Treating Obsessive Compulsive Disorder with Cognitive Behavior Therapy (CBT): A Case Study

The present case study is about a 23 year’s old married man from a middle socioeconomic status Muslim family residing in Islamabad. He came with the signs of obsessive compulsive disorder such as obsessions, compulsions, superstitious thinking with comorbid depression, low mood, somatic complaints, anxiety, nervousness, tension, isolation and hostility. He was having these symptoms since 2006 to 2021. The present case study was conducted to assess the efficacy of cognitive behavior therapy (CBT) for individuals suffering with obsessive compulsive disorder. Case study continued for 12 sessions of cognitive behaviors therapy. 3 (1-3) sessions were conducted in initial phase, 5 sessions (4-9) were conducted in middle phase and 3 (10-12) sessions were conducted in termination phase and 2 follow up sessions after termination phase. Patient’s improvement was started in middle phase of the treatment; he seemed hopeful and motivated in getting better. After the end of the middle phase, he was almost symptom free. Further at the termination phase, patient’s symptoms were distinctly reduced and relapse prevention tactics were taught to him for dealing with his obsessive compulsive disorder symptoms in future. It was confirmed that CBT is an efficient therapy to treat obsessive compulsive disorder symptoms and improve well-being.

Dynamics of the termination of global alliances: probing the past, analyzing the present and defining the frontiers for future research

PurposeWhile the number of global alliance terminations in the business world has grown steadily during the past few decades, the scholarly literature on strategic alliance (SA) termination remains limited. This research paper aims to perform a bibliometric analysis of the literature on alliance termination and propose a model for future research agenda that links the termination phase to the pre-alliance termination phase and post alliance termination phase.Design/methodology/approachA search query on global alliance termination identified a total of 69 research papers from the Scopus database, and a bibliometric analysis was performed using the bibliometrix R-package and VOSviewer. The analysis further used the TCCM framework to review the set of papers.FindingsThis research analysis reveals that, compared to the pre-formation, formation, and process stages of alliances, limited research has been undertaken on global alliance termination. The bibliometric analysis and TCCM framework provide a complete view of the extant literature on global alliance termination from different dimensions and act as the which as the foundation for a developing the research agenda that links pre-alliance termination phase and post-alliance termination phase to that of alliance termination phase.Research limitations/implicationsThe proposed research agenda is unique as it integrates multiple phases in the alliance lifecycle with global alliance termination phase and develops a distinct view for future research that emphasizes on the post-alliance termination phase.Practical implicationsThe bibliometric analysis provides a precise snapshot of the state of the literature on global alliance termination. The research agenda developed provides a direction for further academic research that links alliance termination not only to pre-alliance termination phase but also to the post-alliance termination phase that is nascently explored in the literature.Originality/valueThis study is among the few to review and synthesize the literature on global alliance termination. It, therefore, functions as a catalyst to draw global scholars' attention. Further, it provides global researchers with direction by proposing a global research agenda.

IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming

To understand the role of polyploid giant cancer cells (PGCCs) in drug resistance and disease relapse, we examined the mRNA expression profile of PGCCs following treatment with paclitaxel in ovarian cancer cells. An acute activation of IL-6 dominated senescence-associated secretory phenotype lasted 2–3 weeks and declined during the termination phase of polyploidy. IL-6 activates embryonic stemness during the initiation of PGCCs and can reprogram normal fibroblasts into cancer-associated fibroblasts (CAFs) via increased collagen synthesis, activation of VEGF expression, and enrichment of CAFs and the GPR77 + /CD10 + fibroblast subpopulation. Blocking the IL-6 feedback loop with tocilizumab or apigenin prevented PGCC formation, attenuated embryonic stemness and the CAF phenotype, and inhibited tumor growth in a patient-derived xenograft high-grade serous ovarian carcinoma model. Thus, IL-6 derived by PGCCs is capable of reprogramming both cancer and stromal cells and contributes to the evolution and remodeling of cancer. Targeting IL-6 in PGCCs may represent a novel approach to combating drug resistance.

Phase 3

This chapter highlights the importance of the termination phase to the practice of TFPP. Attachment dysregulation and feelings of abandonment and rage come to the fore within the therapeutic relationship during termination. Careful handling of this process is crucial in helping the PTSD patient move past symptoms to effect therapeutic change. Issues that commonly arise during termination are feelings of loss and mourning, anxiety surrounding separations, aggravation of mistrust and anger, and fantasies and fears of helplessness. Feelings of pride and gratitude may also emerge. Termination is a challenging time in TFPP, and this chapter also focuses on common countertransference concerns and ways of avoiding pitfalls. Clinical vignettes of TFPP terminations are provided.

Termination

This chapter elaborates on the termination phase of acute IPT, already briefly discussed in Chapter 3 of this book. It describes the need to consolidate and reinforce treatment gains; to ask the patient why he or she is feeling better; and to acknowledge feelings associated with the role transition of ending treatment. Patients who have not improved in brief IPT should be offered alternative effective treatment. The chapter also addresses indications for and utilization of making a new therapeutic contract for continuation and maintenance IPT and the likelihood that extending treatment will be beneficial in the setting of ongoing disaster.

Identification of potential key genes associated with termination phase of rat liver regeneration through microarray analysis

Background and objective: Liver regeneration (LR) is a complex process influenced by various genes and pathways, the majority of the of research on LR focus on the initiation and proliferation phase while studies on termination phase is lacking. We aimed to identify potential genes and reveal the underlying the molecular mechanisms involved in the precise regulation of liver size during the termination phase of LR. Materials and methods: We obtained the rat liver tissue gene datasets (GSE63742) collected following partial hepatectomy (PH) from the Gene Expression Omnibus (GEO) of the National Center for Biotechnology Information (NCBI), from which, this study screened the late stage LR samples (7 days post-PH) using the R/Bioconductor packages for the identification of differentially expressed genes (DEGs). Afterwards, we performed enrichment analysis using the database for annotation visualization and integrated discovery (DAVID) online tool. Moreover, the Search Tool for the Retrieval of Interacting proteins (STRING) database was employed to construct protein-protein interaction (PPI) networks based on those identified DEGs; the PPI network was then used by Cytoscape software to predict hub genes and nodes. Animal experimentation (Rat PH model) was performed to acquire liver tissues which were then used for western blot analysis to verify our results. Results: The present study identified together 74 significant DEGs, among which, 51 showed up-regulation while 23 presented as down-regulated. As revealed by KEGG pathway enrichment analysis, DEGs were mostly related to pathways such as retinol metabolism, steroid hormone synthesis, transforming growth factor-β (TGF-β) and mitogen-activated protein kinase (MAPK) signaling. In addition, as suggested by GO enrichment analysis, DEGs were mostly related to the cyclooxygenase P450 pathway, negative regulation of Notch signaling pathway, aromatase activity, steroid hydroxylase activity, exosomes, and extracellular domain. Analyses based on STRING database and Cytoscape software identified genes like Ste2 and Btg2 as the hub genes in the termination stage LR. The obtained results were confirmed by Western blot analysis. Conclusions: Taken together, the microarray analysis in this study suggests that DEGs such as Ste2 and Btg2 are the hub genes, which are associated with the regulation of termination stage LR, while the molecular mechanisms are possibly related to the MAPK and TGF-β signal transduction pathways.

Balanço eletrolítico estratégico na ração de suínos criados em clima quente

The effect of Dietary Electrolyte Balance (EB) in rations for growing and finished swine under high temperatures ambient was evaluated. Two hundred male castrated pigs with initial average 25,3±1.3 kg were allotted in completely randomized experimental design with five treatments T1 diet without supplemented electrolyte 191 mEq/kg; T2 (supl B) diet supplementd with sodium bicarbonate (NaHCO3) 250 mEq/kg; T3 (supl B+C) diet supplemented with (NaHCO3) and potassium chloride (KCl) 250 mEq/kg; T4 (supl B) diet supplemented with (NaHCO3) 300 mEq/kg; T5 (supl B+C) diet supplemented (NaHCO3) and (KCl) 300 mEq/kg and four replication and 10 pigs per experimental unit. The average weight of the animals was 68,8±3,4 kg. The performance parameters evaluated were the feed intake (FI), the daily gain (DG), finished weight (FW), nitrogen intake (NI), lysine intake (LI), efficiency of N utilization for weight gain (ENUWG), efficiency of L utilization for weight gain (ELUWG) and the gain:feed ration and physiologic parameters to respiratory frequency (RF) and rectal temperature (RT). Blood was colleted to measure serum concentration of Na, Cl and K. The average temperature was 29,65±1,80ºC with (RU) of 69,6±10,4%. The levels of EB decreased (P<0,05) the (FI) and improved (NI). The others performance parameters evaluated weren’t influenced by treatments (P>0,05). In the termination phase the supplementation with sodium bicarbonate and or potassium chloride with 250 or 300 mEq/kg can be used to correct electrolyte balance under heat stress.

KOMUNIKASI TERAPEUTIK DALAM KONSELING ANTARA KONSELOR DAN PASIEN PENYALAHGUNAAN NARKOBADI KLINIK BADAN NARKOTIKA NASIONAL PROVINSI JAWA BARAT

The purpose of this study was to determine Therapeutic Communication in Counseling between Counselors and Drug Abuse Patients. To answer the research objectives, the four focus of the researcher, namely the pre-interaction phase, the orientation phase, the working phase, and the termination phase of Counselor Therapeutic Communication in Rehabilitating Drug Abuse Patients at the National Narcotics Agency Clinic of West Java Province.This study uses qualitative research methods with descriptive studies. The number of informants in this study were four people, consisting of three key informants and one supporting informant. Data collection techniques used in this study are literature study, internet searching, indepth interviews, non-participant observation and documentation.The results of research conducted by the Clinical Counselor of the National Narcotics Board of West Java Province are the pre-interaction phase where the counselor studies patient data. The orientation phase in which the counselor performs the Screening approach and builds trusting relationships with the patient and the Assessment of the counselor ensures patient safety as well as establishes a counseling service plan, and a termination phase where a drug abuse counseling service has been completed and will be referred to post-rehabilitation

Therapeutic Communications Phase In Children Down Syndrom: Case Study In Bantul, Yogyakarta

Therapeutic communication is an attempt at healing through communication. In the case of Down Syndrome child therapy, therapists are required to pay attention to factors that influence the implementation of therapy so that communication is carried out effectively so that healing goals can be achieved. This study intends to describe the therapeutic communication phase of therapists with children with Down syndrome in forming independence in SLBN 1 Bantul, Yogyakarta. This study uses a qualitative descriptive type with 2 (two) pairs of informants, PT and LN . Data obtained through interviews, observations, and documentation. Based on the results of the study, it can be concluded that there are four therapeutic communication phases which include the pre-interaction phase, the orientation phase, the work phase, and the termination phase. In the work phase, the therapist uses YouTube in play therapy. The use of this new media has been proven to improve children's moods and thus speed healing. The four phases of therapeutic communication have been carried out effectively by a therapist informant and it is proven that children with down syndrome can experience changes toward healing in increasing independence, interacting, and building caring attitudes. The other informants did not carry out the four phases of therapeutic communication to the maximum, causing children to be lazy to attend school and slow to develop towards a better direction. Keywords: therapeutic communication, pre-interaction phase, orientation phase, work phase, termination phase