Ultrasound parameters of pelvic organs and their age-related changes in a cohort of asymptomatic postmenopausal women: A community-based study

2020 ◽  
Vol 26 (3) ◽  
pp. 147-154
Author(s):  
Thiran D Dias ◽  
Thilina S Palihawadana ◽  
Malitha Patabendige ◽  
Mary BC Motha ◽  
Hithanadura J de Silva
Keyword(s):  
Postmenopausal Women ◽  
Endometrial Thickness ◽  
Hormone Replacement ◽  
Sri Lankan ◽  
Community Based ◽  
Pelvic Organs ◽  
Age Related ◽  
Pelvic Ultrasonography ◽  
Ultrasound Parameters ◽  
Age Related Changes

Objective To describe the ultrasound parameters of pelvic organs and their age-related changes in a cohort of asymptomatic postmenopausal women and to describe the prevalence of ultrasound-detected pathologies in a Sri Lankan population. Study design A large community-based longitudinal study using a randomly selected sample of postmenopausal women who have never used hormone replacement therapy. Main outcome measures Uterine, endometrial and ovarian measurements at pelvic ultrasonography as described by the International Endometrial Tumor Analysis and the International Ovarian Tumor Analysis groups. Results A total of 815 postmenopausal women were approached and all volunteered to participate. This included women between the ages of 45 and 74 years with a median (interquartile range (IQR)) of 62.0 (10.0) years. The median (IQR) uterine volume was 18.1 (17) ml, while the median (IQR) of right and left ovarian volumes were 17.3 (22.9) ml and 18.2 (21.5) ml. Both uterine and ovarian volumes showed an age-related decline (p < 0.01). Furthermore, the ovarian volumes demonstrated an increase in size with a higher body mass index (p < 0.03 for left and p < 0.01 for right, respectively). Median (IQR) endometrial thickness among the population was 3.0 (1.0) mm and there was no age-related change observed. Sixty-one women had an ultrasound-detected gynaecological pathology with a prevalence of 7.5% (95% confidence interval (CI) 5.6–9.5). Conclusions This study aimed at describing ultrasound parameters of pelvic organs among postmenopausal women of Sri Lanka was able to provide the reference values for uterine and ovarian volume among asymptomatic postmenopausal women. Both uterine and ovarian volumes demonstrated an age-related decline, whereas the endometrial thickness does not seem to relate to the age.

Anabolic Hormones in Aging Women: Effects of Supplementation vs. Physical Activity

2004 ◽  
Vol 29 (1) ◽  
pp. 76-89 ◽  
Author(s):  
Jennifer L. Copeland
Keyword(s):  
Physical Activity ◽  
Bone Mass ◽  
Physical Function ◽  
Older Women ◽  
Hormone Replacement ◽  
Endocrine System ◽  
Anabolic Hormones ◽  
Age Related ◽  
Aging Women ◽  
Age Related Changes

Aging is associated with a decline in bone mass, muscle mass, strength, and physical function, and women are more likely to suffer from these physical changes than men. The model presented in this paper illustrates the age related changes in anabolic hormones and how this may partly explain the diminished physical function of older women. The model can also be used to identify potential sites of intervention that could delay the atrophy of the musculoskeletal system. Various pharmacological hormone therapies have been shown to be beneficial, but there may be health risks associated with their use. There is evidence that regular physical activity is related to higher levels of anabolic hormones in older persons, therefore exercise could be an alternative to drugs for slowing the age related changes in the endocrine system. However, some research suggests that the hormone response to exercise is blunted in older women. This lower hormonal response may not be a consequence of aging per se but instead may result from secondary characteristics of aging such as a decline in physical fitness and exercise intensity or changes in body composition. Further research is needed to determine whether exercise-induced increases in endogenous hormones have clinical significance in improving muscle or bone mass in aging women. Key words: hormone replacement therapy, exercise, sex steroids, growth hormone, IGF-I

Age-Related Changes in Thyroid Function: A Longitudinal Study of a Community-Based Cohort

2011 ◽  
pp. OR15-6-OR15-6
Author(s):  
John P Walsh ◽  
Alexandra P Bremner ◽  
Suzanne J Brown ◽  
Peter Feddema ◽  
Peter J Leedman ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Thyroid Function ◽  
Community Based ◽  
Age Related ◽  
Age Related Changes

Effect of hormone replacement therapy on age-related increase in carotid artery intima-media thickness in postmenopausal women

2000 ◽  
Vol 153 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Florence A. Tremollieres ◽  
Fabienne Cigagna ◽  
Cathy Alquier ◽  
Colette Cauneille ◽  
Jean-Michel Pouilles ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Carotid Artery ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Hormone Replacement ◽  
Intima Media Thickness ◽  
Media Thickness ◽  
Age Related ◽  
Related Increase

scholarly journals The role of steroid receptors in the pathogenesis of adenomyosis in the presence of concomitant endometrial pathology in postmenopause

2019 ◽  
Vol 25 (1) ◽  
pp. 45-54
Author(s):  
G.Yu. Honcharenko
Keyword(s):  
Postmenopausal Women ◽  
Comparison Group ◽  
Steroid Receptors ◽  
Eutopic Endometrium ◽  
Immunohistochemical Reaction ◽  
Age Related ◽  
Endometrial Pathology ◽  
Er Expression ◽  
Age Related Changes

Determining the pathogenesis of adenomyosis in postmenopausal women is promising, as it will allow a more thorough study of the mechanisms of hormonal changes and resolve issues related to adenomyosis in women of reproductive age. The purpose of the study is to establish the role of steroid receptors in the pathogenesis of adenomyosis in the presence of concomitant endometrial pathology in postmenopausal women. Study material is removed uteri with parovaria from 117 patients of 49-76 years old. The cases were divided into 4 groups depending on the presence of adenomyosis (AM) and background pathology (endometrioid carcinoma of the endometrium (ECE) and endometrial hyperplasia (EHP)): 1) 27 women with adenomyosis and EHP; 2) 30 women with adenomyosis and ECE; 3) 30 women with adenomyosis and age-related changes in the endometrium; 4) 30 women with age-related changes without AM (comparison group). The immunohistochemical reaction was carried out using primary antibodies to estrogen (ER), progesterone (PR) and androgen (AR) receptors. Statistical processing was carried out using parametric methods of variation statistics (calculated the arithmetic mean, standard deviation, confidence interval, Student criterion). The predominance of the ER expression in the glandular and stromal components of the eutopic endometrium in the presence of AM and hyperplastic processes was compared with the comparison group (p<0.01). A high level of ER expression is characteristic of the epithelium of the endometrium with EHP (7.333±0.314) and ECE (6.200±0.712) rather than for the endometrium with atrophic changes in the presence of AM (4.433±0.773). In the stroma, a high ER activity was detected with EHP (7.148±0.276) rather than with atrophic changes (4.567±0.738) and ECE (4.167±0.602). It was established that in the epithelium of adenomyosis foci, ER expression indices were lower in atrophy (3.433±1.074) than with AM foci in ECE (4.667±0.526) and EHP (5.148±0.745). In the stroma of adenomyosis foci, ER expression is higher in EHP than in ECE and atrophy. The activity of PR in the eutopic endometrium decreases from simple non-typical to complex atypical EHP and in patients with adenomyosis and ECE, as the degree of differentiation of cells of ECA decreases (from G1 to G3 ECE). A minimal expression of PR was found in the comparison group. In the cells of internal endometriosis there were positive indices of immunohistochemical reaction with PR. There were obtained minimum scores for receptor expression of AR in eu- and ectopic endometria. Conclusion: adenomyosis foci have a regulatory effect on the uterine endometrium, stimulating the expression of ER and, to a lesser extent, PR, and do not affect the level of AR in the eutopic endometrium.

EFFECTS OF OESTROGEN AND PROGESTERONE ON AGE-RELATED CHANGES IN ARTERIES OF POSTMENOPAUSAL WOMEN

1997 ◽  
Vol 24 (6) ◽  
pp. 457-459 ◽  
Author(s):  
Yu-Lu Liang ◽  
Helena Teede ◽  
Louise M. Shiel ◽  
Adrian Thomas ◽  
Robyn Craven ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Age Related ◽  
Age Related Changes

scholarly journals Feasibility of population screening tests to establish a healthy ageing trajectory

2019 ◽  
Vol 7 ◽  
pp. 205031211882244 ◽  
Author(s):  
Susan J Gordon ◽  
Karen A Grimmer ◽  
Nicky Baker ◽  
Elaine Bell ◽  
John Coveney ◽  
...  
Keyword(s):  
Functional Decline ◽  
Community Dwelling ◽  
Healthy Ageing ◽  
Test Battery ◽  
Screening Tests ◽  
Rapid Review ◽  
Community Based ◽  
Age Related ◽  
Foot Sensation ◽  
Age Related Changes

Objectives: There are no agreed comprehensive tests for age-related changes to physical, emotional, mental and social functioning. Research into declining function focuses on those 75 years and older and little is known about age-related changes in younger people. The aims of this project were (1) to ascertain a comprehensive test battery that could underpin community-based health screening programmes for people aged 40–75 years and pilot both (2) community-based recruitment and (3) the utility, acceptability, response burden and logistics. Methods: A total of 11 databases were searched using a broad range of relevant terms. An identified comprehensive, recent, high-quality systematic review of screening instruments for detection of early functional decline for community-dwelling older people identified many relevant tools; however, not all body systems were addressed. Therefore, lower hierarchy papers identified in the rapid review were included and expert panel consultation was conducted before the final test battery was agreed. Broad networks were developed in one Australian city to aid pilot recruitment of community-dwellers 40–75 years. Recruitment and testing processes were validated using feasibility testing with 12 volunteers. Results: The test battery captured (1) online self-reports of demographics, health status, sleep quality, distress, diet, physical activity, oral health, frailty and continence; and (2) objective tests of anthropometry; mobility; lung function; dexterity; flexibility, strength and stability; hearing; balance; cognition and memory; foot sensation; and reaction time. Recruitment and testing processes were found to be feasible. Conclusion: This screening approach may provide new knowledge on healthy ageing in younger people.

scholarly journals Age-related changes in crown and root length in Sri Lankan Sinhalese

2009 ◽  
Vol 51 (4) ◽  
pp. 587-592 ◽  
Author(s):  
Chantha K. Jayawardena ◽  
Anushka P. Abesundara ◽  
Deepthi C. Nanayakkara ◽  
Malkanthi S. Chandrasekara
Keyword(s):  
Root Length ◽  
Sri Lankan ◽  
Age Related ◽  
Age Related Changes

scholarly journals Uterine peristalsis and junctional zone: correlation with age and postmenopausal status

2016 ◽  
Vol 58 (2) ◽  
pp. 224-231 ◽  
Author(s):  
Kayo Kiguchi ◽  
Aki Kido ◽  
Masako Kataoka ◽  
Fuki Shitano ◽  
Koji Fujimoto ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Cine Mri ◽  
Moderate Correlation ◽  
Resonance Imaging ◽  
Junctional Zone ◽  
Age Related ◽  
Postmenopausal Status ◽  
Magnetic Resonance Imaging Mri ◽  
Age Related Changes ◽  
Uterine Peristalsis

Background Although age-related change of junctional zone (JZ) of the uterus has been known, there has been no previous systematic study of age-related changes of uterine peristalsis that is observed as the wave conduction of the thickest or darkest area within the JZ. Purpose To examine the age-related changes of uterine peristalsis in pre and postmenopausal women using cine magnetic resonance imaging (MRI), and to determine the correlation between peristalsis and JZ on T2-weighted (T2W) imaging. Material and Methods Cine MRI analysis was performed in 64 premenopausal volunteers and in 43 postmenopausal women. The peristaltic frequency, JZ detectability, and JZ thickness were evaluated and compared between the two groups. In the premenopausal group, the correlations between age and each item was examined. In the postmenopausal group, the number of years after menopause was used instead of age. The correlation between peristaltic frequency and JZ detectability or thickness was also analyzed. Results Peristaltic frequency and JZ detectability significantly differed between the two groups, while JZ thickness did not. Peristaltic frequency did not vary significantly with age before menopause and no peristalsis was observed after menopause. JZ detectability did not change significantly with age or number of years after menopause, while JZ thickness significantly increased with age before menopause, but did not vary after menopause. A significant moderate correlation was observed between JZ detectability and peristaltic frequency, but not between JZ thickness and peristaltic frequency. Conclusion Uterine peristalsis frequency did not change significantly according to age, but observed peristalsis on MRI significantly decreased after menopause.

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