scholarly journals Secondary Metabolites of the Endophytic Fungus Chaetomium globosum Isolated From Coptis chinensis

2021 ◽  
Vol 16 (9) ◽  
pp. 1934578X2110445
Author(s):  
Jia-Cheng Ji ◽  
Pan-Pan Wei ◽  
Xiao-Yang Han ◽  
Zheng-Hui Li ◽  
Hong-Lian Ai ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Early Childhood Development ◽  
Childhood Development ◽  
Chaetomium Globosum ◽  
Resonance Spectroscopy ◽  
Ionization Mass ◽  
Two Dimensional ◽  
Coptis Chinensis ◽  
Relative Configuration ◽  
One Dimensional

A new steroid, chaetglotone (1), together with 3 known compounds (2-4), were isolated from Chaetomium globosum, which is an endophytic fungus isolated from the root of Coptis chinensis Franch . The new compound was characterized by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometer. The relative configuration and absolute configuration of 1 were further determined via the DP4 + and Early Childhood Development protocols, separately.

scholarly journals A new tetracyclic diterpenoid from the seeds of Euphorbia lathyris

2020 ◽  
Vol 44 (5-6) ◽  
pp. 322-325
Author(s):  
Lie-Feng Ma ◽  
Yue Zhang ◽  
Xuan Zhang ◽  
Meng-Jia Chen ◽  
Zha-Jun Zhan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
High Resolution ◽  
Spectroscopic Data ◽  
Resonance Spectroscopy ◽  
Ionization Mass ◽  
Two Dimensional ◽  
Detailed Interpretation ◽  
A Minor ◽  
Euphorbia Lathyris

Eupholathone, a minor diterpenoid with an unusual tetracyclic skeleton, was obtained from the seeds of Euphorbia lathyris, along with two known lathyrane diterpenoids, euphorbia factors L2 and L3. The structure of eupholathone was elucidated by detailed interpretation of its spectroscopic data, especially two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry.

scholarly journals Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1730 ◽  
Author(s):  
Shagufta Perveen ◽  
Jawaher Alqahtani ◽  
Raha Orfali ◽  
Hanan Y. Aati ◽  
Areej M. Al-Taweel ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spectroscopic Analysis ◽  
Antimicrobial Properties ◽  
Ionization Mass ◽  
Two Dimensional ◽  
One Dimensional ◽  
Aerial Parts ◽  
Pathogenic Microbes ◽  
Antibacterial And Antifungal ◽  
New Metabolites

Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3–9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1–9 were screened against seven different pathogenic microbes, and compounds 1–3 showed a potent antifungal activity.

scholarly journals New Metabolites from Endophytic Fungus Chaetomium globosum CDW7

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2873 ◽  
Author(s):  
Wei Yan ◽  
Ling-Ling Cao ◽  
Yang-Yang Zhang ◽  
Ran Zhao ◽  
Shuang-Shuang Zhao ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Protective Efficacy ◽  
Indole Alkaloid ◽  
Chaetomium Globosum ◽  
Ionization Mass ◽  
In Vivo Test ◽  
Sclerotinia Rot ◽  
Spectroscopic Analyses ◽  
New Metabolites

Five metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7. Compounds 1 and 2 were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds 3–5 were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (3) exhibited antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.97 μg/mL. In vivo test showed that 3 displayed a protective efficacy of 64.3% against rape Sclerotinia rot at the dosage of 200 μg/mL, comparable to that of carbendazim (69.2%).

Triterpenoids with α-glucosidase inhibitory activities from the roots of Codonopsis pilosula var. modesta

2020 ◽  
pp. 174751982097996
Author(s):  
Bing Li ◽  
Ru-Yue Wang ◽  
Ye Zhao ◽  
Yi-Fan Yu ◽  
Zhan-Xin Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Electrospray Ionization ◽  
Ionization Mass ◽  
Two Dimensional ◽  
One Dimensional ◽  
Etoh Extract ◽  
Codonopsis Pilosula ◽  
Spectroscopic Analyses ◽  
Inhibitory Activities

A new taraxerane-type triterpenoid, codopimodol A (1), together with two known triterpenoids (2 and 3), were isolated from the EtOH extract of the roots of Codonopsis pilosula var. modesta (Campanulaceae). The structure of the new compound was identified by high-resolution electrospray ionization mass spectrometry and extensive spectroscopic analyses, particularly one-dimensional and two-dimensional NMR and IR. All the compounds were first isolated from C. pilosula var. modesta. Compounds 1 and 3 exhibited potential α-glucosidase inhibitory activities.

Structure elucidation and antimicrobial activities of five compounds from Artemisia integrifolia L

2019 ◽  
Vol 74 (9-10) ◽  
pp. 275-278
Author(s):  
Qing-Hu Wang ◽  
Yan-Hua Xu ◽  
Wen-Qiang Bao ◽  
Bi-Le-Ge-Tu Pa ◽  
Jun-Sheng Hao
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Structure Elucidation ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Ionization Mass ◽  
Spectroscopic Methods ◽  
Two Dimensional ◽  
One Dimensional ◽  
Nmr Techniques

Abstract A new compound, integracid (1), together with four known compounds were isolated from the dichloromethane (CH2Cl2) extract from Artemisia integrifolia L. The structures of compounds (1–5) were elucidated by spectroscopic methods, including ultraviolet, infrared (IR), high resolution-electrospray ionization-mass spectrometry (HR-ESI-MS) and extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) techniques, and by comparison with data reported in the references. Antibacterial activities of the compounds were evaluated against various bacteria.

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