MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain
2015 ◽
Vol 4
(11)
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pp. 205846011560963
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Keyword(s):
Recently, the “glymphatic system” of the brain has been discovered in rodents, which is a paravascular, transparenchymal route for clearance of excess brain metabolites and distribution of compounds in the cerebrospinal fluid. It has already been demonstrated that intrathecally administered gadolinium (Gd) contrast medium distributes along this route in rats, but so far not in humans. A 27-year-old woman underwent magnetic resonance imaging (MRI) with intrathecal administration of gadobutrol, which distributed throughout her entire brain after 1 and 4.5 h. MRI with intrathecal Gd may become a tool to study glymphatic function in the human brain.
1999 ◽
Vol 37
(2)
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pp. 467-470
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2015 ◽
Vol 59
(2)
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pp. 317-319
2017 ◽
Vol 2017
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pp. 1-4
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2018 ◽
Vol 49
(1)
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pp. 181-189
2021 ◽