scholarly journals Comparative effects of target-controlled infusion of anesthetic sufentanil and remifentanil on inflammatory factors and oxidative stress indicators in patients of colorectal cancer

2019 ◽  
Vol 17 ◽  
pp. 205873921986328
Author(s):  
Xiaohui Chen ◽  
Zhongyuan Hu ◽  
Wenjun Yan ◽  
Yabing Ma ◽  
Man He ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colorectal Cancer ◽  
Adverse Reactions ◽  
Inflammatory Factors ◽  
Stress Indicators ◽  
Target Controlled Infusion ◽  
Extubation Time ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress ◽  
Remifentanil Group

This study was designed to compare the recovery of target-controlled infusion of sufentanil and remifentanil in patients of colorectal cancer. In total, 104 patients were randomly divided into sufentanil and remifentanil groups. One group was given target-controlled infusion of sufentanil, while the other group received remifentanil. Inflammatory factors and oxidative stress indicators were measured at 10 min before induction of anesthesia (T1), 1 h (T2), 24 h (T3), and 72 h (T4) after surgery. Adverse reactions were also compared. The extubation and recovery time of sufentanil group were longer than remifentanil group. The levels of CRP, IL-8, and IL-4 in sufentanil group and remifentanil group increased continuously. CRP contents at T3, T4, and IL-8 and IL-4 contents at T2, T3, and T4 of remifentanil group were lower ( P < 0.05). The incidence of adverse reactions in sufentanil group was 15.4%, which was significantly ( P < 0.05) lower than remifentanil group (28.8%). The recovery and extubation time of sufentanil were longer than remifentanil, while the remifentanil can effectively reduce the levels of inflammatory factors and oxidative stress.

Theranostic TEMPO-functionalized Ru(ii) complexes as photosensitizers and oxidative stress indicators

2017 ◽  
Vol 46 (2) ◽  
pp. 445-454 ◽  
Author(s):  
Jing Yang ◽  
Qian Cao ◽  
Wei-Liang Hu ◽  
Rui-Rong Ye ◽  
Liang He ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Photodynamic Therapy ◽  
Polypyridyl Complexes ◽  
Stress Indicators ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

New TEMPO-functionalized Ru(ii) polypyridyl complexes displayed greatly improved PDT efficacy, capable of simultaneously monitoring cellular oxidative stress during photodynamic therapy.

scholarly journals NEUROPROTECTIVE EFFECT OF WATERMELON (CITRULLUS LANATUS) PULP JUICE ON SCOPOLAMINE-INDUCED MEMORY DEFICITS IN SWISS ALBINO MICE: THE ROLE OF ACETYLCHOLINESTERASE AND OXIDATIVE STRESS

2021 ◽  
Vol 12 (3) ◽  
pp. 52-56
Author(s):  
Divya N ◽  
Amudha P ◽  
Viveka K Priya
Keyword(s):  
Oxidative Stress ◽  
Ache Activity ◽  
Citrullus Lanatus ◽  
Neuroprotective Effect ◽  
Memory Deficits ◽  
Memory Deficit ◽  
Stress Indicators ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

The effect of Watermelon (Citrullus lanatus) Pulp Juice (WPJ) on scopolamine (SCOP) induced memory deficits is due to the involvement of oxidative stress and AChE activity. The juice was obtained by crushing the pulp in blender and three different concentrations of 100%, 50% and 25% was administration to prevent memory deficit by evaluating changes of AChE activity and oxidative stress indicators (SOD, CAT, LPO and GPx) induced by scopolamine. These results provide evidence that WPJ is an alternative to protect SCOP induced memory deficits in mice by involvement of oxidative stress and AChE activity.

scholarly journals Folic Acid Can Reduce Hyperhomocysteinemia-induced Vascular Damage by Immune/Inflammatory Response in Spontaneously Hypertensive Rats

2020 ◽  
Author(s):  
Lihua Zhang ◽  
Zhongliang li ◽  
Changcheng Xing ◽  
Ning Gao ◽  
Ping Cao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Spontaneously Hypertensive Rats ◽  
Vascular Damage ◽  
Inflammatory Factors ◽  
Hypertensive Rats ◽  
Stress Indicators ◽  
Spontaneously Hypertensive ◽  
Inflammatory Molecules ◽  
Oxidative Stress Indicators

Abstract Background Hypertension associated with hyperhomocysteinemia (HHcy) is correlated with a high risk of vascular diseases. However, the mechanisms of HHcy-associated hypertensive vascular damage and the efficacy of folic acid (FA) as a treatment have not been fully elucidated. The aim of the present study was to evaluate the role of immune/inflammatory molecules and oxidizing factors in HHcy-associated hypertensive vascular damage, and to observe the intervention effect of FA on the two vascular injury factors. Methods Wistar-Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) were administered DL-Hcy intraperitoneally to mimic HHcy and hypertension associated with HHcy for 12 weeks. WKYs and SHRs were randomized into WKY group, HHcy group, SHR group, SHR + HHcy group and SHR + HHcy + FA group. Mean tail artery blood pressure, plasma Hcy, serum SOD and MDA of rats in each group were compared. The thoracic aorta and bilateral carotid artery of rats were harvested for morphometric and immunostaining analyses. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were used to detect the expression of immune/inflammatory molecules such as TNF-α, IL-6, NF-κB p65/Rela and NF-κB2 and oxidative factors such as Nox2 and Nox4. Results We found that vascular inflammatory factors of vascular adhesion protein-1 (VAP-1), interleukin-6 (IL-6), and nuclear factor-κ-gene binding (NF-κB) p65/Rela in HHcy-associated hypertensive rats were significantly higher than those in SHRs (P༜0.05). While the oxidative stress indicators of Nox2 and Nox4 in HHcy-associated hypertensive rats were not significantly higher than those in SHRs (P༞0.05). Compared with SHRs, FA intervention in HHcy-associated hypertensive rats significantly increased serum superoxide dismutase (SOD) levels (P = 0.000) and significantly reduced vascular inflammatory factors of IL-6 and NF-κB p65/Rela (P༜0.05), but did not significantly change the oxidative stress indicators of Nox2 and Nox4 (P༞0.05). Conclusions HHcy-induced immune/inflammatory response plays a dominant role in vascular damage of HHcy-associated hypertensive rats. In addition to reducing the negative effects of HHcy, FA might involve unique antioxidant effects and inhibition of immune/inflammatory overreaction for HHcy-associated hypertensive rats.

scholarly journals Spirulina Maxima Decreases Endothelial Damage and Oxidative Stress Indicators in Patients with Systemic Arterial Hypertension: Results from Exploratory Controlled Clinical Trial

2018 ◽  
Author(s):  
Jesús Martínez-Sámano ◽  
Adriana Torres-Montes de Oca ◽  
Oscar Ivan Luqueño-Bocardo ◽  
Patricia V. Torres-Durán ◽  
Marco Antonio Juárez-Oropeza
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase ◽  
Arterial Hypertension ◽  
Endothelial Damage ◽  
Oxidized Glutathione ◽  
Spirulina Maxima ◽  
Stress Indicators ◽  
Systemic Arterial Hypertension ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

1) Background: Spirulina (Arthrospira) maxima has shown beneficial effects such anti-dyslipidemic, antiviral, antioxidant and antihypertensive. However, there are few and limited clinical studies. 2) Methods: a prospective, randomized, parallel pilot study of 4.5 g administration of Spirulina maxima or placebo for 12 weeks in 16 patients with systemic arterial hypertension undergoing treatment with ACE inhibitors was performed to assess the effects on endothelial damage and oxidative stress indicators. The blood levels of sICAM-1, sVCAM-1, endothelin-1, and sE-selectin were quantified; the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and concentrations of reduced glutathione, oxidized glutathione, and thiobarbituric acid reactive susbtances, were also quantified before and after the treatment period. 3) Results: There were statistically significant (p &lt; 0.05) decreases in systolic blood pressure, sVCAM-1, sE-selectin and endothelin-1 levels, and increases in glutathione peroxidase activity and oxidized glutathione levels. 4) Conclusion: The effects found in the present study agree with antihypertensive and antioxidant effects previously reported for Spirulina maxima. However, this is the first report about the effects on indicators of endothelial damage. More research in this field is necessary to gain an insight into the effects of Spirulina on these indicators.&nbsp; &nbsp;

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