scholarly journals New Constituents From the Roots and Stems of Paramignya trimera

2019 ◽  
Vol 14 (6) ◽  
pp. 1934578X1986101 ◽  
Author(s):  
Tran Thu Huong ◽  
Vu Thi Ha ◽  
To Dao Cuong ◽  
Ninh The Son ◽  
Tran Quoc Toan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Spectral Analysis ◽  
Magnetic Resonance ◽  
Medicinal Plant ◽  
Electrospray Ionization ◽  
Liver Diseases ◽  
Methanol Extract ◽  
Ionization Mass ◽  
New Compounds

Paramignya trimera (Oliv.) Guill. (Rutaceae), mostly distributed in the southern regions of Vietnam, has been used as a medicinal plant for treatment of liver diseases and cancer. From the methanol extract of the roots and stems of P. trimera, 3 new compounds (1-3) were isolated, including ninhvanin B (1), paramitrimerol (2), and parabacunoic acid (3), and a known alkaloid, citrusinine-I (4). The structures of these compounds were elucidated by electrospray ionization mass spectrometry and nuclear magnetic resonance spectral analysis, as well as by comparison with literature data.

Synthesis and antifungal activity of camphoric acid-based acylhydrazone compounds

Holzforschung ◽  
2014 ◽  
Vol 68 (8) ◽  
pp. 889-895 ◽  
Author(s):  
Xian-Li Ma ◽  
Fang-Yao Li ◽  
Wen-Gui Duan ◽  
Jing-Ni Liao ◽  
Zhi-duo Lin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Fourier Transform ◽  
Antifungal Activity ◽  
Magnetic Resonance ◽  
Electrospray Ionization ◽  
Condensation Reaction ◽  
Ionization Mass ◽  
Camphoric Acid ◽  
C Nmr

Abstract In the search of novel potent bioactive compounds, 18 novel camphoric acid-based acylhydrazone compounds 4a–4r were designed and synthesized by the condensation reaction of N-amino camphorimide (3) with substituted benzaldehyde based on camphoric acid as the starting material. The target compounds were characterized by means of Fourier transform infrared (FTIR), 1H nuclear magnetic resonance (NMR), 13C NMR, electrospray ionization-mass spectrometry (ESI-MS), and elemental analysis. The preliminary bioassay showed that the following camphoric acid-based compounds exhibited excellent antifungal activity with an inhibition ratio of 95% against Physalospora piricola at the concentration of 50 μg ml-1: o-bromophenyl acylhydrazone (4f), p-bromophenyl acylhydrazone (4g), p-methoxyphenyl acylhydrazone (4m), and p-hydroxyphenyl acylhydrazone (4p).

scholarly journals A new phenyl alkyl ester and a new combretin triterpene derivative from Combretum fragrans F. Hoffm (Combretaceae) and antiproliferative activity

2020 ◽  
Vol 18 (1) ◽  
pp. 1523-1531
Author(s):  
Isaac Silvère Gade ◽  
Corinne Chadeneau ◽  
Richard Tagne Simo ◽  
Emmanuel Talla ◽  
Alex De Theodore Atchade ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Antiproliferative Activity ◽  
Structure Elucidation ◽  
Methanol Extract ◽  
Stem Bark ◽  
Mass Spectrometry Data ◽  
C6 Cells ◽  
New Compounds

AbstractThis work concerns the isolation and structure elucidation of compounds obtained from the extract of leaves and stem bark of Combretum fragrans F. Hoffm. Both extracts and some isolated compounds were tested for antiproliferative activity on glioblastoma (U87MG and C6 cells) and prostate (PC-3 cells) cancer cell lines using XTT (2,3-bis[2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxyanilide inner salt) assay. The dichloromethane/methanol (1:1) extract of the leaves led to the isolation of two new compounds such as fragransinate (1) and combretin C (2), alongside five known compounds such as combretin A (3), belamcanidin (4), cirsilineol (5), velutin (6), and a mixture of β-sitosterol-3-O-β-d-glucopyranoside (10a) and stigmasterol-3-O-β-d-glucopyranoside (10b), whereas the methanol extract of the stem bark led to the isolation of three known compounds betulinic acid (7), bellericagenin B (8), and a mixture of β-sitosterol (9a) and stigmasterol (9b). The structure of compounds was elucidated by nuclear magnetic resonance and mass spectrometry data. The methanol extract of the stem bark showed a powerful antiproliferative activity on all tested cells, as well as the extract of leaves which also showed important cytotoxicity effect. Compound (3) showed good antiproliferative activity particularly on U87MG and PC-3 cells, whereas compound (5) exhibits moderated activity. Compounds (2) and (8) were not active on all tested cells.

scholarly journals One New Terphenyl Glycoside From a Sponge-Derived Fungus Trichoderma reesei (HN-2016-018)

2020 ◽  
Vol 15 (2) ◽  
pp. 1934578X2090775
Author(s):  
Saif Ur Rehman ◽  
Jing-Shuai Wu ◽  
Lu-Jia Yang ◽  
Shi Ting ◽  
Chang-Lun Shao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Electrospray Ionization ◽  
Trichoderma Reesei ◽  
Electrospray Ionization Mass Spectrometry ◽  
Inhibitory Activity ◽  
Spectroscopic Analysis ◽  
Ionization Mass

One new terphenyl glycoside (1), gliocladinin D, together with 4 known compounds (2-5) were isolated from the sponge-derived fungus Trichoderma reesei (HN-2016-018). The structure of the new compound was elucidated by the comprehensive spectroscopic analysis, including 1-dimensional and 2-dimensional nuclear magnetic resonance, and high-resolution electrospray ionization mass spectrometry. Compound 3 exhibited moderate Topo I inhibitory activity.

Sign in / Sign up

Export Citation Format

Share Document