Age-Related Changes of Urinary Collagen Crosslinks and Serum Osteocalcin in Postmenopausal Women.

Objective To describe the ultrasound parameters of pelvic organs and their age-related changes in a cohort of asymptomatic postmenopausal women and to describe the prevalence of ultrasound-detected pathologies in a Sri Lankan population. Study design A large community-based longitudinal study using a randomly selected sample of postmenopausal women who have never used hormone replacement therapy. Main outcome measures Uterine, endometrial and ovarian measurements at pelvic ultrasonography as described by the International Endometrial Tumor Analysis and the International Ovarian Tumor Analysis groups. Results A total of 815 postmenopausal women were approached and all volunteered to participate. This included women between the ages of 45 and 74 years with a median (interquartile range (IQR)) of 62.0 (10.0) years. The median (IQR) uterine volume was 18.1 (17) ml, while the median (IQR) of right and left ovarian volumes were 17.3 (22.9) ml and 18.2 (21.5) ml. Both uterine and ovarian volumes showed an age-related decline (p < 0.01). Furthermore, the ovarian volumes demonstrated an increase in size with a higher body mass index (p < 0.03 for left and p < 0.01 for right, respectively). Median (IQR) endometrial thickness among the population was 3.0 (1.0) mm and there was no age-related change observed. Sixty-one women had an ultrasound-detected gynaecological pathology with a prevalence of 7.5% (95% confidence interval (CI) 5.6–9.5). Conclusions This study aimed at describing ultrasound parameters of pelvic organs among postmenopausal women of Sri Lanka was able to provide the reference values for uterine and ovarian volume among asymptomatic postmenopausal women. Both uterine and ovarian volumes demonstrated an age-related decline, whereas the endometrial thickness does not seem to relate to the age.

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Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6

AJP Renal Physiology ◽

10.1152/ajprenal.00038.2006 ◽

2006 ◽

Vol 291 (6) ◽

pp. F1177-F1183 ◽

Cited By ~ 31

Author(s):

Monique van Abel ◽

Sylvie Huybers ◽

Joost G. J. Hoenderop ◽

Annemiete W. C. M. van der Kemp ◽

Johannes P. T. M. van Leeuwen ◽

...

Keyword(s):

Vitamin D ◽

Mrna Levels ◽

Serum Osteocalcin ◽

Intestinal Epithelial ◽

Receptor Mrna ◽

Age Related ◽

Age Dependent ◽

Elder People ◽

Age Related Changes

Aging is associated with alterations in Ca2+ homeostasis, which predisposes elder people to hyperparathyroidism and osteoporosis. Intestinal Ca2+ absorption decreases with aging and, in particular, active transport of Ca2+ by the duodenum. In addition, there are age-related changes in renal Ca2+ handling. To examine age-related changes in expression of the renal and intestinal epithelial Ca2+ channels, control (TRPV5+/+) and TRPV5 knockout (TRPV5−/−) mice aged 10, 30, and 52 wk were studied. Aging of TRPV5+/+ mice resulted in a tendency toward increased renal Ca2+ excretion and significantly decreased intestinal Ca2+ absorption, which was accompanied by reduced expression of TRPV5 and TRPV6, respectively, despite increased serum 1,25(OH)2D3 levels. Similarly, in TRPV5−/− mice the existing renal Ca2+ loss was more pronounced in elder animals, whereas the compensatory intestinal Ca2+ absorption and TRPV6 expression declined with aging. In both mice strains, aging resulted in a resistance to 1,25(OH)2D3 and diminished renal vitamin D receptor mRNA levels, whereas serum Ca2+ levels remained constant. Furthermore, 52-wk-old TRPV5−/− mice showed severe hyperparathyroidism, whereas PTH levels in elder TRPV5+/+ mice remained normal. In 52-wk-old TRPV5−/− mice, serum osteocalcin levels were increased in accordance with the elevated PTH levels, suggesting an increased bone turnover in these mice. In conclusion, downregulation of TRPV5 and TRPV6 is likely involved in the impaired Ca2+ (re)absorption during aging. Moreover, TRPV5−/− mice likely develop age-related hyperparathyroidism and osteoporotic characteristics before TRPV5+/+ mice, demonstrating the importance of the epithelial Ca2+ channels in Ca2+ homeostasis.

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Serum osteocalcin in dairy cows: Age-related changes and periparturient variation

Research in Veterinary Science ◽

10.1016/j.rvsc.2010.12.007 ◽

2011 ◽

Vol 91 (2) ◽

pp. 196-198 ◽

Cited By ~ 8

Author(s):

Reiichiro Sato ◽

Ken Onda ◽

Hideharu Ochiai ◽

Tsunenori Iriki ◽

Yukio Yamazaki ◽

...

Keyword(s):

Dairy Cows ◽

Serum Osteocalcin ◽

Age Related ◽

Age Related Changes

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The role of steroid receptors in the pathogenesis of adenomyosis in the presence of concomitant endometrial pathology in postmenopause

Reports of Morphology ◽

10.31393/morphology-journal-2019-25(1)-07 ◽

2019 ◽

Vol 25 (1) ◽

pp. 45-54

Author(s):

G.Yu. Honcharenko

Keyword(s):

Postmenopausal Women ◽

Comparison Group ◽

Steroid Receptors ◽

Eutopic Endometrium ◽

Immunohistochemical Reaction ◽

Age Related ◽

Endometrial Pathology ◽

Er Expression ◽

Age Related Changes

Determining the pathogenesis of adenomyosis in postmenopausal women is promising, as it will allow a more thorough study of the mechanisms of hormonal changes and resolve issues related to adenomyosis in women of reproductive age. The purpose of the study is to establish the role of steroid receptors in the pathogenesis of adenomyosis in the presence of concomitant endometrial pathology in postmenopausal women. Study material is removed uteri with parovaria from 117 patients of 49-76 years old. The cases were divided into 4 groups depending on the presence of adenomyosis (AM) and background pathology (endometrioid carcinoma of the endometrium (ECE) and endometrial hyperplasia (EHP)): 1) 27 women with adenomyosis and EHP; 2) 30 women with adenomyosis and ECE; 3) 30 women with adenomyosis and age-related changes in the endometrium; 4) 30 women with age-related changes without AM (comparison group). The immunohistochemical reaction was carried out using primary antibodies to estrogen (ER), progesterone (PR) and androgen (AR) receptors. Statistical processing was carried out using parametric methods of variation statistics (calculated the arithmetic mean, standard deviation, confidence interval, Student criterion). The predominance of the ER expression in the glandular and stromal components of the eutopic endometrium in the presence of AM and hyperplastic processes was compared with the comparison group (p<0.01). A high level of ER expression is characteristic of the epithelium of the endometrium with EHP (7.333±0.314) and ECE (6.200±0.712) rather than for the endometrium with atrophic changes in the presence of AM (4.433±0.773). In the stroma, a high ER activity was detected with EHP (7.148±0.276) rather than with atrophic changes (4.567±0.738) and ECE (4.167±0.602). It was established that in the epithelium of adenomyosis foci, ER expression indices were lower in atrophy (3.433±1.074) than with AM foci in ECE (4.667±0.526) and EHP (5.148±0.745). In the stroma of adenomyosis foci, ER expression is higher in EHP than in ECE and atrophy. The activity of PR in the eutopic endometrium decreases from simple non-typical to complex atypical EHP and in patients with adenomyosis and ECE, as the degree of differentiation of cells of ECA decreases (from G1 to G3 ECE). A minimal expression of PR was found in the comparison group. In the cells of internal endometriosis there were positive indices of immunohistochemical reaction with PR. There were obtained minimum scores for receptor expression of AR in eu- and ectopic endometria. Conclusion: adenomyosis foci have a regulatory effect on the uterine endometrium, stimulating the expression of ER and, to a lesser extent, PR, and do not affect the level of AR in the eutopic endometrium.

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EFFECTS OF OESTROGEN AND PROGESTERONE ON AGE-RELATED CHANGES IN ARTERIES OF POSTMENOPAUSAL WOMEN

Clinical and Experimental Pharmacology and Physiology ◽

10.1111/j.1440-1681.1997.tb01225.x ◽

1997 ◽

Vol 24 (6) ◽

pp. 457-459 ◽

Cited By ~ 47

Author(s):

Yu-Lu Liang ◽

Helena Teede ◽

Louise M. Shiel ◽

Adrian Thomas ◽

Robyn Craven ◽

...

Keyword(s):

Postmenopausal Women ◽

Age Related ◽

Age Related Changes

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Uterine peristalsis and junctional zone: correlation with age and postmenopausal status

Acta Radiologica ◽

10.1177/0284185116639768 ◽

2016 ◽

Vol 58 (2) ◽

pp. 224-231 ◽

Cited By ~ 3

Author(s):

Kayo Kiguchi ◽

Aki Kido ◽

Masako Kataoka ◽

Fuki Shitano ◽

Koji Fujimoto ◽

...

Keyword(s):

Postmenopausal Women ◽

Cine Mri ◽

Moderate Correlation ◽

Resonance Imaging ◽

Junctional Zone ◽

Age Related ◽

Postmenopausal Status ◽

Magnetic Resonance Imaging Mri ◽

Age Related Changes ◽

Uterine Peristalsis

Background Although age-related change of junctional zone (JZ) of the uterus has been known, there has been no previous systematic study of age-related changes of uterine peristalsis that is observed as the wave conduction of the thickest or darkest area within the JZ. Purpose To examine the age-related changes of uterine peristalsis in pre and postmenopausal women using cine magnetic resonance imaging (MRI), and to determine the correlation between peristalsis and JZ on T2-weighted (T2W) imaging. Material and Methods Cine MRI analysis was performed in 64 premenopausal volunteers and in 43 postmenopausal women. The peristaltic frequency, JZ detectability, and JZ thickness were evaluated and compared between the two groups. In the premenopausal group, the correlations between age and each item was examined. In the postmenopausal group, the number of years after menopause was used instead of age. The correlation between peristaltic frequency and JZ detectability or thickness was also analyzed. Results Peristaltic frequency and JZ detectability significantly differed between the two groups, while JZ thickness did not. Peristaltic frequency did not vary significantly with age before menopause and no peristalsis was observed after menopause. JZ detectability did not change significantly with age or number of years after menopause, while JZ thickness significantly increased with age before menopause, but did not vary after menopause. A significant moderate correlation was observed between JZ detectability and peristaltic frequency, but not between JZ thickness and peristaltic frequency. Conclusion Uterine peristalsis frequency did not change significantly according to age, but observed peristalsis on MRI significantly decreased after menopause.

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Sex- and age-related changes in bone and serum osteocalcin

Calcified Tissue International ◽

10.1007/bf02555041 ◽

1990 ◽

Vol 46 (3) ◽

pp. 179-182 ◽

Cited By ~ 61

Author(s):

Dirk Vanderschueren ◽

Greet Gevers ◽

Greet Raymaekers ◽

Paul Devos ◽

Jan Dequeker

Keyword(s):

Serum Osteocalcin ◽

Age Related ◽

Age Related Changes

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Phytoestrogens in treatment of climacteric syndrome as an alternative to menopausal hormone therapy

Obstetrics Gynecology and Reproduction ◽

10.17749/2313-7347/ob.gyn.rep.2020.186 ◽

2020 ◽

Author(s):

M. I. Mazitova ◽

I. R. Talipova ◽

R. R. Mardieva

Keyword(s):

Hormone Therapy ◽

Cardiovascular System ◽

Postmenopausal Women ◽

Menopausal Hormone Therapy ◽

International Literature ◽

Climacteric Syndrome ◽

Sexual Symptoms ◽

Age Related ◽

Plant Compounds ◽

Age Related Changes

Russian and international literature over the last 5 years was observed to study the use of phytoestrogens in treatment of climacteric syndrome. Effects of isoflavones as the main group of phytoestrogens on vasomotor, cognitive, psychological, urogenital and sexual symptoms as well as their action on the cardiovascular system, bones, and metabolic age-related changes are considered. Phytoestrogens administration is concluded to be perspective as an alternative to menopausal hormone therapy. It is reasonable to conduct further extensive researches to evaluate the effectiveness and safety of the use of the plant compounds in postmenopausal women.

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Age-related changes in pre- and postmenopausal women investigated with 18F-fluoride PET—a preliminary study

Skeletal Radiology ◽

10.1007/s00256-011-1318-9 ◽

2011 ◽

Vol 41 (8) ◽

pp. 947-953 ◽

Cited By ~ 6

Author(s):

Seiji Kurata ◽

Kazuya Shizukuishi ◽

Ukihide Tateishi ◽

Tomohiro Yoneyama ◽

Ayako Hino ◽

...

Keyword(s):

Postmenopausal Women ◽

Age Related ◽

Preliminary Study ◽

18F Fluoride ◽

Age Related Changes

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Associations between age-related changes in bone microstructure and strength and dietary acid load in a cohort of community-dwelling, healthy men and postmenopausal women

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqaa191 ◽

2020 ◽

Vol 112 (4) ◽

pp. 1120-1131

Author(s):

Maria Papageorgiou ◽

Fanny Merminod ◽

Thierry Chevalley ◽

Bert van Rietbergen ◽

Serge Ferrari ◽

...

Keyword(s):

Postmenopausal Women ◽

Bone Microstructure ◽

Community Dwelling ◽

Mineral Density ◽

Healthy Men ◽

Dietary Acid Load ◽

Age Related ◽

Dietary Acid ◽

Acid Load ◽

Age Related Changes

ABSTRACT Background The importance of dietary acid load (DAL) in the pathogenesis of osteoporosis is still debated. Age-related changes in bone microstructure and strength in relation to DAL remain largely unexplored. Objectives We investigated the associations between changes in areal and volumetric bone mineral density (BMD), bone microstructure and strength, fracture risk, and DAL in a prospective cohort of 65-y-old healthy men and postmenopausal women. Methods Potential renal acid load (PRAL; mEq/d) was calculated as a DAL proxy to characterize participants’ diet as alkaline (Alk-D; PRAL < −5), neutral (Neut-D; −5 ≤ PRAL ≤ 5), or acidic (Acid-D; PRAL >5). We measured areal BMD (aBMD) by DXA, and distal radius and tibia bone microstructure using high-resolution peripheral quantitative computed tomography, at baseline (n = 853) and after 6.1 ± 1.4 y (n = 708). Bone strength was estimated using finite element analyses at baseline and after 3.0 ± 0.5 y (n = 613). Prevalent and incident fractures were recorded. Results The majority of the participants (59%) had an Alk-D, while 23% had a Neut-D, and 18% an Acid-D. Baseline aBMD and bone microstructure and strength did differ or were slightly better in women or men with an Acid-D versus those consuming an Alk-D or Neut-D. Indeed, women with an Acid-D had higher trabecular number (P = 0.010 vs. Alk-D; P = 0.001 vs. Neut-D), while men had higher hip and radius aBMD (P = 0.008 and 0.024 vs. Neut-D, respectively) and radius strength (P = 0.026 vs. Neut-D). Over the follow-up, women in the Acid-D group experienced lower cortical and endocortical bone loss at the radius than did the Alk-D and Neut-D groups (cortical thickness, P = 0.008 and < 0.001; trabecular area, P = 0.001 and < 0.001, respectively). No association between fractures and PRAL was observed. Conclusions These null or favourable associations between baseline values or changes in aBMD, bone microstructure and strength, and DAL in this cohort of 65-y-old healthy individuals do not support adverse DAL-mediated effects on bone. This trial was registered at http://www.isrctn.com as ISRCTN11865958.

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