scholarly journals Correlation of Mutation Patterns with Patient Age in 2656 Cases with 11 Different Hematological Malignancies

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 16-17
Author(s):  
Anna Stengel ◽  
Manja Meggendorfer ◽  
Wolfgang Kern ◽  
Torsten Haferlach ◽  
Claudia Haferlach
Keyword(s):  
Hematological Malignancies ◽  
Older Age ◽  
Patient Age ◽  
Equal Distribution ◽  
Bivariate Correlation ◽  
Total Cohort ◽  
Age Related ◽  
Patient Âgé ◽  
Younger Age ◽  
Age Dependent

Background: Generally, DNA damage is counterbalanced by multiple pathways for DNA repair. However, by disturbances of this equilibrium, somatic cells accumulate mutations during development and aging. This increase has been implicated to be a major cause of not only aging but also of cancer development. Moreover, mutations in some genes (mainly DNMT3A, TET2, ASXL1) that are known to be present in patients with AML or MDS were also detected in individuals without hematological neoplasms (clonal hematopoiesis of indeterminate potential, CHIP) in an age-related manner. Aim: We correlated the mutation frequencies of 122 selected genes in 2656 cases with 11 different hematological malignancies (number of cases per entity ≥50 each) with age of the respective patients. Methods: Whole-genome sequencing (WGS) was performed for all 2656 patients. For this, 151bp paired-end reads were generated on NovaSeq 6000 machines (Illumina, San Diego, CA). For correlation analysis, the Pearson correlation coefficient (bivariate correlation) was used (SPSS version 19.0.0 software, IBM Corporation, Armonk, NY). For comparison of median values, the independent samples t test was applied (SPSS). All reported p-values are two-sided and were considered significant at p<0.05. Results: The age of the analyzed cohorts differed strongly, ranging from 37 years (median; range: 11 - 91 years) in T-ALL, 54 years (43 - 88) in FL and 54 years (0.1 - 93) in B-ALL to 73 years (23 - 93) in MDS and 74 years (50 - 92) in aCML. In the cohort of 2656 patients, totally 5709 mutations in the 122 analyzed genes were detected. A correlation of age with the numbers of mutations per patient was detected for the total cohort (median for patients ≤60 years: 1; >60 years: 2; p<0.001) and for AML (p<0.001), B-ALL (p=0.015), CLL (0.039), MDS (p<0.001), MPN (p<0.001) and T-ALL (p=0.005), but not for aCML, CML, FL, LPL and MM. This effect was less pronounced when CHIP-related genes (ASXL1, DNMT3A, TET2) were omitted from the cohort (total cohort: p=0.025; AML: 0.001; MDS: 0.001). When correlating the mutation frequencies with age, the strongest influence was found for AML, as 17 genes were significantly mutated in an age-related manner: mutations in KIT, POT1, RAD21, U2AF2 and WT1 were significantly correlated with younger age, whereas for ASXL1, BCOR, BCRR3, DNMT3A, ETV6, IDH2, RUNX1, SRSR2, TET2, TP53, U2AF1 and PHF6, a significant correlation with older age was observed. Of note, most mutations correlating with younger age were associated to an aberration known to occur itself in younger age, e.g. the vast majority of KIT mutations in AML were associated with t(8;21)(q22;q22)/RUNX1-RUNX1T1 or inv(16)(p13q22)/CBFB-MYH11 (22/25 cases, 88%), a similar observation was detected for RAD21 in AML (associated with t(8;21) in 8/19 cases, 42%). Age-dependent mutational profiles were also detected for CLL, B-ALL, MDS, MPN, T-ALL, FL, MM and LPL (see Table). No age-dependent differences in mutational patterns were detected for aCML and CML. The genes that were found to be mutated in most entities in older patients comprised TET2 (in 6 entities), TP53 (n=4), DNMT3A (n=3), ASXL1, BCOR, EZH2, GATA2 and IDH2 (n=2, respectively). By contrast, POT1 was found to be preferentially mutated in younger patients in 2 entities (AML and LPL). Moreover, for some mutations the relation to patient age was entity-specific: PHF6 mutations were correlated to younger age in CLL (median age mutated vs. unmutated: 43 years vs 67 years), but to older age in AML (74 vs. 68), similar to CD79B (older age: CLL, 93 vs. 67; younger age: LPL, 52 vs. 71) and NRAS (older age: T-ALL, 75 vs. 34, younger age: AML, 63 vs. 69, and MM, 65 vs. 70). Interestingly, all of the age-correlations that were detected recurrently remain even if CHIP-related genes were omitted from the cohort. Conclusions: (1) A number of mutations were found to be correlated to older age across entites, comprising CHIP-related (TET2, DNMT3A, ASXL1) but also other genes (e.g. TP53, EZH2, BCOR, GATA2, IDH2). These correlations were found to be independent of the presence of CHIP-related mutations. (2) A lower number of mutations was correlated with younger age and associated with other age-related aberrations. (3) Some mutations show varying age-relation dependent on the entity, e.g. PHF6 mutations (CLL, younger age; AML, older age; T-ALL, equal distribution), proposing differences in mutation mechanisms or selection dependent on the respective entitiy. Disclosures No relevant conflicts of interest to declare.

Classification of saphenous refluxes: implications for treatment

2008 ◽  
Vol 23 (1) ◽  
pp. 2-9 ◽  
Author(s):  
P Pittaluga ◽  
S Chastanet ◽  
B Rea ◽  
R Barbe
Keyword(s):  
Venous Insufficiency ◽  
Clinical Symptoms ◽  
Varicose Veins ◽  
Stage Iv ◽  
Older Age ◽  
Patient Age ◽  
Burning Pain ◽  
Venous Ulcers ◽  
Patient Âgé ◽  
Younger Age

Objective To determine the possible correlations of patient age, symptoms and signs with findings of Doppler duplex examination in limbs with varicose veins. Methods A total of 2275 ultrasound examinations were done on 2275 limbs of 1751 patients (421 men and 1330 women). Ages ranged from 21 to 94 years (mean 50). Symptoms of aching, heaviness, burning pain (venous neuropathy) were recorded, and signs of ankle hyperpigmentation, scars of healed ulcers and presence of open venous ulcers were noted. Results Presence of symptoms was associated with advancing patient age (50.7 vs. 48.8 years). Varicose veins without great saphenous reflux correlated with younger age (43 vs. 53.5 years). Presence of saphenofemoral junctional incompetence correlated with an older age (54.7 vs. 49.8 years), and reflux to the ankle (Hach stage IV) also correlated with older age (mean 63.7 years). A younger age was associated with less advanced signs (C0–C2: 49.1 vs. C4–C6: 60.1 years). Saphenous vein reflux without clinical varices was associated with more advanced signs (C4–C6: 21.3%). Conclusions Ageing is associated with advancing clinical symptoms, signs and increasing multifocal reflux in limbs with venous insufficiency. These facts support the concept of early treatment of venous insufficiency before predictable deterioration occurs.

scholarly journals Mutational patterns and their correlation to CHIP-related mutations and age in hematological malignancies

2021 ◽  
Author(s):  
Anna Stengel ◽  
Constance Baer ◽  
Wencke Walter ◽  
Manja Meggendorfer ◽  
Wolfgang Kern ◽  
...  
Keyword(s):  
Hematological Malignancies ◽  
Median Number ◽  
Patient Age ◽  
High Frequencies ◽  
Hematological Neoplasms ◽  
Patient Âgé ◽  
Younger Age ◽  
Genetic Landscape ◽  
Insight Into

Acquired somatic mutations are crucial for the development of the majority of cancers. We performed a comprehensive comparative analysis of the mutational landscapes and their correlation to CHIP-related (clonal hematopoiesis of indeterminate potential) mutations and patient age of 122 genes in 3096 cases with 28 different hematological malignancies. Differences were observed regarding (i) the median number of mutations (highest, median n=4: aCML, CMML, MDS/MPN-U, s-AML; lowest, n=0, CML, MLN-eo, MGUS, PPBL), (ii) specificity of certain mutations (high frequencies in e.g. aCML (ASXL1, 86%), FL (KMT2D, 87%; CREBBP, 73%), HCL (BRAF, 100%), LPL (MYD88, 98%; CXCR4, 51%), MPN (JAK2, 68%)), (iii) distribution of mutations (broad distribution within/across the myeloid/lymphoid lineage e.g. for TET2, ASXL1, DNMT3A, TP53, BCOR, ETV6), (iv) correlation of mutations to patient age (correlated to older age across entites: e.g. TET2, DNMT3A, ASXL1, TP53, EZH2, BCOR, GATA2, IDH2; younger age: e.g. KIT, POT1, RAD21, U2AF2; WT1), (v) correlation of mutation number per patient with age (total cohort (p<0.001), AML (p<0.001), B-ALL (p=0.015), CLL (0.039), MDS (p<0.001), MPN (p<0.001), T-ALL (p=0.005)). Moreover, we observed high frequencies of mutations in RUNX1, SRSF2, IDH2, NRAS, EZH2 in cases comprising at least one DTA mutation (DNMT3A, TET2, ASXL1), while in cases without DTA mutations TP53, KRAS, WT1, SF3B1 were more frequent across entities, suggesting differences in pathophysiology. These results give further insight into the complex genetic landscape and the role of DTA mutations in hematological neoplasms and define mutation-driven entities (MDS/MPN overlap, s-AML) in comparison to entities defined by chromosomal fusions (CML, MLN-eo).

scholarly journals Early CT features of COVID-19 pneumonia, association with patients’ age and duration of presenting complaint

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Reem M. EL Kady ◽  
Hosam A. Hassan ◽  
Tareef S. Daqqaq ◽  
Rania Makboul ◽  
Hanan Mosleh Ibrahim
Keyword(s):  
Pleural Effusion ◽  
Ground Glass Opacity ◽  
Ct Imaging ◽  
Older Age ◽  
Ground Glass ◽  
Imaging Features ◽  
Age Group ◽  
Patient Age ◽  
Atypical Features ◽  
Patient Âgé

Abstract Background Coronavirus disease (COVID-19) is a respiratory syndrome with a variable degree of severity. Imaging is a vital component of disease monitoring and follow-up in coronavirus pulmonary syndromes. The study of temporal changes of CT findings of COVID-19 pneumonia can help in better understanding of disease pathogenesis and prediction of disease prognosis. In this study, we aim to determine the typical and atypical CT imaging features of COVID-19 and discuss the association of typical CT imaging features with the duration of the presenting complaint and patients’ age. Results The lesions showed unilateral distribution in 20% of cases and bilateral distribution in 80% of cases. The lesions involved the lower lung lobes in 30% of cases and showed diffuse involvement in 58.2% of cases. The lesions showed peripheral distribution in 74.5% of cases. The most common pattern was multifocal ground glass opacity found in 72.7% of cases. Atypical features like cavitation and pleural effusion can occur early in the disease course. There was significant association between increased number of the lesions, bilaterality, diffuse pattern of lung involvement and older age group (≥ 50 years old) and increased duration of presenting complaint (≥ 4 days). There was significant association between crazy-paving pattern and increased duration of presenting complaint. No significant association could be detected between any CT pattern and increased patient age. Conclusion The most common CT feature of COVID-19 was multifocal ground glass opacity. Atypical features like cavitation and pleural effusion can occur early in the course of the disease. Our cases showed more extensive lesions with bilateral and diffuse patterns of distribution in the older age group and with increased duration of presenting complaint. There was a significant association between crazy-paving pattern and increased duration of presenting complaint. No significant association could be detected between any CT pattern and increased patient age.

Postoperative outcomes following closed head injury and craniotomy for evacuation of hematoma in patients older than 80 years

2012 ◽  
Vol 116 (1) ◽  
pp. 234-245 ◽  
Author(s):  
Darryl Lau ◽  
Abdulrahman M. El-Sayed ◽  
John E. Ziewacz ◽  
Priya Jayachandran ◽  
Farhan S. Huq ◽  
...  
Keyword(s):  
Head Injury ◽  
Hospital Stay ◽  
Intracranial Hemorrhage ◽  
Closed Head Injury ◽  
Older Age ◽  
Postoperative Outcomes ◽  
Medical Attention ◽  
Patient Age ◽  
Patient Âgé ◽  
Closed Head

Object Advances in the management of trauma-induced intracranial hematomas and hemorrhage (epidural, subdural, and intraparenchymal hemorrhage) have improved survival in these conditions over the last several decades. However, there is a paucity of research investigating the relation between patient age and outcomes of surgical treatment for these conditions. In this study, the authors examined the relation between patient age over 80 years and postoperative outcomes following closed head injury and craniotomy for intracranial hemorrhage. Methods A consecutive population of patients undergoing emergent craniotomy for evacuation of intracranial hematoma following closed head trauma between 2006 and 2009 was identified. Using multivariable logistic regression models, the authors assessed the relation between age (> 80 vs ≤ 80 years) and postoperative complications, intensive care unit stay, hospital stay, morbidity, and mortality. Results Of 103 patients, 27 were older than 80 years and 76 patients were 80 years of age or younger. Older age was associated with longer length of hospital stay (p = 0.014), a higher rate of complications (OR 5.74, 95% CI 1.29–25.34), and a higher likelihood of requiring rehabilitation (OR 3.28, 95% CI 1.13–9.74). However, there were no statistically significant differences between the age groups in 30-day mortality or ability to recover to functional baseline status. Conclusions The findings suggest that in comparison with younger patients, patients over 80 years of age may be similarly able to return to preinjury functional baselines but may require increased postoperative medical attention in the forms of rehabilitation and longer hospital stays. Prospective studies concerned with the relation between older age, perioperative parameters, and postoperative outcomes following craniotomy for intracranial hemorrhage are needed. Nonetheless, the findings of this study may allow for more informed decisions with respect to the care of elderly patients with intracranial hemorrhage.

scholarly journals SAT-168 Adrenal Incidentalomas: Impact of Patient Age on Referral Rates for Endocrine Evaluation

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Anthony Fryer ◽  
Sarah Hancock ◽  
Cherian George ◽  
Basil George Issa ◽  
Simon Lea ◽  
...  
Keyword(s):  
Age Groups ◽  
Adrenal Incidentaloma ◽  
Older Age ◽  
Age Group ◽  
Adrenal Incidentalomas ◽  
Patient Age ◽  
Radiology Reports ◽  
Patient Âgé ◽  
Mri Scans ◽  
Ct And Mri

Abstract It is estimated that the prevalence of adrenal incidentaloma increases with age: ~3% of those aged 50 years, rising to 10% in those >70 years (1). Given the aging population together with increased utilisation of cross-sectional imaging in the UK (eg CT urogram, MR angiogram), we explored the proportion of patients with adrenal incidentaloma by age based on current imaging trends. Furthermore, there is no information currently available on the relationship between age and pattern of endocrine referrals. We extracted data for all CT and MRI scans from Jan 2018-Oct 2019 and used key phrases in radiology reports (eg adrenal adenoma/lesion/mass/nodule/incidentaloma, incidental adrenal, indeterminate adrenal) to identify potential lesions. We also extracted data on patient age and referral patterns as identified by a logged referral or an attendance (new or follow-up) to endocrine clinic 3 months post index scan, stratified by 10 year age groups. Where possible, we excluded false hits (eg no adrenal lesion). Preliminary data showed that, of the 2604 potential lesions identified by CT and MRI scans, 78.7% were on patients aged over 60 years. The numbers of identified lesions gradually increased with age to a peak in the 71-80 year age group after which these declined. Whilst patients younger that 60 years had fewer potential lesions identified, they were more likely to be referred to endocrine services (73 out of 55 patients; 13.2%) than those in the older age group (168 out of 2049; 8.2%; p<0.001). Indeed there was a statistically significant trend towards decreasing referral with age group (Chi-squared test for trend; p<0.001). In conclusion, patients over 60 years have a higher number of potential adrenal incidentalomas. However, this group is less likely to be referred for endocrine evaluation. This is particularly concerning given the large number of scans requested and the higher prevalence of incidentalomas in this age group. This study represents preparatory work on innovations to enhance case detection, particularly in the older age groups (2). 1. Fassnacht M, Arlt W, Bancos I, et al. Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline. Eur J Endocrinol. 2016;175:G1-G34 2. Hanna FWF, Issa BG, Lea SC, George C, Golash A, Firn M, Ogunmekan S, Maddock E, Sim J, Xydopoulos G, Fordham R, Fryer AA. Adrenal lesions found incidentally: how to improve clinical and cost-effectiveness. BMJ Open Quality. 2019;In press.

Age-dependent Characteristics in Women with Breast Cancer: Mastectomy and Reconstructive Trends at an Urban Academic Institution

2016 ◽  
Vol 82 (3) ◽  
pp. 227-235 ◽  
Author(s):  
Katherine A. Rodby ◽  
Emilie Robinson ◽  
Kirstie K. Danielson ◽  
Karina P. Quinn ◽  
Anuja K. Antony
Keyword(s):  
Breast Cancer ◽  
Breast Reconstruction ◽  
Academic Institution ◽  
Bilateral Mastectomy ◽  
Autologous Reconstruction ◽  
Age Related ◽  
Younger Age ◽  
Age Dependent ◽  
Statistical Trends ◽  
Oncologic Treatment

Breast reconstruction is an important aspect of treatment after breast cancer. Postmastectomy reconstruction bears a significant impact on a woman's postsurgical confidence, sexuality, and overall well-being. Previous studies have inferred that women under age 40 years have unique characteristics that distinguish them from an older cohort. Identifying age-dependent trends will assist with counseling women on mastectomy and reconstruction. To identify age-dependent trends, 100 consecutive women were sampled from a prospectively maintained breast reconstruction database at an urban academic institution from June 2010 through June 2013. Women were placed into two cohorts <40 and ≥40 as well cohorts by decade (20s, 30s, 40s, 50s, and 60s). Statistical trends were reported as odds of risk per year of increasing age using logistic regression; linear regression, χ2, and Fischer's exact were used to compare <40 and ≥40 and split cohorts for comparison. Comorbidities, tumor staging, oncologic treatment including chemotherapy and radiation, disease characteristics and genetics, and mastectomy, reconstructive and symmetry procedures were evaluated. Statistical analysis was performed using SAS software. In 100 patients of the sample study cohort, 151 reconstructions were performed. Increasing age was associated with one or more comorbidities [odds ratio (OR) = 1.07, P = 0.005], whereas younger age was associated with metastatic disease (OR = 0.88, P = 0.006), chemotherapy (OR = 0.94, P = 0.01), and radiation (OR = 0.94, P = 0.006); split cohorts demonstrated similar trends ( P < 0.005). Mastectomy and reconstructive characteristics associated with younger age included bilateral mastectomy (OR = 0.94, P = 0.004), tissue expander (versus autologous flap) (OR = 0.94, P = 0.009), extra high implant type (OR = 0.94, P = 0.049), whereas increasing use of autologous flaps and contralateral mastopexy symmetry procedures (OR = 1.09, P = 0.02) were associated with an aging cohort. Increasing age was not associated with an increasing likelihood of complications ( P = 0.75). Age-related factors play a role in the treatment of patients with breast cancer. Younger women typically present with more aggressive features requiring oncologic treatment including chemotherapy and radiation. Mastectomy and reconstructive choices also demonstrate age-dependent characteristics. Women in younger age groups are more likely to pursue risk-reduction procedures and implant-based strategies, whereas older women had a higher propensity for abdominal-based autologous reconstruction. In addition, preferential reconstructive strategies correlate with age-dependent archetypical features of the breast (higher profile implants in younger patients; autologous reconstruction on affected side mimicking natural ptosis, and contralateral mastopexy in older patients). These trends seem to be consistent with each increasing year of age. Age-related preferences and expectations, age-dependent body habitus and breast shape, and lifetime risk play a role in the choices pursued for mastectomy and reconstruction.

Older Age Is An Independent Risk Factor in AML

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 555-555
Author(s):  
Thomas Buchner ◽  
Wolfgang E. Berdel ◽  
Claudia Haferlach ◽  
Susanne Schnittger ◽  
Torsten Haferlach ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Patients ◽  
Normal Karyotype ◽  
Older Age ◽  
Age Group ◽  
Risk Profiles ◽  
Mutation Status ◽  
Younger Patients ◽  
Age Related ◽  
Younger Age

Abstract Among the entire patients with AML the majority is 60 years of age or older. In present German multicenter AML Cooperative Group (AMLCG) trial the proportion of these older patients amounts to 54% of all 2734 patients enrolled and receiving intensive chemotherapy. While older age AML is increasingly recognized as a main challenge the therapeutic outcome unlike that in younger patients has remained constantly poor. Thus, the patients of ≥ 60y show an overall survival (OS) of 13% and a relapse rate (RR) of 82% at 5y versus 40% and 52% in younger patients. Age related differences in treatment and in risk profiles are commonly used to explain the differences in outcome. In the AMLCG 99 trial including 2734 patients 16 to 85 (median 61) years of age we investigated factors determining the disease biology and outcome. For induction treatment patients received standard dose TAD and high-dose AraC 3 (age &lt; 60y) and 1 (≥ 60y) g/m² × 6/mitoxantrone (HAM) or randomly HAM-HAM, for consolidation TAD, and for maintenance monthly reduced TAD randomized (in patients &lt; 60y) against autologous SCT. When compared with patients younger than 60y older patients had more frequent secondary AML (29% vs 17%, p&lt; 0.0001), unfavorable cytogenetics (29% vs 23%, p= 0.0004), less frequent favorable cytogenetics (4% vs 12%, p&lt; 0.0001), and NPM1mut/FLT3-ITDneg status (26% vs 34%, p&lt; 0.009) in those with normal karyotype, and overall even lower median WBC (7.360 vs 12.600/μl, p&lt; 0.0001) and LDH (340 vs 413 U/l, p&lt; 0.0001). A multivariate analysis identified independent risk factors determining therapeutic endpoints such as CR rate, OS, RR, and RFS. With similar results across all endpoints, risk factors for OS were age ≥ 60y (HR 1.96, 95% CI 1.75–2.17), AML secondary to MDS or cytotoxic treatment (1.28, 1.14–1.45), unfavorable karyotype (2.17, 1.92– 2.44), WBC &gt; 20×10³/μl (1.15, 1.02– 1.30), LDH &gt; 700U/L (1.32, 1.15– 1.52), favorable karyotype (0.49, 0.38– 0.63) and female gender (0.90, 0.81– 0.99). In the 891 patients with normal karyotype and complete mutation status risk factors for OS were age ≥ 60y (2.00, 1.64– 2.44), and NPM1mut/FLT3-ITDneg (0.39, 0.30– 0.49). Risk factors for RR overall were age ≥ 60y (2.04, 1.75– 2.38), unfavorable karyotype (2.08, 1.47– 2.13), LDH (1.41, 1.16– 1.72) and favorable karyotype (0.40, 0.29– 0.56). In patients with normal karyotype and complete mutation status risk factors for RR were age ≥ 60y (2.00, 1.56– 2.63), and NPM1mut/FLT3-ITDneg (0.32, 0.23– 0.43). Testing the role of older age in favorable subgroups, the 198 patients with CBF leukemia show an OS at 5 years of 27.5 (95% CI 12.0– 43.0) % in the older versus 69.4 (60.7– 78.2) % in the younger age group, and a RR of 56.6 (35.7– 77.3) % versus 25.0 (15.6– 34.4) %. Comparatively, the 264 patients with a normal karyotype and NPM1mut/FLT3-ITDneg show an OS of 37.1 (26.6– 47.5) % in the older versus 71.9 (63.4– 80.4) % in the younger age group, and a RR of 61.0 (47.8– 74.2) % versus 23.0 (14.0– 32.0) %. There was no influence by randomized treatment variables on any therapeutic endpoint. Conclusion: Considering the prognostic spectrum of all major historic or genetic subgroups older age maintains its dominant role not explained by age related differences in risk profiles. Even within CBF leukemias and sole NPM1 mutation as the best prognostic categories older age predicts for markedly shorter OS and higher RR. Thus, understanding older age AML requires further genetic and epigenetic work.

scholarly journals Analysis of Heart Rate Variability to Predict Patient Age in a Healthy Population

2007 ◽  
Vol 46 (02) ◽  
pp. 191-195 ◽  
Author(s):  
M. Matteucci ◽  
L. Mainardi ◽  
V. D. Corino
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Healthy Subjects ◽  
Principal Component ◽  
Healthy Population ◽  
Good Prediction ◽  
Patient Age ◽  
Age Related ◽  
Patient Âgé ◽  
Non Linear

Summary Objectives : To estimate age of healthy subjects by means of the heart rate variability (HRV) parameters thus assessing the potentiality of HRV indexes as a biomarker of age. Methods : Long-term indexes of HRV in time domain, frequency domain and non-linear parameters were computed on 24-hour recordings in a dataset of 63 healthy subjects (age range 20-76 years old). Then, as interbeat dynamics markedly change with age, showing a reduced HRV in older subjects, we tried to capture age-related influence on HRV by principal component analysis and to predict the subject age by means of a feedforward neural network. Results : The network provides good prediction of patient age, even if a slight overestimation in the younger subjects and a slight underestimation in the older ones were observed. In addition, the important contribution of non-linear indexes to prediction is underlined. Conclusions : HRV as a predictor of age may lead to the definition of a new biomarker of aging.

scholarly journals Interpretation of Sweat Sodium Results—The Effect of Patient Age

1989 ◽  
Vol 26 (1) ◽  
pp. 38-43 ◽  
Author(s):  
J M Kirk ◽  
A Westwood
Keyword(s):  
Cystic Fibrosis ◽  
Retrospective Study ◽  
Reference Ranges ◽  
Older Children ◽  
Patient Age ◽  
Age Related ◽  
Patient Âgé ◽  
Sweat Sodium ◽  
Sweat Tests

In a retrospective study of sweat tests performed on 650 patients, sweat sodium was shown to increase with age in children without cystic fibrosis. The clearest separation of children with and without cystic fibrosis was in the youngest infants, while the highest proportion of repeatedly equivocal results was in the older children. Applying age-related reference ranges did not resolve the equivocal cases without also missing some cases of cystic fibrosis.

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