Synthesis of Ester-linked Docetaxel-glycoside Conjugate and Its Application to Drug Delivery System using Immunoliposome Targeted with Trastuzumab
2016 ◽
Vol 11
(11)
◽
pp. 1934578X1601101
◽
Keyword(s):
Chemo-enzymatic synthesis of the ester-linked monosaccharide conjugate of docetaxel, 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside, was achieved by using lactase as a biocatalyst. The water-solubility and, EE and LE values for the liposome of 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside were much higher than those of docetaxel. The immunoliposome containing 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside showed effective suppression of tumor growth.
Keyword(s):
Keyword(s):
2021 ◽
Vol 14
(4)
◽
pp. 5519-5228
2021 ◽
Vol 70
(1)
◽
2013 ◽
Vol 7
(46)
◽
pp. 2918-2927
Keyword(s):
Keyword(s):
2019 ◽
2020 ◽
Vol 20
(18)
◽
pp. 2169-2189
2020 ◽