scholarly journals Single-Dose Pinitol Ingestion Suppresses Post-Prandial Glucose Levels: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

2019 ◽  
Vol 14 (12) ◽  
pp. 1934578X1989081
Author(s):  
Yoshio Suzuki ◽  
Keishoku Sakuraba ◽  
Takuya Wada ◽  
Naoya Watabane ◽  
Seijiro Wada ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Single Dose ◽  
Blood Glucose ◽  
Crossover Trial ◽  
Postprandial Blood Glucose ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Glucose Levels ◽  
Blood Glucose Levels

Limited studies have demonstrated that chronic consumption of pinitol improved glucose tolerance, and single-dose ingestion (0.6 g) 60 minutes prior to meals suppressed postprandial glucose levels in patients with type 2 diabetes mellitus. However, higher doses (6 g) were required in healthy people who ingested pinitol with a meal. This randomized, double-blind, placebo-controlled, crossover trial was conducted to clarify the effect of 0.6 g of pinitol with a meal on postprandial blood glucose levels in healthy adults. Twenty volunteers aged 18 to 25 years participated in this study. Participants visited the laboratory after an overnight fast. After measuring fasting blood glucose levels (FBG), they consumed test food (0.6 g of pinitol or placebo) and then ate breakfast (577 kcal; protein 14.0 g; fat 5.6 g; and carbohydrate 117.7 g). Blood glucose levels were measured immediately after eating and at 30, 60, 90, and 120 minutes after breakfast. Participants’ mean FBG level was 102.6 ± 8.2 mg/dL. Participants were categorized by their FBG as normal ( n = 5; ≤99 mg/dL) or impaired glucose tolerance (IGT) ( n = 15; 100-125 mg/dL). The incremental area under the curve of blood glucose over 120 minutes after the meal was significantly suppressed by pinitol in the IGT group ( P < 0.05), but not in the normal group. Therefore, pinitol was considered to maintain postprandial blood glucose levels in healthy people with IGT, and may contribute to the prevention of type 2 diabetes.

scholarly journals Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial

Diabetologia ◽  
2018 ◽  
Vol 62 (2) ◽  
pp. 233-237 ◽  
Author(s):  
Mladen Savikj ◽  
Brendan M. Gabriel ◽  
Petter S. Alm ◽  
Jonathon Smith ◽  
Kenneth Caidahl ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Crossover Trial ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals Lysulin: Natural nutritional support to bring better health to people with diabetes and prediabetes

2019 ◽  
Vol 2 (6) ◽  
pp. 149
Author(s):  
John Frederick Burd
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Nutritional Support ◽  
Nutritional Supplements ◽  
Double Blind ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
High Fructose ◽  
Diet And Exercise

Obesity and type 2 diabetes, both worldwide epidemics, are drastic problems that can be ameliorated dramatically through the combination of lifestyle changes (especially diet and exercise) the treatment of drugs and nutritional supplements [1].  Lysulin is a patent-pending nutritional supplement that contains lysine, zinc and vitamin C [2]. Through double-blind placebo-controlled studies, it has been shown to help people with prediabetes [3] and type 2 diabetes [4] in promoting better glycemic control and lowering their HbA1c.Historically, supplements have had a bad reputation due to aggressive marketing of unsubstantiated claims.  That being said, Lysulin is firmly grounded on a foundation of 25 years of research, development and clinical studies. These studies show the ingredients in Lysulin can lower blood glucose and glycated proteins – the cause of diabetes complications.  In addition, double-blind placebo-controlled studies found that Lysulin improves glycemic control in people with diabetes and may also slow or even halt the progression from prediabetes to type 2 diabetes [3,4].Glucose is essential in providing the human body an energy source.  Glucose relies on the hormone, insulin, to enter our cells to provide the energy we need for everyday living. However, while everyone needs a certain amount of glucose for daily energy production, excessive glucose is dangerously toxic to the body (primarily as a result of protein glycation).  In addition, fructose (from High Fructose Corn Syrup) does not utilize insulin to enter the liver or our cells, and thus enters them easily and immediately turns into fat [5]. Poor diets, along with increased consumption of High Fructose Corn Syrup (HFCS), have lead to the high rates of obesity and diabetes that we see today. The pandemic of type 2 diabetes, which is expected to affect at least 250 million people worldwide by 2020 and 642 million by 2040 [6], is the result of diets high in carbohydrates, HFCS and sugar, along with the lack of commensurate exercise.  This lifestyle leads to insulin resistance, caused by the glycation of insulin and insulin receptors [7], which results in high concentrations of glucose in the bloodstream.  The therapy for type 2 diabetes begins with attempts to control glucose through diet and exercise. If this fails, oral drugs are prescribed.  If these fail to show improvements in blood glucose levels, insulin injections are given. Over 30% of people with type 2 diabetes are using insulin injections to control their blood glucose levels [6]. There is vast literature documenting the role of nutraceuticals and functional foods in managing the alterations in metabolism and improving the health of people with chronic disease [8, 9].  To make up for the fact that important nutrients are lost during the processing of food, adding nutritional supplements to our daily routine, in addition to consuming a low-carbohydrate diet, can have profound benefits.   A well-balanced diet, along with exercise and the right nutritional supplements, can provide the foundation for a lifetime of well-being and good health.Keywords: Diabetes, Nutritional Support, Lysulin, Lysine, Zinc, Vitamin V, HbA1c

Efeitos dos Programas de Treinamento Aeróbio, de Força e Combinado na Glicose Sanguínea em Diabéticos do Tipo 2: uma Revisão Sistemática/ Effects of Aerobic, Strength and Combined Programs Training on Blood Glucose in Type 2 Diabetic: a Systematic Review.

1970 ◽  
Vol 5 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Alexandre de Souza E Silva ◽  
Maria Paula Gonçalves Mota
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Training Program ◽  
Aerobic Training ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Pubmed Database

O trabalho tem como objetivo analisar os estudos que avaliaram os efeitos dos programas de treinamento aeróbio, força e combinado nos níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Foi utilizado o método de revisão sistemática, sendo utilizada a base de dados PubMed. As palavras chaves utilizadas para pesquisa foram training and diabetes. Foram identificados 484 artigos originais. Apenas 17 estudos respeitaram os critérios de inclusão. Os resultados evidenciam que os programas de treinamento aeróbio diminuíram os níveis de glicose. O programa de treinamento de força também foi favorável à diminuição dos níveis de glicose sanguínea. Já o programa de treinamento combinado não demonstrou efeitos favoráveis no controle da glicose sanguínea. Conclui-se que o programa de treinamento aeróbio e de força ajudam a controlar os níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Palavras-chave: diabetes mellitus, treinamento, glicose.ABSTRACTThe study aims to analyze the studies that evaluated the effects of aerobic, strength and combined programs training in blood glucose levels in people with type 2 diabetes. We used a systematic review method and is used to PubMed database. The key words used for searching were training and diabetes. We identified 484 original articles. Only 17 studies complied with the inclusion criteria. The results show that aerobic training programs decreased glucose levels. The strength training program was also favorable to decrease in blood glucose levels. But the combined training program has not shown favorable effects on blood glucose control. We conclude that the aerobic training and strength helps control blood glucose levels in individuals with type 2 diabetes. Keywords: diabetes mellitus, training, glucose.

scholarly journals Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Musri Musman ◽  
Mauli Zakia ◽  
Ratu Fazlia Inda Rahmayani ◽  
Erlidawati Erlidawati ◽  
Safrida Safrida
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Phyllanthus Emblica ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Phenolic Extract

Abstract Background Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. Methods The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence. Results The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. Conclusion The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.

Role of Digital Engagement in Diabetes Care Beyond Measurement: Retrospective Cohort Study (Preprint)

2020 ◽  
Author(s):  
Yifat Fundoiano-Hershcovitz ◽  
Abigail Hirsch ◽  
Sharon Dar ◽  
Eitan Feniger ◽  
Pavel Goldstein
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glucose Levels ◽  
Monthly Average ◽  
Diabetes Outcomes ◽  
Blood Glucose Levels ◽  
Average Blood Glucose ◽  
Tagging Behavior ◽  
Digital Engagement

BACKGROUND The use of remote data capture for monitoring blood glucose and supporting digital apps is becoming the norm in diabetes care. One common goal of such apps is to increase user awareness and engagement with their day-to-day health-related behaviors (digital engagement) in order to improve diabetes outcomes. However, we lack a deep understanding of the complicated association between digital engagement and diabetes outcomes. OBJECTIVE This study investigated the association between digital engagement (operationalized as tagging of behaviors alongside glucose measurements) and the monthly average blood glucose level in persons with type 2 diabetes during the first year of managing their diabetes with a digital chronic disease management platform. We hypothesize that during the first 6 months, blood glucose levels will drop faster and further in patients with increased digital engagement and that difference in outcomes will persist for the remainder of the year. Finally, we hypothesize that disaggregated between- and within-person variabilities in digital engagement will predict individual-level changes in blood glucose levels. METHODS This retrospective real-world analysis followed 998 people with type 2 diabetes who regularly tracked their blood glucose levels with the Dario digital therapeutics platform for chronic diseases. Subjects included “nontaggers” (users who rarely or never used app features to notice and track mealtime, food, exercise, mood, and location, n=585) and “taggers” (users who used these features, n=413) representing increased digital engagement. Within- and between-person variabilities in tagging behavior were disaggregated to reveal the association between tagging behavior and blood glucose levels. The associations between an individual’s tagging behavior in a given month and the monthly average blood glucose level in the following month were analyzed for quasicausal effects. A generalized mixed piecewise statistical framework was applied throughout. RESULTS Analysis revealed significant improvement in the monthly average blood glucose level during the first 6 months (<i>t</i>=−10.01, <i>P</i>&lt;.001), which was maintained during the following 6 months (<i>t</i>=−1.54, <i>P</i>=.12). Moreover, taggers demonstrated a significantly steeper improvement in the initial period relative to nontaggers (<i>t</i>=2.15, <i>P</i>=.03). Additional findings included a within-user quasicausal nonlinear link between tagging behavior and glucose control improvement with a 1-month lag. More specifically, increased tagging behavior in any given month resulted in a 43% improvement in glucose levels in the next month up to a person-specific average in tagging intensity (<i>t</i>=−11.02, <i>P</i>&lt;.001). Above that within-person mean level of digital engagement, glucose levels remained stable but did not show additional improvement with increased tagging (<i>t</i>=0.82, <i>P</i>=.41). When assessed alongside within-person effects, between-person changes in tagging behavior were not associated with changes in monthly average glucose levels (<i>t</i>=1.30, <i>P</i>=.20). CONCLUSIONS This study sheds light on the source of the association between user engagement with a diabetes tracking app and the clinical condition, highlighting the importance of within-person changes versus between-person differences. Our findings underscore the need for and provide a basis for a personalized approach to digital health.

scholarly journals Study on the prevalence of dyslipidemia in type 2 diabetes mellitus

2019 ◽  
Vol 6 (3) ◽  
pp. 786
Author(s):  
Eda Dayakar ◽  
C. Sathya Sree ◽  
E. Sanjay
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Type 2 Diabetic

Background: Diabetes mellitus is a common health problem globally. Dyslipidaemia is a major risk factor to develop cardiovascular disease in diabetics. They present study was undertaken to find out the prevalence of dyslipidaemia in type 2 diabetic patients.Methods: The present study was a cross sectional study consisting of 46 (23 male and 23 female) known type 2 diabetes mellitus patients. Age, gender, duration of diabetes, body mass index (BMI) was recorder in all the diabetic patients.  Fasting blood glucose levels, total cholesterol, triglycerides, HDL, LDL, VLDL levels were measured using standard methods and recorded.Results: The average total cholesterol, triglycerides, LDL, HDL and VLDL were 200±42mg/dl, 169.62±89.79mg/dl, 132.45±36.38mg/dl,39.1±16.6mg/dl and 35.85±17.09mg/dl respectively. The incidence of occurrence of hypercholesterolemia was 58.6% and hypertriglyceridemia 36.9%. Increased levels of LDL were observed in 30 (65.2%) patients and reduced HDL was observed in 43 (93.4%) patients. The incidence rate of dyslipidaemia was higher in female diabetic patients when compared to male diabetic patients.Conclusions: Awareness on the dyslipidaemia and its risk factors should be provided to the type 2 diabetic patients as they are more prone to get cardiovascular disease and lipid profile also should be monitored regularly along with blood glucose levels.

scholarly journals Effect of glucose on reduced glutathione level in Malay uncomplicated type 2 diabetes patients

2021 ◽  
pp. 13
Author(s):  
Subandrate ◽  
Raafqi Ranasasmita
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Free Radical ◽  
Reduced Glutathione ◽  
Normal Subjects ◽  
Random Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetes Patients

Background: Increasing blood sugar level may increase free radical compounds in type 2 diabetes. Free radical compounds can cause oxidative stress, thereby decreasing endogenous antioxidants such as reduced glutathione (GSH). Objective: This study aimed to determine whether random blood glucose levels affect GSH in type 2 diabetes patients within the Malay race. Methods: This study was observational with case-control, involving 25 patients with uncomplicated type 2 diabetes (receiving metformin and/or glimipiride) and 25 healthy controls. Random blood glucose levels were determined using ACCU-CHECK® Kit. Blood GSH levels were determined by Sigma GSH Assay Kit. Results: Results show that type 2 diabetes patients have a significantly lower random blood glucose level compared with those of age-matched normal subjects (p<0.0001). Type 2 diabetic patients had significantly lower levels of GSH (p=0.00) than those of age-matched normal subjects. We found a moderate negative correlation (r=-0.437 and p=0.02) between the level of random blood glucose and the level of GSH. Conclusion: The depletion of GSH during hyperglycemia may neutralize the free radicals indirectly generated by the abundant of glucose.  

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