scholarly journals Chemical Constituents of Euonymus glabra

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001
Author(s):  
Jie Ren ◽  
Yang-Guo Xie ◽  
Xing Wang ◽  
Shi-Kai Yan ◽  
Hui-Zi Jin ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Phenolic Compound ◽  
Chemical Constituents ◽  
No Production ◽  
Spectroscopic Methods ◽  
Inhibitory Effects ◽  
Raw264.7 Macrophages ◽  
Circular Dichroism Analysis ◽  
Inhibitory Activities ◽  
Circular Dichroïsm

One new phenolic compound (1) and one new flavan (2), together with eight known compounds (3–10) were isolated from the stems and twigs of Euonymus glabra Roxb. Their structures were elucidated mainly on the basis of 1D and 2D spectroscopic methods and circular dichroism analysis. In addition, compounds 1–10 were tested for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Compounds 1–5 and 7 exhibited moderate inhibitory activities with IC50 values ranged from 5.1 to 11.9 μM.

scholarly journals Chemical Constituents of the Leaves of Butterbur (Petasites japonicus) and Their Anti-Inflammatory Effects

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 806 ◽  
Author(s):  
Jin Su Lee ◽  
Miran Jeong ◽  
Sangsu Park ◽  
Seung Mok Ryu ◽  
Jun Lee ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Chemical Constituents ◽  
Water Extract ◽  
Docking Studies ◽  
Hot Water ◽  
Chemical Structures ◽  
Raw264.7 Macrophages ◽  
Cox 2 ◽  
Circular Dichroïsm ◽  
Petasites Japonicus

Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur (Petasites japonicus) along with six known compounds. The chemical structures of lignans 1 and 2 were elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE2) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compound 1 in RAW264.7 cells. Furthermore, compounds 1 and 3 exhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.

scholarly journals Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 529
Author(s):  
Sun ◽  
Cao ◽  
Xiao ◽  
Zhang ◽  
Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Circular Dichroism ◽  
Absolute Configuration ◽  
2D Nmr ◽  
Cytotoxic Activities ◽  
No Production ◽  
Inhibitory Effects ◽  
Electronic Circular Dichroism ◽  
Spectroscopic Analyses ◽  
Circular Dichroïsm

Four new diterpenoids, named aspidoptoids A–D (1–4), together with two known analogues (5–6) were isolated from Aspidopterys obcordata vine. Aspidoptoids A–B (1–2) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B (2) possesses a rare 3,10-oxybridge. Their structures and absolute configuration were determined by extensive spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR) and electronic circular dichroism (ECD) calculation. In addition, all the isolates were evaluated for their cytotoxic activities and inhibitory effects on the nitric oxide (NO) production.

scholarly journals Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7191
Author(s):  
Sheng-Yuan Zhang ◽  
Zi-Wei Li ◽  
Jie Xu ◽  
Qiu-Ling Chen ◽  
Min Song ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Indole Alkaloids ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Monoterpenoid Indole Alkaloids ◽  
Ic50 Values ◽  
Vasorelaxant Activity ◽  
Inhibitory Activities ◽  
Circular Dichroïsm

Three novel monoterpenoid indole alkaloids gardflorine A (1), gardflorine B (2), and gardflorine C (3) were isolated from the leaves of Gardneria multiflora. Their structures, including absolute configurations, were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and circular dichroism experiments. All the compounds were evaluated for their vasorelaxant and acetylcholinesterase (AChE) inhibitory activities. Compound 1 exhibited potent vasorelaxant activity, with an EC50 value of 8.7 μM, and compounds 2 and 3 showed moderate acetylcholinesterase (AChE) inhibitory activities, with IC50 values of 26.8 and 29.2 μM, respectively.

Chemical Constituents from Chloranthus elatior and Their Inhibitory Effect on Human Dihydroorotate Dehydrogenase

Planta Medica ◽  
2021 ◽  
Author(s):  
Qian Yang ◽  
An Jia ◽  
Xizi Liu ◽  
Shiyi Han ◽  
Siyang Fan
Keyword(s):  
Circular Dichroism ◽  
Chemical Constituents ◽  
Inhibitory Effect ◽  
Mass Spectrometric ◽  
Dihydroorotate Dehydrogenase ◽  
Active Compounds ◽  
Electronic Circular Dichroism ◽  
Aerial Parts ◽  
Ic50 Values ◽  
Circular Dichroïsm

AbstractA new sesquiterpene, chlorantholide G (1), a new sesquiterpene dimer, elatiolactone (2), and 2 new diterpenes, elatiorlabdane B (3) and elatiorlabdane C (4), together with 51 known compounds, were isolated from the aerial parts of Chloranthus elatior. The new structures including their absolute configurations were mainly established by mass spectrometric, NMR, and electronic circular dichroism experiments. All isolated compounds were tested for their anti-hDHODH activity. (4S,6R)-4-hydroxy-6-isopropyl-3-methylcyclohex-2-enone (5) and (4S,5R,9S,10R)-8(17),12,14-labdatrien-18-oic acid (29) were the most active compounds with IC50 values of 18.7 and 30.7 µM, respectively.

Infrared, Raman and ultraviolet with circular dichroism analysis and theoretical calculations of tedizolid

2016 ◽  
Vol 1115 ◽  
pp. 136-143 ◽  
Author(s):  
Katarzyna Michalska ◽  
Mikołaj Mizera ◽  
Kornelia Lewandowska ◽  
Judyta Cielecka-Piontek
Keyword(s):  
Circular Dichroism ◽  
Theoretical Calculations ◽  
Circular Dichroism Analysis ◽  
Circular Dichroïsm

scholarly journals α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nguyen Phuong Thao ◽  
Pham Thanh Binh ◽  
Nguyen Thi Luyen ◽  
Ta Manh Hung ◽  
Nguyen Hai Dang ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Inhibitory Effects ◽  
Meoh Extract ◽  
Inhibitory Activities ◽  
Isolated Compound ◽  
New Compounds ◽  
Modified Mosher’S Method

As part of an ongoing search for new natural products from medicinal plants to treat type 2 diabetes, two new compounds, a megastigmane sesquiterpenoid sulfonic acid (1) and a new cyclohexylethanoid derivative (2), and seven related known compounds (3–9) were isolated from the leaves of Wedelia chinensis (Osbeck.) Merr. The structures of the compounds were conducted via interpretation of their spectroscopic data (1D and 2D NMR, IR, and MS), and the absolute configurations of compound 1 were determined by the modified Mosher’s method. The MeOH extract of W. chinensis was found to inhibit α-amylase and α-glucosidase inhibitory activities as well as by the compounds isolated from this extract. Furthermore, compound 7 showed the strongest effect with IC50 values of 112.8 ± 15.1 μg/mL (against α-amylase) and 785.9 ± 12.7 μg/mL (against α-glucosidase). Compounds 1, 8, and 9 showed moderate α-amylase and α-glucosidase inhibitory effects. Other compounds showed weak or did not show any effect on both enzymes. The results suggested that the antidiabetic properties from the leaves of W. chinensis are not simply a result of each isolated compound but are due to other components such as the accessibility of polyphenolic groups to α-amylase and α-glucosidase activities.

scholarly journals Microsporols A-C from the Plant Endophytic Fungus Pestalotiopsis microspora

2015 ◽  
Vol 10 (10) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Xianfu Wu ◽  
Yadan Wang ◽  
Shuchun Liu ◽  
Xinzhong Liu ◽  
Liangdong Guo
Keyword(s):  
Circular Dichroism ◽  
Endophytic Fungus ◽  
Solid Substrate ◽  
Solid Substrate Fermentation ◽  
Inhibitory Effects ◽  
Pestalotiopsis Microspora ◽  
The Absolute ◽  
Circular Dichroïsm

Three new ambuic acid derivatives, microsporols A-C (1-3) and the known compound ambuic acid (4), were isolated from the solid-substrate fermentation cultures of the plant endophytic fungus Pestalotiopsis microspora. Their structures were elucidated primarily by NMR experiments. The absolute configurations of the 6,7-diol moiety in 1 and 2 were assigned using the Snatzke's method, whereas that of 3 was deduced by circular dichroism (CD) exciton chirality method. Compounds 1, 3, and 4 showed moderate 5-lipoxygenase (5-LOX) inhibitory effects.

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