Anticancer Activity and Chemical Composition of Leaf Essential Oil from Solidago canadensis L. in China

2011 ◽  
Vol 347-353 ◽  
pp. 1584-1589 ◽  
Author(s):  
De Qiang Li ◽  
Sheng Hao Pan ◽  
Xi Wu Zhu ◽  
Lin Tan ◽  
Yue Fen Cao
Keyword(s):  
Essential Oil ◽  
Leaf Tissue ◽  
Bornyl Acetate ◽  
Cytotoxic Activities ◽  
Solidago Canadensis ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Effect Level ◽  
Main Components

The essential oil was obtained at yield of 0.30% by hydrodistillation from fresh leaf tissue of Solidago canadensis L. collected from Zhejiang Province, China. GC and GC/MS analysis identified 46 components, representing 94.6% of the leaf oil. The main components were (-)germacrene D (28.4%), bornyl acetate (9.2%), D-Limonene (5.0%). The essential oil was tested for cytotoxic activities against three tumor cell lines. The inhibitory concentrations of the essential oil at 50% effect level (IC50) were 68.1 μg/ml for SMMC-7721, 71.4 μg/ml for SGC-7901, and 156.9 μg/ml for Hala, respectively.

scholarly journals Chemical Composition and Cytotoxic Activity of the Leaf Essential Oil of Ocotea tonduzii from Monteverde, Costa Rica

2007 ◽  
Vol 2 (7) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Anita Bansal ◽  
Debra M. Moriarity ◽  
Sayaka Takaku ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activities ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Oil Components ◽  
Mcf 7

The leaf essential oil of Ocotea tonduzii from Monteverde, Costa Rica has been obtained by hydrodistillation and analyzed by GC-MS. The principal constituents of O. tonduzii leaf oil were the monoterpenes α-pinene (41.4%) and pinene (25.1%) and the sesquiterpenes α-humulene (6.9%), β-caryophyllene (5.8%), and germacrene D (3.8%). O. tonduzii leaf oil was notably cytotoxic on MCF-7, MDA-MB-231, MDA-MB-468, and UACC-257 cells in vitro. The major essential oil components showed cytotoxic activities comparable to doxorubicin ( LC50, 20–70 μg/mL).

scholarly journals Composition and in-vitro CytotoxicActivities of the Leaf Essential Oil of Beilschmiedia erythrophloia from Taiwan

2013 ◽  
Vol 8 (1) ◽  
pp. 1934578X1300800
Author(s):  
Yu-Chang Su ◽  
Chen-Lung Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cytotoxic Activities ◽  
Anticancer Activities ◽  
Leaf Essential Oil ◽  
Main Components ◽  
Type Apparatus

This study investigated the chemical composition and in-vitro cytotoxic activities of the essential oil isolated from the leaf of Beilschmiedia erythrophloia. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Fifty-five compounds were identified, representing 100% of the oil. The main components identified were β-caryophyllene (22.6%), α-humulene (21.9%), terpinen-4-ol (5.3%), cis-β-ocimene (5.1%), sabinene (5.0%) and limonene (4.5%). The anticancer activities of oil were evaluated. The results showed that the oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells.

scholarly journals Leaf Essential Oil Composition of Five Species of Beilschmiedia from Monteverde, Costa Rica

2007 ◽  
Vol 2 (1) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
William N. Setzer ◽  
William A. Haber
Keyword(s):  
Costa Rica ◽  
Essential Oil ◽  
Carbonyl Compounds ◽  
Essential Oil Composition ◽  
Chemical Compositions ◽  
Oil Composition ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Cis And Trans

The leaf essential oils of five species of Beilschmiedia from Monteverde, Costa Rica (Beilschmiedia alloiophylla, B. brenesii, B. costaricensis, B. tilaranensis, and an undescribed Beilschmiedia species “chancho blanco”) have been obtained by hydrodistillation and analyzed by GC-MS in order to discern the differences and similarities between the volatile chemical compositions of these species. The principal constituents of B. alloiophylla leaf oil were germacrene D (18.9%), cis- and trans-β-ocimene (18.8% and 9.3%, respectively), α-pinene (11.8%), and bicyclogermacrene (9.1%). The leaf oil of B. brenesii was composed largely of the sesquiterpenes germacrene D (19.3%), β-caryophyllene (13.4%), α-copaene (9.0%), α-humulene (8.1%), and δ-cadinene (5.8%), and the carbonyl compounds 2-undecanone (12.8%), trans-2-hexenal (8.8%), and 2-tridecanone (3.8%). α-Bisabolol (72.1%) dominated the leaf oil of B. costaricensis, while B. tilaranensis had germacrene D (54.9%), β-caryophyllene (14.8%), and δ-cadinene (5.1%) as major components. Beilschmiedia “chancho blanco” leaf oil was composed largely of β-caryophyllene (16.6%), bicyclogermacrene (14.1%), and α-pinene (12.1%).

scholarly journals Composition of Essential Oils from Leaves and Flowers of Stachys Germanica Subsp. Salviifolia (Ten.) Gams (Labiatae) and Related Secretory Structures

2009 ◽  
Vol 4 (6) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Claudia Giuliani ◽  
Roberto Maria Pellegrino ◽  
Bruno Tirillini ◽  
Laura Maleci Bini
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Glandular Trichomes ◽  
Secretory Structures ◽  
Epidermal Surface ◽  
Germacrene D ◽  
Different Types ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
First Time

The essential oils from both leaves (L) and flowers (F) of Stachys germanica subsp. salviifolia (Ten.) Gams (Labiatae/Lamiaceae) from Italy were analyzed by GC-MS for the first time. The distribution, morphology and histochemistry of the different types of glandular trichomes present on the epidermal surface were also determined. Twenty-nine constituents, representing 89.4% of the total leaf oil, and forty-one compounds, forming 97.8% of the total flower oil, were identified. Germacrene D (39.4%), phytol (10.2%), β-bourbonene (3.5%) and β-ylangene (3.3%) were recognized as the main constituents of the leaf essential oil, while limonene (24.1%), β-pinene (18.7%), germacrene D (12.8%) and ( E)-nerolidol (6.6%) were the main compounds of the flower essential oil.

scholarly journals Composition, in vitro Anti-inflammatory, Antioxidant and Antimicrobial Activities of the Leaf Essential Oil of Machilus konishii from Taiwan

2016 ◽  
Vol 11 (9) ◽  
pp. 1934578X1601100
Author(s):  
Yu-Chang Su ◽  
Kuan-Ping Hsu ◽  
Chen-Lung Ho
Keyword(s):  
Essential Oil ◽  
Antimicrobial Activities ◽  
Raw 264.7 ◽  
Nitric Oxide Production ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Anti Inflammatory ◽  
Main Components ◽  
Antioxidant And Antimicrobial Activities

The chemical composition and in vitro anti-inflammatory, antioxidant and antimicrobial activities of the leaf essential oil of Machilus konishii has been investigated. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC–FID and GC–MS. Sixty-six compounds were identified, representing 100% of the oil. The main components identified were α-pinene (33.9%), β-pinene (13.9%), and thymol (12.0%). The leaf oil was able to reduce nitric oxide production by lipopolysaccharide-activated murine macrophages RAW 264.7 without reducing the cell viability. In addition, the leaf oil showed strong antioxidant and antimicrobial activities. The major ingredient of the oil that was responsible for the anti-inflammatory, antioxidant and antimicrobial activities was thymol.

scholarly journals Essential Oil Composition and Antibacterial Activity of Monticalia greenmaniana (Asteraceae)

2012 ◽  
Vol 7 (2) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
José Cárdenas ◽  
Janne Rojas ◽  
Luís Rojas-Fermin ◽  
María Lucena ◽  
Alexis Buitrago
Keyword(s):  
Antibacterial Activity ◽  
Essential Oil ◽  
Mass Spectra ◽  
Essential Oil Composition ◽  
Gram Negative Bacteria ◽  
Oil Composition ◽  
Aerial Parts ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil

The essential oils from fresh aerial parts of Monticalia greenmaniana (Hieron) C. Jeffrey (Asteraceae) collected in March, were analyzed by GC/MS. Oil yields (w/v) of 0.1% (flowers), 0.07%, (stems) and 0.1% (leaves) were obtained by hydrodistillation. Thirteen, sixteen and eighteen components, respectively, were identified by comparison of their mass spectra with those in the Wiley GC-MS Library data base. The major components of the flower and stem oils were 1-nonane (38.8% flowers; 33.5% stems), α-pinene (29.0% flowers; 14.8% stems) and germacrene D (15.6% flowers; 18.6% stems). However, in the leaf oil, germacrene D was observed at 50.7%, followed by β-cedrene at 8.4 %. The leaf essential oil showed a broad spectrum of antibacterial activity against the important human pathogenic Gram-positive and Gram-negative bacteria Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 19433), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Klebsiella pneumoniae (ATCC 25955) with MIC values ranging from 75 to 6000 ppm.

scholarly journals Composition and Antimicrobial Activities of the Leaf Essential Oil of Machilus kusanoi from Taiwan

2011 ◽  
Vol 6 (2) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Chen-Lung Ho ◽  
Kuang-Ping Hsu ◽  
Yen-Hsueh Tseng ◽  
Eugene I-Chen Wang ◽  
Pei-Chun Liao ◽  
...  
Keyword(s):  
Essential Oil ◽  
Wood Decay ◽  
Antimicrobial Activities ◽  
Sesquiterpene Hydrocarbons ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Main Components

The hydrodistillated leaf essential oil of Machilus kusanoi was analyzed to determine its composition and yield. Twenty-three compounds were identified, the main components being β-caryophyllene (23.3%), β-eudesmol (17.1%), α-terpineol (16.0%), n-dodecanal (14.2%), and n-decanal (10.4%). Sesquiterpene hydrocarbons (28.1%) and non-terpenoids (25.0%) were the predominant groups of compounds. The leaf oil exhibited excellent antimicrobial and anti-wood-decay fungal activities.

scholarly journals Composition and Antimicrobial Activity of the Leaf Essential oil of Litsea kostermansii from Taiwan

2009 ◽  
Vol 4 (8) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Chen-Lung Ho ◽  
Eugene I-Chen Wang ◽  
Kuang-Ping Hsu ◽  
Pei-Yeh Lee ◽  
Yu-Chang Su
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Antimicrobial Activities ◽  
Sesquiterpene Hydrocarbons ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Main Components

The hydrodistillated leaf essential oil of Litsea kostermansii was analyzed to determine its composition and yield. Seventy-three compounds were identified, the main components being β-eudesmol (22.5%), γ-eudesmol (18.6%), δ-selinene (8.5%), α-eudesmol (6.0%), and γ-muurolene (4.7%). Oxygenated sesquiterpenes (66.2%) and sesquiterpene hydrocarbons (32.8%) were the predominant groups of compounds. The leaf oil exhibited excellent antimicrobial activities.

scholarly journals Natural Variability in Enantiomeric Composition of Bioactive Chiral Terpenoids in the Essential Oil of Solidago Canadensis L. from Uttarakhand, India

2008 ◽  
Vol 3 (2) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Chandan S. Chanotiya ◽  
Anju Yadav
Keyword(s):  
Essential Oil ◽  
Narrow Range ◽  
Enantiomeric Excess ◽  
Natural Variability ◽  
Biologically Active ◽  
Enantiomeric Composition ◽  
Bornyl Acetate ◽  
Solidago Canadensis ◽  
Capillary Gc ◽  
Germacrene D

The natural variability in the enantiomeric distribution of biologically active chiral terpenoids in Solidago canadensis L. essential oil from Kumaon was evaluated by enantioselective capillary GC, capillary GC, and GC-MS. Germacrene D, a sesquiterpene hydrocarbon, was noticed as the major compound, contributing 56.7%, 75.5% and 69.7% to the samples, while other constituents with variable compositions were limonene (0.2 to 12.5%), bornyl acetate (2.1 to 2.9%), δ-elemene (2.4 to 3.2), β-elemene (1.3 to 1.8%), and elemol (1.4 to 2.6%). The enantiomeric excess has been determined for germacrene D with (+)-enantiomer (>41.8% to >47%) dominating over the (-)-enantiomer in all the samples. Furthermore, there has been above 95% enantiomeric excess for ( R)-(+)-limonene (>95.1% to >99%), whereas moderate to low excess for (1 R)-(+)-α-pinene (>47.9%), and (1 S)-(-)-β-pinene (>30.3%) was established. Notably, only (-)-bornyl acetate was found as a single enantiomer with >99% enantiomeric excess. However, for all the identified chiral terpenoids, the enantiomeric distribution varied within only a narrow range in all the samples.

scholarly journals Chemical Composition, Antimicrobial, and Cytotoxic Activities of the Essential Oil of Otostegia fruticosa subsp. schimperi from Yemen

2017 ◽  
Vol 12 (6) ◽  
pp. 1934578X1701200
Author(s):  
Nasser A. Awadh Ali ◽  
Ebtesam Hasan Alhamzy ◽  
Bhuwan K. Chhetri ◽  
Noura S. Dosoky ◽  
William N. Setzer
Keyword(s):  
Mass Spectrometry ◽  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Gas Chromatography ◽  
Essential Oil ◽  
Gas Chromatography Mass Spectrometry ◽  
Cytotoxic Activities ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Mcf 7

The leaf essential oil of Otostegia fruticosa subsp. schimperi (Lamiaceae) was obtained by hydrodistillation and analyzed by gas chromatography – mass spectrometry (GC-MS). The major components in the leaf oil were τ-cadinol (9.3%), β-caryophyllene (8.8%), and bornyl formate (5.2%) as well as two unidentified diterpenoids (12.7% and 9.4%, respectively). The leaf oil was screened for antibacterial ( Bacillus cereus, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), antifungal ( Aspergillus niger, Candida albicans, and Botrytis cinerea), and cytotoxic (MCF-7 and MDA-MB-231) activity. The oil did not show antimicrobial or antifungal activity, but it showed very good cytotoxicity against MCF-7 (IC50 = 55.1 μg/mL) and MDA-MB-231 (IC50 = 70.3 μg/mL) cell lines.

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