scholarly journals Antileishmanial Activity of Compounds Isolated from Sassafras albidum

2015 ◽  
Vol 10 (7) ◽  
pp. 1934578X1501000
Author(s):  
Divya Pulivarthi ◽  
Kelly Marie Steinberg ◽  
Lianet Monzote ◽  
Abel Piñón ◽  
William N. Setzer
Keyword(s):  
Natural Products ◽  
Stem Bark ◽  
Antileishmanial Activity ◽  
Bark Extract ◽  
Neglected Tropical Disease ◽  
Mouse Macrophage ◽  
Efficient Treatment ◽  
Sassafras Albidum ◽  
Potential Source ◽  
Stem Bark Extract

Leishmaniasis is a neglected tropical disease caused by Leishmania parasitic protozoa, which currently lacks efficient treatment. Natural products have shown promise as a potential source for antiprotozoal drugs. This work focuses on the antileishmanial potential of Sassafras albidum (Lauraceae) bark extract. The crude bark extract of S. albidum showed excellent antileishmanial activity with an IC50 value less than 12.5 μg/mL against promastigotes of L. amazonensis. The chloroform stem bark extract of S. albidum was subjected to preparative column chromatography. Five compounds were isolated, purified by recrystallization, and identified as sesamin, spinescin, β-sitosterol, hexatriacontanal, and 1-triacontanol. Antileishmanial and cytotoxic screening were performed on these compounds. Sesamin exhibited the best activity against L. amazonensis with an IC50 of 15.8 μg/mL and was not cytotoxic to mouse macrophage cells ( CC50 > 100 μg/mL).

The paradox of natural products as pharmaceuticalsExperimental evidences of a mango stem bark extract

2007 ◽  
Vol 55 (5) ◽  
pp. 351-358 ◽  
Author(s):  
A NUNEZSELLES ◽  
R DELGADOHERNANDEZ ◽  
G GARRIDOGARRIDO ◽  
D GARCIARIVERA ◽  
M GUEVARAGARCIA ◽  
...  
Keyword(s):  
Natural Products ◽  
Stem Bark ◽  
Bark Extract ◽  
Stem Bark Extract

scholarly journals Antimalarial Activity of Stem Bark of Periploca linearifolia during Early and Established Plasmodium Infection in Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Wubetu Yihunie Belay ◽  
Abyot Endale Gurmu ◽  
Zewdu Birhanu Wubneh
Keyword(s):  
Local Community ◽  
Antimalarial Activity ◽  
Stem Bark ◽  
Negative Control ◽  
Bark Extract ◽  
Control Groups ◽  
Potential Source ◽  
Stem Bark Extract

Background. In Ethiopia, stem bark of Periploca linearifolia is used for the treatment of malaria by the local community and demonstrated antimalarial activity in vitro. Despite its in vitro antimalarial activity, no scientific study has been carried out to verify its activity in vivo. Therefore, the aim of the study was to evaluate the antimalarial activity of Periploca linearifolia stem bark extract in mice. Methods. The dried stem bark of Periploca linearifolia was extracted with 80% methanol and evaluated for its antimalarial activity on both early and established Plasmodium berghei infected mice. The extract was prepared at graded doses of 200, 400, and 600 mg/kg. Chloroquine and distilled water were administered to the positive and negative control groups, respectively. Results. The crude extract, at all tested doses, suppressed parasitemia significantly (p<0.05) for 200 and 400 mg/kg and (p<0.001) for 600 mg/kg. The suppression values at these doses were 56.98, 43.33, and 38.17 percent, respectively. Periploca linearifolia extract also demonstrated schizonticidal activity in the established malaria infection. Conclusion. The plant Periploca linearifolia has a promising antimalarial activity in mice, supporting its in vitro finding. Thus, it could be considered as a potential source to develop new antimalarial agent.

Sequestered uptake of chromium(VI) by Irvingia gabonensis stem bark extract anchored silica gel

2021 ◽  
Author(s):  
James F. Amaku ◽  
Segun A. Ogundare ◽  
Kovo G. Akpomie ◽  
Comfort M. Ngwu ◽  
Jeanet Conradie
Keyword(s):  
Silica Gel ◽  
Stem Bark ◽  
Bark Extract ◽  
Chromium Vi ◽  
Irvingia Gabonensis ◽  
Stem Bark Extract

scholarly journals Carbohydrate digestive enzymes are inhibited by Poincianella pluviosa stem bark extract: relevance on type 2 diabetes treatment

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Camila Gabriel Kato-Schwartz ◽  
Anacharis Babeto de Sá-Nakanishi ◽  
Ana Carolina Guidi ◽  
Geferson de Almeida Gonçalves ◽  
Fernanda Giacomini Bueno ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Digestive Enzymes ◽  
Stem Bark ◽  
Bark Extract ◽  
Diabetes Treatment ◽  
Type 2 Diabetes Treatment ◽  
Stem Bark Extract

scholarly journals Effect of Carica papaya L. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin

2020 ◽  
Vol 151 ◽  
pp. 01011
Author(s):  
Safrida Safrida ◽  
Mustafa Sabri
Keyword(s):  
Body Weight ◽  
Carica Papaya ◽  
Stem Bark ◽  
Negative Control ◽  
Diabetic Rats ◽  
Cholesterol Concentration ◽  
Bark Extract ◽  
Treatment Groups ◽  
Randomized Design ◽  
Stem Bark Extract

This study was designed to determine the effect of Carica papaya L. stem bark extracts on cholesterol concentration in rats induced with glibenclamide. A completely randomized design was used for the experiment which consisted of 6 treatment groups, each group consisted of four rats, as follows:1) KN (negative control, non-diabetic rats); KP, diabetic rats given glibenclamide 10 mg/kg body weight; EP 1, diabetic rats given 0 mg/kg body weight/day extract; EP2, diabetic rats given 100 mg/kg body weight/day extract; and EP3, diabetic rats given 200 mg/kg body weight/day extract, EP4, diabetic rats given 300 mg/kg body weight/day extract for 28 day. The results showed that C. papaya L. stem bark extract decreased (P<0.05) cholesterol levels in diabetic rats. It was concluded that C. papaya L. stem bark extract had potential as anti-hypercholesterolemic in diabetic rats.

Sub-chronic Study of Aqueous Stem Bark Extract of Senna siamea in Rats

2012 ◽  
Vol 5 (6) ◽  
pp. 314-321 ◽  
Author(s):  
A. Mohammed ◽  
S.B. Mada ◽  
H.M. Yakasai
Keyword(s):  
Stem Bark ◽  
Bark Extract ◽  
Senna Siamea ◽  
Chronic Study ◽  
Stem Bark Extract
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