scholarly journals Is There an Association Between Hyperbaric Oxygen Therapy and Improved Outcome of Deep Chemical Peeling? A Randomized Pilot Clinical Study

2018 ◽  
Vol 26 (4) ◽  
pp. 250-255 ◽  
Author(s):  
Itay Wiser ◽  
Averbuch Sagie Roni ◽  
Ella Ziv ◽  
Mony Friedman ◽  
Shay Efraty ◽  
...  
Keyword(s):  
Clinical Study ◽  
Adverse Events ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Chronic Wounds ◽  
Recovery Period ◽  
Control Group ◽  
Severity Scores ◽  
Chemical Peeling

Background: Phenol chemical peeling (PCP) treatment is associated with prolonged recovery and sustained adverse events. Hyperbaric oxygen therapy (HBOT) is known to accelerate wound healing. The purpose of the current study was to evaluate the effect of HBOT on PCP recovery period and adverse events. Methods: This is a pilot randomized controlled clinical study. Women following PCP underwent 5 consecutive daily HBOT sessions, compared with PCP alone. Pain, pruritus, erythema, crusting, scaling, and edema were daily evaluated up to 28 days following PCP. Photographs taken on days 14 and 35 following PCP were assessed. Confidence to appear in public was assessed 14 days following PCP. Results: Eight participants equally assigned to HBOT and control groups. Lower severity scores for erythema, scaling, and pruritus were documented in the HBOT group (mean difference 1.19, P = .006; .84, P = .04; and 2.19, P = .001, respectively). Photographic assessment severity score was higher for skin tightness, edema, erythema, crusting, and scaling in the control group on day 14 post PCP ( P < .05) and for erythema on day 35 post PCP ( P < .05). Epithelialization percentage was higher in the HBOT group on day 14 post PCP compared with controls (98.5% ± 1% vs 94.2% ± 1%; P = .021). The HBOT group scored higher in confidence to appear in public (20.8 ± 1.7 vs 14.5 ± 1.3; P = .029). Conclusion: Hyperbaric oxygen therapy following PCP is associated with faster recovery as assessed by both patients and caregivers. So far, HBOT was mainly used in the treatment of problematic or chronic wounds. Our study suggests expanding the indications in which hyperbaric oxygen treatment is applicable and recommended.

scholarly journals Adverse reactions of hyperbaric oxygen therapy - case description of a generalised seizure

2016 ◽  
Vol 54 (1) ◽  
pp. 19-22
Author(s):  
Kinga Grobelska ◽  
Monika Betyna ◽  
Ewa Zieliński
Keyword(s):  
Adverse Events ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Medical Staff ◽  
Oxygen Therapy ◽  
Adverse Reactions ◽  
Careful Analysis ◽  
Healing Wound ◽  
Termination Phase ◽  
Fourth Session

Abstract Hyperbaric oxygen therapy (HBOT) is a safe treatment, provided fulfilling certain rules of patient qualifications to treatment, as well as supervision over the course of therapy by qualified medical staff. Side effects reported in the literature are rare, and are usually mild and transient. Professional medical staff allows minimising the adverse events occurrence. The scale of complications is unknown, especially in Polish hyperbaric center. Careful analysis could be used to develop prevention procedures for patients of hyperbaric oxygen therapy. Hyperbaric Oxygen Centre and Wound Treatment in Bydgoszcz during 28 months performed hyperbaric oxygen therapy (HBOT) in case of 423 patients. During this period, adverse events occurred occasionally. 17 cases have been reported. Authors described study case 77 year-old patient who was admitted due to non-healing wound-left lower abdomen (state after radiotherapy). During the fourth session, on decompression phase patient have had a generalized seizure (tonic-clonic). The decompression was stopped, the oxygen supply was disconnected but only after the drug administration seizures terminated. The most likely causative agent of the adverse reactions of the patient treated with HBOT was the oxygen toxic effect on the brain tissue. However, analyzing the circumstances of the seizure termination: phase of decompression at the pressure 2ATA and lack of oxygen disconnection response, it cannot be excluded other causes of this complication.

Hyperbaric oxygen therapy for chronic wounds

2012 ◽  
Author(s):  
Peter Kranke ◽  
Michael H Bennett ◽  
Marrissa Martyn-St James ◽  
Alexander Schnabel ◽  
Sebastian E Debus
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Chronic Wounds

scholarly journals Assessing the effect of hyperbaric oxygen therapy in breast cancer patients with late radiation toxicity (HONEY trial): a trial protocol using a trial within a cohort design

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
M. C. T. Batenburg ◽  
H. J. G. D. van den Bongard ◽  
C. E. Kleynen ◽  
W. Maarse ◽  
A. Witkamp ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Intervention Studies ◽  
Control Group ◽  
Radiation Toxicity ◽  
Breast Cancer Patients ◽  
Randomized Controlled

Abstract Background Breast cancer treatment with radiotherapy can induce late radiation toxicity, characterized by pain, fibrosis, edema, impaired arm mobility, and poor cosmetic outcome. Hyperbaric oxygen therapy (HBOT) has been proposed as treatment for late radiation toxicity; however, high-level evidence of effectiveness is lacking. As HBOT is standard treatment and reimbursed by insurers, performing classic randomized controlled trials is difficult. The “Hyperbaric OxygeN therapy on brEast cancer patients with late radiation toxicity” (HONEY) trial aims to evaluate the effectiveness of HBOT on late radiation toxicity in breast cancer patients using the trial within cohorts (TwiCs) design. Methods The HONEY trial will be conducted within the Utrecht cohort for Multiple BREast cancer intervention studies and Long-term evaluation (UMBRELLA). Within UMBRELLA, breast cancer patients referred for radiotherapy to the University Medical Centre Utrecht are eligible for inclusion. Patients consent to collection of clinical data and patient-reported outcomes and provide broad consent for randomization into future intervention studies. Patients who meet the HONEY in- and exclusion criteria (participation ≥ 12 months in UMBRELLA, moderate/severe breast or chest wall pain, completed primary breast cancer treatment except hormonal treatment, no prior treatment with HBOT, no contraindications for HBOT, no clinical signs of metastatic or recurrent disease) will be randomized to HBOT or control group on a 2:1 ratio (n = 120). Patients in the control group will not be informed about participation in the trial. Patients in the intervention arm will undergo 30–40 HBOT treatment sessions in a high pressure chamber (2.4 atmospheres absolute) where they inhale 100% oxygen through a mask. Cohort outcome measures (i.e., physical outcomes, quality of life, fatigue, and cosmetic satisfaction) of the HBOT group will be compared to the control group at 3 months follow-up. Discussion This pragmatic trial within the UMBELLA cohort was designed to evaluate the effectiveness of HBOT on late radiation toxicity in breast cancer patients using the TwiCs design. Use of the TwiCs design is expected to address issues encountered in classic randomized controlled trials, such as contamination (i.e., HBOT in the control group) and disappointment bias, and generate information about acceptability of HBOT. Trial registration ClinicalTrials.gov. NCT04193722. Registered on 10 December 2019.

scholarly journals Hyperbaric oxygen for severe traumatic brain injury: a randomized trial

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052093982
Author(s):  
Xianliang Zhong ◽  
Aijun Shan ◽  
Jianzhong Xu ◽  
Jian Liang ◽  
Ying Long ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hyperbaric Oxygen ◽  
Severe Traumatic Brain Injury ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Vital Signs ◽  
Neurological Function ◽  
Control Group ◽  
Experimental Group

Objective The present study aimed to explore the effects of hyperbaric oxygen therapy on the prognosis and neurological function of patients with severe traumatic brain injury. Methods A prospective study was carried out in 88 patients diagnosed with severe brain injury at our hospital and they were enrolled as research participants and randomly assigned to control and experimental groups (n = 44 per group) using a random number table method. Both groups underwent routine treatment. Patients in the experimental group were administered hyperbaric oxygen therapy approximately 1 week after admission when their vital signs had stabilized. Results No significant intergroup differences were observed in the Glasgow Coma Scale (GCS) and U.S. National Institutes of Health Stroke Scale (NIHSS) scores before treatment. However, after oxygen treatment, compared with the control group, the experimental group showed higher GCS and lower NIHSS scores. The GCS score at admission, tracheotomy status, and first hyperbaric oxygen therapy duration were independent prognostic factors in patients with severe traumatic brain injury. Conclusion Hyperbaric oxygen therapy may promote recovery of neurological function and improve the cognitive function and prognosis of patients with severe traumatic brain injury.

scholarly journals The use of hyperbaric oxygen therapy to treat chronic wounds: A review

2008 ◽  
Vol 16 (3) ◽  
pp. 321-330 ◽  
Author(s):  
Jennifer A. Thackham ◽  
D.L. Sean McElwain ◽  
Robert J. Long
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Chronic Wounds

scholarly journals The Effects of Hyperbaric Oxygen Therapy on Experimental Colon Anastomosis After Preoperative Chemoradiotherapy

2013 ◽  
Vol 98 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Ramazan Yildiz ◽  
Mehmet Fatih Can ◽  
Gokhan Yagci ◽  
Taner Ozgurtas ◽  
Metin Guden ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Preoperative Chemoradiotherapy ◽  
Colon Resection ◽  
Burst Pressure ◽  
Control Group ◽  
Albino Rats ◽  
Colon Anastomosis ◽  
Significant Difference

Abstract The aim of the present study was to investigate the effect of hyperbaric oxygen therapy (HBOT) on colon anastomosis after chemoradiotherapy (CRT). Sixty female Wistar-Albino rats were divided into 5 groups and underwent left colon resection and end-to-end anastomosis. CRT simulation was performed on 2 sham groups before the anastomosis, and 1 of these groups was administered additional postoperative HBOT. Two groups were administered CRT before the anastomosis, and 1 of them received additional postoperative HBOT. On postoperative day 5, all groups underwent relaparotomy; burst pressure was measured and samples were obtained for histopathologic and biochemical analysis. There was a significant weight loss in the CRT groups and postoperative HBOT had an improving effect. Significantly decreased burst pressure values increased up to the levels of the controls after HBOT. Hydroxyproline levels were elevated in all groups compared to the control group. Hydroxyproline levels decreased with HBOT after CRT. No significant difference was observed between the groups regarding fibrosis formation at the anastomosis site. However, regression was observed in fibrosis in the group receiving HBOT after CRT. Preoperative CRT affected anastomosis and wound healing unfavorably. These unfavorable effects were alleviated by postoperative HBOT. HBOT improved the mechanical and biochemical parameters of colon anastomosis in rats.

scholarly journals A Three Species Model to Simulate Application of Hyperbaric Oxygen Therapy to Chronic Wounds

2009 ◽  
Vol 5 (7) ◽  
pp. e1000451 ◽  
Author(s):  
Jennifer A. Flegg ◽  
Donald L. S. McElwain ◽  
Helen M. Byrne ◽  
Ian W. Turner
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Chronic Wounds

scholarly journals Application of Local Hyperbaric Oxygen Therapy With Use of Device Laserobaria – S in the Treatment of Chronic Wounds

2016 ◽  
Vol 57 (4) ◽  
pp. 29-35
Author(s):  
Aleksander Sieroń ◽  
Jarosław Pasek ◽  
Mikołaj Pietrzak ◽  
Grzegorz Cieślar
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Chronic Wounds ◽  
Healing Process ◽  
Lower Extremities ◽  
Therapeutic Effects ◽  
Atherosclerotic Lesions ◽  
Number Of Patients ◽  
Therapeutic Mechanism

Abstract For many years now we have been observing a growing number of patients with amputations performed on lower extremities due to chronic wounds occurring as a result of atherosclerotic lesions in peripheral arteries, thromboembolism as well as due to chronic ischaemia in lower extremities. Modern physical medicine is systematically enhancing treatment possibilities for patients with chronic wounds by an introduction of innovative therapeutic devices into clinical practice, which often allow to prevent amputations, accelerate the healing process, and, most of all, alleviate or completely eliminate pain. The article presents the therapeutic mechanism and methodology of one of such methods - local hyperbaric oxygen therapy with the use of a device called LASEROBARIA - S, alongside a description of its therapeutic effects in the case of two patients.

scholarly journals The knowledge and opinions of urology doctors in turkey of hyperbaric oxygen therapy in radiation-induced hemorrhagic cystitis: a survey study

2021 ◽  
pp. 148-158
Author(s):  
Kübra Özgök Kangal ◽  
Kübra Canarslan Demir
Keyword(s):  
Hyperbaric Oxygen ◽  
Treatment Option ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Hemorrhagic Cystitis ◽  
Recovery Period ◽  
Survey Study ◽  
Effective Treatment Option ◽  
Patient Admissions ◽  
Radiation Induced

Objective: Radiation-induced hemorrhagic cystitis (RHC) is an accepted hyperbaric oxygen therapy (HBOT) indication. We aimed to analyze the knowledge and the opinions of urology physicians on HBOT in RHS patients with a survey. Materials and Methods: The questionnaires were conducted face to face or online on urology physicians. Results: Seventy-seven urology physicians participated in our study. Physicians have been working for 11 ± 10.5 years in the field of Urology. The 84.4% of our physicians had an average of 0-10 RHC patient administration in a year. However, the majority of the participants stated that they have never referred RHC patients to HBOT. Similarly, 48.1% of the physicians stated that they have insufficient knowledge of HBOT for their specialty. On the other hand, the majority were not sure about the HBOT as an effective treatment option in RHC patients (54.5%), about the cost-effectiveness of HBOT for RHC (66.2%), and the ability of HBOT on shortening the recovery period of RHC patients (49.9%). We observed that physicians who did not have any knowledge on HBOT had statistically significantly lower RHC patient referral rates to HBOT and had more negative opinions on the effectiveness of HBOT in RHC patients (respectively p<0.001, p=0.002). Likewise, physicians who had RHC patient admissions had statistically significantly more positive opinions about HBOT in terms of treatment efficiency, shortening the recovery period, and being a safe treatment option in RHC patients compared to the physicians who did not have any RHC patient admissions (respectively p<0.001, p<0,001, p<0.001). Conclusion: We found that the urology physicians’ knowledge of HBOT application in RHC patients was insufficient. Thus, we realized that they were doubtful about HBOT as an effective RHC treatment option. Likewise, we found out that most of the urology physicians do not refer RHC patients for HBOT. Keywords: hyperbaric oxygen therapy, cystitis, radiation injuries, bladder, urologists

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