The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community

2022 ◽  
pp. 2101821
Author(s):  
Jenna McNeill ◽  
Ariel Chernofsky ◽  
Matthew Nayor ◽  
Farbod N. Rahaghi ◽  
Raul San Jose Estepar ◽  
...  
Keyword(s):  
Lung Function ◽  
Oxygen Uptake ◽  
Blood Vessel ◽  
Exercise Capacity ◽  
Cardiorespiratory Fitness ◽  
Cardiopulmonary Exercise Testing ◽  
Pulmonary Vasculature ◽  
Uptake Efficiency ◽  
Vessel Volume ◽  
Oxygen Uptake Efficiency Slope

IntroductionCardiorespiratory fitness is not limited by pulmonary mechanical reasons in the majority of adults. However, the degree to which lung function contributes to exercise response patterns among ostensibly healthy individuals remains unclear.MethodsWe examined 2314 Framingham Heart Study participants who underwent cardiopulmonary exercise testing (CPET) and pulmonary function testing. We investigated the association of FEV1, FVC, FEV1/FVC and DLCO with the primary outcome of peak VO2, along with other CPET parameters using multivariable linear regression. Finally, we investigated the association of total and peripheral pulmonary blood vessel volume with peak VO2.ResultsWe found lower FEV1, FVC and DLCO were associated with lower peak VO2. For example, a one-liter lower FEV1 and FVC were associated with 7.1% (95% CI: 5.1%, 9.1%) and 6.0% (95% CI: 4.3%, 7.7%) lower peak VO2, respectively. By contrast, FEV1/FVC ratio was not associated with peak VO2. Lower lung function was associated with lower oxygen uptake efficiency slope oxygen pulse slope, VO2 at AT, VE at AT and breathing reserve. In addition, lower total and peripheral pulmonary blood vessel volume were associated with a lower peak VO2.ConclusionIn a large, community-based cohort of adults, we found lower FEV1, FVC and DLCO were associated with lower exercise capacity, as well as oxygen uptake efficiency slope and ventilatory efficiency. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak VO2. These findings underscore the importance of lung function and blood vessel volume as contributors to overall exercise capacity.

scholarly journals Oxygen uptake efficiency slope: a reliable surrogate parameter for exercise capacity in healthy and cardiac children?

2020 ◽  
Vol 105 (12) ◽  
pp. 1167-1174
Author(s):  
Arthur Gavotto ◽  
D'arcy Vandenberghe ◽  
Hamouda Abassi ◽  
Helena Huguet ◽  
Valerie Macioce ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Tertiary Care ◽  
Multivariable Analysis ◽  
Female Gender ◽  
Index Number ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Uptake Efficiency ◽  
Oxygen Uptake Efficiency Slope

ObjectivesCardiopulmonary exercise test (CPET) provides accurate evaluation of physical capacity and disease severity in children with congenital heart disease (CHD). However, full participation to obtain optimal measure of VO2max may be difficult. As an alternative, the oxygen uptake efficiency slope (OUES) is a reproducible and reliable parameter measured during CPET, which does not require a maximal exercise to be interpretable. This study aimed to evaluate the OUES of a large cohort of children with CHD, in comparison with healthy controls. We also intended to identify, in this specific population, the clinical and CPET variables associated with the OUES.MethodsThis cross-sectional study was carried out between November 2010 and September 2015 in two tertiary care paediatric and congenital cardiology centres.Results709 children were included (407 CHD and 302 healthy controls). The association of clinical characteristics with weight-normalised OUES (OUESkg) was studied using a multivariable analysis. The mean OUESkg was significantly lower in CHD than in healthy controls (38.6±8.5 and 43.9±8.5; p<0.001, respectively), especially in the most severe CHD. The OUESkg correlated with VO2max (r=0.85, p<0.001), with cut-off values for normal exercise capacity of 38.4 in boys and 31.0 in girls. The decrease of OUESkg was associated with increased age, increased Body Mass Index, number of cardiac catheter or surgical procedures, female gender and decreased forced vital capacity (Z-score).ConclusionThe OUES is significantly impaired in children with CHD and strongly correlates with VO2max. The OUES has the same clinical determinants as VO2max and therefore may be of interest in submaximal exercise.Trial registration numberNCT01202916.

Validity Of Six-minute Oxygen Uptake Efficiency Slope In Obese Children To Determine Cardiorespiratory Fitness

2016 ◽  
Vol 48 ◽  
pp. 1023
Author(s):  
Jeff S. Coombes ◽  
Concetta E. Masterson ◽  
Matthew P. Wallen ◽  
Charlotte B. Ingul ◽  
Peter S.W Davies ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Cardiorespiratory Fitness ◽  
Obese Children ◽  
Uptake Efficiency ◽  
Oxygen Uptake Efficiency Slope

Validity of the Oxygen Uptake Efficiency Slope in Children With Cystic Fibrosis and Mild-To-Moderate Airflow Obstruction

2012 ◽  
Vol 24 (1) ◽  
pp. 129-141 ◽  
Author(s):  
Bart C. Bongers ◽  
Erik H.J. Hulzebos ◽  
Bert G.M. Arets ◽  
Tim Takken
Keyword(s):  
Cystic Fibrosis ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Ventilatory Threshold ◽  
Airflow Obstruction ◽  
Exercise Duration ◽  
Uptake Efficiency ◽  
Cardiopulmonary Exercise ◽  
Cardiopulmonary Exercise Capacity ◽  
Oxygen Uptake Efficiency Slope

Purpose: The oxygen uptake efficiency slope (OUES) has been proposed as an ‘effort-independent’ measure of cardiopulmonary exercise capacity, which could be used as an alternative measurement for peak oxygen uptake (VO2peak) in populations unable or unwilling to perform maximal exercise. The aim of the current study was to investigate the validity of the OUES in children with cystic fibrosis (CF). Methods: Exercise data of 22 children with CF and mild to moderate airflow obstruction were analyzed and compared with exercise data of 22 healthy children. The OUES was calculated using data up to three different relative exercise intensities, namely 50%, 75%, and 100% of the total exercise duration, and normalized for body surface area (BSA). Results: Only the OUES/BSA using the first 50% of the total exercise duration was significantly different between the groups. OUES/BSA values determined at different exercise intensities differed significantly within patients with CF and correlated only moderately with VO2peak and the ventilatory threshold. Conclusion: The OUES is not a valid submaximal measure of cardiopulmonary exercise capacity in children with mild to moderate CF, due to its limited distinguishing properties, its nonlinearity throughout progressive exercise, and its moderate correlation with VO2peak and the ventilatory threshold.

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