scholarly journals Human immunodeficiency virus-related conditions in children and adults with hemophilia: rates, relationship to CD4 counts, and predictive value

Blood ◽  
1993 ◽  
Vol 81 (3) ◽  
pp. 828-834 ◽  
Author(s):  
ME Eyster ◽  
CS Rabkin ◽  
MW Hilgartner ◽  
LM Aledort ◽  
MV Ragni ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Weight Loss ◽  
Herpes Zoster ◽  
Oral Candidiasis ◽  
Age Groups ◽  
Relative Hazard ◽  
Cd4 Counts ◽  
Persistent Fever ◽  
Immunodeficiency Virus ◽  
Immunodeficiency Syndrome

Abstract To further elucidate the natural history of human immunodeficiency virus (HIV) infection, we studied intermediate HIV-related conditions occurring before acquired immunodeficiency syndrome (AIDS) in a prospectively observed multicenter cohort of 738 HIV-infected persons with hemophilia. We analyzed the frequency in adults and children of common HIV-related conditions and the relative risk of AIDS after occurrence of these conditions, controlling for age at seroconversion and the percentage of CD4+ lymphocytes. Thrombocytopenia was the most frequently observed condition with cumulative incidences of 43% +/- 7% in adults and 27% +/- 6% in children and adolescents by 10 years after seroconversion. Oral candidiasis, fever, weight loss, and non-AIDS pneumonia were two to four times more common in adults than children, whereas herpes zoster risk was similar in the two age groups. HIV- related conditions were infrequent during the first 4 years of infection, particularly in children. With the exception of thrombocytopenia, mean CD4 counts were less than 350 cells/microL at the onset of the conditions. The relative hazard of AIDS after oral candidiasis was 18 in children and 3.8 in adults. Relative hazard in adults was also increased after persistent fever (10), weight loss (3.2), and non-AIDS pneumonia (2.2). Herpes zoster and thrombocytopenia were not significantly associated with AIDS in either age group. We conclude that intermediate HIV-related conditions occur more frequently in adults than in children with hemophilia. Persistent fever is the strongest predictor of AIDS in adults, whereas oral candidiasis is the strongest predictor in children. These findings should facilitate the design and conduct of clinical trials as well as the management of HIV- infected children and adults.

scholarly journals Human immunodeficiency virus-related conditions in children and adults with hemophilia: rates, relationship to CD4 counts, and predictive value

Blood ◽  
1993 ◽  
Vol 81 (3) ◽  
pp. 828-834 ◽  
Author(s):  
ME Eyster ◽  
CS Rabkin ◽  
MW Hilgartner ◽  
LM Aledort ◽  
MV Ragni ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Weight Loss ◽  
Herpes Zoster ◽  
Oral Candidiasis ◽  
Age Groups ◽  
Relative Hazard ◽  
Cd4 Counts ◽  
Persistent Fever ◽  
Immunodeficiency Virus ◽  
Immunodeficiency Syndrome

To further elucidate the natural history of human immunodeficiency virus (HIV) infection, we studied intermediate HIV-related conditions occurring before acquired immunodeficiency syndrome (AIDS) in a prospectively observed multicenter cohort of 738 HIV-infected persons with hemophilia. We analyzed the frequency in adults and children of common HIV-related conditions and the relative risk of AIDS after occurrence of these conditions, controlling for age at seroconversion and the percentage of CD4+ lymphocytes. Thrombocytopenia was the most frequently observed condition with cumulative incidences of 43% +/- 7% in adults and 27% +/- 6% in children and adolescents by 10 years after seroconversion. Oral candidiasis, fever, weight loss, and non-AIDS pneumonia were two to four times more common in adults than children, whereas herpes zoster risk was similar in the two age groups. HIV- related conditions were infrequent during the first 4 years of infection, particularly in children. With the exception of thrombocytopenia, mean CD4 counts were less than 350 cells/microL at the onset of the conditions. The relative hazard of AIDS after oral candidiasis was 18 in children and 3.8 in adults. Relative hazard in adults was also increased after persistent fever (10), weight loss (3.2), and non-AIDS pneumonia (2.2). Herpes zoster and thrombocytopenia were not significantly associated with AIDS in either age group. We conclude that intermediate HIV-related conditions occur more frequently in adults than in children with hemophilia. Persistent fever is the strongest predictor of AIDS in adults, whereas oral candidiasis is the strongest predictor in children. These findings should facilitate the design and conduct of clinical trials as well as the management of HIV- infected children and adults.

scholarly journals Sonographic detection of abdominal pathologies in human immunodeficiency virus/acquired immunodeficiency syndrome patients and its correlation with CD4 counts – A prospective analysis

2020 ◽  
Vol 0 ◽  
pp. 1-8
Author(s):  
Tejas Kanthrao Mankeshwar ◽  
Ashok Kumar Sharma
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymph Nodes ◽  
Acquired Immunodeficiency Syndrome ◽  
Cd4 Count ◽  
Aids Patients ◽  
Cd4 Counts ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Objectives: Abdominal pathologies are the second most common after pulmonary diseases in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Ultrasonography (USG) is a vital imaging technique for the evaluation of abdominal pathologies. This study was aimed at evaluating the abdominal pathologies using USG in HIV/AIDS and further analysis of its correlation with CD4 count. Material and Methods: The present study was carried out on 392 HIV-positive patients with abnormal abdominal sonographic findings. All data were analyzed by Chi-square test and one-way analysis of variance using SPSS 16.0 software. Results: Of these 392 patients, 66.3% were males, the mean age was 35.7 years, (range 7–64 years) and most of them were in 4th decade. On ultrasonographic evaluation, spleen was involved in 45.2% patients and liver as well as lymph nodes each was involved in 43.6% patients. Other cases displayed ascites and bowel thickening in 5.3% and 3.8% patients, respectively. Less involvement of kidney (2.3%), pancreas (1.5%), and biliary system (1.3%) was observed. In addition, pathologies such as hepatomegaly, splenomegaly, splenic microabscess, focal pancreatic lesion, mesenteric, and periportal lymphadenopathy showed significant correlation with CD4 counts. Lymphoma was found in 1% of patients, involving liver, pancreas, and retroperitoneal lymph nodes. Conclusion: Our study highlights the clinical utility of abdominal USG in HIV/AIDS patients. CD4 counts largely affect the differential diagnosis in HIV/AIDS patients. USG findings interpreted in the context of CD4 count may help in guiding the exact diagnosis.

scholarly journals Karakteristik pasien, jenis terapi, dan tingkat imunosupresi hasil terapi pada wanita penderita HIV/AIDS dengan kandidiasis oralPatient characteristics, type of therapy, and immunosuppression level of therapy outcomes in HIV/AIDS female patients with oral candidiasis

2020 ◽  
Vol 32 (2) ◽  
pp. 150
Author(s):  
An Nisaa Mardhatillah ◽  
Sri Tjahajawati ◽  
Irna Sufiawati
Keyword(s):  
High School ◽  
Human Immunodeficiency Virus ◽  
Oral Candidiasis ◽  
Patient Characteristics ◽  
Therapy Outcomes ◽  
Female Patients ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Pendahuluan: Human Immunodeficiency Virus (HIV) adalah virus yang menyerang sel darah putih dan menyebabkan kumpulan gejala klinis yang disebut Acquired Immunodeficiency Syndrome (AIDS). HIV/AIDS menjadi faktor predisposisi infeksi kandidiasis oral. Ketidakadilan gender serta minimnya pengetahuan tentang kesehatan reproduksi dan hak seksualitas menyebabkan kerentanan penularan infeksi HIV/AIDS terhadap wanita. Penelitian ini bertujuan untuk mengetahui karakteristik pasien, jenis terapi, dan tingkat imunosupresi pada wanita penderita HIV/AIDS dengan kandidiasis oral. Metode: Jenis penelitian deskriptif menggunakan data sekunder berupa rekam medis pasien HIV/AIDS tahun 2013-2017, dengan kriteria inklusi wanita penderita kandidiasis oral,  terapi ARV, tingkat imunosupresi. berdasarkan jumlah sel T CD4. Kriteria eksklusi adalah penderita yang berhenti mengikuti penelitian sebelum selesai. Hasil: Terdapat 116 dari 328 (35%) pasien wanita penderita HIV/AIDS mengalami kandidiasis oral. Kelompok sosial mayoritas adalah ibu rumah tangga. Sejumlah 83 dari 84 sampel (99%) berada pada tingkat imunosupresi berat sebelum penerapan ARV. Jumlah wanita HIV/AIDS dengan kandidiasis oral terbanyak yaitu pada usia 20-30 tahun (44%), 68% berstatus ibu rumah tangga (atau tidak bekerja), dengan pendidikan terakhir mayoritas Sekolah Menengah Atas (SMA) sebanyak 53%, dan sebanyak 68% status pernikahannya menikah atau memiliki pasangan tetap. Simpulan: Sebagian besar wanita penderita HIV/AIDS mengalami infeksi oportunistik kandidiasis oral. Karakteristik wanita penderita HIV/AIDS adalah mayoritas berusia 20-30 tahun, memiliki tingkat pendidikan SMA, berasal dari kalangan ibu rumah tangga / tidak memiliki pekerjaan, dan memiliki status menikah atau memiliki pasangan tetap. Jenis terapi yang banyak diberikan adalah terapi ARV lini pertama. Tingkat imunosupresi pada wanita penderita HIV/AIDS dengan kandidiasis oral yang diberikan terapi ARV mayoritas masuk ke dalam kategori tingkat imunosupresi sedang.Kata kunci: Wanita, kandidiasis oral, HIV/AIDS. ABSTRACTIntroduction: Human Immunodeficiency Virus (HIV) is a virus that attacks white blood cells and causes several clinical symptoms called Acquired Immunodeficiency Syndrome (AIDS). HIV/AIDS is a predisposing factor for oral candidiasis infection. Gender inequality and lack of knowledge regarding reproductive health and sexuality rights lead to the vulnerability of HIV/AIDS infection in women. This study was aimed to determine the patient characteristics, type of therapy, and the immunosuppression level of therapy outcomes of the female patients with oral candidiasis. Methods: The research was descriptive using the secondary data from medical records of HIV-AIDS patients in the period of 2013-2017. Inclusion criteria were female patients with oral candidiasis, treated with ARV-type medication, immunosuppression based on the t-cell CD4 level. Results: There were 116 out of 328 (35%) HIV/AIDS female patients with oral candidiasis. The majority of the social groups were housewives. There was 83 out of 84 samples (99%) at the level of severe immunosuppression prior to the application of ARV medications. The highest number of HIV/AIDS female patients with oral candidiasis was at the age of 20-30 years (44%), 68% were housewives (or unoccupied), the majority of their last education was high school graduate (53%), and 68% of their marital status was married or had a permanent partner. Conclusion: Most HIV/AIDS female patients experience opportunistic infection (oral candidiasis). The patients’ characteristics were the majority in 20-30 years old age group, have a high school education level, homemakers / unoccupied, and have the marital status of married or had a permanent partner. The type of therapy mostly given was first-line ARV therapy. The majority of HIV / AIDS female patients with oral candidiasis who were given ARV therapy were in the moderate immunosuppression level.Keywords: Female, oral candidiasis, HIV/AIDS.

scholarly journals Depression in Children with HIV Infection: A Case Series

2005 ◽  
Vol 10 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Joshua Caballero ◽  
Katalin I. Koranyi ◽  
Michael T. Brady ◽  
Milap C. Nahata
Keyword(s):  
Human Immunodeficiency Virus ◽  
Depressive Symptoms ◽  
Adverse Events ◽  
Pediatric Patients ◽  
Case Series ◽  
Cd4 Counts ◽  
Viral Loads ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

About 46,000 individuals younger than 25 years of age currently have a diagnosis of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). During their lifetime, approximately one-third of patients with HIV may develop depression. While antidepressants have been studied in adults with HIV, no data exist to support the use of antidepressants in children and adolescents with HIV. We report a case series of seven pediatric patients with HIV who were prescribed antidepressants. Six of seven patients had mild to moderate improvements in depressive symptoms. None of our patients experienced any suicidal ideations, and adverse events were minor. No drug-drug interactions were reported, and no significant changes in CD4 counts, CD4 percentages, or viral loads occurred during antidepressant therapy. Placebo-controlled, randomized studies are needed to confirm our results in this patient population.

Tingkat Pengetahuan Mahasiswa Tentang Hiv/Aids Di Akademi Kebidanan Sandi Karsa Makassar

2017 ◽  
Vol 5 (2) ◽  
pp. 1-12
Author(s):  
Nur Syamsi NL
Keyword(s):  
Human Immunodeficiency Virus ◽  
Acquired Immunodeficiency Syndrome ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

AIDS (Acquired Immunodeficiency Syndrome) adalah syndrom yang timbul akibat adanya virus HIV (Human Immunodeficiency Virus) yang menyerang sistem kekebalan tubuh manusia. HIV/AIDS dapat menular melalui darah, sperma, cairan vagina, dan ASI (Air Susu Ibu). Penelitian ini dilakukan di Akademi Kebidanan Sandi Karsa Makassar yang terletak di jalan Bung lorong 2, Kelurahan Tamalanrea, Kecamatan Tamalanrea Jaya, Makassar. Jenis penelitian yang digunakan dalam penelitian ini bersifat deskriptif. Besarnya sampel yang digunakan adalah 30 responden dari 600 populasi yang dipilih secara Total Sampling. Di mana dalam pengambilan data digunakan instrumen berupa kuesioner yang dibagikan kepada responden. Dari keseluruhan responden didapatkan tingkat pengetahuan mahasiswa Akademi Kebidanan Sandi Karsa Makassar yang diteliti didapat 15 mahasiswa (50%) yang tingkat pengetahuan baik tentang HIV/AIDS dan terdapat 14 mahasiswa (46,7%) yang tingkat pengetahuan cukup tentang HIV/AID dan terdapat 1 mahasiswa (3,3%) yang tingkat pengetahuan kurang tentang HIV/AIDS

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