Hematin administration to an adult with lead intoxication
Keyword(s):
Abstract Lead poisoning and acute intermittent porphyria (AIP) may exhibit similar neurologic manifestations, and they have in common elevated excretion of urinary aminolevulinic acid (ALA). Despite their similarities, the possible pathophysiologic connection between AIP and lead poisoning in not known. Because intravenous hematin administration has produced biochemical improvement in AIP, a hematin trial in lead intoxication was of interest with respect to some of the heme metabolism abnormalities observed in the condition. Significant diminution of urinary ALA and coproporphyrin excretion occurred in association with intravenous hematin administration.
1991 ◽
Vol 1056
(1)
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pp. 57-63
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2022 ◽
Vol 8
(4)
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pp. 274-277
Keyword(s):
2013 ◽
Vol 85
(3)
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pp. 1207-1214
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1968 ◽
Vol 17
(2)
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pp. 164-171
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Molecular and Biochemical Studies of Acute Intermittent Porphyria in 196 Patients and Their Families
2002 ◽
Vol 48
(11)
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pp. 1891-1900
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