scholarly journals Dibromopyrrole Alkaloids from the Marine Sponge Acanthostylotella sp

2009 ◽  
Vol 4 (1) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Sherif Saeed Ebada ◽  
RuAngelie Edrada-Ebel ◽  
Nicole J. de Voogd ◽  
Victor Wray ◽  
Peter Proksch
Keyword(s):  
Natural Products ◽  
Carboxylic Acid ◽  
Methyl Ester ◽  
Marine Sponge ◽  
Two Dimensional ◽  
New Compounds

Fourteen dibromopyrrole alkaloids were isolated from the marine sponge Acanthostylotella sp. collected in Indonesia. In addition to the known compounds 4,5-dibromo-N-(methoxy-methyl)-1 H-pyrrole-2-carboxamide (7), 4,5-dibromo-1 H-pyrrole-2-carboxamide (8), mukanadin D (9), (±)-longamide B methyl ester (10), (±)-longamide B (11), (±)-longamide (12), 3,4-dibromo-1 H-pyrrole-2-carboxamide (13), 2-cyano-4,5-dibromo-1 H-pyrrole (14), six compounds were isolated that proved to be new natural products including acanthamides A – D (1 – 4), methyl 3,4-dibromo-1 H-pyrrole-2-carboxylate (5) and 3,5-dibromo-1 H-pyrrole-2-carboxylic acid (6). The structures of the new compounds were unequivocally identified based on one and two dimensional NMR and on HRFTMS as well as by comparison with the literature.

New Dibenzofurans and Depsides From the Lichen Bunodophoron patagonicum

1994 ◽  
Vol 47 (7) ◽  
pp. 1335 ◽  
Author(s):  
JA Elix ◽  
JA Elix ◽  
DA Venables ◽  
DA Venables ◽  
M Wedin ◽  
...  
Keyword(s):  
Natural Products ◽  
Carboxylic Acid ◽  
Methyl Ester ◽  
Benzoic Acid ◽  
Total Synthesis

The lichen Bunodophoron patagonicum has been shown to contain five new dibenzo -furans: ascomatic acid (3,7-dimethoxy-1,9-dimethyldibenzofuran-2-carboxylic acid) (2) and the corresponding methyl ester (3); 7-O-methylnorascomatic acid (3-hydroxy-7-methoxy-1,9-dimethyldibenzofuran-2-carboxylic acid) (4) and the corresponding methyl ester (5); and norascomatic acid (3,7-dihydroxy-1,9-dimethyldibenzofuran-2-carboxylic acid) (6). The lichen also contains two new depsides : patagonic acid [2-hydroxy-4-(2′-hydroxy-4′-methoxy-6′-methyl-benzoyloxy)-6-(2′-oxononyl)benzoic acid] (10) and isopatagonic acid [2-hydroxy-4-(2′-hydroxy-4′-methoxy-6′-(2′-oxononyl) benzoyloxy )-6-methylbenzoic acid] (11). The structure of all new natural products was confirmed by total synthesis.

scholarly journals POTENTIAL MARINE-DERIVED FUNGI ISOLATED FROM SPONGE IN PRODUCE NEW AND BENEFICIAL COMPOUNDS

2020 ◽  
Vol 2 (1) ◽  
pp. 52-66
Author(s):  
Wendy Alexander Tanod ◽  
Muliadin ◽  
Yeldi S. Adel ◽  
Didit Kustantio Dewanto
Keyword(s):  
Molecular Structure ◽  
Natural Products ◽  
Marine Sponge ◽  
Marine Organism ◽  
Chemical Compounds ◽  
Active Metabolites ◽  
Drug Compounds ◽  
Pharmacologically Active ◽  
New Compounds

Marine organisms are a source of natural products and produce compounds with a molecular structure that is unique and useful. Thousands of new compounds have biological activitity for anticancer, antiviral, and antimicrobial. This compounds isolated from various marine organism, including from marine-derived fungi. Investigation of chemical compounds from marine-derived fungi isolated from sponge has increased steadily, indicating the important role of marine-derived fungi in the discovery of drug compounds. The sponge has produced various kinds of fungi, which have reported to provide a variety of pharmacologically active metabolites and structurally diverse. Study literature showed that many fungal genera isolated from the marine sponge dominated the genus Acremonium, Aspergillus, Penicillium, Phoma, and Fusarium. The high proportion of genera and new compounds showed that the fungi isolated from the sponge could develop.

Three New Benzoic Acid Derivatives from the Glandular Excretion of Eriodictyon sessilifolium (Hydrophyllaceae)

1988 ◽  
Vol 43 (5-6) ◽  
pp. 337-340 ◽  
Author(s):  
Francisco J. Arriaga-Giner ◽  
Eckhard Wollenweber ◽  
Ingrid Schober ◽  
George Yatskievych
Keyword(s):  
Natural Products ◽  
Carboxylic Acid ◽  
Methyl Ester ◽  
Benzoic Acid ◽  
Glandular Trichomes ◽  
Acid Methyl Ester ◽  
Spectroscopic Methods ◽  
Flavonoid Aglycones ◽  
Benzoic Acid Derivatives ◽  
Acid Methyl

Eriodictyon sessilifolium, an endemic Hydrophyllaceae of Baja California (Mexico), has been studied for the natural products exuded by glandular trichomes covering its leaves and stems. Major components of this exudate were isolated and identified by spectroscopic methods to be 4-hydroxy-3-(2,3-dihydroxy-3-methylbutyl)-benzoic acid methyl ester (1), the natural methyl ester of anodendroic acid (2), and 2,2-dimethyl-3-hydroxychroman-6-carboxylic acid methyl ester (3). Possible biosynthetic relations between these new natural products are considered. In addition, 9 known flavonoid aglycones were identified as exudate constituents.

Marine Sponge-Associated Fungi as Potential Novel Bioactive Natural Product Sources for Drug Discovery: A Review

2020 ◽  
Vol 20 (19) ◽  
pp. 1966-2010
Author(s):  
Bin Zhang ◽  
Ting Zhang ◽  
Jianzhou Xu ◽  
Jian Lu ◽  
Panpan Qiu ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Marine Sponge ◽  
Biological Activities ◽  
Structural Diversity ◽  
Bioactive Natural Products ◽  
Future Potential ◽  
New Compounds ◽  
Bioactive Natural Product ◽  
Structural Classes

Marine sponge-associated fungi are promising sources of structurally interesting and bioactive secondary metabolites. Great plenty of natural products have been discovered from spongeassociated fungi in recent years. Here reviewed are 571 new compounds isolated from marine fungi associated with sponges in 2010-2018. These molecules comprised eight different structural classes, including alkaloids, polyketides, terpenoids, meroterpenoids, etc. Moreover, most of these compounds demonstrated profoundly biological activities, such as antimicrobial, antiviral, cytotoxic, etc. This review systematically summarized the structural diversity, biological function, and future potential of these novel bioactive natural products for drug discovery.

Trunculin-F and Contrunculin-A and -B: Novel Oxygenated Norterpenes From a Southern Australian Marine Sponge, Latrunculia conulosa

1993 ◽  
Vol 46 (9) ◽  
pp. 1363 ◽  
Author(s):  
MS Butler ◽  
RJ Capon
Keyword(s):  
Methyl Ester ◽  
Natural Product ◽  
Marine Sponge ◽  
Coastal Waters ◽  
Spectroscopic Analysis ◽  
Marine Natural Product ◽  
New Compounds ◽  
Absolute Stereochemistry

A specimen of Latrunculia conulosa from southern Australian coastal waters, previously observed to contain conulosin-A (6) and conulosin-B (7), has also been found to yield the known marine natural product trunculin-C methyl ester (14), along with three new norterpenes, trunculin-F (10), contrunculin-A (11) and contrunculin-B (12). Trunculin-F (10) was isolated, characterized and identified as its methyl ester (13), and its absolute stereochemistry determined by Horeau analysis. The structures for all new compounds were secured by detailed spectroscopic analysis.

scholarly journals Complete Assignment ofH1andC13NMR Spectra of 1,2,4-Trisubstituted Pyrroles

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Elsa Anselmi ◽  
Mohamed Abarbri ◽  
Alain Duchêne ◽  
Sandrine Lamandé-Langle ◽  
Jérôme Thibonnet
Keyword(s):  
Carboxylic Acid ◽  
Nmr Spectra ◽  
Cross Coupling ◽  
Ester Group ◽  
Two Dimensional ◽  
Allylic Amination ◽  
One Pot ◽  
Complete Assignment ◽  
New Compounds ◽  
C Nmr

1,2,4-Trisubstituted pyrroles were synthesized with an original one-pot domino allylic amination/palladium-catalysed Sonogashira cross-coupling and heterocyclisation process.1H and13C NMR spectra were assigned for twelve new compounds containing different substituents in positions 1 and 2, and a carboxylic acid or ester group in position 4. Each assignment was based on the combination of one, and two-dimensional experiments (APT, COSY, HMBC).

Synthesis of Spongidine A, D and Petrosaspongiolide L Methyl Ester Using Pyridine C-H Functionalization

2019 ◽  
Author(s):  
Florian Bartels ◽  
Manuela Weber ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Methyl Ester ◽  
Hydrogen Atom ◽  
Phospholipase A2 ◽  
Late Stage ◽  
Hydrogen Atom Transfer ◽  
Ring System ◽  
Tetracyclic Core ◽  
Intramolecular Hydrogen ◽  
Phospholipase A2 Inhibitors

<div>An efficient strategy for the synthesis of the potent phospholipase A2 inhibitors spongidine A and D is presented. The tetracyclic core of the natural products was assembled via an intramolecular hydrogen atom transfer‐initiated Minisci reaction. A divergent late‐stage functionalization of the tetracyclic ring system was also used to achieve a concise synthesis of petrosaspongiolide L methyl ester.</div>

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