
Author(s):  
Bernhard Wernly ◽  
Moritz Mirna ◽  
Richard Rezar ◽  
Christine Prodinger ◽  
Christian Jung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Basic Science ◽  
Left Ventricular ◽  
Specific Cell ◽  
Therapeutic Effects ◽  
Cell Processing

Although reperfusion therapy has improved outcomes, acute myocardial infarction (AMI) is still associated with both significant mortality and morbidity. Once irreversible myocardial cell death due to ischemia and reperfusion sets in, scarring leads to reduction in left ventricular function and subsequent heart failure. Regenerative cardiovascular medicine experienced a boost in the early 2000s when regenerative effects of bone marrow stem cells in a murine model of AMI were described. Translation from an animal model to stem cell application in a clinical setting was rapid and the first large trials in humans suffering from AMI were conducted. However, high initial hopes were early shattered by inconsistent results of randomized clinical trials in patients suffering from AMI treated with stem cells. Hence, we provide an overview of both basic science and clinical trials carried out in regenerative cardiovascular therapies. Possible pitfalls in specific cell processing techniques and trial design are discussed as these factors influence both basic science and clinical outcomes. We address possible solutions. Alternative mechanisms and explanations for effects seen in both basic science and some clinical trials are discussed here, with special emphasis on paracrine mechanisms via growth factors, exosomes, and microRNAs. Based on these findings, we propose an outlook in which stem cell therapy, or therapeutic effects associated with stem cell therapy, such as paracrine mechanisms, might play an important role in the future. Optimizing stem cell processing and a better understanding of paracrine signaling as well as its effect on cardioprotection and remodeling after AMI might improve not only AMI research, but also our patients’ outcomes.

Angiogenesis and cancer: A cross-talk between basic science and clinical trials (the “do ut des” paradigm)

2006 ◽  
Vol 59 (1) ◽  
pp. 40-50 ◽  
Author(s):  
Gilberto de Castro Junior ◽  
Fabio Puglisi ◽  
Evandro de Azambuja ◽  
Nagi S. El Saghir ◽  
Ahmad Awada
Keyword(s):  
Clinical Trials ◽  
Cross Talk ◽  
Basic Science
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