scholarly journals Analysis of Danshen and Twelve Related Salvia Species

2012 ◽  
Vol 7 (1) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Luyang Lu ◽  
Yuan Liu ◽  
Zhifeng Zhang ◽  
Hao Zhang
Keyword(s):  
Rosmarinic Acid ◽  
Chinese Herb ◽  
Tanshinone Iia ◽  
Traditional Chinese Herb ◽  
The Way

Danshen is a commonly used traditional Chinese herb, but over twenty Salvia species are used as Danshen by local herbalists. In this study, twelve Salvia species from the plateau of Sichuan and Yunnan Provinces were collected, analyzed and compared with Danshen by HPLC. The results showed that most of the Salvia species were good sources of rosmarinic acid and tanshinones. The highest amount of both rosmarinic acid and tanshinone IIA were found in S. przewalskii Maxim. These results pave the way for a better therapeutic exploitation of these plants.

scholarly journals Tanshinone IIA attenuates Aβ-induced neurotoxicity by down-regulating COX-2 expression and PGE2 synthesis via inactivation of NF-κB pathway in SH-SY5Y cells

2019 ◽  
Vol 26 (1) ◽  
Author(s):  
Lijiao Geng ◽  
Wei Liu ◽  
Yong Chen
Keyword(s):  
Salvia Miltiorrhiza ◽  
Chinese Herb ◽  
Amyloid Β ◽  
Tanshinone Iia ◽  
Dependent Manner ◽  
Neuroprotective Effects ◽  
Cellular Events ◽  
Traditional Chinese Herb ◽  
Cox 2 ◽  
Radix Salvia Miltiorrhiza

Abstract Amyloid-β (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer’s disease (AD). Tanshinone IIA (Tan IIA), extracted from traditional Chinese herb Radix salvia miltiorrhiza, possesses anti-oxidant and anti-inflammatory actions, as well as neuroprotective effects. The present study aims to explore the possible mechanism by which Tan IIA attenuated Aβ-induced neurotoxicity. Exposure of SH-SY5Y cells to different concentrations of Aβ led to neurotoxicity by reducing cell viability, inducing cell apoptosis and increasing neuroinflammation in a dose-dependent manner. Moreover, Aβ treatment promoted cyclooxygenase-2 (COX-2) expression and Prostaglandin E2 (PGE2) secretion, and activated nuclear transcription factor kappa (NF-κB) pathway in SH-SY5Y cells. However, pretreatment of SH-SY5Y cells with Tan IIA prior to Aβ prevented these Aβ-induced cellular events noticeably. These data suggested that Tan IIA exerted its neuroprotective action by alleviating Aβ-induced increase in COX-2 expression and PGE2 secretion via inactivation of NF-κB pathway.

scholarly journals Characterization of the complete chloroplast genome of traditional Chinese herb, Solanum japonense Nakai. (Solanaceae)

2021 ◽  
Vol 6 (1) ◽  
pp. 211-213
Author(s):  
Xiaoxia Zhang ◽  
Xiaofeng Zhang ◽  
Huan Wang ◽  
Shilong Chen ◽  
Tingfeng Cheng ◽  
...  
Keyword(s):  
Chloroplast Genome ◽  
Chinese Herb ◽  
Complete Chloroplast Genome ◽  
Traditional Chinese Herb

scholarly journals The complete chloroplast genome of Isodon rubescens, a traditional Chinese herb

2021 ◽  
Vol 6 (2) ◽  
pp. 337-338
Author(s):  
Zhiyong Yue ◽  
Yan Wang ◽  
Baozhen Zhou ◽  
Hanping Wang
Keyword(s):  
Chloroplast Genome ◽  
Chinese Herb ◽  
Complete Chloroplast Genome ◽  
Traditional Chinese Herb

scholarly journals Traditional Chinese Herb Combined with Surgery versus Surgery for Varicocele Infertility: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Rong-liang Dun ◽  
Min Yao ◽  
Long Yang ◽  
Xue-jun Cui ◽  
Jian-min Mao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Chinese Herb ◽  
Chinese Herbs ◽  
Cochrane Library ◽  
Dichotomous Data ◽  
Surgery Group ◽  
Traditional Chinese Herb ◽  
The Cochrane Library

Objective. The objective of this study was to conduct a systematic review to assess the effectiveness and safety of traditional Chinese herb combined with surgery for male varicocele infertility compared to surgery.Methods. Randomized controlled trials (RCTs) data of traditional Chinese herbs combined with surgery for male varicocele fertility versus surgery were collected by searching the Cochrane Library, Embase, PubMed, and Chinese databases. The risk of bias was assessed using Cochrane Handbook. Study outcomes were presented as risk ratios (RRs) for dichotomous data.Results. Seventeen of 72 potentially relevant trials met the inclusion criteria. The methodological qualities of the RCTs were low. Compared with the surgery group, the traditional Chinese herb combined with surgery group had superiority in pregnancy rate at 3-month (RR=1.76, andP=0.008), 6-month (RR=1.58, andP=0.0005), and 2-year (RR=1.58, andP=0.0005) follow-ups. No RCT was found to describe the side effects.Conclusion. On considering the low methodological quality of RCTs, there was no enough evidence on traditional Chinese herb with surgery for male varicocele infertility, and more high-quality RCTs of large sample sizes are required.

scholarly journals Rituals in Traditional Chinese Medicine: Taking a Case of Infertility as an Example

2022 ◽  
pp. 9-12
Author(s):  
Jian Liang ◽  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Medical Practice ◽  
Chinese Herb ◽  
Well Being ◽  
Close Connection ◽  
Research Topics ◽  
Whole Process ◽  
Traditional Chinese Herb ◽  
The World

Ritual is one of the most classic research topics in the field of Anthropology, and rituals have close connection with medial practice. However, the research on this topic from the experience of Traditional Chinese Medicine is limited. This paper presents the whole story that a patient suffering from infertility got cured got cured by a doctor of Traditional Chinese Medicine(TCM) and finally became a mother. With the detailed description of each medical practice, including pulse-taking, traditional Chinese herb therapy, and postpartum confinement, this paper analyzes the ritualized elements in the whole process, interprets how ritual play a role in the practice of TCM, and points out ritual’s essential significance in contributing to human’s well being and adjusting the relationships between individual and the world.

scholarly journals Icaritin: A Novel Natural Candidate for Hematological Malignancies Therapy

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Xiao-Jing Yang ◽  
Ya-Ming Xi ◽  
Zi-Jian Li
Keyword(s):  
Hematological Malignancies ◽  
Treatment Options ◽  
Chinese Herb ◽  
Cell Types ◽  
Hematologic Malignancies ◽  
Cytotoxic Effects ◽  
Novel Treatment ◽  
Traditional Chinese Herb ◽  
Current Therapies ◽  
Underlying Mechanisms

Hematological malignancies including leukemia and lymphoma can severely impact human health. With the current therapies combined with chemotherapy, stem cell transplantation, radiotherapy, and immunotherapy, the prognosis of hematologic malignancies improved significantly. However, most hematological malignancies are still incurable. Therefore, research for novel treatment options was continuing with the natural product as one source. Icaritin is a compound extracted from a traditional Chinese herb,Epimedium Genus, and demonstrated an antitumor effect in various neoplasms including hematological malignancies such as leukemia, lymphoma, and multiple myeloma. In hematological malignancies, icaritin showed multiple cytotoxic effects to induce apoptosis, arrest the cell cycle, inhibit proliferation, promote differentiation, restrict metastasis and infiltration, and suppress the oncogenic virus. The proved underlying mechanisms of the cytotoxic effects of icaritin are different in various cell types of hematological malignancies but associated with the critical cell signal pathway, including PI3K/Akt, JAK/STAT3, and MAPK/ERK/JNK. Although the primary target of icaritin is still unspecified, the existing evidence indicates that icaritin is a potential novel therapeutic agent for neoplasms as with hematological malignancies. Here, in the field of hematology, we reviewed the reported activity of icaritin in hematologic malignancies and the underlying mechanisms and recognized icaritin as a candidate for therapy of hematological malignancies.

scholarly journals Protective Effects of Active Compounds from Salviae miltiorrhizae Radix against Glutamate-Induced HT-22 Hippocampal Neuronal Cell Death

Processes ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. 914
Author(s):  
Hung Manh Phung ◽  
Sullim Lee ◽  
Ki Sung Kang
Keyword(s):  
Cell Death ◽  
Rosmarinic Acid ◽  
Calcium Influx ◽  
Salvia Miltiorrhiza ◽  
Neuroprotective Effect ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Salvianolic Acid B ◽  
Tanshinone Iia ◽  
Salvianolic Acid

Oxidative stress is considered one of the factors that cause dysfunction and damage of neurons, causing diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease (PD).Recently, natural antioxidant sources have emerged as one of the main research areas for the discovery of potential neuroprotectants that can be used to treat neurological diseases. In this research, we assessed the neuroprotective effect of a 70% ethanol Salvia miltiorrhiza Radix (SMR) extract and five of its constituent compounds (tanshinone IIA, caffeic acid, salvianolic acid B, rosmarinic acid, and salvianic acid A) in HT-22 hippocampal cells. The experimental data showed that most samples were effective in attenuating the cytotoxicity caused by glutamate in HT-22 cells, except for rosmarinic acid and salvianolic acid B. Of the compounds tested, tanshinone IIA (TS-IIA) exerted the strongest effect in protecting HT-22 cells against glutamate neurotoxin. Treatment with 400 nM TS-IIA restored HT-22 cell viability almost completely. TS-IIA prevented glutamate-induced oxytosis by abating the accumulation of calcium influx, reactive oxygen species, and phosphorylation of mitogen-activated protein kinases. Moreover, TS-IIA inhibited glutamate-induced cytotoxicity by reducing the activation and phosphorylation of p53, as well as by stimulating Akt expression. This research suggested that TS-IIA is a potential neuroprotective component of SMR, with the ability to protect against neuronal cell death induced by excessive amounts of glutamate.

scholarly journals Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Jie Qi ◽  
Jianguo Cui ◽  
Baobin Mi ◽  
Xiaohong Yan ◽  
Wenwen Xu ◽  
...  
Keyword(s):  
Chinese Herb ◽  
Atherosclerotic Lesion ◽  
Ang Ii ◽  
Knockout Mouse Model ◽  
Pharmacological Mechanism ◽  
Traditional Chinese Herb ◽  
Channel Expression ◽  
Dose Dependent Fashion ◽  
Apoe Knockout Mouse

Isoliquiritigenin (ISL) is a flavonoid isolated mainly from the licorice plant, a traditional Chinese herb. ISL has shown anticancer, anti-inflammatory, antioxidant, and antidiabetic activities. However, the pharmaceutical effects of ISL on atherosclerosis are seldom explored. In this study, we used apolipoprotein E (ApoE) knockout mouse model and angiotensin II- (Ang II-) stimulated vascular smooth muscle cells (VSMCs) to elucidate the pharmacological mechanism of ISL to inhibit atherosclerosis. We found that in ApoE−/− mice ISL could attenuate atherosclerotic lesion, reduce serum lipid levels, and inhibit TRPC5 expression. In vitro, ISL inhibited Ang II-stimulated proliferation of VSMCs and suppressed Ang II-induced TRPC5 and PCNA expressions in a dose-dependent fashion. In conclusion, our findings provide novel insight into the pharmacological effects of ISL on atherosclerosis and suggest that ISL is beneficial for cardiovascular protection.

scholarly journals Is the traditional Chinese herb “Artemisia annua” possible to fight against COVID-19?

2020 ◽  
Vol 9 (3) ◽  
pp. 100474 ◽  
Author(s):  
Siukan Law ◽  
Albert Wingnang Leung ◽  
Chuanshan Xu
Keyword(s):  
Artemisia Annua ◽  
Chinese Herb ◽  
Traditional Chinese Herb
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