Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A

2011 ◽  
Vol 6 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Michel White ◽  
Augusto C. Montezano ◽  
Rhian M. Touyz
Keyword(s):  
Angiotensin Ii ◽  
Cyclosporine A ◽  
Cardiac Fibroblasts ◽  
Calcineurin Inhibitors ◽  
Differential Effects

Class- and Molecule-specific Differential Effects of Angiotensin II Type 1 Receptor Blockers

2013 ◽  
Vol 19 (17) ◽  
pp. 3002-3008 ◽  
Author(s):  
Satoshi Imaizumi ◽  
Shin-ichiro Miura ◽  
Eiji Yahiro ◽  
Yoshinari Uehara ◽  
Issei Komuro ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Differential Effects ◽  
Receptor Blockers

Luteolin Antagonizes Angiotensin II-Dependent Proliferation and Collagen Synthesis of Cultured rat Cardiac Fibroblasts

2015 ◽  
Vol 16 (5) ◽  
pp. 430-439 ◽  
Author(s):  
Tingting Wang ◽  
Defeng Pan ◽  
Yingying Zhang ◽  
Dongye Li ◽  
Yanbin Zhang ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Collagen Synthesis ◽  
Cardiac Fibroblasts

scholarly journals Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts.

1994 ◽  
Vol 269 (30) ◽  
pp. 19626-19632
Author(s):  
W. Schorb ◽  
T.C. Peeler ◽  
N.N. Madigan ◽  
K.M. Conrad ◽  
K.M. Baker
Keyword(s):  
Angiotensin Ii ◽  
Tyrosine Phosphorylation ◽  
Cardiac Fibroblasts ◽  
Neonatal Rat ◽  
Protein Tyrosine Phosphorylation ◽  
Protein Tyrosine

scholarly journals β-Catenin Overexpression Reduces Myocardial Infarct Size through Differential Effects on Cardiomyocytes and Cardiac Fibroblasts

2006 ◽  
Vol 281 (41) ◽  
pp. 30979-30989 ◽  
Author(s):  
Joo-Yong Hahn ◽  
Hyun-Ju Cho ◽  
Jang-Whan Bae ◽  
Hyung-Sun Yuk ◽  
Kwang-il Kim ◽  
...  
Keyword(s):  
Infarct Size ◽  
Cardiac Fibroblasts ◽  
Myocardial Infarct ◽  
Myocardial Infarct Size ◽  
Differential Effects

PPARβ/δ activation inhibits angiotensin II-induced collagen type I expression in rat cardiac fibroblasts

2007 ◽  
Vol 460 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Huijie Zhang ◽  
Rongbiao Pi ◽  
Ruifang Li ◽  
Ping Wang ◽  
Futian Tang ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Collagen Type ◽  
Cardiac Fibroblasts ◽  
Collagen Type I ◽  
Type I

Tanshinone IIA Inhibits Angiotensin II-Induced Cell Proliferation in Rat Cardiac Fibroblasts

2011 ◽  
Vol 39 (02) ◽  
pp. 381-394 ◽  
Author(s):  
Paul Chan ◽  
Ju-Chi Liu ◽  
Li-Jen Lin ◽  
Po-Yuan Chen ◽  
Tzu-Hurng Cheng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Proliferation ◽  
Angiotensin Ii ◽  
Cardiac Fibroblasts ◽  
Tanshinone Iia ◽  
No Production ◽  
Ang Ii ◽  
Erk Phosphorylation ◽  
Enos Phosphorylation ◽  
Ros Formation

Tanshinone IIA extracted from Danshen, a popular medicinal herb used in traditional Chinese medicine, exhibits cardio-protective effects. However, the mechanism of its cardioprotective effect is not well established. The aims of this study were to examine whether tanshinone IIA may alter angiotensin II (Ang II)-induced cell proliferation and to identify the putative underlying signaling pathways in rat cardiac fibroblasts. Cultured rat cardiac fibroblasts were pre-treated with tanshinone IIA and stimulated with Ang II, cell proliferation and endothelin-1 (ET-1) expression were examined. The effect of tanshinone IIA on Ang II-induced reactive oxygen species (ROS) formation, and extracellular signal-regulated kinase (ERK) phosphorylation were also examined. In addition, the effect of tanshinone IIA on nitric oxide (NO) production, and endothelial nitric oxide synthase (eNOS) phosphorylation were tested to elucidate the intracellular mechanism. The increased cell proliferation and ET-1 expression by Ang II (100 nM) were partially inhibited by tanshinone IIA. Tanshinone IIA also inhibited Ang II-increased ROS formation, and ERK phosphorylation. In addition, tanshinone IIA was found to increase the NO generation, and eNOS phosphorylation. NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NOS, and the short interfering RNA transfection for eNOS markedly attenuated the inhibitory effect of tanshinone IIA on Ang II-induced cell proliferation. The results suggest that tanshinone IIA prevents cardiac fibroblast proliferation by interfering with the generation of ROS and involves the activation of the eNOS-NO pathway.

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