A practical chlorination of tert-butyl esters with PCl3 generating acid chlorides
Keyword(s):
For the first time, using PCl3, a range of tert-butyl esters is chlorinated successfully, allowing access of both aromatic acid chlorides and aliphatic acid chlorides in good yields. The method features simple reaction conditions and wide substrate scope. Various tert-butyl esters including aryl esters, alkenyl esters, and alkyl esters were tolerated well in the reaction. A plausible mechanism is proposed.
2017 ◽
Vol 82
(6)
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pp. 3245-3251
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2016 ◽
Vol 88
(3)
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pp. 207-214
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2018 ◽
Vol 55
(1B)
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pp. 152
2006 ◽
Vol 36
(21)
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pp. 3117-3123
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