scholarly journals Advances in immunotherapy for colorectal cancer: a review

2020 ◽  
Vol 13 ◽  
pp. 175628482091752 ◽  
Author(s):  
Gol Golshani ◽  
Yue Zhang
Keyword(s):  
Colorectal Cancer ◽  
Literature Review ◽  
Cancer Survival ◽  
Advanced Colorectal Cancer ◽  
Advanced Disease ◽  
Survival Rates ◽  
Cancer Treatments ◽  
Gastrointestinal Malignancies ◽  
Current Role

Immunotherapy is a new and exciting modality of cancer treatments. Its role in gastrointestinal malignancies has been promising, especially in advanced disease. Although various therapies are available for treatment of advanced colorectal cancer, survival rates for these patients remain very poor. The application of immunotherapy in colorectal cancer has shown remarkable results for a subset of patients with mismatch-repair-deficient mutations or microsatellite instability in their tumors. This literature review evaluates the current role of immunotherapy in advanced colorectal cancer, potential challenges clinicians face with immunotherapy-based regimens, and the possible future approach of combined modality immunotherapy.

scholarly journals Colorectal cancer survival rates in Ghana: A retrospective hospital-based study

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0209307 ◽  
Author(s):  
Francis Agyemang-Yeboah ◽  
Joseph Yorke ◽  
Christian Obirikorang ◽  
Emmanuella Nsenbah Batu ◽  
Emmanuel Acheampong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Survival ◽  
Survival Rates ◽  
Colorectal Cancer Survival

scholarly journals Current Role of Radiotherapy in the Management of Oral Cavity Squamous Cell Carcinoma

2020 ◽  
pp. 194338752097141
Author(s):  
William M. Mendenhall ◽  
Adam L. Holtzman ◽  
Roi Dagan ◽  
Curtis M. Bryant ◽  
Kathryn E. Hitchcock ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Advanced Disease ◽  
Current Role ◽  
Extranodal Extension ◽  
Postoperative Setting ◽  
Extent Of Disease

Study Design: Literature review. Objective: To review the current role of radiotherapy (RT) in the management of oral cavity squamous cell carcinoma (SCC). Methods: Review of selected literature. Results: T1-T2N0 SCCs may be treated with either RT alone or surgery with a high likelihood of cure. The pendulum swung toward surgery with postoperative RT (PORT) added depending on the pathological findings in the mid 1980s. Patients with positive margins, extranodal extension (ENE), and/or 4 or more positive nodes receive concomitant chemotherapy (POCRT). Patients with T3-T4 and/or positive regional nodes are treated with surgery and PORT alone or POCRT. The likelihood of cure is moderate to low depending on extent of disease. The likelihood of major complications ranges from 10% to 30% depending on the method of reconstruction and the aggressiveness of postoperative PORT/POCRT. Patients with very advanced disease are treated with palliative RT, chemotherapy, or supportive care. Conclusions: The role of RT in the management of oral cavity SCC is primarily in the postoperative setting with palliative RT being reserved for those with very advanced disease where the likelihood of cure is remote.

Current role of rufinamide in the treatment of childhood epilepsy: Literature review and treatment guidelines

2014 ◽  
Vol 18 (6) ◽  
pp. 685-690 ◽  
Author(s):  
Giangennaro Coppola ◽  
Frank Besag ◽  
Raffaella Cusmai ◽  
Olivier Dulac ◽  
Gerhard Kluger ◽  
...  
Keyword(s):  
Literature Review ◽  
Treatment Guidelines ◽  
Childhood Epilepsy ◽  
Current Role
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