scholarly journals Acetylation of C/EBPε is a prerequisite for terminal neutrophil differentiation

Blood ◽  
2015 ◽  
Vol 125 (11) ◽  
pp. 1782-1792 ◽  
Author(s):  
Marije Bartels ◽  
Anita M. Govers ◽  
Veerle Fleskens ◽  
Ana Rita Lourenço ◽  
Cornelieke E. Pals ◽  
...  
Keyword(s):  
Transcriptional Activity ◽  
Key Points ◽  
Specific Granules ◽  
Neutrophil Differentiation

Key Points C/EBPε acetylation regulates C/EBPε transcriptional activity. C/EBPε acetylation is required for neutrophil differentiation and the formation of neutrophil-specific granules.

scholarly journals NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation

2018 ◽  
Vol 2 (12) ◽  
pp. 1412-1416
Author(s):  
Louise E. Hogan ◽  
Christian Körner ◽  
Kristen Hobbs ◽  
Camille R. Simoneau ◽  
Cassandra Thanh ◽  
...  
Keyword(s):  
Cell Death ◽  
Transcriptional Activity ◽  
Cell Activation ◽  
Hematopoietic Cell Transplantation ◽  
Nk Cell ◽  
Killer Cell ◽  
Graft Versus Host ◽  
Key Points ◽  
Hiv 1

Key Points Graft-versus-host effects may lead to HIV-1 reactivation and cell death of infected pre-HCT CD4+ T cells. Natural killer cell activation correlates with in vitro HIV-1 transcriptional activity in the setting of HCT.

scholarly journals Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Blood ◽  
2013 ◽  
Vol 121 (22) ◽  
pp. 4541-4550 ◽  
Author(s):  
Hanna L. M. Rajala ◽  
Samuli Eldfors ◽  
Heikki Kuusanmäki ◽  
Arjan J. van Adrichem ◽  
Thomas Olson ◽  
...  
Keyword(s):  
Transcriptional Activity ◽  
Somatic Mutations ◽  
Sh2 Domain ◽  
Lymphocytic Leukemia ◽  
Large Granular Lymphocytic Leukemia ◽  
Key Points ◽  
First Time ◽  
Lgl Leukemia

Key Points Somatic mutations were discovered for the first time in the SH2 domain of the STAT5b gene in LGL leukemia. The mutations are activating and lead to increased phosphorylation and transcriptional activity of STAT5b.

scholarly journals Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation

Blood ◽  
1995 ◽  
Vol 85 (3) ◽  
pp. 812-817 ◽  
Author(s):  
N Borregaard ◽  
M Sehested ◽  
BS Nielsen ◽  
H Sengelov ◽  
L Kjeldsen
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Myeloid Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Specific Granules ◽  
Normal Human ◽  
Neutrophil Differentiation ◽  
Normal Human Bone Marrow ◽  
Marrow Cells

Differentiation and maturation of myeloid cells is characterized by the sequential acquisition of two distinct cytoplasmic granule subsets, azurophil granules and specific granules. We recently showed the existence of a third granule subset, gelatinase granules. To investigate whether appearance of gelatinase granules marks a further step in maturation of myeloid cells beyond the appearance of specific granules, we sorted normal human bone marrow cells into one of three groups according to maturity by centrifugation on Percoll density gradients. The biosynthesis of myeloperoxidase (MPO) (an azurophil granule marker), lactoferrin and neutrophil gelatinase-associated lipocalin NGAL (specific granules markers) and gelatinase was then studied in each of these groups. We found that gelatinase was synthesized mainly in the group containing band cells and segmented cells. This contrasted with lactoferrin and NGAL, which were synthesized almost exclusively in the group containing myelocytes and metamyelocytes, and with MPO, which was mainly synthesized in the group containing myeloblasts and promyelocytes. Immunocytochemistry was in full agreement with the biosynthesis data, and showed that gelatinase appears in band cells, whereas NGAL and lactoferrin both appear in myelocytes. Thus, acquisition of gelatinase granules marks a step in neutrophil differentiation beyond the appearance of specific granules.

TBLR1 fuses to retinoid acid receptor α in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia

Blood ◽  
2014 ◽  
Vol 124 (6) ◽  
pp. 936-945 ◽  
Author(s):  
Yirui Chen ◽  
Shouyun Li ◽  
Chunlin Zhou ◽  
Chengwen Li ◽  
Kun Ru ◽  
...  
Keyword(s):  
Acute Promyelocytic Leukemia ◽  
Transcriptional Activity ◽  
Fusion Gene ◽  
Chromosomal Translocation ◽  
Promyelocytic Leukemia ◽  
Acid Receptor ◽  
Key Points ◽  
Retinoid Acid

Key Points A novel RARα fusion gene, TBLR1-RARα, was found in rare cases of APL with t(3;17) chromosomal translocation. TBLR1-RARα exhibited diminished transcriptional activity by recruiting more corepressors compared with RARα.

scholarly journals Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells

Blood ◽  
2013 ◽  
Vol 121 (10) ◽  
pp. 1677-1689 ◽  
Author(s):  
Hironori Matsushima ◽  
Shuo Geng ◽  
Ran Lu ◽  
Takashi Okamoto ◽  
Yi Yao ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Hybrid Population ◽  
Gm Csf ◽  
Key Points ◽  
Neutrophil Differentiation

Key Points Both immature and mature neutrophils differentiate into a previously unrecognized hybrid population when cultured with GM-CSF. The resulting hybrids exhibit dual phenotype and functionality of both neutrophils and dendritic cells.

scholarly journals Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma

Blood ◽  
2016 ◽  
Vol 127 (5) ◽  
pp. 605-615 ◽  
Author(s):  
Nitin K. Agarwal ◽  
Chae H. Kim ◽  
Kranthi Kunkalla ◽  
Hiroyasu Konno ◽  
Youley Tjendra ◽  
...  
Keyword(s):  
B Cell ◽  
Transcriptional Activity ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Key Points ◽  
The Stability ◽  
Large B Cell

Key Points IKKβ, independently of NF-κB, regulates the stability and transcriptional activity of GLI1 oncogene. Combined inhibition of IKKβ and GLI1 activities synergistically decreases DLBCL cell viability in vivo and in vitro.

scholarly journals Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects

Blood ◽  
2013 ◽  
Vol 122 (25) ◽  
pp. 4090-4093 ◽  
Author(s):  
Jacqueline Stockley ◽  
Neil V. Morgan ◽  
Danai Bem ◽  
Gillian C. Lowe ◽  
Marie Lordkipanidzé ◽  
...  
Keyword(s):  
Amino Acid ◽  
Dna Binding ◽  
Transcriptional Activity ◽  
Dense Granule ◽  
Amino Acid Substitutions ◽  
Dna Binding Domain ◽  
Excessive Bleeding ◽  
Key Points ◽  
Dense Granule Secretion ◽  
Granule Secretion

Key Points Novel FLI1 and RUNX1 alterations were identified in 6 of 13 patients with excessive bleeding and platelet granule secretion defects. Two FLI1 alterations predicting amino acid substitutions in the DNA-binding domain of FLI1 abolished transcriptional activity of FLI1.

scholarly journals Genomic impact of transient low-dose decitabine treatment on primary AML cells

Blood ◽  
2013 ◽  
Vol 121 (9) ◽  
pp. 1633-1643 ◽  
Author(s):  
Jeffery M. Klco ◽  
David H. Spencer ◽  
Tamara L. Lamprecht ◽  
Shawn M. Sarkaria ◽  
Todd Wylie ◽  
...  
Keyword(s):  
Transcriptional Activity ◽  
Low Dose ◽  
Global Hypomethylation ◽  
Key Points

Key Points Decitabine treatment of in vitro expanded primary AML samples leads to global hypomethylation. Highly methylated CpGs are most affected by decitabine-induced hypomethylation, with little influence on transcriptional activity.

scholarly journals The molecular genetic background leading to the formation of the human erythroid-specific Xga/CD99 blood groups

2018 ◽  
Vol 2 (15) ◽  
pp. 1854-1864 ◽  
Author(s):  
Chih-Chun Yeh ◽  
Ching-Jin Chang ◽  
Yuh-Ching Twu ◽  
Chen-Chung Chu ◽  
Bi-Shan Liu ◽  
...  
Keyword(s):  
Blood Group ◽  
Genetic Background ◽  
Transcriptional Activity ◽  
Molecular Genetic ◽  
Genomic Region ◽  
Blood Groups ◽  
Key Points

Key Points SNP rs311103 is associated with human erythroid-specific Xga/CD99 blood group phenotypes. The erythroid GATA1 factor binds to the polymorphic rs311103 genomic region differentially, which affects transcriptional activity.

scholarly journals DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo

Blood ◽  
2013 ◽  
Vol 122 (17) ◽  
pp. 2978-2986 ◽  
Author(s):  
Beau R. Webber ◽  
Michelina Iacovino ◽  
Si Ho Choi ◽  
Jakub Tolar ◽  
Michael Kyba ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Transcriptional Activity ◽  
Direct Interaction ◽  
Key Points ◽  
Dna Methylation Profile ◽  
Promoter Usage ◽  
Distal Promoter ◽  
Definitive Hematopoiesis

Key Points DNA methylation profile of Runx1 locus correlates with transcriptional activity and promoter usage during blood development. Distal promoter hypomethylation is a novel signature of definitive hematopoiesis and is promoted in vitro by direct interaction with HoxB4.

Sign in / Sign up

Export Citation Format

Share Document