Targeting the gut–lung microbiota axis by means of a high-fibre diet and probiotics may have anti-inflammatory effects in COVID-19 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 is a 2019 novel coronavirus, which only in the European area has led to more than 300,000 cases with at least 21,000 deaths. This manuscript aims to speculate that the manipulation of the microbial patterns through the use of probiotics and dietary fibers consumption may contribute to reduce inflammation and strengthen the immune system response in COVID-19 infection. The reviews of this paper are available via the supplemental material section.

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SARS-CoV-2: Some Aspects of Molecular Evolution, Cellular Pathogenesis, and Immune System Mechanism Elusion

Applied Sciences ◽

10.3390/app112411605 ◽

2021 ◽

Vol 11 (24) ◽

pp. 11605

Author(s):

Angela Quirino ◽

Nadia Marascio ◽

Giorgio Settimo Barreca ◽

Luigia Gallo ◽

Aida Giancotti ◽

...

Keyword(s):

Immune System ◽

Molecular Evolution ◽

Side Effects ◽

Severe Acute Respiratory Syndrome ◽

Vaccine Development ◽

Medical Intervention ◽

System Response ◽

Molecular Features ◽

Immune System Response ◽

Cellular Pathogenesis

The purpose of this review is to address some of the latest aspects regarding molecular features, pathogenic mechanisms, and immune system response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on recent publications in this field from March 2020 to May 2021. Interpretation keys for periodic re-emergence of coronavirus infections and other lethal viral pandemics are suggested. Antibody-dependent enhancement (ADE) and other potential mechanisms of immune system deception are put forward. Therefore, vaccine development must take into account ADE and other unwanted side effects of immune-based medical intervention. Features reported in our review will allow both clinicians and basic science researchers to take home ideas to improve their knowledge about SARS-CoV-2.

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Abstract #412 Impact of High Fibre Diet on Cardiovascular Risk Markers in Comorbidity of Hypertension and Type 2 Diabetes

Endocrine Practice ◽

10.1016/s1530-891x(20)47173-3 ◽

2018 ◽

Vol 24 ◽

pp. 102

Author(s):

Rohit Kapoor ◽

Shivam Kapoor ◽

Rishabh Kapoo

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Risk ◽

Risk Markers ◽

High Fibre Diet ◽

Fibre Diet ◽

High Fibre

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Author Correction to: Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation

BMC Biology ◽

10.1186/s12915-021-01066-5 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Chee Kin Then ◽

Salome Paillas ◽

Xuedan Wang ◽

Alix Hampson ◽

Anne E. Kiltie

Keyword(s):

Relative Abundance ◽

High Fibre Diet ◽

Fibre Diet ◽

High Fibre

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NCMP-05. DECODING THE IMMUNE SYSTEM RESPONSE TO LEPTOMENINGEAL METASTASIS

Neuro-Oncology ◽

10.1093/neuonc/noaa215.517 ◽

2020 ◽

Vol 22 (Supplement_2) ◽

pp. ii124-ii124

Author(s):

Jan Remsik ◽

Xinran Tong ◽

Ugur Sener ◽

Danille Isakov ◽

Yudan Chi ◽

...

Keyword(s):

Immune System ◽

Immune Cells ◽

Leptomeningeal Metastasis ◽

System Response ◽

Idle State ◽

The Central Nervous System ◽

Health And Disease ◽

Immune System Response ◽

Therapeutic Protocols ◽

Brain And Spinal Cord

Abstract For decades, the central nervous system was considered to be an immune privileged organ with limited access to systemic immunity. However, the leptomeninges, the cerebrospinal fluid (CSF)-filled anatomical structure that protects the brain and spinal cord, represent a relatively immune-rich environment. Despite the presence of immune cells, complications in the CSF, such as infectious meningitis and a neurological development of cancer known as leptomeningeal metastasis, are difficult to treat and are frequently fatal. We show that immune cells entering the CSF are held in an ‘idle’ state that limits their cytotoxic arsenal and antigen presentation machinery. To understand this underappreciated neuroanatomic niche, we used unique mouse models and rare patient samples to characterize its cellular composition and critical signaling events in health and disease at a single-cell resolution. Revealing the mediators of CSF immune response will allow us to re-evaluate current therapeutic protocols and employ rational combinations with immunotherapies, therefore turning the patient’s own immune system into an active weapon against pathogens and cancer.

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Hauora Tãne: Mãori Men, Health Behaviours, and the Stages of Change Model

Australian Journal of Rehabilitation Counselling ◽

10.1017/s1323892200000089 ◽

2005 ◽

Vol 11 (2) ◽

pp. 136-145

Author(s):

Jo Paddison ◽

Hemi Heta ◽

Ross Flett

Keyword(s):

Behaviour Change ◽

Stages Of Change ◽

Sun Exposure ◽

Health Behaviours ◽

Public Health Programs ◽

High Fibre Diet ◽

Fibre Diet ◽

High Fibre ◽

Men Health ◽

Managing Stress

Understanding the distribution of Mãori across stages of health behaviour change (precontemplation, contemplation, preparation, action, maintenance) may inform the development of public health programs. In a replication and extension of a study by Nigg et al. (1999) we described the distribution of 73 Mãori male questionnaire respondents (age 18 to 59 years) across these stages for 8 healthy behaviours (avoiding dietary fat, eating fibre, reducing weight, regularly exercising, reducing stress, reducing sun exposure, using sunblock, and conducting cancer self-examinations). Respondents were also asked to rate their general health, health worries, and health locus of control. Evidence found of a continuum of change for ‘ignoring’, to ‘thinking about1 to ‘performing’ healthy behaviour provides moderate support for the idea that behaviour change is not an all-or-nothing event. There were no significant age effects. Respondents who rated their health more positively were more likely to report using sunblock, exercising regularly, and eating a high fibre diet. Respondents who felt they had more control over their health were more likely to eat a diet high in fibre. Eating a high fibre diet, exercising and managing stress were most strongly associated with the other health behaviours which may illustrate the concept of gateway behaviours proposed by Nigg et al. (1999).

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