The paradox of natural products as pharmaceuticalsExperimental evidences of a mango stem bark extract

2007 ◽  
Vol 55 (5) ◽  
pp. 351-358 ◽  
Author(s):  
A NUNEZSELLES ◽  
R DELGADOHERNANDEZ ◽  
G GARRIDOGARRIDO ◽  
D GARCIARIVERA ◽  
M GUEVARAGARCIA ◽  
...  
Keyword(s):  
Natural Products ◽  
Stem Bark ◽  
Bark Extract ◽  
Stem Bark Extract

scholarly journals Antileishmanial Activity of Compounds Isolated from Sassafras albidum

2015 ◽  
Vol 10 (7) ◽  
pp. 1934578X1501000
Author(s):  
Divya Pulivarthi ◽  
Kelly Marie Steinberg ◽  
Lianet Monzote ◽  
Abel Piñón ◽  
William N. Setzer
Keyword(s):  
Natural Products ◽  
Stem Bark ◽  
Antileishmanial Activity ◽  
Bark Extract ◽  
Neglected Tropical Disease ◽  
Mouse Macrophage ◽  
Efficient Treatment ◽  
Sassafras Albidum ◽  
Potential Source ◽  
Stem Bark Extract

Leishmaniasis is a neglected tropical disease caused by Leishmania parasitic protozoa, which currently lacks efficient treatment. Natural products have shown promise as a potential source for antiprotozoal drugs. This work focuses on the antileishmanial potential of Sassafras albidum (Lauraceae) bark extract. The crude bark extract of S. albidum showed excellent antileishmanial activity with an IC50 value less than 12.5 μg/mL against promastigotes of L. amazonensis. The chloroform stem bark extract of S. albidum was subjected to preparative column chromatography. Five compounds were isolated, purified by recrystallization, and identified as sesamin, spinescin, β-sitosterol, hexatriacontanal, and 1-triacontanol. Antileishmanial and cytotoxic screening were performed on these compounds. Sesamin exhibited the best activity against L. amazonensis with an IC50 of 15.8 μg/mL and was not cytotoxic to mouse macrophage cells ( CC50 > 100 μg/mL).

Sequestered uptake of chromium(VI) by Irvingia gabonensis stem bark extract anchored silica gel

2021 ◽  
Author(s):  
James F. Amaku ◽  
Segun A. Ogundare ◽  
Kovo G. Akpomie ◽  
Comfort M. Ngwu ◽  
Jeanet Conradie
Keyword(s):  
Silica Gel ◽  
Stem Bark ◽  
Bark Extract ◽  
Chromium Vi ◽  
Irvingia Gabonensis ◽  
Stem Bark Extract

scholarly journals Carbohydrate digestive enzymes are inhibited by Poincianella pluviosa stem bark extract: relevance on type 2 diabetes treatment

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Camila Gabriel Kato-Schwartz ◽  
Anacharis Babeto de Sá-Nakanishi ◽  
Ana Carolina Guidi ◽  
Geferson de Almeida Gonçalves ◽  
Fernanda Giacomini Bueno ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Digestive Enzymes ◽  
Stem Bark ◽  
Bark Extract ◽  
Diabetes Treatment ◽  
Type 2 Diabetes Treatment ◽  
Stem Bark Extract

scholarly journals Effect of Carica papaya L. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin

2020 ◽  
Vol 151 ◽  
pp. 01011
Author(s):  
Safrida Safrida ◽  
Mustafa Sabri
Keyword(s):  
Body Weight ◽  
Carica Papaya ◽  
Stem Bark ◽  
Negative Control ◽  
Diabetic Rats ◽  
Cholesterol Concentration ◽  
Bark Extract ◽  
Treatment Groups ◽  
Randomized Design ◽  
Stem Bark Extract

This study was designed to determine the effect of Carica papaya L. stem bark extracts on cholesterol concentration in rats induced with glibenclamide. A completely randomized design was used for the experiment which consisted of 6 treatment groups, each group consisted of four rats, as follows:1) KN (negative control, non-diabetic rats); KP, diabetic rats given glibenclamide 10 mg/kg body weight; EP 1, diabetic rats given 0 mg/kg body weight/day extract; EP2, diabetic rats given 100 mg/kg body weight/day extract; and EP3, diabetic rats given 200 mg/kg body weight/day extract, EP4, diabetic rats given 300 mg/kg body weight/day extract for 28 day. The results showed that C. papaya L. stem bark extract decreased (P<0.05) cholesterol levels in diabetic rats. It was concluded that C. papaya L. stem bark extract had potential as anti-hypercholesterolemic in diabetic rats.

Sub-chronic Study of Aqueous Stem Bark Extract of Senna siamea in Rats

2012 ◽  
Vol 5 (6) ◽  
pp. 314-321 ◽  
Author(s):  
A. Mohammed ◽  
S.B. Mada ◽  
H.M. Yakasai
Keyword(s):  
Stem Bark ◽  
Bark Extract ◽  
Senna Siamea ◽  
Chronic Study ◽  
Stem Bark Extract
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