Therapy for myeloproliferative neoplasms: when, which agent, and how?

Abstract Myeloproliferative neoplasms, including polycythemia vera (PV), essential thrombocythemia, and myelofibrosis (MF) (both primary and secondary), are recognized for their burdensome symptom profiles, life-threatening complications, and risk of progression to acute leukemia. Recent advancements in our ability to diagnose and prognosticate these clonal malignancies have paralleled the development of MPN-targeted therapies that have had a significant impact on disease burden and quality of life. Ruxolitinib has shown success in alleviating the symptomatic burden, reducing splenomegaly and improving quality of life in patients with MF. The role and clinical expectations of JAK2 inhibition continues to expand to a variety of investigational arenas. Clinical trials for patients with MF focus on new JAK inhibitors with potentially less myelosuppression (pacritinib) or even activity for anemia (momelotinib). Further efforts focus on combination trials (including a JAK inhibitor base) or targeting new pathways (ie, telomerase). Similarly, therapy for PV continues to evolve with phase 3 trials investigating optimal frontline therapy (hydroxyurea or IFN) and second-line therapy for hydroxyurea-refractory or intolerant PV with JAK inhibitors. In this chapter, we review the evolving data and role of JAK inhibition (alone or in combination) in the management of patients with MPNs.

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Therapy for myeloproliferative neoplasms: when, which agent, and how?

Blood ◽

10.1182/blood-2014-05-577635 ◽

2014 ◽

Vol 124 (24) ◽

pp. 3529-3537 ◽

Cited By ~ 59

Author(s):

Holly L. Geyer ◽

Ruben A. Mesa

Keyword(s):

Quality Of Life ◽

Disease Burden ◽

Myeloproliferative Neoplasms ◽

Jak Inhibitors ◽

Symptom Profiles ◽

Risk Of Progression ◽

Life Threatening ◽

Jak2 Inhibition

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Resveratrol: A new potential therapeutic agent for melanoma?

Current Medicinal Chemistry ◽

10.2174/0929867326666191212101225 ◽

2019 ◽

Vol 26 ◽

Cited By ~ 2

Author(s):

Mohamad Hossein Pourhanifeh ◽

Kazem Abbaszadeh-Goudarzi ◽

Mohammad Goodarzi ◽

Sara G.M. Piccirillo ◽

Alimohammad Shafiee ◽

...

Keyword(s):

Quality Of Life ◽

Therapeutic Agent ◽

Current Knowledge ◽

Treatment Resistance ◽

Anti Cancer ◽

Apoptosis Inducer ◽

Life Threatening ◽

First Time

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

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Pain with Life-Threatening Illness: Its Perception and Control Are Inextricably Linked with Quality of Life

Pain Research and Management ◽

10.1155/2000/971487 ◽

2000 ◽

Vol 5 (4) ◽

pp. 271-275 ◽

Cited By ~ 5

Author(s):

S Robin Cohen ◽

Balfour M Mount

Keyword(s):

Quality Of Life ◽

Pain Control ◽

Essential Role ◽

Pain Perception ◽

Life Threatening Illness ◽

Emotional Aspects ◽

Life Threatening ◽

And Control

This article describes how the quality of life of people with a life-threatening illness is affected by pain, and how their pain is influenced by all aspects of their quality of life. These aspects include the physical, psychological, cognitive, social, and spiritual and existential domains. This concept of pain is placed in the context of Ron Melzack's work highlighting the essential role of cognitive and emotional aspects of pain perception, and their influence on pain control. These issues continue to be a guiding force in the authors' own work and that of many others working in the field.

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