scholarly journals Anti-allergic Inflammatory Effects of Cyanogenic and Phenolic Glycosides from the Seed of Prunus persica

2013 ◽  
Vol 8 (12) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Geum Jin Kim ◽  
Hyun Gyu Choi ◽  
Ji Hyang Kim ◽  
Sang Hyun Kim ◽  
Jeong Ah Kim ◽  
...  
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
Prunus Persica ◽  
Methanol Extract ◽  
Phenolic Glycosides ◽  
Inhibitory Effects ◽  
Gene Expressions ◽  
Human Mast Cells ◽  
Tnf Α ◽  
Necrosis Factor

A methanol extract of the seed of Prunus persica (Rosaceae) was found to inhibit histamine release in human mast cells. Activity-guided fractionation of the methanol extract yielded three cyanogenic glycosides (1–3) and other phenolic compounds (4–8). To evaluate their anti-allergic and anti-inflammatory activities, the isolates (1–8) were tested for their inhibitory effects on histamine release and on the gene expressions of tumor necrosis factor (TNF)-α and interleukin (IL)–6 in human mast cells. Of these, phenolic glycosides 7 and 8 suppressed histamine release and inhibited the pro-inflammatory cytokines TNF-α and IL-6. These results suggest that isolates from P. persica are among the anti-allergic inflammatory principles in this medicinal plant.

scholarly journals Anti-allergic Inflammatory Activities of Compounds of Amomi Fructus

2015 ◽  
Vol 10 (4) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Hyun Gyu Choi ◽  
In-Gyu Je ◽  
Geum Jin Kim ◽  
Hyukjae Choi ◽  
Sang Hyun Kim ◽  
...  
Keyword(s):  
Mast Cells ◽  
Benzoic Acid ◽  
Histamine Release ◽  
Vanillic Acid ◽  
Inhibitory Effects ◽  
Human Mast Cells ◽  
Tnf Α ◽  
Necrosis Factor ◽  
Pro Inflammatory Cytokines ◽  
Methoxybenzoic Acid

Activity-guided isolation of compounds from the fruits of Amomum xanthioides resulted in the purification of fourteen phenolic compounds, 4-hydroxy-benzaldehyde (1), 3,4-dihydroxybenzaldehyde (2), 3,5-dimethoxy-4-methylbenzaldehyde (3), syringic aldehyde (4), benzoic acid (5), 3,4-dihydroxy benzoic acid (6), vanillic acid (7), 3-hydroxy-2-methoxybenzoic acid (8), o-vanillic acid (9), phenylacetic acid (10), tyrosol (11), pyrocatechol (12), 1,2,4,5-tetramethoxybenzene (13), and 3,3′,5,5′-tetramethoxybiphenyl-4,4′-diol (14). To evaluate the anti-allergic inflammatory activities of these compounds, we examined the inhibitory effects of the isolates (1-14) on histamine release and on the expressions of tumor necrosis factor (TNF)-α and interleukin (IL)–6 genes by using human mast cells. Of the tested compounds, 9, 11, and 13 suppressed histamine release from mast cells, and all isolates attenuated the expressions of the pro-inflammatory cytokines, TNF-α and IL-6 genes in human mast cells.

scholarly journals Phenolic Glycosides from Lindera obtusiloba and their Anti-allergic Inflammatory Activities

2013 ◽  
Vol 8 (2) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Hyun Gyu Choi ◽  
Hwa Dong Lee ◽  
Sang Hyun Kim ◽  
Min Kyun Na ◽  
Jeong Ah Kim ◽  
...  
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
Proinflammatory Cytokines ◽  
Allergic Inflammation ◽  
Positive Control ◽  
Phenolic Glycosides ◽  
Gene Expressions ◽  
Human Mast Cells ◽  
Tnf Α ◽  
Lindera Obtusiloba

Eight phenolic glycosides, tachioside (1), isotachioside (2), koaburaside (3), 2,6-dimethoxy-4-hydroxyphenyl-1- O-ß-D-glucopyranoside (4), 4,6-dihydroxy-2- methoxyphenyl-1- O-β-D-glucopyranoside (5), a mixture of erigeside C (6a) and salidroside (6b), and 6-hydroxyphenyl)-1- O-β-D-glucopyranoside (7) were isolated from the stems of Lindera obtusiloba Blume. The structures of the isolates were determined by 1H-, 13C-NMR, COSY, HMQC, and HMBC spectroscopy. To evaluate their anti-allergic inflammatory activities, the inhibitory effects of isolates (1-7) on histamine release and on the gene expressions of tumor necrosis factor (TNF)-α and interleukin (IL)-6 were examined using human mast cells; previous studies have reported that TNF-α and IL-6 release from mast cells is positively related to the severity of allergic symptoms. Of the tested compounds, koaburaside (3), 2,6-dimethoxy-4-hydroxyphenyl-1- O-ß-D- glucopyranoside (4), and (6-hydroxyphenyl)-1- O-β-D-glucopyranoside (7) suppressed histamine release from mast cells as compared with gallic acid (positive control). In particular, 6-hydroxyphenyl)-1- O-β-D-glucopyranoside (7) attenuated the gene expressions of the proinflammatory cytokines TNF-α and IL-6 in human mast cells. Our results support the notion that phenolic glycosides isolated from L. obtusiloba inhibit mast-cell-derived allergic inflammation, histamine, and proinflammatory cytokines.

scholarly journals Enzymatic Synthesis and Anti-Allergic Activities of Curcumin Oligosaccharides

2010 ◽  
Vol 3 ◽  
pp. BCI.S2768 ◽  
Author(s):  
Kei Shimoda ◽  
Hiroki Hamada
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
Enzymatic Synthesis ◽  
Antibody Formation ◽  
Cyclodextrin Glucanotransferase ◽  
Enzymatic Method ◽  
Inhibitory Effects ◽  
Peritoneal Mast Cells ◽  
Rat Peritoneal Mast Cells ◽  
Suppressive Action

Curcumin 4‘- O-glucooligosaccharides were synthesized by a two step-enzymatic method using almond β-glucosidase and cyclodextrin glucanotransferase (CGTase). Curcumin was glucosylated to curcumin 4‘- O-β-D-glucopyranoside by almond β-glucosidase in 19% yield. Curcumin 4‘- O-β-D-glucopyranoside was converted into curcumin 4‘- O-β-glucooligosaccharides, i.e. 4‘- O-β-maltoside (51%) and 4‘- O-β-maltotrioside (25%), by further CGTase-catalyzed glycosylation. Curcumin 4‘- O-β-glycosides showed suppressive action on IgE antibody formation and inhibitory effects on histamine release from rat peritoneal mast cells.

scholarly journals Human Mast Cells Release Metalloproteinase-9 on Contact with Activated T Cells: Juxtacrine Regulation by TNF-α

2001 ◽  
Vol 167 (7) ◽  
pp. 4008-4016 ◽  
Author(s):  
Dana Baram ◽  
Gayle G. Vaday ◽  
Pazit Salamon ◽  
Ilana Drucker ◽  
Rami Hershkoviz ◽  
...  
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Activated T Cells ◽  
Human Mast Cells ◽  
Tnf Α ◽  
Metalloproteinase 9

scholarly journals Inhibitory effects of stilbenes on histamine release from rat mast cells

1984 ◽  
Vol 36 ◽  
pp. 232
Author(s):  
Makoto Matsumoto ◽  
Tamiko Suzuki ◽  
Masaatsu K. Uchida
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
Inhibitory Effects ◽  
Rat Mast Cells

scholarly journals Chemical Constituents of the Root of Angelica tenuissima and their Anti-allergic Inflammatory Activity

2017 ◽  
Vol 12 (5) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Hyun Gyu Choi ◽  
In-Gyu Je ◽  
Geum Jin Kim ◽  
Joo-Won Nam ◽  
Sang Hee Shim ◽  
...  
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
Methanolic Extract ◽  
Chemical Constituents ◽  
Inflammatory Activity ◽  
Plant Source ◽  
Chemical Structures ◽  
Human Mast Cells ◽  
Reported Data ◽  
First Time

A phthalide, levistolide A (1), and six coumarins, demethylsuberosin (2), fraxetin (3), (-)-marmesinin (4), 3'( S)- O-β-D-glucopyranosyl-3’,4'-dihydroxanthyletin (5), 3'( R)- O-β-D-glucopyranosyl-3’,4'-dihydroxanthyletin (6), and isopraeroside IV (7) were isolated from the methanolic extract of the roots of Angelica tenuissima Nakai. Their chemical structures were confirmed by comparing spectroscopic and reported data. All seven compounds were isolated for the first time from this plant source. The anti-allergic activities of compounds 1-7 were examined using human mast cells, and compounds 1-3 at 10 μM potently suppressed IL-6 expression and inhibited histamine release from human mast cells by more than 30%.

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