scholarly journals Antifungal and Antioxidant Pyrrole Derivative from Piper Pedicellatum

2013 ◽  
Vol 8 (10) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Chandan Tamuly ◽  
Partha P. Dutta ◽  
Manobjyoti Bordoloi ◽  
Jayanta Bora
Keyword(s):  
Aspergillus Niger ◽  
Pathogenic Fungi ◽  
Spectroscopic Studies ◽  
Curvularia Lunata ◽  
Plant Pathogenic Fungi ◽  
Arunachal Pradesh ◽  
Frap Assay ◽  
X Ray ◽  
X Ray Crystallography ◽  
Fungal Organisms

In continuation of our search for efficient pest control natural products from the flora of the South Eastern Sub-Himalayan biodiversity region, we have investigated wild edible Piper pedicellatum C. DC (Piperaceae) from Arunachal Pradesh, India against five important plant pathogenic fungi through an activity guided method, and a new compound, pedicellamide, was isolated. The structure was determined on the basis of extensive spectroscopic studies and confirmed by X-ray crystallography. The compound exhibited antifungal activities against the phytopathogenic fungal organisms Rhizoctonia solani (MIC 38.4 ± 1.6 μg/mL), Fusarium oxysporum (MIC 29.7 ± 0.8 μg/mL), Aspergillus niger (MIC 48.6 ± 0.7 μg/mL), Puccinia gramini (MIC 46.8 ± 1.4 μg/mL) and Curvularia lunata (MIC 49.1 ± 0.1μg/mL). Additionally, the antioxidant potential of the compound was estimated by DPPH, ABTS and FRAP assay and found to be 2.87 ± 0.20, 2.19 ± 0.13 and 3.96 ± 0.17 VCEAC (μM/g), respectively.

Activity of Armillarisin B in vitro against Plant Pathogenic Fungi

2009 ◽  
Vol 64 (11-12) ◽  
pp. 790-792 ◽  
Author(s):  
Jin-Wen Shen ◽  
Bing-Ji Ma ◽  
Wen Li ◽  
Hai-You Yu ◽  
Ting-Ting Wu ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Methanolic Extract ◽  
Pathogenic Fungi ◽  
2D Nmr ◽  
Spectroscopic Studies ◽  
Gibberella Zeae ◽  
Plant Pathogenic Fungi ◽  
Fruiting Bodies ◽  
Bioassay Guided Fractionation

The methanolic extract of the fruiting bodies of the mushroom Armillariella tabescens was found to show antifungal activity against Gibberella zeae. The active compound was isolated from the fruiting bodies of A. tabescens by bioassay-guided fractionation of the extract and identifi ed as armillarisin B. Armillarisin B eventually corresponds to 2-hydroxy-2- phenylpropanediamide and its structure was confi rmed on the basis of spectroscopic studies including 2D NMR experiments.

Coordination chemistry of thioether–pyridazine macrocycles. III. Synthetic, structural, and spectroscopic studies of Cu(II), Cu(II)Cu(I), and Cu(I) complexes of a hexathiapyridazinophane macrocyclic ligand

1993 ◽  
Vol 71 (7) ◽  
pp. 1086-1093 ◽  
Author(s):  
Liqin Chen ◽  
Laurence K. Thompson ◽  
John N. Bridson
Keyword(s):  
Mass Spectrometry ◽  
Macrocyclic Ligand ◽  
Spectroscopic Studies ◽  
Orthorhombic System ◽  
Space Group ◽  
X Ray ◽  
X Ray Crystallography ◽  
Triclinic System ◽  
Square Planar ◽  
Copper Centre

The preparation and properties of the thioether–pyridazine macrocycle (L4; C16H20S6N4) containing two pyridazine subunits, and its Cu(II), Cu(II)Cu(I), and Cu(I) complexes are described. The ligand is characterized by 1H nuclear magnetic resonance and mass spectrometry, and the complexes by infrared, eleetronic spectra, and magnetism, and in some cases by X-ray crystallography. The complex [Cu2(L4)Cl4]x, (1) crystallized in the triclinic system, space group [Formula: see text] with a = 8.6204(8) Å, b = 9.850(1) Å, c = 8.348(1) Å, α = 111.46(1)°, β = 102.50(1)°, γ = 71.818(9)°, V = 622.6(1) Å3, and Z = 1 (R = 0.043, Rw = 0.042 for 1312 reflections). Two monodentate pyridazine rings in the same ligand bind to one trans square-planar copper centre (CuN2Cl2) with two sulfurs from each ligand binding to another trans square-planar copper centre (CuS2Cl2) to form a polynuclear chain. The complex [Cu(L4)Cl2] (3) crystallized in the triclinic system, space group [Formula: see text] with a = 11.001(1) Å, b = 12.888(2) Å, c = 8.704(1) Å, α = 102.89(1)°, β = 103.36(1)°,γ = 75.84(1)°, V = 1145.8(3) Å3 and Z = 2 (R = 0.056, Rw = 0.044 for 2059 reflections). A trans square-planar structure (CuN2Cl2) exists for 3 with monodentate pyridazines. [Cu(L4)(NO3)2] (4) crystallized in the orthorhombic system, space group P212121, with a = 15.148(2) Å, b = 15.562(3) Å, c = 11.064(1) Å, V = 2608.2(7) Å3 and Z = 4 (R = 0.039, Rw = 0.034 for 1864 reflections). Two monodentate pyridazine rings and two bidentate nitrates bind to a pseudo-octahedral copper(II) centre.

scholarly journals Synthesis and Antimicrobial Activity of Calycanthaceous Alkaloid Analogues

2016 ◽  
Vol 11 (10) ◽  
pp. 1934578X1601101
Author(s):  
Shaojun Zheng ◽  
Longbo Li ◽  
Yu Wang ◽  
Rui Zhu ◽  
Hogjin Bai ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Structural Modification ◽  
Antimicrobial Agents ◽  
Pathogenic Fungi ◽  
Curvularia Lunata ◽  
Plant Pathogenic Fungi ◽  
H Nmr ◽  
High Degree ◽  
Derivatives Of ◽  
C Nmr

A series of 24 novel derivatives of the calycanthaceous alkaloids with a tetrahydropyrroloindol-based core structure was synthesized from tryptophan in good yields. Their structures were characterized by IR, 1H NMR, and 13C NMR spectroscopy and ESI-MS. The synthesized compounds were evaluated against a wide variety of plant pathogenic fungi. Compound a9 exhibited a high degree of activity against Curvularia lunata, with 91.0% activity at a concentration of 100 μg mL−1 and with an EC50 of 44.6 μg mL−1. a7, a8, a13, and a17 exhibited high degrees of activity against Sclerotinia sclerotiorum, with a8 being the most effective with an EC50 of 38.4 μg mL−1. Compound a9 illustrated activity against Botrytis cinerea, with an EC50 of 79.5 μg mL−1. Considering the compounds evaluated, the alkyl substituents of the chain may contribute to the significant variations in fungicidal potency. The structure antifungal activity relationships are also discussed. These results will pave the way for further design, structural modification, and development of calycanthaceous alkaloids as antimicrobial agents.

Syntheses and Spectroscopic Studies of Some New Diazaphospholes and Diazaphosphorinanes. Crystal Structure of 4

2005 ◽  
Vol 60 (10) ◽  
pp. 1021-1026 ◽  
Author(s):  
Khodayar Gholivand ◽  
Zahra Shariatinia ◽  
Mehrdad Pourayoubi ◽  
Sedigheh Farshadian
Keyword(s):  
Crystal Structure ◽  
Ir Spectroscopy ◽  
Spectroscopic Studies ◽  
Coupling Constants ◽  
Crystalline Lattice ◽  
Polymeric Chain ◽  
Ring Strain ◽  
One Dimensional ◽  
X Ray ◽  
X Ray Crystallography

New diazaphospholes and diazaphosphorinanes with formula were synthesized and characterized by 1H, 13C, 31P NMR and IR spectroscopy and elemental analysis. The structure of compound 1 has been determined by X-ray crystallography. A one-dimensional polymeric chain was observed in the crystalline lattice produced by intermolecular -P=O. . .H-N- and -C=O. . .H-N-hydrogen bonds. Compounds 1 and 2 contain five-membered rings and show high values for 2J(PNH) and 2J(P,C) coupling constants due to the ring strain. These constants are reduced seriously in compounds with six-membered rings. In compound 6 with CCl3C(O)NH moiety, all phosphorus-hydrogen couplings are zero.

The first naphthodiazaphosphorinane in the solid phase; syntheses, spectroscopic studies and X-ray crystallography of some new 1,3,2-diheterophosphorus compounds

2009 ◽  
Vol 20 (3) ◽  
pp. 481-488 ◽  
Author(s):  
Khodayar Gholivand ◽  
Zahra Shariatinia ◽  
Sheida Ansar ◽  
Seyedeh Mahdieh Mashhadi ◽  
Farzaneh Daeepour
Keyword(s):  
Solid Phase ◽  
Spectroscopic Studies ◽  
X Ray ◽  
X Ray Crystallography

scholarly journals Comparison of the Photochemical Reaction of Photoactive Yellow Protein in Crystal with Reaction in Solution1

2003 ◽  
Vol 17 (2-3) ◽  
pp. 345-353 ◽  
Author(s):  
Eriko Mano ◽  
Hironari Kamikubo ◽  
Yasushi Imamoto ◽  
Mikio Kataoka
Keyword(s):  
Photochemical Reaction ◽  
Structural Changes ◽  
Spectroscopic Studies ◽  
Crystalline Lattice ◽  
Photoactive Yellow Protein ◽  
X Ray ◽  
X Ray Crystallography ◽  
Solution Condition ◽  
Active Intermediate ◽  
Ectothiorhodospira Halophila

Photoactive yellow protein (PYP) is a photoreceptor protein for the negative phototaxis ofEctothiorhodospira halophila. The crystal structures of several photo‒intermediates have been revealed by X-ray crystallography. In the crystal structure of the active intermediate, PYPM, no significant structural changes were observed except for the vicinity of the chromophore. On the contrary, spectroscopic studies with solution condition demonstrated that global structural changes occur during the photo‒cycle. In order to reveal the origin of the discrepancies, we measured the reaction kinetics upon illumination under crystal condition and to compare them with those observed under solution condition. The reactive portion decreases with the increase of crystallinity. The rate constant of PYPMdecay also decreases with the increase of crystallinity. These results suggest two possibilities: (1) PYP in crystal does not react by the illumination; (2) the photoreaction rate is highly accelerated in crystal. Consequently, the photoreaction in crystal is considered to be highly influenced by the force constraint from crystalline lattice.

Coordination chemistry of thioether–pyridazine macrocycles. I. Synthetic, structural, and spectroscopic studies of Cu(II) and Cu(I) complexes of novel thioether–pyridazine macrocycles that contain two or three pyridazine subunits

1992 ◽  
Vol 70 (7) ◽  
pp. 1886-1896 ◽  
Author(s):  
Liqin Chen ◽  
Laurence K. Thompson ◽  
John N. Bridson
Keyword(s):  
Copper Complexes ◽  
Spin Exchange ◽  
Spectroscopic Studies ◽  
Esr Spectra ◽  
Monoclinic System ◽  
Space Group ◽  
X Ray ◽  
X Ray Crystallography ◽  
Triclinic System ◽  
Square Planar

The preparations of thioether–pyridazine macrocycles containing three (L1) and two (L2) pyridazine subunits and their copper complexes are described. The ligands are characterized by 1H nuclear magnetic resonance and mass spectrometry and in one case by X-ray crystallography, and the complexes by infrared, electronic, and electron spin resonance (esr) spectra and in some cases by X-ray crystallography. The complex [Cu3(L1)2Cl6]•2CHCl3 (1) crystallized in the triclinic system, space group [Formula: see text] with a = 13.661(2) Å, b = 14.174(3) Å, c = 9.412(2) Å, α = 101.08(2)°, β = 96.94(2)°, γ = 75.76(2)°, V = 1728.2(6) Å3, and Z = 2 (R = 0.056, Rw = 0.048 for 2080 reflections). Two monodentate pyridazine rings in each ligand bind to one square-planar copper centre with the third monodentate pyridazine in each ligand linking the two to the central square-planar copper. The complex [Cu(L2)Cl2] (2) crystallized in the orthorhombic system, space group Pnma, with a = 8.571(1) Å, b = 16.104(3) Å, c = 13.961(2) Å, V = 1927(1) Å3, and Z = 4 (R = 0.037, Rw = 0.033 for 1070 reflections). A cis square-planar structure exists for 2 with monodentate pyridazines. [Cu(L2)2]•(ClO4)2•CH3CN•CHCl3 (5) crystallized in the triclinic system, space group [Formula: see text] with a = 12.888(4) Å, b = 17.462(6) Å, c = 10.906(1) Å, α = 96.07(2)°, β = 104.18(2)°, γ = 94.51(2)°, V = 2352(1) Å3, and Z = 2 (R = 0.053, Rw = 0.044 for 2941 reflections). Two ligands involving monodentate pyridazine rings bind to a square-planar copper(II) centre. The protonated ligand salt [L2H](ClO4)•H2O (6) crystallized in the monoclinic system, space group P21/n, with a = 14.762(4) Å, b = 8.637(5) Å, c = 16.267(4) Å, β = 92.78(2)°, V = 2072(1) Å3, and Z = 4 (R = 0.064, Rw = 0.053 for 1456 reflections). No sulfur coordination is observed in these complexes and there is no apparent spin exchange in the trinuclear derivative.

scholarly journals Inhibition of Fungal Plant Pathogens by Aqueous Extracts of Arum cyreniacum

2021 ◽  
pp. 1-6
Author(s):  
Ahmed A. Abdulrraziq ◽  
Sami M. Salih ◽  
Sultan F. Alnomasy ◽  
Ziyad M. Aldosari ◽  
Bader S. Alotaibi
Keyword(s):  
Aspergillus Niger ◽  
Fusarium Solani ◽  
Plant Pathogens ◽  
Pathogenic Fungi ◽  
Inhibitory Effect ◽  
Plant Pathogenic Fungi ◽  
Dependent Manner ◽  
Aqueous Extracts ◽  
Fungal Plant Pathogens ◽  
The Family

Arum cyreniacum is an important member of the family of Araceae because of its bio-activities. Hence this work aimed to establish a link between Arum cyreniacum and its uses as bio-control against plant pathogenic fungi which had never hitherto been established. This work was carried out to evaluate the activity of the aqueous extracts of tubers, leaves, and flowers of Arum cyreniacum against three different types of pathogenic fungi, Fusarium solani, Rhizopus microspores and Aspergillus niger. The antifungal activity of the aqueous extracts of Arum cyreniacum was determined by poisoned food technique. The results showed that Arum cyreniacum had an inhibitory effect in a dose-dependent manner on Fusarium solani, Rhizopus microspores, while Aspergillus niger was resistant to all extracts. However, the great inhibition activity against tested fungi was associated with increasing concentrations of the aqueous extracts of Arum cyreniacum. Data in this work indicated that the use of Arum cyreniacum could be a valid alternative for bio-control of plant pathogenic fungi.

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