scholarly journals Antidiabetic Effects of the Auricularia auricular Polysaccharides Simulated Hydrolysates in Experimental Type-2 Diabetic Rats

2018 ◽  
Vol 13 (2) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Aoxue Lu ◽  
Meng Shen ◽  
Zhiyu Fang ◽  
Yaoyao Xu ◽  
Mengen Yu ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Diabetic Control Group ◽  
Diabetes Model ◽  
Experimental Type ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

A model of type-2 diabetes mellitus (T2DM) using high-fat diet and low-dose STZ was established to assess the antidiabetic effects of Auricularia auricular polysaccharides simulated hydrolysates (AAPHs) obtained from the dried fruiting body of A. auricular. AAPHs were administered intragastrically (i.g.) at the dose of 0.15 g/kg b. W. to diabetic Wistar rats for 4 weeks. Results show that AAPHs was demonstrated to exhibit significant diminution in T-CHO and LDL-C levels (P < 0.05 or P < 0.01) compared to the diabetic control group. In addition, the secretion level of GLP-1 were different with the diabetes model group from 0 to 30 min, and had a tendency to alleviate weight loss. The current study suggests that AAPHs might be incorporated as a supplement in diabetic agents or combined with other health-care foods.

scholarly journals EFFECTS OF CHROMIUM PICOLINATE ON OXIDATIVE STRESS AND HYPERGLYCEMIA IN EXPERIMENTAL TYPE 2 DIABETIC RATS

2018 ◽  
Vol 11 (10) ◽  
pp. 532 ◽  
Author(s):  
Hamİt Uslu ◽  
GÖzde Atİla Uslu
Keyword(s):  
Fasting Blood Glucose ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Chromium Picolinate ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetic Control Group ◽  
Experimental Type

Objective: In this study, we aimed to determine the effects of chromium picolinate (CrPic) on diabetes, one of the most common and fatal diseases in the world, and its associated oxidative damages.Methods: CrPic (100 μg/kg) and metformin (1000 mg/kg) were orally administered for 21 days in rats with nicotinamide + streptozotocin-induced Type 2 diabetes.Results: Significant decreases in fasting blood glucose levels were observed 14 days after initial administration in both CrPic (p<0.01) and metformin (p<0.001) groups compared with a diabetic control group (DC). Malondialdehyde (MDA) levels of all tissues were significantly higher in the DC group than in a normoglycemic control group (p<0.001). MDA levels of the CrPic group significantly decreased in heart (p<0.05) and liver (p<0.01) tissues. Glutathione (GSH) and catalase (CAT) levels in heart, kidney, and liver tissues increased in CrPic group (GSH p<0.001, p<0.05, and p<0.01; CAT p<0.001, p<0.001, and p<0.05, respectively). Superoxide dismutase enzyme levels significantly increased in CrPic group in the liver tissue (p>0.001), but no such changes were observed in heart and kidney tissues (p>0.05).Conclusion: The results obtained from this study indicate that CrPic may be effective in alleviating hyperglycemia and its consequent oxidative damage in experimental Type 2 diabetes.

Antidiabetic effects ofEmbelia ribesextract in high fat diet and low dose streptozotocin-induced type 2 diabetic rats

2013 ◽  
Vol 7 (3-4) ◽  
pp. 186-196 ◽  
Author(s):  
Uma Bhandari ◽  
Hemantkumar Somabhai Chaudhari ◽  
Geetika Khanna ◽  
Abul Kalam Najmi
Keyword(s):  
High Fat Diet ◽  
Low Dose ◽  
Diabetic Rats ◽  
High Fat ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

Antidiabetic Effects of Total Flavonoids from Litsea Coreana leve on Fat-Fed, Streptozotocin-Induced Type 2 Diabetic Rats

2010 ◽  
Vol 38 (04) ◽  
pp. 713-725 ◽  
Author(s):  
Yun-Xia Lu ◽  
Qiu Zhang ◽  
Jun Li ◽  
Yu-Xiu Sun ◽  
Ling-Yun Wang ◽  
...  
Keyword(s):  
Body Weight ◽  
Diabetic Rats ◽  
Control Group ◽  
Chow Diet ◽  
Total Flavonoids ◽  
Alcohol Extract ◽  
Oxidation Stress ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

This study was initiated to determine the possible antidiabetic effects of total flavonoids of Litsea Coreana leve (TFLC), an alcohol extract from the dried leaves of Litsea Coreana leve, on type 2 diabetic rats. Male Sprague-Dawley rats ( n = 40, 160–180 g) were divided into two groups and fed with normal chow diet (Normal Control group) or high-fat diet (HFD) for a period of 4 weeks. After 4 weeks of dietary manipulation, the HFD-fed rats were injected with 30 mg/kg streptozocin (STZ) to induce diabetes 72 hours after STZ injection. These diabetic rats were randomly divided into 3 groups ( n = 10): Diabetic Control group, Diabetic + TFLC group and Diabetic + PIO group. Diabetic + TFLC group and Diabetic + PIO group were orally administered with 400 mg/kg TFLC or 10 mg/kg pioglitazone (all suspended in 0.5% CMC-Na) respectively for 6 weeks. All rats were examined for body weight, serum and hepatic biochemical indices, content of malondialdehyde (MDA), activities of superoxide dismutase (SOD) and pathological changes in liver and pancreas, as well as protein tyrosine phosphatase 1B (PTP1B) expression in liver. The diabetic rats became obese, insulin resistant, hyperglycemic and hyperlipidemic. Treatment with TFLC showed a significant increase in insulin sensitivity, serum HDL-C level and SOD activities, meanwhile marked decrease in body weight, serum FFA, TC, TG, LDL-C, CRP, MDA content. TFLC also attenuated pathologic alterations in liver and pancreatic islet. Furthermore, TFLC was found to decrease the expression of PTP1B in diabetic rat liver. These results suggested that TFLC could ameliorate hyperglycemia, hyperlipoidemia, inflammation and oxidation stress, as well as insulin resistance of type 2 diabetic rats.

scholarly journals EFFECT OF CANNA INDICA L. EXTRACT AGAINST CAFFEINE-NICOTINE CO-ADMINISTRATION-INDUCED EXAGGERATION IN TYPE 2 DIABETIC RATS

2017 ◽  
Vol 10 (4) ◽  
pp. 347 ◽  
Author(s):  
Subhash T Kumbhar ◽  
Hemant D Une ◽  
Dayanand M Kannur ◽  
Shriniwas P Patil
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Control ◽  
Serum Glucose ◽  
Control Group ◽  
Standard Drug ◽  
Canna Indica ◽  
Diabetic Control Group ◽  
Type 2 Diabetic ◽  
Group Extract

Objective: This study was designed to evaluate the protective effect of Canna indica L. extract against caffeine-nicotine administration-induced type 2 diabetes exaggeration in rats.Methods: A study was conducted for three weeks in four rat groups (n=6); viz.  type 2 diabetic control group, a caffeine-nicotine diabetic control group (20mg/kg, 0.4mg/kg, ip twice daily),  and Canna indica L. extract and caffeine-nicotine treatment group and  standard drug treated caffeine-nicotine diabetic group (Glibencamide, 5mg/kg, once daily). Type 2 diabetes was induced by two weeks high fatty diet and a single dose streptozotocin (50mg/kg, ip) on 1th day of the study in all groups. Blood and urine samples were collected every week for serum biochemical analysis.Results: Results of extract treatment and standard drug treatment were compared with untreated caffeine-nicotine co-administration group. Difference in each relevant serum parameter was analyzed through ANOVA and Dunett’s t test. Extract treated caffeine-nicotine-diabetic group showed about 150-200mg/dL (p<0.001) reduction in the serum glucose than untreated caffeine-nicotine-diabetic control group. Extract treatment reduces serum glucose by 10-15 mg/dL than glibenclamide treatment with higher significance (p<0.001). Extract treatment showed better results than standard drug in liver and kidney function test and exhibited its better potential in controlling diabetic complications. Extract treatment increased HDL-C and reduced triglycerides, LDL-C, VLDL-C and TC much better and with higher significance than standard drug. Extract treatment reduced TC by at least 60-80mg/dL (p<0.01) in comparison to caffeine-nicotine-diabetic control group. Extract treatment reduced 10-15mg/dL of more total cholesterol than that of standard drug.Conclusion: Caffeine-nicotine co-administration-induced exaggeration of type 2 diabetes was better treated by CI extract than that of standard drug gibenclamide. Keywords: Type 2 diabetes, Streptozotocin, Caffeine, Nicotine, Diabetic complication, Rat

scholarly journals Beneficial Hypoglycemic, Hypolipidemic Effects of Aerial Branches and Roots Extract of Eryngium caeruleum M. Bieb on Streptozotocin-Induced Diabetes Model in Rats

2021 ◽  
Author(s):  
Aryaneh Sardarbandeh ◽  
Mohammad Reza Delnavazi ◽  
Mohammad Sharifzadeh ◽  
Mohammad Sharifzadeh ◽  
Masoumeh Ghajarieh Sepanlou ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Lipid ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Animal Blood ◽  
Hydroalcoholic Extract ◽  
Diabetic Control Group ◽  
Diabetes Model ◽  
Male Wistar Rats

Eryngium caeruleum (Apiacea) is native to the northern forests of Iran. The anti-diabetic effect of other species of the genus Eryngium has already been reported in previous studies. In this study, the anti-diabetic effect of this extract on animal blood lipid factors was investigated. Hydroalcoholic extract was obtained from different parts of the plant, including roots, leaves, and aerial branches with fruits were prepared by maceration with 70% ethanol. Oral acute toxicity of the extracts was assayed in different doses of 2000, 4000, and 8000 mg/kg in rats. To induce diabetes in the studied animals, 60-70 mg/kg of streptozotocin (STZ) was injected intraperitoneally (IP). For the purpose of this study, 72 male Wistar rats were randomly divided into different groups of normal, diabetic, and positive controls (metformin 500 mg/kg) as well as 9 diabetic groups that orally received 200, 400, and 800 mg/kg of extracts. The effects of the treatment with extracts for a 14-day period were investigated on weight, blood glucose, and lipid profile. By comparing the control groups with the groups of hydroalcoholic extracts of E. caeruleum showed that the most effective sample on weight gain and also on reducing blood glucose was the group receiving 800 mg/kg of the aerial branches extract (P < 0.01 and P < 0.001, respectively) after 14 days. As well, the most effective sample on lowering the blood lipid factors was the hydroalcoholic extract of the root of E. coareleum with a dose of 200 mg/kg, which showed a significant effect on lowering total cholesterol in diabetic rats compared to the diabetic controls (P < 0.05). Hydroalcoholic extract of leaves with 200 mg/kg also showed a better effect on lowering the LDL and VLDL levels compared to the diabetic control group (P < 0.001). The results of pancreatic histology in the samples showed that the extracts of the aerial branch and root (800 mg/kg) had significant effects on the regeneration of the islets of Langerhans compared to the diabetic control group. In conclusion, E. caeruleum could significantly improve glycemic and lipid profiles in diabetic rats.

scholarly journals Lipidaemic and Hepatic Status of Type 2 Diabetic Rats Treated with the Polyherbal Capsule Glucoblock

2020 ◽  
pp. 6-15
Author(s):  
O. N. Briggs ◽  
K. N. Elechi-Amadi ◽  
F. C. Ezeiruaku ◽  
R. E. Teme
Keyword(s):  
Liver Enzyme ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Diabetic Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
High Fat ◽  
Treatment Groups ◽  
Type 2 Diabetic

The scourge of diabetes has led to an increase in the use of complementary and alternative medicine. The lack of regulation and control leads to the indiscriminate use of these herbals, with potential risk to patients. Aim: This study evaluates the lipidaemic and hepatic status of type 2 diabetic rats treated with the polyherbal capsule glucoblock. Methodology: A total of 35 male Wistar albino rats weighing between 120-220 g were used for this study. The rats were placed on high fat diet and diabetes was induced by a single intraperitoneal injection of freshly prepared streptozotocin (STZ) (45 mg/kg body wt). Fasting plasma glucose (FPG) was determined using the glucose oxidase method. Total Cholesterol (TC), Triglyceride (TG) and High Density Lipoprotein Cholesterol (HDL-C) were determined using enzymatic methods. Low Density Lipoprotein Cholesterol (LDL-C) was calculated using the Friedewald’s equation. Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) were determined using Reitman-Frankel method, while alkaline phosphatase (ALP) was determined using the colorimetric phenolphthalein method. Liver sections were stained using haematoxylin and eosin (H&E) staining technique, and phytochemical analysis was also done on the herbal capsule. Results: The results show no significant differences in TC levels in all groups compared to the negative control. TG level was significantly higher in the diabetic control group when compared to the negative control. TG level in the singular treatment groups were significantly lower, but the combination group (glibenclamide + glucoblock) showed no significant difference compared to the diabetic control. The negative control had significantly higher HDL-C compared to the diabetic control and treatment groups. There were no significant differences in HDL-C levels in all the treatment groups, when compared to the diabetic control. The negative control had significantly lower LDL-C compared to the diabetic control and treatment groups. There were no significant differences in LDL-C levels in all the treatment groups, when compared to the diabetic control. ALT, AST and ALP levels were significantly higher in the diabetic control, but was significantly reduced to normal levels by the treatments. Liver sections of the negative control showed normal histoarchitecture. The diabetic control showed inflammation and fatty deposition. The treatment groups showed a nearly normal histoarchitecture, with fatty deposits. Conclusion: High fat diet in combination with a sub-diabetic dose of streptozotocin produced significant diabetes in the Wistar rats with dyslipidaemia and elevated liver enzyme levels. The anti-diabetic treatments, glibenclamide and glucoblock did not correct the dyslipidaema caused by diabetes. However, the treatments had equipotent hepatoprotective effect and restored liver enzyme levels to normal as well as improving liver histology.

scholarly journals ANTIDIABETIC EFFECTS OF [10]-GINGEROL IN STREPTOZOTOCIN- AND HIGH-FAT DIET-INDUCED DIABETIC RATS

2019 ◽  
pp. 77-80
Author(s):  
ASHUTOSH KUMAR YADAV ◽  
REETU ◽  
ARUN GARG
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Blood Glucose ◽  
High Fat Diet ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
High Fat ◽  
Antidiabetic Effects

Objective: India is the “diabetes capital of the world” with 62.4 million Indians having type 2 diabetes in 2011. A major risk factor for insulin resistance is obesity, which is generally caused by regular physical inactivity and high-fat diet (HFD). Obesity and diabetes are closely related to each other as about 80% of diabetics are obese. Obesity is a common finding in type 2 diabetes. The objective of the study was to investigate the antidiabetic effects of [10]-gingerol in streptozotocin (STZ)- and HFD-induced diabetic rats. Methods: Wistar rats were used for the study. Animals were divided into six groups. The six groups in this study were, Group I (normal control), Group II (diabetic control), Group III (glibenclamide at 5 mg/kg p.o.), Group IV (orlistat at 60 mg/kg p.o.), Group V ([10]-gingerol at 15 mg/kg p.o.), and Group VI [10]-gingerol (30 mg/kg p.o.), respectively. The antidiabetic activity was assessed using blood glucose level, body weight, and various biochemical parameters such as serum total cholesterol (TC) level, triglyceride (TG) level, high-density lipoproteins (HDLs), total protein (TP), serum alanine transaminase, and aspartate aminotransferase (serum glutamic-oxaloacetic transaminase), respectively. Results: [10]-gingerol exhibited an antidiabetic effect by significantly decreased the level of blood glucose, body weight, TC, TG, TP, and increase HDL. The results of the study demonstrated that the treatment with [10]-gingerol significantly (p<0.05) and dose dependently prevented STZ- and HFD-induced diabetic rats. Conclusions: The findings of the study suggest that [10]-gingerol possesses potential antidiabetic activity as it lowers serum glucose level.

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