Prenylated Xanthones and a Benzophenone from Baphia Kirkii

From the ethanol extract of the whole stem of Baphia kirkii, three new prenylated xanthones, baphikixanthones A-C, have been isolated together with a new benzophenone, baphikinone, and two common steroids, stigmasterol and β–sitosterol. The structures of the new compounds were established by using NMR spectroscopic and mass spectral analysis.

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An efficient multicomponent synthesis of 1H-pyrano[2,3-d]pyrimidine-2,4(3H,5H)-dione derivatives and evaluation of their α-amylase and α-glucosidase inhibitory activity

Journal of Chemical Research ◽

10.1177/1747519820964048 ◽

2020 ◽

pp. 174751982096404

Author(s):

Mamata Devendra Naik ◽

Yadav D Bodke ◽

Prashantha J ◽

Jayanth K Naik

Keyword(s):

Nuclear Magnetic Resonance ◽

Enzyme Activity ◽

Spectral Analysis ◽

Spectroscopic Techniques ◽

Multicomponent Synthesis ◽

Mass Spectral Analysis ◽

Mass Spectral ◽

Inhibitory Potential ◽

New Compounds

In this paper, we report the synthesis of novel 1 H-pyrano[2,3- d]pyrimidine-2,4(3 H,5 H)-dione derivatives 5(a–j) by a facile multicomponent reaction. The structures of all the newly synthesized compounds were characterized by different spectroscopic techniques including infrared, nuclear magnetic resonance (1H and 13C) and mass spectral analysis. All the new compounds were assessed for their in vitro α-amylase and α-glucosidase enzyme inhibitory potential. The results of the assays revealed that all compounds showed different enzyme inhibition activities. The concentration required to inhibit enzyme activity is less in the case of α-glucosidases than for α-amylases, that is, the synthesized compounds are more potent in arresting α-glucosidase enzyme activity.

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SYNTHESIS, CHARACTERIZATION, AND ANTHELMINTIC ACTIVITY OF NOVEL BENZOTHIAZOLE DERIVATIVES CONTAINING INDOLE MOIETIES

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i3.30530 ◽

2019 ◽

pp. 321-325

Author(s):

ALETI RAJAREDDY ◽

SRINIVAS MURTHY M

Keyword(s):

Spectral Analysis ◽

Fourier Transform ◽

Infrared Spectroscopy ◽

Magnetic Resonance ◽

Fourier Transform Infrared Spectroscopy ◽

Anthelmintic Activity ◽

Mass Spectral Analysis ◽

Standard Drug ◽

Mass Spectral ◽

Benzothiazole Derivatives

Objective: The objective of this study was to synthesize and evaluate the anthelmintic activity (AA) of novel benzothiazole derivatives containing indole moieties (BDIM). Methods: The present works which involve the substituted isatin Schiff bases undergo acetylating and reacting with 2-aminobenzothiazole to give novel BDIM. Results: All the newly synthesized molecules (5a-5o) were characterized by Fourier-transform infrared spectroscopy, H_nuclear magnetic resonance, and mass spectral analysis along with physical data. The biological potentials of the newly synthesized compounds are evaluated for their AA using an Indian earthworm (Pheretima posthuma), and albendazole was used as standard drug. Conclusion: The synthesized compound 5f, 5n, and 5o showed good AA, whereas others exhibited significant activities.

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